| WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells. | WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells.
Datta A, Biswas K, Sommers JA, Thompson H, Awate S, Nicolae CM, Thakar T, Moldovan GL, Shoemaker RH, Sharan SK, Brosh RM Jr., Free PMC Article | 12/11/2021 |
| These results suggest that a great number of endoplasmic reticulum (ER) gene products are regulated at the post-transcriptional level in the liver of Wrn mutant mice exhibiting an ER stress response. | Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein.
Aumailley L, Roux-Dalvai F, Kelly I, Droit A, Lebel M., Free PMC Article | 06/30/2018 |
| A mislocalization of the Wrn mutant protein in the liver endoplasmic reticulum fraction increased oxidative stress in that cellular compartment. Vitamin C reversed this oxidative stress. | Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase.
Aumailley L, Dubois MJ, Garand C, Marette A, Lebel M. | 09/10/2016 |
| The deleterious effects of the helicase-deficient Wrn protein are mediated by the dysfunction of several cellular organelles. | Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.
Aumailley L, Garand C, Dubois MJ, Johnson FB, Marette A, Lebel M., Free PMC Article | 06/4/2016 |
| Data suggest that, in the context of Wrn deficiency-related telomere dysfunction, loss of p16Ink4a function could prevent cells from senescence. | Loss of p16(Ink4a) function rescues cellular senescence induced by telomere dysfunction.
Zhang X, Wu X, Tang W, Luo Y., Free PMC Article | 10/31/2015 |
| The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers. | The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.
Chung L, Onyango D, Guo Z, Jia P, Dai H, Liu S, Zhou M, Lin W, Pang I, Li H, Yuan YC, Huang Q, Zheng L, Lopes J, Nicolas A, Chai W, Raz D, Reckamp KL, Shen B., Free PMC Article | 04/11/2015 |
| Studies show that in the context of Myc-associated tumorigenesis, loss of Wrn amplifies the DNA damage response, both in preneoplastic and neoplastic tissue, engaging activation of tumor suppressor pathways. | MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
Moser R, Toyoshima M, Robinson K, Gurley KE, Howie HL, Davison J, Morgan M, Kemp CJ, Grandori C., Free PMC Article | 10/20/2012 |
| embryonic fibroblasts lacking a functional Wrn helicase inhibited the immortalization of Safb1-null cells. These results indicate that an intact Wrn protein is required for immortalization and tumorigenesis in Safb1-null mice. | The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold attachment factor B1 deficient mice.
Lachapelle S, Oesterreich S, Lebel M., Free PMC Article | 08/13/2011 |
| BCR/ABL-mediated stimulation of WRN modulates the efficiency and fidelity of major DSB repair mechanisms to protect leukemia cells from apoptosis and to facilitate genomic instability. | BCR/ABL stimulates WRN to promote survival and genomic instability.
Slupianek A, Poplawski T, Jozwiakowski SK, Cramer K, Pytel D, Stoczynska E, Nowicki MO, Blasiak J, Skorski T., Free PMC Article | 05/7/2011 |
| WRN has a role in processing specific types of homologous recombination intermediates as well as an important function in nonhomologous recombination | Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes.
Rahn JJ, Lowery MP, Della-Coletta L, Adair GM, Nairn RS., Free PMC Article | 02/5/2011 |
| results demonstrate that WRN loss confers a strong cellular phenotype in early passage human - though not mouse - primary fibroblasts. | Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.
Dhillon KK, Sidorova JM, Albertson TM, Anderson JB, Ladiges WC, Rabinovitch PS, Preston BD, Monnat RJ Jr., Free PMC Article | 04/12/2010 |
| Wrn null mice have impaired glucose homeostasis and fat metabolism, and may be a useful model to investigate metabolic conditions associated with aging | Hyperinsulinemia and insulin resistance in Wrn null mice fed a diabetogenic diet.
Moore G, Knoblaugh S, Gollahon K, Rabinovitch P, Ladiges W., Free PMC Article | 01/21/2010 |
| Genetic cooperation between this protein and poly(ADP-ribose) polymerase-1 prevent chromatid breaks, complex chromosomal rearrangements, and cancer in mice. | Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice.
Lebel M, Lavoie J, Gaudreault I, Bronsard M, Drouin R., Free PMC Article | 01/21/2010 |
| Amino acid residues 31-238 of WRN play a critical role in 3'-5' exonuclease domain activity. | Probing the roles of active site residues in the 3'-5' exonuclease of the Werner syndrome protein.
Choi JM, Kang SY, Bae WJ, Jin KS, Ree M, Cho Y. | 01/21/2010 |
| random mutagenesis process in PARP-1 null/Wrn (sequence deletion) mouse fibroblasts. | Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.
Lavoie J, Carter R, Drouin R, Lebel M. | 01/21/2010 |
| Mutations in the Walker A motifs of the two proteins revealed that WRNIP1, but not WRN, must bind ATP before an efficient interaction can occur. | Analyses of the interaction of WRNIP1 with Werner syndrome protein (WRN) in vitro and in the cell.
Kawabe Y, Seki M, Yoshimura A, Nishino K, Hayashi T, Takeuchi T, Iguchi S, Kusa Y, Ohtsuki M, Tsuyama T, Imamura O, Matsumoto T, Furuichi Y, Tada S, Enomoto T. | 01/21/2010 |