| Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway. | Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway.
Dong X, Luo Y, Lu S, Ma H, Zhang W, Zhu Y, Sun G, Sun X., Free PMC Article | 12/25/2021 |
| Transient expression of WNT2 promotes somatic cell reprogramming by inducing beta-catenin nuclear accumulation. | Transient Expression of WNT2 Promotes Somatic Cell Reprogramming by Inducing β-Catenin Nuclear Accumulation.
Kimura M, Nakajima-Koyama M, Lee J, Nishida E., Free PMC Article | 11/18/2017 |
| Study indicates essential roles for Wnt2 and Wnt3 in chronic restraint stress-induced depression-like behaviors and antidepressant. | The antidepressant roles of Wnt2 and Wnt3 in stress-induced depression-like behaviors.
Zhou WJ, Xu N, Kong L, Sun SC, Xu XF, Jia MZ, Wang Y, Chen ZY., Free PMC Article | 11/11/2017 |
| Upregulation of Wnt2 expression enhanced WISP-1 and promoted vascular smooth muscle cell migration and intimal thickening. | Wnt2 and WISP-1/CCN4 Induce Intimal Thickening via Promotion of Smooth Muscle Cell Migration.
Williams H, Mill CA, Monk BA, Hulin-Curtis S, Johnson JL, George SJ. | 06/24/2017 |
| Wnt 2 levels were markedly down-regulated by retinoic acid in pancreatic stellar cells and chronic pancreatitis. | Retinoic Acid Ameliorates Pancreatic Fibrosis and Inhibits the Activation of Pancreatic Stellate Cells in Mice with Experimental Chronic Pancreatitis via Suppressing the Wnt/β-Catenin Signaling Pathway.
Xiao W, Jiang W, Shen J, Yin G, Fan Y, Wu D, Qiu L, Yu G, Xing M, Hu G, Wang X, Wan R., Free PMC Article | 07/2/2016 |
| We propose that the WNT2/CTNNB1 pathway regulates CX43 expression and gap junction intercellular communication in granulosa cells by modulating CTNNB1 stability and localization in adherens junctions | The canonical WNT2 pathway and FSH interact to regulate gap junction assembly in mouse granulosa cells.
Wang HX, Gillio-Meina C, Chen S, Gong XQ, Li TY, Bai D, Kidder GM. | 10/26/2013 |
| Pdgf signaling potentiates Wnt2-Wnt7b signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung | Wnt ligands signal in a cooperative manner to promote foregut organogenesis.
Miller MF, Cohen ED, Baggs JE, Lu MM, Hogenesch JB, Morrisey EE., Free PMC Article | 12/22/2012 |
| Expression of WNT2 in pancreatic cancer cells suppresses anoikis, enhances anchorage-independent sphere formation, and increases metastatic propensity in vivo. | RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis.
Yu M, Ting DT, Stott SL, Wittner BS, Ozsolak F, Paul S, Ciciliano JC, Smas ME, Winokur D, Gilman AJ, Ulman MJ, Xega K, Contino G, Alagesan B, Brannigan BW, Milos PM, Ryan DP, Sequist LV, Bardeesy N, Ramaswamy S, Toner M, Maheswaran S, Haber DA., Free PMC Article | 09/1/2012 |
| Wnt2 plays strong positive stage-specific role in cardiogenesis through non-canonical Wnt pathway in murine ES cells. | Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway.
Onizuka T, Yuasa S, Kusumoto D, Shimoji K, Egashira T, Ohno Y, Kageyama T, Tanaka T, Hattori F, Fujita J, Ieda M, Kimura K, Makino S, Sano M, Kudo A, Fukuda K. | 07/14/2012 |
| show that Wnt2 signaling is necessary and sufficient for activation of a transcriptional and signaling network critical for smooth muscle specification and differentiation including myocardin/Mrtf-B and the signaling factor Fgf10 | Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression.
Goss AM, Tian Y, Cheng L, Yang J, Zhou D, Cohen ED, Morrisey EE., Free PMC Article | 10/1/2011 |
| Wnt2 expression is downregulated at lung bud stage in the nitrofen model. Optical projection tomography is potentially a useful approach to visualize both gene expression and morphology during very early stages of lung development. | Embryonic Wnt gene expression in the nitrofen-induced hypoplastic lung using 3-dimensional imaging.
Takayasu H, Murphy P, Sato H, Doi T, Puri P. | 12/4/2010 |
| The canonical WNT signaling pathway is intact in mouse granulosa cells and that WNT2 can act through beta-catenin, likely downstream of FZD9, to regulate DNA synthesis. | WNT2 regulates DNA synthesis in mouse granulosa cells through beta-catenin.
Wang HX, Li TY, Kidder GM., Free PMC Article | 08/30/2010 |
| Results identify Wnt2 as a novel regulator of dopaminergic progenitors and dopaminergic neuron development. | Wnt2 regulates progenitor proliferation in the developing ventral midbrain.
Sousa KM, Villaescusa JC, Cajanek L, Ondr JK, Castelo-Branco G, Hofstra W, Bryja V, Palmberg C, Bergman T, Wainwright B, Lang RA, Arenas E., Free PMC Article | 05/3/2010 |
| Wnt2 works in a feedforward transcriptional loop with Gata6 to regulate posterior cardiac development. | Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development.
Tian Y, Yuan L, Goss AM, Wang T, Yang J, Lepore JJ, Zhou D, Schwartz RJ, Patel V, Cohen ED, Morrisey EE., Free PMC Article | 04/12/2010 |
| These data demonstrate that mesenchymal stem cells from mice and humans produce Wnt proteins and TGF-beta1 that respectively stimulate lung fibroblast proliferation and matrix production. | Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts.
Salazar KD, Lankford SM, Brody AR., Free PMC Article | 01/21/2010 |
| Data reveal that canonical Wnt2/2b signaling is required for the specification of lung endoderm progenitors in the developing foregut. | Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut.
Goss AM, Tian Y, Tsukiyama T, Cohen ED, Zhou D, Lu MM, Yamaguchi TP, Morrisey EE., Free PMC Article | 01/21/2010 |
| Study revealed new domains of expression for Wnt2, Wnt2b, Wnt5b, Wnt6, Wnt7b, Wnt9a, Wnt10a, Wnt10b, Wnt11 and Wnt16, in the limb. | Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.
Witte F, Dokas J, Neuendorf F, Mundlos S, Stricker S. | 01/21/2010 |
| FMR1, MECP2, and WNT2 expression were drastically down regulated in the Fragile X mouse brain. | Altered expression of Autism-associated genes in the brain of Fragile X mouse model.
Zhang A, Shen CH, Ma SY, Ke Y, El Idrissi A. | 01/21/2010 |
| Upregulation by GATA6 in differentiating embryonal carcinoma cells is mediated by the direct binding of GATA-factor(s) to the Wnt2 promoter, suggesting Wnt2 is an immediate downstream target of GATA-factor regulation during early cardiogenesis. | Wnt2 is a direct downstream target of GATA6 during early cardiogenesis.
Alexandrovich A, Arno M, Patient RK, Shah AM, Pizzey JA, Brewer AC. | 01/21/2010 |
| Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies | Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies.
Wang H, Gilner JB, Bautch VL, Wang DZ, Wainwright BJ, Kirby SL, Patterson C. | 01/21/2010 |