| Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB. | Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB.
Eliasen AU, Pedersen CET, Rasmussen MA, Wang N, Soverini M, Fritz A, Stokholm J, Chawes BL, Morin A, Bork-Jensen J, Grarup N, Pedersen O, Hansen T, Linneberg A, Mortensen PB, Hougaard DM, Bybjerg-Grauholm J, Bækvad-Hansen M, Mors O, Nordentoft M, Børglum AD, Werge T, Agerbo E, Söderhall C, Altman MC, Thysen AH, McKennan CG, Brix S, Gern JE, Ober C, Ahluwalia TS, Bisgaard H, Pedersen AG, Bønnelykke K. | 09/24/2022 |
| The role of CDHR3 in susceptibility to otitis media. | The role of CDHR3 in susceptibility to otitis media.
Hirsch SD, Elling CL, Bootpetch TC, Scholes MA, Hafrén L, Streubel SO, Pine HS, Wine TM, Szeremeta W, Prager JD, Einarsdottir E, Yousaf A, Baschal EE, Rehman S, Bamshad MJ, Nickerson DA, Riazuddin S, Leal SM, Ahmed ZM, Yoon PJ, Kere J, Chan KH, Mattila PS, Friedman NR, Chonmaitree T, Frank DN, Ryan AF, Santos-Cortez RLP., Free PMC Article | 02/26/2022 |
| Genetic impact of CDHR3 on the adult onset of asthma and COPD. | Genetic impact of CDHR3 on the adult onset of asthma and COPD.
Shigemasa R, Masuko H, Hyodo K, Kitazawa H, Kanazawa J, Yatagai Y, Iijima H, Naito T, Saito T, Hirota T, Tamari M, Sakamoto T, Hizawa N. | 11/6/2021 |
| Polymorphisms in the airway epithelium related genes CDHR3 and EMSY are associated with asthma susceptibility. | Polymorphisms in the airway epithelium related genes CDHR3 and EMSY are associated with asthma susceptibility.
Zhang M, Chen G, Wang Y, Wu SQ, Sandford AJ, He JQ., Free PMC Article | 07/31/2021 |
| Genetic susceptibility to severe childhood asthma and rhinovirus-C maintained by balancing selection in humans for 150 000 years. | Genetic susceptibility to severe childhood asthma and rhinovirus-C maintained by balancing selection in humans for 150 000 years.
O'Neill MB, Laval G, Teixeira JC, Palmenberg AC, Pepperell CS., Free PMC Article | 07/10/2021 |
| Cadherin-related family member 3 upregulates the effector functions of eosinophils. | Cadherin-related family member 3 upregulates the effector functions of eosinophils.
Nakagome K, Shimizu T, Bochkov YA, Noguchi T, Kobayashi T, Soma T, Ueki S, Gern JE, Nagata M., Free PMC Article | 06/26/2021 |
| Cadherin-related family member 3 gene impacts childhood asthma in Chinese children. | Cadherin-related family member 3 gene impacts childhood asthma in Chinese children.
Leung TF, Tang MF, Leung ASY, Kong APS, Liu TC, Chan RWY, Ma RCW, Sy HY, Chan JCN, Wong GWK. | 12/26/2020 |
| The rs6967330 SNP of CDHR3 confers risk of severe childhood asthma exacerbations, likely through increasing HRV-C infection levels and protein surface localization. | Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbations.
Everman JL, Sajuthi S, Saef B, Rios C, Stoner AM, Numata M, Hu D, Eng C, Oh S, Rodriguez-Santana J, Vladar EK, Voelker DR, Burchard EG, Seibold MA., Free PMC Article | 06/20/2020 |
| Polymorphisms in CDHR3 rs6967330 locus (G-->A) previously associated with childhood asthma were related to differences in CDHR3 expression and epithelial cell function. The rs6967330 A allele was associated with higher overall protein expression and RV-C binding and replication compared with the rs6967330 G allele. The rs6967330 A allele was associated with earlier ciliogenesis and higher FOXJ1 expression. | CDHR3 Asthma-Risk Genotype Affects Susceptibility of Airway Epithelium to Rhinovirus C Infections.
Basnet S, Bochkov YA, Brockman-Schneider RA, Kuipers I, Aesif SW, Jackson DJ, Lemanske RF Jr, Ober C, Palmenberg AC, Gern JE., Free PMC Article | 05/9/2020 |
| A single nucleotide polymorphism (rs6967330) in CDHR3 increases cell surface expression of this protein and, as a result, also promotes Human rhinovirus-C infections and illnesses. | Rhinoviruses and Their Receptors.
Basnet S, Palmenberg AC, Gern JE., Free PMC Article | 02/15/2020 |
| A genome-wide association study (GWAS) focusing on childhood asthma with recurrent severe exacerbations revealed a nonsynonymous SNP (rs6967330) in the CDHR3 (cadherin-related family member 3) gene that was associated specifically with this phenotype. | Cadherin-related Family Member 3 Genetics and Rhinovirus C Respiratory Illnesses.
Bønnelykke K, Coleman AT, Evans MD, Thorsen J, Waage J, Vissing NH, Carlsson CJ, Stokholm J, Chawes BL, Jessen LE, Fischer TK, Bochkov YA, Ober C, Lemanske RF Jr, Jackson DJ, Gern JE, Bisgaard H., Free PMC Article | 07/13/2019 |
| In summary, the CDHR3 asthma-risk variant at rs6967330 was not associated with severe RSV bronchiolitis. | CDHR3 gene variation and childhood bronchiolitis.
Husby A, Pasanen A, Waage J, Sevelsted A, Hodemaekers H, Janssen R, Karjalainen MK, Stokholm J, Chawes BL, Korppi M, Wennergren G, Heinzmann A, Bont L, Bisgaard H, Bønnelykke K., Free PMC Article | 06/1/2019 |
| we have determined that carriers of rs6967330 are at significantly increased risk for CRS. | Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis.
Chang EH, Willis AL, McCrary HC, Noutsios GT, Le CH, Chiu AG, Mansfield CJ, Reed DR, Brooks SG, Adappa ND, Palmer JN, Cohen NG, Stern DA, Guerra S, Martinez FD., Free PMC Article | 04/13/2019 |
| Our study supports the concept that the CDHR3 variant is an important susceptibility factor for severe adult asthma in individuals who develop the disease in early life. | Genetic association of the functional CDHR3 genotype with early-onset adult asthma in Japanese populations.
Kanazawa J, Masuko H, Yatagai Y, Sakamoto T, Yamada H, Kaneko Y, Kitazawa H, Iijima H, Naito T, Saito T, Noguchi E, Konno S, Nishimura M, Hirota T, Tamari M, Hizawa N. | 05/26/2018 |
| CDHR3 is a susceptibility locus for early childhood Asthma with severe exacerbations. | Rhinovirus in the Pathogenesis and Clinical Course of Asthma.
Jamieson KC, Warner SM, Leigh R, Proud D. | 04/30/2016 |
| the asthma susceptibility gene product CDHR3 mediates RV-C entry into host cells, and suggest that rs6967330 mutation could be a risk factor for RV-C wheezing illnesses. | Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication.
Bochkov YA, Watters K, Ashraf S, Griggs TF, Devries MK, Jackson DJ, Palmenberg AC, Gern JE., Free PMC Article | 08/1/2015 |
| the role of CDHR3 variants in the development of asthma with severe exacerbations based on genome-wide association study in Denmark | A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
Bønnelykke K, Sleiman P, Nielsen K, Kreiner-Møller E, Mercader JM, Belgrave D, den Dekker HT, Husby A, Sevelsted A, Faura-Tellez G, Mortensen LJ, Paternoster L, Flaaten R, Mølgaard A, Smart DE, Thomsen PF, Rasmussen MA, Bonàs-Guarch S, Holst C, Nohr EA, Yadav R, March ME, Blicher T, Lackie PM, Jaddoe VW, Simpson A, Holloway JW, Duijts L, Custovic A, Davies DE, Torrents D, Gupta R, Hollegaard MV, Hougaard DM, Hakonarson H, Bisgaard H. | 03/8/2014 |