| Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase and Glucosylceramides. | Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase and Glucosylceramides.
Sutter CH, Azim S, Wang A, Bhuju J, Simpson AS, Uberoi A, Grice EA, Sutter TR., Free PMC Article | 09/25/2023 |
| Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease. | Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease.
Komuro M, Nagane M, Endo R, Nakamura T, Miyamoto T, Niwa C, Fukuyama T, Harashima H, Aihara N, Kamiie J, Suzuki R, Yamashita T. | 03/19/2022 |
| Crucial role of glucosylceramide synthase in the regulation of stem cell-like cancer cells in B16F10 murine melanoma. | Crucial role of glucosylceramide synthase in the regulation of stem cell-like cancer cells in B16F10 murine melanoma.
Ghosh S, Juin SK, Bhattacharyya Majumdar S, Majumdar S. | 12/25/2021 |
| The cell division gene PCNA was significantly overexpressed in SK2(-/-) cells, suggesting a cross regulation between sphingosine kinases and Ceramide glucosyltransferase. | The cross roles of sphingosine kinase 1/2 and ceramide glucosyltransferase in cell growth and death.
Qin J, Kilkus JP, Dawson G. | 09/15/2018 |
| we report the development of a novel, orally available glucosylceramide synthase inhibitor (Genz-682452) with pharmacological and safety profiles that have potential for treating Fabry disease. | Efficacy of Enzyme and Substrate Reduction Therapy with a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease.
Ashe KM, Budman E, Bangari DS, Siegel CS, Nietupski JB, Wang B, Desnick RJ, Scheule RK, Leonard JP, Cheng SH, Marshall J., Free PMC Article | 06/11/2016 |
| These results suggest that neuronal glucosylceramide synthase expression modulates mediobasal hypothalamus insulin signaling and white adipose tissue function in fasted mice. | Fasting-Induced Lipolysis and Hypothalamic Insulin Signaling Are Regulated by Neuronal Glucosylceramide Synthase.
Herzer S, Meldner S, Gröne HJ, Nordström V. | 01/16/2016 |
| we measured the expression and activities of Pgp and GCS, UDP-glucose levels, cellular uptake of C12-NBD-ceramide (a fluorescent analogue of ceramide) and ceramide-induced cell death in S and R cells. | Reduced UDP-glucose Levels Are Associated with P-glycoprotein Over-expression in L1210 Cells and Limit Glucosylceramide Synthase Activity.
Turáková K, Pavlíková L, Messingerová L, Lakatoš B, Breier A, Sulová Z. | 08/8/2015 |
| Data indicate that verexpression of glucosylceramide synthase in myotubes induces glucosylceramide but enhances insulin signaling. | Ceramides and glucosylceramides are independent antagonists of insulin signaling.
Chavez JA, Siddique MM, Wang ST, Ching J, Shayman JA, Summers SA., Free PMC Article | 04/12/2014 |
| Data indicate that mice fed D- threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), an inhibitor of glucosylceramide synthase and lactosylceramide synthase showed marked reduction in tumor volume. | Use of a glycolipid inhibitor to ameliorate renal cancer in a mouse model.
Chatterjee S, Alsaeedi N, Hou J, Bandaru VV, Wu L, Halushka MK, Pili R, Ndikuyeze G, Haughey NJ., Free PMC Article | 12/28/2013 |
| The present work demonstrates that hypothalamic integration of metabolic signals requires neuronal expression of glucosylceramide synthase (GCS; UDP-glucose:ceramide glucosyltransferase). | Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.
Nordström V, Willershäuser M, Herzer S, Rozman J, von Bohlen Und Halbach O, Meldner S, Rothermel U, Kaden S, Roth FC, Waldeck C, Gretz N, de Angelis MH, Draguhn A, Klingenspor M, Gröne HJ, Jennemann R., Free PMC Article | 09/7/2013 |
| Data indicate that mice with cerebroside sulfotransferases (Cst) and UDP-glucose:ceramide glucosyltransferase (Ugcg)/Cst deficiency had lower ammonium excretion. | Sulfatides are required for renal adaptation to chronic metabolic acidosis.
Stettner P, Bourgeois S, Marsching C, Traykova-Brauch M, Porubsky S, Nordström V, Hopf C, Koesters R, Sandhoff R, Wiegandt H, Wagner CA, Gröne HJ, Jennemann R., Free PMC Article | 08/31/2013 |
| glycosphingolipids in hepatocytes are not essential for sterol, glucose, or lipoprotein metabolism. Ugcg inhibitors exert their effect on hepatocytes either independently of GSL or mediated by other (liver) cell types. | Hepatic glycosphingolipid deficiency and liver function in mice.
Jennemann R, Rothermel U, Wang S, Sandhoff R, Kaden S, Out R, van Berkel TJ, Aerts JM, Ghauharali K, Sticht C, Gröne HJ. | 05/31/2010 |
| Ugcg and Ugt8a deficient oligodendroglial did not exhibit any phenotypic or myelin structural abnormalities; abundant and structurally intact myelin can form in their absence | Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice.
Saadat L, Dupree JL, Kilkus J, Han X, Traka M, Proia RL, Dawson G, Popko B., Free PMC Article | 03/15/2010 |
| Shortly after birth UgcG deficient mice showed dysfunction of cerebellum and peripheral nerves, associated with structural defects | [Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth].
Jennemann R, Sandhoff R, Wiegandt H, Gröne HJ. | 01/21/2010 |