U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    KIF6 kinesin family member 6 [ Homo sapiens (human) ]

    Gene ID: 221458, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    Submit: New GeneRIFCorrection

    GeneRIFPubMed TitleDate
    Motor protein Kif6 regulates cilia motility and polarity in brain ependymal cells.

    Motor protein Kif6 regulates cilia motility and polarity in brain ependymal cells.
    Takagishi M, Yue Y, Gray RS, Verhey KJ, Wallingford JB., Free PMC Article

    		03/1/2024
    KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection.

    KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection.
    Velasco JJ, Li Y, Ziganshin BA, Zafar MA, Rizzo JA, Ma D, Zang H, Kalyanasundaram A, Elefteriades JA., Free PMC Article

    		03/2/2023
    Impact of 719Trp>Arg Polymorphism of KIF 6 Gene on Contrast Induced Nephropathy in Patients Undergoing Coronary Angiography or Percutaneous Coronary Intervention.

    Impact of 719Trp>Arg Polymorphism of KIF 6 Gene on Contrast Induced Nephropathy in Patients Undergoing Coronary Angiography or Percutaneous Coronary Intervention.
    Barbieri L, Verdoia M, Suryapranata H, Carugo S, De Luca G., Free PMC Article

    		06/18/2022
    Are KIF6 and APOE polymorphisms associated with power and endurance athletes?

    Are KIF6 and APOE polymorphisms associated with power and endurance athletes?
    Wojciechowicz B, Laguette MN, Sawczuk M, Humińska-Lisowska K, Maciejewska-Skrendo A, Ficek K, Michałowska-Sawczyn M, Leońska-Duniec A, Kaczmarczyk M, Chycki J, Trybek G, September AV, Cięszczyk P.

    		09/25/2021
    The result suggests that KIF6 rs20455 polymorphism may not be associated with coronary heart disease susceptibility. (Meta-analysis)

    Association between KIF6 rs20455 polymorphism and the risk of coronary heart disease (CHD): a pooled analysis of 50 individual studies including 40,059 cases and 64,032 controls.
    Li Y, Chen Z, Song H., Free PMC Article

    		08/11/2018
    his represents the first study implicating KIF6 variants with obesity in men, and point to the possible involvement of this genetic locus in the known gender-related differences in coronary artery disease.

    Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population.
    Angelini S, Rosticci M, Massimo G, Musti M, Ravegnini G, Consolini N, Sammarini G, D'Addato S, Rizzoli E, Botbayev D, Borghi C, Cantelli-Forti G, Cicero AF, Hrelia P., Free PMC Article

    		07/28/2018
    The Trp719Arg polymorphism of the KIF6 gene is an important risk factor for developing myocardial infarction and that allele 719Arg may have a protective association to present coronary heart disease in all populations [review; meta-analysis]

    The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis.
    Ruiz-Ramos D, Hernández-Díaz Y, Tovilla-Zárate CA, Juárez-Rojop I, López-Narváez ML, González-Castro TB, Torres-Hernández ME, Baños-González MA., Free PMC Article

    		07/15/2017
    The absence of Trp719Arg polymorphism association with coronary artery disease (CAD) and CAD in stratified myocardial infarction cases indicates that the polymorphism is not associated with an increased risk among CAD patients from the Eastern Province of Saudi Arabia

    Investigation of KIF6 Trp719Arg gene polymorphism in a case-control study of coronary artery disease and non-fatal myocardial infarction in the Eastern Province of Saudi Arabia.
    Vatte C, Cyrus C, Al Shehri AM, Chathoth S, Almansori M, Al-Nafaie A, Al-Ali R, Al-Muhanna F, Asselbergs FW, Al-Ali A., Free PMC Article

    		01/28/2017
    KIF6 polymorphism rs20455 had a significant association with Coronary Heart Disease; statin therapy was more effective in rs20455 carriers than non-carriers

    Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran.
    Hamidizadeh L, Haji Hosseini Baghdad Abadi R, Babaee Baigi MA, Dastsooz H, Khazaei Nejhad A, Fardaei M.

    		08/6/2016
    KIF6 719Arg allele may increase the risk of T2DM and T2DM + CHD only in Han Chinese men by modulating lipid metabolism.

    Novel KIF6 polymorphism increases susceptibility to type 2 diabetes mellitus and coronary heart disease in Han Chinese men.
    Wu G, Li GB, Dai B, Zhang DQ., Free PMC Article

    		07/25/2015
    Our case-control study suggests that Trp719Arg of KIF6 gene is associated with coronary heart disease in female Han Chinese through a post hoc analysis.

    Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect.
    Peng P, Lian J, Huang RS, Xu L, Huang Y, Ba Y, Yang X, Huang X, Dong C, Zhang L, Ye M, Zhou J, Duan S., Free PMC Article

    		05/25/2013
    KIF6 719Arg allele was not an independent risk factor for angiographic coronary artery disease(CAD)susceptibility in northern China Han populations; it was associated with a significantly higher TG level, which may indicate increased myocardial infarction risk in angiographic CAD patients

    Association of KIF6 variant with lipid level and angiographic coronary artery disease events risk in the Han Chinese population.
    Wu G, Li GB, Dai B., Free PMC Article

    		03/9/2013
    These data suggest that decreased availability of functional KLF6 contributes to clinical prostate cancer progression.

    KLF6 loss of function in human prostate cancer progression is implicated in resistance to androgen deprivation.
    Liu X, Gomez-Pinillos A, Loder C, Carrillo-de Santa Pau E, Qiao R, Unger PD, Kurek R, Oddoux C, Melamed J, Gallagher RE, Mandeli J, Ferrari AC., Free PMC Article

    		11/17/2012
    In a meta-analysis involving 144,931 participants, the KIF6 719Arg allele was not associated with the relative risk of cardiovascular disease

    A common KIF6 polymorphism increases vulnerability to low-density lipoprotein cholesterol: two meta-analyses and a meta-regression analysis.
    Ference BA, Yoo W, Flack JM, Clarke M., Free PMC Article

    		05/26/2012
    Assessment of KIF6 genotype is not useful in predicting low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.

    KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.
    Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ.

    		05/26/2012
    Carriers of the KIF6 719Arg allele were not at increased risk of CAD/non-fatal MI in a case-control study of Indians (Indo-Europeans) living in Western India.

    Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians.
    Bhanushali AA, Contractor A, Shah VT, Das BR.

    		05/5/2012
    In patients with type 2 diabetes mellitus on hemodialysis, KIF6 Trp719Arg genotypes were not associated with adverse cardiovascular outcomes during follow-up or with the efficacy of atorvastatin therapy.

    Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and cardiovascular risk and efficacy of atorvastatin among subjects with diabetes on dialysis: the 4D study.
    Hoffmann MM, März W, Genser B, Drechsler C, Wanner C.

    		04/7/2012
    Discovered influence of polymorphic marker Trp719Arg of KIF6 gene on individual response to therapy with 10 mg/day of atorvastatin.

    [Association of a polymorphic marker Trp719Arg of KIF6 gene with effects of atorvastatin and simvastatin in patients with early ischemic heart disease].
    Koroleva OS, Pushkov AA, Blagodatskikh KA, Baranova OA, Azizova OA, Nosikov VV, Reznichenko NE, Zateĭshchikov DA.

    		01/28/2012
    A combination of KIF6 719Arg carrier status and C-reactive protein levels modestly improves the prediction of risk of myocardial infarction among white men.

    The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study.
    Shiffman D, O'Meara ES, Rowland CM, Louie JZ, Cushman M, Tracy RP, Devlin JJ, Psaty BM., Free PMC Article

    		01/28/2012
    Use of KIF6 genotyping to guide statin therapy is not warranted in this heart protection trial, since no impact is found on KIF6 genotype, vascular risk or statin response.

    No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study.
    Hopewell JC, Parish S, Clarke R, Armitage J, Bowman L, Hager J, Lathrop M, Collins R, MRC/BHF Heart Protection Study Collaborative Group.

    		07/23/2011
    Carriers of the KIF6 719Arg allele were not at increased risk of non-fatal myocardial infarction.

    Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population.
    Bare LA, Ruiz-Narvaéz EA, Tong CH, Arellano AR, Rowland CM, Catanese JJ, Sacks FM, Devlin JJ, Campos H., Free PMC Article

    		02/26/2011
    three highly linked SNPs in the KIF6 region were identified that predict differential reduction of coronary events from statin therapy.

    Genetic variants in the KIF6 region and coronary event reduction from statin therapy.
    Li Y, Sabatine MS, Tong CH, Ford I, Kirchgessner TG, Packard CJ, Robertson M, Rowland CM, Bare LA, Shepherd J, Devlin JJ, Iakoubova OA., Free PMC Article

    		02/5/2011
    review of data supporting association between KIF6 polymorphism and coronary heart disease (CHD) and association between KIF6 polymorphism and event reduction by statin therapy; discuss putative biologic role of this kinesin in the cause of CHD [review]

    KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapy.
    Li Y, Iakoubova OA, Shiffman D, Devlin JJ, Forrester JS, Superko HR.

    		01/1/2011
    the role of polymorphic marker Thr719Arg of kinesin 6 gene in development of ischemic heart disease, myocardial infarction, and in efficacy of therapy with statins (Review)

    [Motor protein Kinesin-6 and ischemic heart disease].
    Koroleva OS, Zateĭshchikov DA.

    		01/1/2011
    Meta-analysis of gene-disease association. (HuGE Navigator)

    Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.
    Assimes TL, Hólm H, Kathiresan S, Reilly MP, Thorleifsson G, Voight BF, Erdmann J, Willenborg C, Vaidya D, Xie C, Patterson CC, Morgan TM, Burnett MS, Li M, Hlatky MA, Knowles JW, Thompson JR, Absher D, Iribarren C, Go A, Fortmann SP, Sidney S, Risch N, Tang H, Myers RM, Berger K, Stoll M, Shah SH, Thorgeirsson G, Andersen K, Havulinna AS, Herrera JE, Faraday N, Kim Y, Kral BG, Mathias RA, Ruczinski I, Suktitipat B, Wilson AF, Yanek LR, Becker LC, Linsel-Nitschke P, Lieb W, König IR, Hengstenberg C, Fischer M, Stark K, Reinhard W, Winogradow J, Grassl M, Grosshennig A, Preuss M, Schreiber S, Wichmann HE, Meisinger C, Yee J, Friedlander Y, Do R, Meigs JB, Williams G, Nathan DM, MacRae CA, Qu L, Wilensky RL, Matthai WH Jr, Qasim AN, Hakonarson H, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser VE, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Martinelli N, Olivieri O, Trabetti E, Malerba G, Pignatti PF, Guiducci C, Mirel D, Parkin M, Hirschhorn JN, Asselta R, Duga S, Musunuru K, Daly MJ, Purcell S, Eifert S, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Cardiogenics, Ouwehand WH, Deloukas P, Scholz M, Cambien F, Huge A, Scheffold T, Salomaa V, Girelli D, Granger CB, Peltonen L, McKeown PP, Altshuler D, Melander O, Devaney JM, Epstein SE, Rader DJ, Elosua R, Engert JC, Anand SS, Hall AS, Ziegler A, O'Donnell CJ, Spertus JA, Siscovick D, Schwartz SM, Becker D, Thorsteinsdottir U, Stefansson K, Schunkert H, Samani NJ, Quertermous T., Free PMC Article

    		12/5/2010
    firstprevious page of 2 nextlast