| Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21. | Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21.
Guo YY, Gao Y, Zhao YL, Xie C, Gan H, Cheng X, Yang LP, Hu J, Shu HB, Zhong B, Lin D, Yao J. | 05/8/2024 |
| Ion channel TRPV2 is critical in enhancing B cell activation and function. | Ion channel TRPV2 is critical in enhancing B cell activation and function.
Li C, Zhao M, Liu X, Li Y, Xu B, Zhou L, Sun X, Sun W, Kang N, Ji Z, Li T, An H, Wang F, Wu C, Ye JY, Zhang JR, Wang Q, Zhao X, Li Z, Liu W., | 02/16/2024 |
| High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling. | High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling.
Wei P, Li L, Ran C, Jin M, Zhao H, Yang K, Wang Y, He H, Jia M, Pan H, Li Q, Guo J. | 02/14/2024 |
| Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta. | Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta.
Perálvarez-Marín A, Solé M, Serrano J, Taddeucci A, Pérez B, Penas C, Manich G, Jiménez M, D'Ocon P, Jiménez-Altayó F. | 01/3/2024 |
| Knockdown of TRPV2 inhibits the migration of RAW264.7 cells toward low fluid shear stress region. | Knockdown of TRPV2 inhibits the migration of RAW264.7 cells toward low fluid shear stress region.
Gao Y, Zhang X, Huo B. | 09/23/2023 |
| The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca[2+] -LRMDA Axis in Myeloid Cells. | The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca(2+) -LRMDA Axis in Myeloid Cells.
Guo YY, Gao Y, Hu YR, Zhao Y, Jiang D, Wang Y, Zhang Y, Gan H, Xie C, Liu Z, Zhong B, Zhang ZD, Yao J., Free PMC Article | 12/24/2022 |
| Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus. | Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus.
Liu G, Liu Y, Niu B, Zhou Y, Peng Q, Yan J, Tang Y, Chen F, Li F, Feng S. | 07/30/2022 |
| Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota. | Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.
Suriano F, Manca C, Flamand N, Depommier C, Van Hul M, Delzenne NM, Silvestri C, Cani PD, Di Marzo V. | 01/1/2022 |
| Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription. | Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription.
Maksoud MJE, Tellios V, Lu WY., Free PMC Article | 12/4/2021 |
| TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. | TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions.
Xu J, Yang Y, Hou Z, Jia H, Wang Y., Free PMC Article | 07/3/2021 |
| Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis. | Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis.
Eubler K, Rantakari P, Gerke H, Herrmann C, Missel A, Schmid N, Walenta L, Lahiri S, Imhof A, Strauss L, Poutanen M, Mayerhofer A., Free PMC Article | 06/5/2021 |
| Production of TRPV2-targeting functional antibody ameliorating dilated cardiomyopathy and muscular dystrophy in animal models. | Production of TRPV2-targeting functional antibody ameliorating dilated cardiomyopathy and muscular dystrophy in animal models.
Iwata Y, Wakabayashi S, Ito S, Kitakaze M. | 09/26/2020 |
| Hsp20-S10F mice treated with probenecid had decreased mortality, hypertrophy, TRPV2 expression and molecular parameters of heart failure. | Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy.
Onusko E, McDermott MR, Robbins N, Liu G, Kranias EG, Rubinstein J, Koch SE., Free PMC Article | 06/27/2020 |
| The iNOS/NO signal pathway up-regulates microglial phagocytosis and increases TRPV2 trafficking to the plasma membrane. | Nitric oxide upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane.
Maksoud MJE, Tellios V, An D, Xiang YY, Lu WY. | 04/18/2020 |
| Osmotic cell swelling activates TRPV2 in mouse beta-cells. | TRPV2 channels mediate insulin secretion induced by cell swelling in mouse pancreatic β-cells.
Sawatani T, Kaneko YK, Doutsu I, Ogawa A, Ishikawa T. | 01/11/2020 |
| TRPV2 has a critical role in mechanical nociception in the adult somatosensory system. | TRPV2 is required for mechanical nociception and the stretch-evoked response of primary sensory neurons.
Katanosaka K, Takatsu S, Mizumura K, Naruse K, Katanosaka Y., Free PMC Article | 11/23/2019 |
| The mast cell is the central structure of acupoints and is activated by acupuncture through TRPV2 channels. | Critical roles of TRPV2 channels, histamine H1 and adenosine A1 receptors in the initiation of acupoint signals for acupuncture analgesia.
Huang M, Wang X, Xing B, Yang H, Sa Z, Zhang D, Yao W, Yin N, Xia Y, Ding G., Free PMC Article | 10/5/2019 |
| TRPV2 expression is profoundly downregulated in alveolar macrophages at early time points of cigarette smoke exposure. Reduced TRPV2-mediated phagocytic function renders the lung susceptible to cigarette smoke-induced alveolar space enlargement. | Reduced transient receptor potential vanilloid 2 expression in alveolar macrophages causes COPD in mice through impaired phagocytic activity.
Masubuchi H, Ueno M, Maeno T, Yamaguchi K, Hara K, Sunaga H, Matsui H, Nagasawa M, Kojima I, Iwata Y, Wakabayashi S, Kurabayashi M., Free PMC Article | 08/10/2019 |
| data suggest that knockout of the TRPV2 channel may attenuate macrophage-dependent pro-inflammatory processes and result in better cardiac recovery. TRPV2 may thus represent a novel therapeutic target for treatment of patients undergoing an acute MI | TRPV2 knockout mice demonstrate an improved cardiac performance following myocardial infarction due to attenuated activity of peri-infarct macrophages.
Entin-Meer M, Cohen L, Hertzberg-Bigelman E, Levy R, Ben-Shoshan J, Keren G., Free PMC Article | 09/16/2017 |
| We conclude that TRPV2 function, as a stretch-activated channel, regulates the development of cardiomyocyte hypertrophy in response to increased afterload. | Transient receptor potential vanilloid 2 function regulates cardiac hypertrophy via stretch-induced activation.
Koch SE, Mann A, Jones S, Robbins N, Alkhattabi A, Worley MC, Gao X, Lasko-Roiniotis VM, Karani R, Fulford L, Jiang M, Nieman M, Lorenz JN, Rubinstein J. | 08/19/2017 |
| These findings suggest that TRPV2 activation via actin reorganization induced by Gq and G12/13 signaling is involved in LPI-stimulated GLP-1 secretion in enteroendocrine L cells. | Lysophosphatidylinositol-induced activation of the cation channel TRPV2 triggers glucagon-like peptide-1 secretion in enteroendocrine L cells.
Harada K, Kitaguchi T, Kamiya T, Aung KH, Nakamura K, Ohta K, Tsuboi T., Free PMC Article | 07/8/2017 |
| Expression of TRPV2 was dramatically increased during the differentiation of brown adipocytes. TRPV2 might be involved in the modulation of brown adipocyte differentiation partially via a calcineurin pathway. | Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes.
Sun W, Uchida K, Takahashi N, Iwata Y, Wakabayashi S, Goto T, Kawada T, Tominaga M. | 07/1/2017 |
| TRPV2 channels are demonstrated here to play a key role in cation influx and dysregulation in dystrophin deficient cardiomyocytes, enhanced in stretching conditions | Axial stretch-dependent cation entry in dystrophic cardiomyopathy: Involvement of several TRPs channels.
Aguettaz E, Lopez JJ, Krzesiak A, Lipskaia L, Adnot S, Hajjar RJ, Cognard C, Constantin B, Sebille S., Free PMC Article | 02/25/2017 |
| TRPV2KO mice show cold intolerance and impaired BAT thermogenesis. | Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue.
Sun W, Uchida K, Suzuki Y, Zhou Y, Kim M, Takayama Y, Takahashi N, Goto T, Wakabayashi S, Kawada T, Iwata Y, Tominaga M., Free PMC Article | 12/17/2016 |
| We conclude that TRPV2 is involved in osmosensation in skeletal muscle fibres, acting in concert with P-SPAK-activated NKCC1 | Osmosensation in TRPV2 dominant negative expressing skeletal muscle fibres.
Zanou N, Mondin L, Fuster C, Seghers F, Dufour I, de Clippele M, Schakman O, Tajeddine N, Iwata Y, Wakabayashi S, Voets T, Allard B, Gailly P., Free PMC Article | 07/2/2016 |