| RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork. | RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork.
Hayran AB, Liabakk NB, Aas PA, Kusnierczyk A, Vågbø CB, Sarno A, Iveland TS, Chawla K, Zahn A, Di Noia JM, Slupphaug G, Kavli B., Free PMC Article | 02/1/2024 |
| FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. | FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.
Feng Y, Li C, Stewart JA, Barbulescu P, Seija Desivo N, Álvarez-Quilón A, Pezo RC, Perera MLW, Chan K, Tong AHY, Mohamad-Ramshan R, Berru M, Nakib D, Li G, Kardar GA, Carlyle JR, Moffat J, Durocher D, Di Noia JM, Bhagwat AS, Martin A., Free PMC Article | 03/5/2022 |
| Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination. | Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination.
Eldin P, Péron S, Galashevskaya A, Denis-Lagache N, Cogné M, Slupphaug G, Briant L., Free PMC Article | 07/10/2021 |
| Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma. | Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma.
Delgado P, Álvarez-Prado ÁF, Marina-Zárate E, Sernandez IV, Mur SM, de la Barrera J, Sanchez-Cabo F, Cañamero M, de Molina A, Belver L, de Yébenes VG, Ramiro AR., Free PMC Article | 01/23/2021 |
| during AID-induced class switch recombination, UNG in association with recombination factors may facilitate the stabilization of the S-S synapse to facilitate efficient recombination. | Uracil-DNA glycosylase is not implicated in the choice of the DNA repair pathway during B-cell class switch recombination.
Ghazzaui N, Issaoui H, Saintamand A, Denizot Y, Boyer F., Free PMC Article | 01/18/2020 |
| We identified a distinct UNG1 isoform variant that is targeted to the cell nucleus where it supports antibody class switching and repairs genomic uracil. We propose that the nuclear UNG1 variant, which in contrast to UNG2 lacks a PCNA-binding motif, may be specialized to act on ssDNA through its ability to bind RPA | Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.
Sarno A, Lundbæk M, Liabakk NB, Aas PA, Mjelle R, Hagen L, Sousa MML, Krokan HE, Kavli B., Free PMC Article | 11/30/2019 |
| we showed that SMUG1 efficiently prevent genomic uracil accumulation, even in the presence of UNG, and identified mutational signatures associated with combined UNG and SMUG1 deficiency. | Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.
Alsøe L, Sarno A, Carracedo S, Domanska D, Dingler F, Lirussi L, SenGupta T, Tekin NB, Jobert L, Alexandrov LB, Galashevskaya A, Rada C, Sandve GK, Rognes T, Krokan HE, Nilsen H., Free PMC Article | 02/23/2019 |
| Pms2/Mlh1 and multiple uracil glycosylases act jointly, each one with a distinct strand bias, to enlarge the immunoglobulin gene mutation spectrum from G-C to A-T bases. | Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.
Girelli Zubani G, Zivojnovic M, De Smet A, Albagli-Curiel O, Huetz F, Weill JC, Reynaud CA, Storck S., Free PMC Article | 08/19/2017 |
| UNG deficiency reduces B cell clonal expansion in the germinal center in mice and blocks the proliferation of tumor B cells expressing AID. | UNG protects B cells from AID-induced telomere loss.
Cortizas EM, Zahn A, Safavi S, Reed JA, Vega F, Di Noia JM, Verdun RE., Free PMC Article | 08/5/2017 |
| UNG might be involved in Tet-mediated DNA demethylation. | Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation.
Xue JH, Xu GF, Gu TP, Chen GD, Han BB, Xu ZM, Bjørås M, Krokan HE, Xu GL, Du YR., Free PMC Article | 05/21/2016 |
| Study showed elevated levels of homocysteine via dietary folic acid deficiency and chronic hypoperfusion negatively affect learning in Ung deficient mice, while increasing GFAP immunoreactivity within the dentate gyrus of the hippocampus | Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment.
Jadavji NM, Farr TD, Lips J, Khalil AA, Boehm-Sturm P, Foddis M, Harms C, Füchtemeier M, Dirnagl U. | 12/5/2015 |
| Ung and Pms2 may exert a mutual backup function for the DNA incision that promotes synthesis by Poleta, each with a distinct strand bias. | Somatic hypermutation at A/T-rich oligonucleotide substrates shows different strand polarities in Ung-deficient or -proficient backgrounds.
Zivojnovic M, Delbos F, Girelli Zubani G, Julé A, Alcais A, Weill JC, Reynaud CA, Storck S., Free PMC Article | 10/4/2014 |
| transcription factor E2A binds to the UNG2 promoter and represses UNG2 expression. | Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.
Wallenius A, Hauser J, Aas PA, Sarno A, Kavli B, Krokan HE, Grundström T. | 07/12/2014 |
| Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase. | Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase.
Yousif AS, Stanlie A, Mondal S, Honjo T, Begum NA., Free PMC Article | 05/31/2014 |
| Our results uncover a specific need for UNG in class-switch recombination for timely and efficient acute Ab responses in vivo | Separation of function between isotype switching and affinity maturation in vivo during acute immune responses and circulating autoantibodies in UNG-deficient mice.
Zahn A, Daugan M, Safavi S, Godin D, Cheong C, Lamarre A, Di Noia JM. | 08/31/2013 |
| Compared with WT mice, UNG deficiency caused elevated frequency of C:G mutations, suggesting that UNG-mediated U excision led to error-free as well as error-prone repair. | Analysis of Ig gene hypermutation in Ung(-/-)Polh(-/-) mice suggests that UNG and A:T mutagenesis pathway target different U:G lesions.
Li S, Zhao Y, Wang JY. | 01/12/2013 |
| we show that AID binds cooperatively with UNG and the mismatch repair proteins Msh2-Msh6 to Ig Smu and Sgamma3 regions | AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].
Ranjit S, Khair L, Linehan EK, Ucher AJ, Chakrabarti M, Schrader CE, Stavnezer J., Free PMC Article | 10/22/2011 |
| analysis of species specific differences between mouse and humans in regulation of SMUG1 and UNG2 | Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.
Doseth B, Visnes T, Wallenius A, Ericsson I, Sarno A, Pettersen HS, Flatberg A, Catterall T, Slupphaug G, Krokan HE, Kavli B., Free PMC Article | 07/16/2011 |
| The frequency of the D-1 mitochondrial (mt)DNA deletion in mtDNA is significantly increased in Ung-deficient mice, hence folate deficiency may contribute to neurodegeneration via mtDNA damage. | Folate deficiency increases mtDNA and D-1 mtDNA deletion in aged brain of mice lacking uracil-DNA glycosylase.
Kronenberg G, Gertz K, Overall RW, Harms C, Klein J, Page MM, Stuart JA, Endres M. | 06/18/2011 |
| Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation. | Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.
Krijger PH, Langerak P, van den Berk PC, Jacobs H., Free PMC Article | 01/21/2010 |
| The concerted action of Msh2 and UNG in stimulating A . T mutations also may have implications for mutagenesis at sites of spontaneous cytidine deamination. | The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.
Frieder D, Larijani M, Collins C, Shulman M, Martin A., Free PMC Article | 01/21/2010 |
| AID and Ung generate staggered double-strand DNA breaks (DSBs) not only by cleaving intact double-strand DNA, but also by processing blunt DSB ends. | AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.
Zan H, Casali P., Free PMC Article | 01/21/2010 |
| uracil-excision repair in oocytes is likely to be mediated by Udg2v2, or alternatively that Udg2v2 is involved in a process related to oocyte-specific maturation by virtue of its cyclin-like domains | The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and its relationship to human and chimpanzee homologues.
Hirst R, Gosden R, Miller D. | 01/21/2010 |
| results indicate UNG is involved in the repair step of immunoglobulin class switch recombination (CSR) yet by an unknown mechanism; dispensability of U removal in the DNA cleavage step of CSR requires reconsideration of the model of DNA deamination by AID | Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.
Begum NA, Kinoshita K, Kakazu N, Muramatsu M, Nagaoka H, Shinkura R, Biniszkiewicz D, Boyer LA, Jaenisch R, Honjo T. | 01/21/2010 |
| Results provide compelling evidence that uracil-DNA glycosylase is of major importance for tissue repair after brain ischemia. | Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase.
Endres M, Biniszkiewicz D, Sobol RW, Harms C, Ahmadi M, Lipski A, Katchanov J, Mergenthaler P, Dirnagl U, Wilson SH, Meisel A, Jaenisch R., Free PMC Article | 01/21/2010 |