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    FCGR3A Fc gamma receptor IIIa [ Homo sapiens (human) ]

    Gene ID: 2214, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Fcgamma-receptor-IIIA bioactivity of circulating and synovial immune complexes in rheumatoid arthritis.

    Fcγ-receptor-IIIA bioactivity of circulating and synovial immune complexes in rheumatoid arthritis.
    Andreeva I, Kolb P, Rodon L, Blank N, Lorenz HM, Merkt W., Free PMC Article

    10/9/2024
    FCGR3A F158V alleles frequency differs in multiple myeloma patients from healthy population.

    FCGR3A F158V alleles frequency differs in multiple myeloma patients from healthy population.
    Constantinides M, Robert N, Multrier C, Coënon L, Campos-Mora M, Jacquard C, Gao F, Zemiti S, Presumey J, Cartron G, Moreaux J, Villalba M., Free PMC Article

    10/3/2024
    Impact of HLA Class I Antigen, Killer Inhibitory Receptor, and FCGR3A Genotypes on Breast Cancer Susceptibility and Tumor Stage.

    Impact of HLA Class I Antigen, Killer Inhibitory Receptor, and FCGR3A Genotypes on Breast Cancer Susceptibility and Tumor Stage.
    Canossi A, Aureli A, Del Beato T, Novelli G, Buonomo O, Rossi P, Venditti A, Papola F, Sconocchia G.

    07/18/2024
    Association of NK cell subsets and cytotoxicity with FCGR3A gene polymorphism in functional NK cell deficiency.

    Association of NK cell subsets and cytotoxicity with FCGR3A gene polymorphism in functional NK cell deficiency.
    Karaselek MA, Kurar E, Keleş S, Güner ŞN, Reisli İ., Free PMC Article

    03/5/2024
    Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis.

    Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis.
    Lee YH, Song GG.

    11/22/2023
    Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent mechanism.

    Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent mechanism.
    Sugawara S, Hueber B, Woolley G, Terry K, Kroll K, Manickam C, Ram DR, Ndhlovu LC, Goepfert P, Jost S, Reeves RK., Free PMC Article

    09/19/2023
    Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis.

    Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis.
    Lee YH, Song GG.

    07/7/2023
    Analysis of FCGR3A-p.176Val variants in women with recurrent pregnancy loss and the association with CD16a expression and anti-HLA antibody status.

    Analysis of FCGR3A-p.176Val variants in women with recurrent pregnancy loss and the association with CD16a expression and anti-HLA antibody status.
    Habets DHJ, Al-Nasiry S, Nagelkerke SQ, Voorter CEM, Spaanderman MEA, Kuijpers TW, Wieten L., Free PMC Article

    04/4/2023
    FcgammaRIIIA activation-mediated up-regulation of glycolysis alters MDSCs modulation in CD4[+] T cell subsets of Sjogren syndrome.

    FcγRIIIA activation-mediated up-regulation of glycolysis alters MDSCs modulation in CD4(+) T cell subsets of Sjögren syndrome.
    Qi J, Zhou X, Bai Z, Lu Z, Zhu X, Liu J, Wang J, Jin M, Liu C, Li X., Free PMC Article

    02/28/2023
    The weaker-binding Fc gamma receptor IIIa F158 allotype retains sensitivity to N-glycan composition and exhibits a destabilized antibody-binding interface.

    The weaker-binding Fc γ receptor IIIa F158 allotype retains sensitivity to N-glycan composition and exhibits a destabilized antibody-binding interface.
    Kremer PG, Barb AW., Free PMC Article

    10/15/2022
    FCGR3A gene duplication, FcgammaRIIb-232TT and FcgammaRIIIb-HNA1a associate with an increased risk of vertical acquisition of HIV-1.

    FCGR3A gene duplication, FcγRIIb-232TT and FcγRIIIb-HNA1a associate with an increased risk of vertical acquisition of HIV-1.
    Ebonwu J, Lassaunière R, Paximadis M, Strehlau R, Gray GE, Kuhn L, Tiemessen CT., Free PMC Article

    10/1/2022
    High-affinity FcgammaRIIIa genetic variants and potent NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) responses contributing to severe COVID-19.

    High-affinity FcγRIIIa genetic variants and potent NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) responses contributing to severe COVID-19.
    Vietzen H, Danklmaier V, Zoufaly A, Puchhammer-Stöckl E., Free PMC Article

    09/3/2022
    FcgammaRIIIa receptor interacts with androgen receptor and PIP5K1alpha to promote growth and metastasis of prostate cancer.

    FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer.
    Larsson PF, Karlsson R, Sarwar M, Miftakhova R, Wang T, Syed Khaja AS, Semenas J, Chen S, Hedblom A, Ali A, Ekström-Holka K, Simoulis A, Kumar A, Wingren AG, Robinson B, Nyunt Wai S, Mongan NP, Heery DM, Öhlund D, Grundström T, Ødum N, Persson JL., Free PMC Article

    07/9/2022
    The CD3zeta adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling.

    The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling.
    Aguilar OA, Fong LK, Ishiyama K, DeGrado WF, Lanier LL., Free PMC Article

    05/7/2022
    Circulating Interleukin-6 and CD16 positive monocytes increase following angioplasty of an arteriovenous fistula.

    Circulating Interleukin-6 and CD16 positive monocytes increase following angioplasty of an arteriovenous fistula.
    Hakki S, Robinson EJ, Robson MG., Free PMC Article

    03/5/2022
    Single-cell analyses identify dysfunctional CD16(+) CD8 T cells in smokers.

    Single-cell analyses identify dysfunctional CD16(+) CD8 T cells in smokers.
    Martos SN, Campbell MR, Lozoya OA, Wang X, Bennett BD, Thompson IJB, Wan M, Pittman GS, Bell DA., Free PMC Article

    02/26/2022
    Persistent Oxidative Stress and Inflammasome Activation in CD14(high)CD16(-) Monocytes From COVID-19 Patients.

    Persistent Oxidative Stress and Inflammasome Activation in CD14(high)CD16(-) Monocytes From COVID-19 Patients.
    Lage SL, Amaral EP, Hilligan KL, Laidlaw E, Rupert A, Namasivayan S, Rocco J, Galindo F, Kellogg A, Kumar P, Poon R, Wortmann GW, Shannon JP, Hickman HD, Lisco A, Manion M, Sher A, Sereti I., Free PMC Article

    02/12/2022
    Significant differences in FcgammaRIIa, FcgammaRIIIa and FcgammaRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children.

    Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children.
    Nasr A, Aljada A, Hamid O, Elsheikh HA, Masuadi E, Al-Bawab A, Alenazi TH, Abushouk A, Salah AM., Free PMC Article

    01/15/2022
    Functional Fc Gamma Receptor Gene Polymorphisms and Long-Term Kidney Allograft Survival.

    Functional Fc Gamma Receptor Gene Polymorphisms and Long-Term Kidney Allograft Survival.
    Wahrmann M, Döhler B, Arnold ML, Scherer S, Mayer KA, Haindl S, Haslacher H, Böhmig GA, Süsal C., Free PMC Article

    12/25/2021
    Impacts of FcgammaRIIB and FcgammaRIIIA gene polymorphisms on systemic lupus erythematous disease activity index.

    Impacts of FcγRIIB and FcγRIIIA gene polymorphisms on systemic lupus erythematous disease activity index.
    Karimifar M, Akbari K, ArefNezhad R, Fathi F, Mousaei Ghasroldasht M, Motedayyen H., Free PMC Article

    12/25/2021
    CD16xCD33 Bispecific Killer Cell Engager (BiKE) as potential immunotherapeutic in pediatric patients with AML and biphenotypic ALL.

    CD16xCD33 Bispecific Killer Cell Engager (BiKE) as potential immunotherapeutic in pediatric patients with AML and biphenotypic ALL.
    Reusing SB, Vallera DA, Manser AR, Vatrin T, Bhatia S, Felices M, Miller JS, Uhrberg M, Babor F., Free PMC Article

    11/22/2021
    The FCGR3A 158 V/V-genotype is associated with decreased survival of renal allografts with chronic active antibody-mediated rejection.

    The FCGR3A 158 V/V-genotype is associated with decreased survival of renal allografts with chronic active antibody-mediated rejection.
    Litjens N, Peeters A, Gestel JK, Klepper M, Betjes M., Free PMC Article

    11/6/2021
    Fc gamma receptor IIIa/CD16a processing correlates with the expression of glycan-related genes in human natural killer cells.

    Fc γ receptor IIIa/CD16a processing correlates with the expression of glycan-related genes in human natural killer cells.
    Patel KR, Rodriguez Benavente MC, Lorenz WW, Mace EM, Barb AW., Free PMC Article

    09/4/2021
    Highly sensitive HPLC analysis and biophysical characterization of N-glycans of IgG-Fc domain in comparison between CHO and 293 cells using FcgammaRIIIa ligand.

    Highly sensitive HPLC analysis and biophysical characterization of N-glycans of IgG-Fc domain in comparison between CHO and 293 cells using FcγRIIIa ligand.
    Kosuge H, Nagatoishi S, Kiyoshi M, Ishii-Watabe A, Tanaka T, Terao Y, Oe S, Ide T, Tsumoto K., Free PMC Article

    09/4/2021
    Investigating expression pattern of eight immune-related genes in pemphigus patients compared with the healthy controls and after rituximab therapy: Potential roles of CTLA4 and FCGR3A genes expression in outcomes of rituximab therapy.

    Investigating expression pattern of eight immune-related genes in pemphigus patients compared with the healthy controls and after rituximab therapy: Potential roles of CTLA4 and FCGR3A genes expression in outcomes of rituximab therapy.
    Tavakolpour S, Mahmoudi H, Karami F, Elikaei Behjati S, Balighi K, Abbasi M, Salehi Farid A, Masoudi J, Balali M, Daneshpazhooh M, Modarressi MH.

    08/21/2021
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