| Specific Knockout of Notch-1 in Macrophages Modulate the Progression of Hepatic Insulin Resistance in HFD Fed Mice via Regulating IRE1alpha-XBP1 Signals. | Specific Knockout of Notch-1 in Macrophages Modulate the Progression of Hepatic Insulin Resistance in HFD Fed Mice via Regulating IRE1α-XBP1 Signals.
Zhou W, Ren S, Lu Y, Wang Y, Feng L, Gao Q. | 05/13/2024 |
| Impaired T cell IRE1alpha/XBP1 signaling directs inflammation in experimental heart failure with preserved ejection fraction. | Impaired T cell IRE1α/XBP1 signaling directs inflammation in experimental heart failure with preserved ejection fraction.
Smolgovsky S, Bayer AL, Kaur K, Sanders E, Aronovitz M, Filipp ME, Thorp EB, Schiattarella GG, Hill JA, Blanton RM, Cubillos-Ruiz JR, Alcaide P., Free PMC Article | 01/3/2024 |
| Identification and functional coordination analysis of gene co-expression networks in different tissues of XBP1 cartilage-specific deficient mice. | Identification and functional coordination analysis of gene co-expression networks in different tissues of XBP1 cartilage-specific deficient mice.
Li X, Pan Y, Liu K, Yang Y, Ye Y, Xu Q, Fan M, Guo F. | 12/5/2023 |
| Essential Role of XBP1 in Maintaining Photoreceptor Synaptic Integrity in Early Diabetic Retinopathy. | Essential Role of XBP1 in Maintaining Photoreceptor Synaptic Integrity in Early Diabetic Retinopathy.
McLaughlin T, Wang G, Medina A, Perkins J, Nihlawi R, Seyfried D, Hu Z, Wang JJ, Zhang SX., Free PMC Article | 12/1/2023 |
| The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis. | The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis.
Duran-Aniotz C, Poblete N, Rivera-Krstulovic C, Ardiles ÁO, Díaz-Hung ML, Tamburini G, Sabusap CMP, Gerakis Y, Cabral-Miranda F, Diaz J, Fuentealba M, Arriagada D, Muñoz E, Espinoza S, Martinez G, Quiroz G, Sardi P, Medinas DB, Contreras D, Piña R, Lourenco MV, Ribeiro FC, Ferreira ST, Rozas C, Morales B, Plate L, Gonzalez-Billault C, Palacios AG, Hetz C., Free PMC Article | 09/12/2023 |
| Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy. | Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy.
Liu Z, Nan P, Gong Y, Tian L, Zheng Y, Wu Z. | 06/26/2023 |
| An XBP1s-PIM-2 positive feedback loop controls IL-15-mediated survival of natural killer cells. | An XBP1s-PIM-2 positive feedback loop controls IL-15-mediated survival of natural killer cells.
Ma S, Han J, Li Z, Xiao S, Zhang J, Yan J, Tang T, Barr T, Kraft AS, Caligiuri MA, Yu J., Free PMC Article | 03/21/2023 |
| Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice. | Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice.
Wang Z, Li Q, Kolls BJ, Mace B, Yu S, Li X, Liu W, Chaparro E, Shen Y, Dang L, Del Águila Á, Bernstock JD, Johnson KR, Yao J, Wetsel WC, Moore SD, Turner DA, Yang W., Free PMC Article | 03/16/2023 |
| [Crosstalk between activating transcription factor 6 and the inositol-requiring enzyme 1-X-box binding protein 1 pathway in oxygen-glucose deprivation/reoxygenation-injured HT22 cells]. | [Crosstalk between activating transcription factor 6 and the inositol-requiring enzyme 1-X-box binding protein 1 pathway in oxygen-glucose deprivation/reoxygenation-injured HT22 cells].
Tang T, Lian Y, Lu L, Xu S, Yu Z. | 03/16/2023 |
| XBP1 Activation Reduces Severity of Polycystic Kidney Disease due to a Nontruncating Polycystin-1 Mutation in Mice. | XBP1 Activation Reduces Severity of Polycystic Kidney Disease due to a Nontruncating Polycystin-1 Mutation in Mice.
Krappitz M, Bhardwaj R, Dong K, Staudner T, Yilmaz DE, Pioppini C, Westergerling P, Ruemmele D, Hollmann T, Nguyen TA, Cai Y, Gallagher AR, Somlo S, Fedeles S., Free PMC Article | 02/4/2023 |
| Polystyrene nanoplastics aggravates lipopolysaccharide-induced apoptosis in mouse kidney cells by regulating IRE1/XBP1 endoplasmic reticulum stress pathway via oxidative stress. | Polystyrene nanoplastics aggravates lipopolysaccharide-induced apoptosis in mouse kidney cells by regulating IRE1/XBP1 endoplasmic reticulum stress pathway via oxidative stress.
Li Z, Xu T, Peng L, Tang X, Chi Q, Li M, Li S. | 01/21/2023 |
| Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury. | Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury.
Liu X, Khalafalla M, Chung C, Gindin Y, Hubchak S, LeCuyer B, Kriegermeier A, Zhang D, Qiu W, Ding X, Fang D, Green R., Free PMC Article | 12/3/2022 |
| Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. | Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.
Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, Hung MD, Vidal R, Fuentealba M, Miedema T, Duran-Aniotz C, Diaz J, Ibaceta-Gonzalez C, Sabusap CM, Bermedo-Garcia F, Mujica P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi SP, Lipton SA, Kennedy BK, Henriquez JP, Cárdenas JC, Plate L, Palacios AG, Hetz C., Free PMC Article | 11/26/2022 |
| The IRE1alpha-XBP1s Arm of the Unfolded Protein Response Activates N-Glycosylation to Remodel the Subepithelial Basement Membrane in Paramyxovirus Infection. | The IRE1α-XBP1s Arm of the Unfolded Protein Response Activates N-Glycosylation to Remodel the Subepithelial Basement Membrane in Paramyxovirus Infection.
Zhao Y, Qiao D, Skibba M, Brasier AR., Free PMC Article | 09/3/2022 |
| XBP1 Regulates the Transcription of HIF-1a in BALB/c Mice with Chronic Rhinosinusitis without Polyps. | XBP1 Regulates the Transcription of HIF-1a in BALB/c Mice with Chronic Rhinosinusitis without Polyps.
Qu X, Li H, Meng L., Free PMC Article | 08/6/2022 |
| Role of XBP1 in regulating the progression of non-alcoholic steatohepatitis. | Role of XBP1 in regulating the progression of non-alcoholic steatohepatitis.
Wang Q, Zhou H, Bu Q, Wei S, Li L, Zhou J, Zhou S, Su W, Liu M, Liu Z, Wang M, Lu L. | 07/23/2022 |
| XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury. | XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury.
Liu Z, Wang M, Wang X, Bu Q, Wang Q, Su W, Li L, Zhou H, Lu L., Free PMC Article | 05/14/2022 |
| XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice. | XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice.
Lee K, Chan JY, Liang C, Ip CK, Shi YC, Herzog H, Hughes WE, Bensellam M, Delghingaro-Augusto V, Koina ME, Nolan CJ, Laybutt DR., Free PMC Article | 05/14/2022 |
| Pharmacologic IRE1alpha kinase inhibition alleviates aortic dissection by decreasing vascular smooth muscle cells apoptosis. | Pharmacologic IRE1α kinase inhibition alleviates aortic dissection by decreasing vascular smooth muscle cells apoptosis.
Zhang W, Wang M, Gao K, Zhong X, Xie Y, Dai L, Liu W, Liu Y, He X, Li S, Madhusudhan T, Wang H, Zeng H., Free PMC Article | 04/23/2022 |
| Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology. | Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology.
El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas-Gervais S, Morais VA, You H, Qi L, Salazar M, Ozcan U, Chami M, Checler F, Alves da Costa C., Free PMC Article | 04/16/2022 |
| The MEK inhibitor U0126 ameliorates diabetic cardiomyopathy by restricting XBP1's phosphorylation dependent SUMOylation. | The MEK inhibitor U0126 ameliorates diabetic cardiomyopathy by restricting XBP1's phosphorylation dependent SUMOylation.
Wang T, Wu J, Dong W, Wang M, Zhong X, Zhang W, Dai L, Xie Y, Liu Y, He X, Liu W, Madhusudhan T, Zeng H, Wang H., Free PMC Article | 03/19/2022 |
| Unspliced XBP1 Counteracts beta-Catenin to Inhibit Vascular Calcification. | Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification.
Yang L, Dai R, Wu H, Cai Z, Xie N, Zhang X, Shen Y, Gong Z, Jia Y, Yu F, Zhao Y, Lin P, Ye C, Hu Y, Fu Y, Xu Q, Li Z, Kong W. | 02/26/2022 |
| Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. | Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity.
Madhavan A, Kok BP, Rius B, Grandjean JMD, Alabi A, Albert V, Sukiasyan A, Powers ET, Galmozzi A, Saez E, Wiseman RL., Free PMC Article | 02/19/2022 |
| Mechanisms of liver injury in high fat sugar diet fed mice that lack hepatocyte X-box binding protein 1. | Mechanisms of liver injury in high fat sugar diet fed mice that lack hepatocyte X-box binding protein 1.
Liu X, Taylor SA, Gromer KD, Zhang D, Hubchak SC, LeCuyer BE, Iwawaki T, Shi Z, Rockey DC, Green RM., Free PMC Article | 02/19/2022 |
| Constitutive expression of spliced XBP1 causes perinatal lethality in mice. | Constitutive expression of spliced XBP1 causes perinatal lethality in mice.
Xu Q, Zhang H, Wang S, Qin C, Lu Y., Free PMC Article | 02/19/2022 |