| Calcium signaling induces partial EMT and renal fibrosis in a Wnt4[mCherry] knock-in mouse model. | Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model.
Naillat F, Deshar G, Hankkila A, Rak-Raszewska A, Sharma A, Prunskaite-Hyyrylainen R, Railo A, Shan J, Vainio SJ. | 05/29/2024 |
| TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway. | TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway.
Song S, Zhang X, Huang Z, Zhao Y, Lu S, Zeng L, Cai F, Wang T, Pei Z, Weng X, Luo W, Lu H, Wei Z, Wu J, Yu P, Shen L, Zhang X, Sun A, Ge J., Free PMC Article | 03/4/2024 |
| A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis. | A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis.
Pavličev M, McDonough-Goldstein CE, Zupan AM, Muglia L, Hu YC, Kong F, Monangi N, Dagdas G, Zupančič N, Maziarz J, Sinner D, Zhang G, Wagner G, Muglia L., Free PMC Article | 02/17/2024 |
| A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis. | A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis.
Cooney RA, Saal ML, Geraci KP, Maynard C, Cleaver O, Hoang ON, Moore TT, Hwang RF, Axelrod JD, Vladar EK., Free PMC Article | 09/1/2023 |
| CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice. | CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice.
Okashita N, Maeda R, Tachibana M., Free PMC Article | 05/13/2023 |
| Loss of WNT4 in the gubernaculum causes unilateral cryptorchidism and fertility defects. | Loss of WNT4 in the gubernaculum causes unilateral cryptorchidism and fertility defects.
Seth A, Bournat JC, Medina-Martinez O, Rivera A, Moore J, Flores H, Rosenfeld JA, Hu L, Jorgez CJ., Free PMC Article | 12/3/2022 |
| Mice Lacking Wnt9a or Wnt4 Are Prone to Develop Spontaneous Osteoarthritis With Age and Display Alteration in Either the Trabecular or Cortical Bone Compartment. | Mice Lacking Wnt9a or Wnt4 Are Prone to Develop Spontaneous Osteoarthritis With Age and Display Alteration in Either the Trabecular or Cortical Bone Compartment.
Teufel S, Wolff L, König U, Kobayashi A, Behringer R, Hartmann C. | 07/23/2022 |
| Wnt4 regulates bone metabolism through IKK-NF-kappaB and ROCK signaling under occlusal traumatic periodontitis. | Wnt4 regulates bone metabolism through IKK-NF-κB and ROCK signaling under occlusal traumatic periodontitis.
Xu W, Lu Q, Qu M, Fan R, Leng S, Wang L, Liu L, Yang F, Zhou X, Huang D, Zhang L. | 05/28/2022 |
| Cell-intrinsic Wnt4 promotes hematopoietic stem and progenitor cell self-renewal. | Cell-intrinsic Wnt4 promotes hematopoietic stem and progenitor cell self-renewal.
Hétu-Arbour R, Tlili M, Bandeira Ferreira FL, Abidin BM, Kwarteng EO, Heinonen KM. | 03/19/2022 |
| Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex. | Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.
Djari C, Sahut-Barnola I, Septier A, Plotton I, Montanier N, Dufour D, Levasseur A, Wilmouth J Jr, Pointud JC, Faucz FR, Kamilaris C, Lopez AG, Guillou F, Swain A, Vainio SJ, Tauveron I, Val P, Lefebvre H, Stratakis CA, Martinez A, Lefrançois-Martinez AM., Free PMC Article | 01/15/2022 |
| Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk. | Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk.
Englund JI, Ritchie A, Blaas L, Cojoc H, Pentinmikko N, Döhla J, Iqbal S, Patarroyo M, Katajisto P., Free PMC Article | 08/7/2021 |
| E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling. | E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling.
Jorgez CJ, Seth A, Wilken N, Bournat JC, Chen CH, Lamb DJ., Free PMC Article | 04/24/2021 |
| Mouse Gonad Development in the Absence of the Pro-Ovary Factor WNT4 and the Pro-Testis Factor SOX9. | Mouse Gonad Development in the Absence of the Pro-Ovary Factor WNT4 and the Pro-Testis Factor SOX9.
Tang F, Richardson N, Albina A, Chaboissier MC, Perea-Gomez A., Free PMC Article | 04/3/2021 |
| Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells. | Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells.
Eliazer S, Muncie JM, Christensen J, Sun X, D'Urso RS, Weaver VM, Brack AS., Free PMC Article | 09/12/2020 |
| Wnt4 induces osteogenesis through both beta-catenin- and noncanonical p38-JNK pathways through distinct receptor complexes. Melatonin promotes bone formation through Wnt4-Fzd1/6-LRP5/6-beta-catenin and Wnt4-Fzd2-JNK-p38 pathways. Melatonin induces Wnt4 expression through the ERK1/2-Pax2-Egr1 pathway. Melatonin suppresses the inhibitory effect of TNF-alpha and NF-kappaB on osteogenesis in a Wnt4-dependent manner. | Wnt4 signaling mediates protective effects of melatonin on new bone formation in an inflammatory environment.
Li X, Li Z, Wang J, Li Z, Cui H, Dai G, Chen S, Zhang M, Zheng Z, Zhan Z, Liu H. | 06/6/2020 |
| These data uncover a novel and unexpected role for Wnt4 in cDC subset differentiation and type 2 immunity. | Cell-Intrinsic Wnt4 Influences Conventional Dendritic Cell Fate Determination to Suppress Type 2 Immunity.
Hung LY, Johnson JL, Ji Y, Christian DA, Herbine KR, Pastore CF, Herbert DR., Free PMC Article | 02/15/2020 |
| Wnt4 and Wnt5a play redundant roles in the development of the female reproductive tract; this may provide insight into the etiology of certain cases of Mullerian agenesis in women. | Targeted ablation of Wnt4 and Wnt5a in Müllerian duct mesenchyme impedes endometrial gland development and causes partial Müllerian agenesis.
St-Jean G, Boyer A, Zamberlam G, Godin P, Paquet M, Boerboom D. | 02/8/2020 |
| WNT4 has an essential role in the regulation of beta-cell functions in mouse pancreatic islets | A High-Fat/High-Sucrose Diet Induces WNT4 Expression in Mouse Pancreatic β-cells.
Kurita Y, Ohki T, Soejima E, Yuan X, Kakino S, Wada N, Hashinaga T, Nakayama H, Tani J, Tajiri Y, Hiromatsu Y, Yamada K, Nomura M. | 12/14/2019 |
| urinary Wnt4 could be a potential noninvasive biomarker for the early detection of tubular injury. | Wnt4 is a novel biomarker for the early detection of kidney tubular injury after ischemia/reperfusion injury.
Zhao SL, Wei SY, Wang YX, Diao TT, Li JS, He YX, Yu J, Jiang XY, Cao Y, Mao XY, Wei QJ, Wang Y, Li B., Free PMC Article | 05/26/2018 |
| SHH-dependent activation of WNT signaling supports regeneration of the cortex following long-term glucocorticoid treatment. | Sonic Hedgehog and WNT Signaling Promote Adrenal Gland Regeneration in Male Mice.
Finco I, Lerario AM, Hammer GD., Free PMC Article | 05/19/2018 |
| Wnt4 and Wnt11 cooperatively contribute to mammalian neuromuscular junction formation. | Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways.
Messéant J, Ezan J, Delers P, Glebov K, Marchiol C, Lager F, Renault G, Tissir F, Montcouquiol M, Sans N, Legay C, Strochlic L. | 09/16/2017 |
| GLP-1 promoted adipogenesis through the modulation of the Wnt4/beta-catenin signaling pathway | Glucagon Like Peptide-1 Promotes Adipocyte Differentiation via the Wnt4 Mediated Sequestering of Beta-Catenin.
Liu R, Li N, Lin Y, Wang M, Peng Y, Lewi K, Wang Q., Free PMC Article | 08/5/2017 |
| Results suggest that the Wnt4 gene encodes signals that are important for various aspects of female reproductive tract development. | Wnt4 coordinates directional cell migration and extension of the Müllerian duct essential for ontogenesis of the female reproductive tract.
Prunskaite-Hyyryläinen R, Skovorodkin I, Xu Q, Miinalainen I, Shan J, Vainio SJ., Free PMC Article | 12/17/2016 |
| Our functional study revealed that WNT4 molecules were involved in regulating zygotic cleavage and early embryogenesis | WNT4-like protein is a cortical granule component in mouse oocytes and functions in regulating preimplantation embryogenesis.
Liu M, Yang HT. | 10/22/2016 |
| Data indicate that a balance between supporting cell self-renewal and differentiation is maintained in the developing ovary by relative Wnt4 protein/beta-catenin and p27Kip1 protein (p27)/Forkhead box L2 (FOXL2) activities. | WNT/β-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary.
Gustin SE, Hogg K, Stringer JM, Rastetter RH, Pelosi E, Miles DC, Sinclair AH, Wilhelm D, Western PS. | 09/10/2016 |