| Targeting tumor cell-to-macrophage communication by blocking Vtn-C1qbp interaction inhibits tumor progression via enhancing macrophage phagocytosis. | Targeting tumor cell-to-macrophage communication by blocking Vtn-C1qbp interaction inhibits tumor progression via enhancing macrophage phagocytosis.
Zhang C, Liu Y, Jiang J, Chen C, Duan Z, Su H, Wang S, Tian B, Shi Y, Xiang R, Luo Y., Free PMC Article | 07/30/2024 |
| Blood Vitronectin Induces Detrimental Brain Interleukin-6 and Correlates With Outcomes After Stroke Only in Female Mice. | Blood Vitronectin Induces Detrimental Brain Interleukin-6 and Correlates With Outcomes After Stroke Only in Female Mice.
Jia C, Malone HM, Keasey MP, Lovins C, Elam J, Hagg T., Free PMC Article | 09/26/2020 |
| these data suggest that leakage of VTN into the subventricular zone reduces the neurogenic response to stroke in female mice | Vitronectin mitigates stroke-increased neurogenesis only in female mice and through FAK-regulated IL-6.
Jia C, Keasey MP, Malone HM, Lovins C, Hagg T., Free PMC Article | 07/25/2020 |
| Vitronectin regulates the multipolar-to-bipolar morphological transition of nitrites via alphavbeta5 integrin. | Vitronectin is Involved in the Morphological Transition of Neurites in Retinoic Acid-Induced Neurogenesis of Neuroblastoma Cell Line Neuro2a.
Sugahara M, Nakaoki Y, Yamaguchi A, Hashimoto K, Miyamoto Y. | 08/17/2019 |
| blood-derived vitronectin (VTN) rapidly and potently activates leukemia inhibitory factor (LIF) and pro-inflammatory interleukin 6 (IL-6) in vitro and after vascular injury in the brain. | Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
Keasey MP, Jia C, Pimentel LF, Sante RR, Lovins C, Hagg T., Free PMC Article | 08/10/2019 |
| VTN had a novel therapeutic potential for the treatment of Radiation-induced lung toxicity. | The positive role of vitronectin in radiation induced lung toxicity: the in vitro and in vivo mechanism study.
Shen TL, Liu MN, Zhang Q, Feng W, Yu W, Fu XL, Cai XW., Free PMC Article | 06/22/2019 |
| The effects of genetic alterations in PAI-1 expression, pharmacologic PAI-1 inhibition and recombinant PAI-1 on smooth muscle cell vitronectin (VN) expression were studied, and vascular VN expression in wild-type and PAI-1-deficient mice was assessed. | Plasminogen activator inhibitor-1 regulates the vascular expression of vitronectin.
Luo M, Ji Y, Luo Y, Li R, Fay WP, Wu J., Free PMC Article | 08/4/2018 |
| this study demonstrates in a mouse infection model that Vn reduces complement-mediated killing of Yersinia enterocolitica O:9 E40 and, thus, improves bacterial survival | Vitronectin Binds to a Specific Stretch within the Head Region of Yersinia Adhesin A and Thereby Modulates Yersinia enterocolitica Host Interaction.
Mühlenkamp MC, Hallström T, Autenrieth IB, Bohn E, Linke D, Rinker J, Riesbeck K, Singh B, Leo JC, Hammerschmidt S, Zipfel PF, Schütz MS., Free PMC Article | 10/21/2017 |
| the TGF-beta-PAI-1-vitronectin-integrin axis may represent a critical convergence of factors in determining the alveolar epithelial cell apoptotic response during lung injury. | The vitronectin RGD motif regulates TGF-β-induced alveolar epithelial cell apoptosis.
Wheaton AK, Velikoff M, Agarwal M, Loo TT, Horowitz JC, Sisson TH, Kim KK., Free PMC Article | 05/20/2017 |
| In vtn knockout mice, neuronal differentiation in the cerebellum was suppressed compared with wild-type mice. | Vitronectin promotes the progress of the initial differentiation stage in cerebellar granule cells.
Hashimoto K, Sakane F, Ikeda N, Akiyama A, Sugahara M, Miyamoto Y. | 10/22/2016 |
| Elevated levels of TIMP3 and vitronectin, acting downstream of Notch3(ECD) deposition, play a role in CADASIL, producing divergent influences on early CBF deficits and later white matter lesions. | Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice.
Capone C, Cognat E, Ghezali L, Baron-Menguy C, Aubin D, Mesnard L, Stöhr H, Domenga-Denier V, Nelson MT, Joutel A., Free PMC Article | 07/30/2016 |
| PAI-1, through its interaction with Vn, exerts multiple deleterious mechanisms to induce AKI. | Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia.
Gupta KK, Donahue DL, Sandoval-Cooper MJ, Castellino FJ, Ploplis VA., Free PMC Article | 12/19/2015 |
| These data suggest that adhesion to vitronectin allows for the uncoupling of fibronectin fibril formation from downstream signaling events by reducing alpha5beta1 integrin activation and fibronectin fibril extension. | Opposing effects of collagen I and vitronectin on fibronectin fibril structure and function.
Gildner CD, Roy DC, Farrar CS, Hocking DC., Free PMC Article | 01/3/2015 |
| Report role of vitronectin in the regulation of angiogenesis induced by VEGF. | Vitronectin regulation of vascular endothelial growth factor-mediated angiogenesis.
Li R, Luo M, Ren M, Chen N, Xia J, Deng X, Zeng M, Yan K, Luo T, Wu J. | 09/6/2014 |
| Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages. | Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages.
Bae HB, Tadie JM, Jiang S, Park DW, Bell CP, Thompson LC, Peterson CB, Thannickal VJ, Abraham E, Zmijewski JW., Free PMC Article | 04/6/2013 |
| the extracellular matrix molecule VN and its neuronal receptor TLCN play a pivotal role in the phosphorylation of ezrin/radixin/moesin proteins and the formation of phagocytic cup-like structures on neuronal dendrites | Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin.
Furutani Y, Kawasaki M, Matsuno H, Mitsui S, Mori K, Yoshihara Y., Free PMC Article | 02/2/2013 |
| VN plays a previously unrecognized role in regulating endothelial permeability via conformational- and integrin-dependent effects on VE-cadherin trafficking. | Vitronectin increases vascular permeability by promoting VE-cadherin internalization at cell junctions.
Li R, Ren M, Chen N, Luo M, Zhang Z, Wu J., Free PMC Article | 10/20/2012 |
| ability of vitronectin to enhance neutrophil viability was dependent on activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 kinases, but not on the p38 kinase | Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways.
Bae HB, Zmijewski JW, Deshane JS, Zhi D, Thompson LC, Peterson CB, Chaplin DD, Abraham E., Free PMC Article | 08/18/2012 |
| These results demonstrate that vitronectin exerts a deleterious role independently from complement, by directing PAI-dependent fibrinolysis in the glomerular compartment. | Vitronectin dictates intraglomerular fibrinolysis in immune-mediated glomerulonephritis.
Mesnard L, Rafat C, Vandermeersch S, Hertig A, Cathelin D, Xu-Dubois YC, Jouanneau C, Keller AC, Ribeil JA, Leite-de-Moraes MC, Rondeau E. | 12/10/2011 |
| the vitronectin-binding capacity of PAI-1 was the primary determinant required for its ability to exacerbate lung scarring induced by intratracheal bleomycin administration | The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice.
Courey AJ, Horowitz JC, Kim KK, Koh TJ, Novak ML, Subbotina N, Warnock M, Xue B, Cunningham AK, Lin Y, Goldklang MP, Simon RH, Lawrence DA, Sisson TH., Free PMC Article | 10/29/2011 |
| Suggest that despite significant interstitial Vtn deposition in the ureteral obstruction model of chronic kidney disease, its fibrogenic role is either nonessential or redundant. | Vitronectin accumulates in the interstitium but minimally impacts fibrogenesis in experimental chronic kidney disease.
López-Guisa JM, Rassa AC, Cai X, Collins SJ, Eddy AA., Free PMC Article | 07/2/2011 |
| Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices | Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices.
Garg N, Goyal N, Strawn TL, Wu J, Mann KM, Lawrence DA, Fay WP., Free PMC Article | 03/12/2011 |
| evaluated the temporal expression pattern of STI1 and Vn and their colocalization with their ligand PrPC, demonstrated that PrPC, STI1, and Vn are coexpressed in most of the embryonic tissues evaluated. | Developmental expression of prion protein and its ligands stress-inducible protein 1 and vitronectin.
Hajj GN, Santos TG, Cook ZS, Martins VR. | 01/21/2010 |
| VN is a key determinant of the antiproliferative effect of PAI-1 overexpression. | Recombinant plasminogen activator inhibitor-1 inhibits intimal hyperplasia.
Wu J, Peng L, McMahon GA, Lawrence DA, Fay WP., Free PMC Article | 01/21/2010 |
| a novel vitronectin-dependent mechanism contributing to the development of acute lung injury. | Involvement of vitronectin in lipopolysaccaride-induced acute lung injury.
Tsuruta Y, Park YJ, Siegal GP, Liu G, Abraham E. | 01/21/2010 |