| FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production. | FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production.
Sun B, Ding P, Song Y, Zhou J, Chen X, Peng C, Liu S., Free PMC Article | 10/2/2024 |
| Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma progression through activation of the GPRIN2 signaling pathway. | Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma progression through activation of the GPRIN2 signaling pathway.
Liu M, Wu S, Wu H, Zhou Y, Zhang X, Zhu D, Jiang J., Free PMC Article | 06/3/2024 |
| METTL3 promotes non-small-cell lung cancer growth and metastasis by inhibiting FDX1 through copper death-associated pri-miR-21-5p maturation. | METTL3 promotes non-small-cell lung cancer growth and metastasis by inhibiting FDX1 through copper death-associated pri-miR-21-5p maturation.
Qian S, Liu J, Liao W, Wang F. | 01/17/2024 |
| Systematic analysis based on the cuproptosis-related genes identifies ferredoxin 1 as an immune regulator and therapeutic target for glioblastoma. | Systematic analysis based on the cuproptosis-related genes identifies ferredoxin 1 as an immune regulator and therapeutic target for glioblastoma.
Dai L, Zhou P, Lyu L, Jiang S., Free PMC Article | 12/29/2023 |
| Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by NMR; modulation by cytochrome P450 substrate and by truncation of the C-terminal tail. | Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by NMR; modulation by cytochrome P450 substrate and by truncation of the C-terminal tail.
Jay N, McGlohon JE, Estrada DF., Free PMC Article | 10/30/2023 |
| Prognostic and immunological role of FDX1 in pan-cancer: an in-silico analysis. | Prognostic and immunological role of FDX1 in pan-cancer: an in-silico analysis.
Liu Z, Miao J., Free PMC Article | 10/30/2023 |
| Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells. | Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.
Joshi PR, Sadre S, Guo XA, McCoy JG, Mootha VK., Free PMC Article | 10/4/2023 |
| FDX1 regulates cellular protein lipoylation through direct binding to LIAS. | FDX1 regulates cellular protein lipoylation through direct binding to LIAS.
Dreishpoon MB, Bick NR, Petrova B, Warui DM, Cameron A, Booker SJ, Kanarek N, Golub TR, Tsvetkov P., Free PMC Article | 10/4/2023 |
| Integrated analyses reveal the prognostic, immunological features and mechanisms of cuproptosis critical mediator gene FDX1 in KIRC. | Integrated analyses reveal the prognostic, immunological features and mechanisms of cuproptosis critical mediator gene FDX1 in KIRC.
Wang Y, Zhang X, Chen G, Xing Q, Zhu B, Wang X. | 08/22/2023 |
| Expression of Ferredoxin1 in cisplatin-resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin. | Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin.
Takahashi R, Kamizaki K, Yamanaka K, Terai Y, Minami Y., Free PMC Article | 05/13/2023 |
| Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome. | Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome.
Xing J, Qiao G, Luo X, Liu S, Chen S, Ye G, Zhang C, Yi J. | 03/23/2023 |
| Copper Death Inducer, FDX1, as a Prognostic Biomarker Reshaping Tumor Immunity in Clear Cell Renal Cell Carcinoma. | Copper Death Inducer, FDX1, as a Prognostic Biomarker Reshaping Tumor Immunity in Clear Cell Renal Cell Carcinoma.
Jiang A, Ye J, Zhou Y, Zhu B, Lu J, Ge S, Qu L, Xiao J, Wang L, Cai C., Free PMC Article | 02/27/2023 |
| Cuproptosis-related gene FDX1 expression correlates with the prognosis and tumor immune microenvironment in clear cell renal cell carcinoma. | Cuproptosis-related gene FDX1 expression correlates with the prognosis and tumor immune microenvironment in clear cell renal cell carcinoma.
Wang T, Liu Y, Li Q, Luo Y, Liu D, Li B., Free PMC Article | 02/15/2023 |
| High expression of cuproptosis-related gene FDX1 in relation to good prognosis and immune cells infiltration in colon adenocarcinoma (COAD). | High expression of cuproptosis-related gene FDX1 in relation to good prognosis and immune cells infiltration in colon adenocarcinoma (COAD).
Wang L, Cao Y, Guo W, Xu J., Free PMC Article | 02/11/2023 |
| Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2. | Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2.
Schulz V, Basu S, Freibert SA, Webert H, Boss L, Mühlenhoff U, Pierrel F, Essen LO, Warui DM, Booker SJ, Stehling O, Lill R., Free PMC Article | 02/11/2023 |
| Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma. | Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma.
Xu J, Hu Z, Cao H, Zhang H, Luo P, Zhang J, Wang X, Cheng Q, Li J., Free PMC Article | 01/14/2023 |
| The role of FDX1 in granulosa cell of Polycystic ovary syndrome (PCOS). | The role of FDX1 in granulosa cell of Polycystic ovary syndrome (PCOS).
Wang Z, Dong H, Yang L, Yi P, Wang Q, Huang D., Free PMC Article | 12/11/2021 |
| Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin. | Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin.
Brixius-Anderko S, Scott EE., Free PMC Article | 09/4/2021 |
| Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin | Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin.
Zhu Q, Mak PJ, Tuckey RC, Kincaid JR., Free PMC Article | 11/4/2017 |
| Data suggest that binding sites between CYP11B1/CYP11B2 and adrenodoxin/ferredoxin-1 exhibit electrostatic interactions at K370 in CYP11B1 and at K366 in CYP11B2 mutant R366K with D79 in adrenodoxin/ferredoxin-1. (CYP11B1 = cytochrome P450 family 11 subfamily B member 1; CYP11B2 = cytochrome P450 family 11 subfamily B member 2) | Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.
Peng HM, Auchus RJ., Free PMC Article | 06/24/2017 |
| FDX1 and FDX2 both bind NFS1 and donate electrons for iron-sulfur cluster biosynthesis. | Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis.
Cai K, Tonelli M, Frederick RO, Markley JL., Free PMC Article | 05/20/2017 |
| TNFSF13 and FDX1 have potential roles in IgAN in the Han Chinese population. This information may be useful in the development of early prognostics for IgAN. | Genetic polymorphisms in TNFSF13 and FDX1 are associated with IgA nephropathy in the Han Chinese population.
Niu D, Gao Y, Xie L, Sun J, Lu W, Jin G, Hao Y, Zhang Y, Yin A, Geng Y, Zhang W, Chen C, Li S. | 08/20/2016 |
| Did not find any positive association between FDX1 SNPs and the risk of IgA nephropathy after adjustment for age and sex, but did find a significant and strong correlation with relevant clinical pathological parameters. | Association between CCDC132, FDX1 and TNFSF13 gene polymorphisms and the risk of IgA nephropathy.
Niu D, Ren Y, Xie L, Sun J, Lu W, Hao Y, Zhang Y, Yin A, Li H, Lv J, Li S. | 08/13/2016 |
| results indicate transcription of FDX1 is regulated by the NR5A family and cAMP signaling, and participates in steroid hormone production in ovarian granulosa ce | Transcriptional regulation of human ferredoxin 1 in ovarian granulosa cells.
Imamichi Y, Mizutani T, Ju Y, Matsumura T, Kawabe S, Kanno M, Yazawa T, Miyamoto K. | 12/14/2013 |
| Data suggest that interference with any of the three related genes, ferredoxin (FDX)1, FDX2 or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis. | Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis.
Shi Y, Ghosh M, Kovtunovych G, Crooks DR, Rouault TA., Free PMC Article | 05/12/2012 |