| Netrin-1 receptor UNC5C cleavage by active delta-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies. | Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies.
Chen G, Kang SS, Wang Z, Ahn EH, Xia Y, Liu X, Sandoval IM, Manfredsson FP, Zhang Z, Ye K., Free PMC Article | 07/23/2022 |
| The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult mice. | The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult mice.
Barroca V, Racine C, Pays L, Fouchet P, Coureuil M, Allemand I. | 04/23/2022 |
| Here, we report that dissociation of UNC5C and polymerized TUBB3, the highly dynamic beta-tubulin isoform in neurons, is essential for netrin-1/UNC5C-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 mutations. | Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.
Shao Q, Yang T, Huang H, Alarmanazi F, Liu G., Free PMC Article | 08/26/2017 |
| UNC5C expression levels increased from the 4-cell stage to the blastocyst stage in fertilized murine embryos. Repression of UNC5C in the anterior nucleus stage inhibited development to the blastocyst stage. | Molecular Effects of Polymorphism in the 3'UTR of Unc-5 homolog C Associated with Conception Rate in Holsteins.
Sugimoto M, Gotoh Y, Kawahara T, Sugimoto Y., Free PMC Article | 04/16/2016 |
| UNC5c expression is enriched in CA3 hippocampal neurons, but UNC5c is not expressed in microglia or perpheral blood mononuclear cells. | A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M, Alzheimer's Disease Genetics Consortium, Mayeux R, Pericak-Vance M, Haines J, Farrer LA, Schellenberg GD, Goate A, Behrens TW, Cruchaga C, Watts RJ, Graham RR., Free PMC Article | 02/14/2015 |
| Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation. | Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation.
Srivatsa S, Parthasarathy S, Britanova O, Bormuth I, Donahoo AL, Ackerman SL, Richards LJ, Tarabykin V., Free PMC Article | 12/20/2014 |
| unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice. This phenotype is identical to that produced by dcc haploinsufficiency and is observed after adolescence. | unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model.
Auger ML, Schmidt ER, Manitt C, Dal-Bo G, Pasterkamp RJ, Flores C. | 03/8/2014 |
| this study suggested that Unc5c plays a broad role in dorsal guidance of axons in the developing hindbrain. | The UNC5C netrin receptor regulates dorsal guidance of mouse hindbrain axons.
Kim D, Ackerman SL., Free PMC Article | 03/26/2011 |
| repression of Unc5c expression by Rhox5 may, in part, mediate the pro-survival function of Rhox5 in the testis | The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c.
Hu Z, Shanker S, MacLean JA 2nd, Ackerman SL, Wilkinson MF. | 01/21/2010 |
| The netrin-1 receptor UNC5c, a proapoptotic molecule that is inhibited by RHOX5, was also regulated in vivo, and is thus a candidate to be downstream of RHOX5 in a prosurvival germ-cell pathway. | Regulation and function of the Rhox5 homeobox gene.
Hu Z, MacLean JA, Bhardwaj A, Wilkinson MF. | 01/21/2010 |
| These results support an important role for UNC5C in spinal accessory motor neuron development. | UNC5C is required for spinal accessory motor neuron development.
Dillon AK, Jevince AR, Hinck L, Ackerman SL, Lu X, Tessier-Lavigne M, Kaprielian Z. | 01/21/2010 |
| Our results provide the first evidence that genes involved in netrin signaling are necessary for proper mammalian spinal motor axon development and trochlear axon guidance. | Motor axon guidance of the mammalian trochlear and phrenic nerves: dependence on the netrin receptor Unc5c and modifier loci.
Burgess RW, Jucius TJ, Ackerman SL., Free PMC Article | 01/21/2010 |