| The TTN p. Tyr4418Ter mutation causes cardiomyopathy in human and mice. | The TTN p. Tyr4418Ter mutation causes cardiomyopathy in human and mice.
Sun W, Liu X, Song L, Tao L, Lai K, Jiang H, Xiao H., Free PMC Article | 02/26/2024 |
| Titin takes centerstage among cytoskeletal contributions to myocardial passive stiffness. | Titin takes centerstage among cytoskeletal contributions to myocardial passive stiffness.
Loescher CM, Linke WA. | 02/20/2024 |
| Urine titin as a novel biomarker for Duchenne muscular dystrophy. | Urine titin as a novel biomarker for Duchenne muscular dystrophy.
Ishii MN, Nakashima M, Kamiguchi H, Zach N, Kuboki R, Baba R, Hirakawa T, Suzuki K, Quinton M. | 04/12/2023 |
| Rbm20[DeltaRRM] Mice, Expressing a Titin Isoform with Lower Stiffness, Are Protected from Mechanical Ventilation-Induced Diaphragm Weakness. | Rbm20(ΔRRM) Mice, Expressing a Titin Isoform with Lower Stiffness, Are Protected from Mechanical Ventilation-Induced Diaphragm Weakness.
van den Berg M, Peters EL, van der Pijl RJ, Shen S, Heunks LMA, Granzier HL, Ottenheijm CAC., Free PMC Article | 01/11/2023 |
| Titin force in muscle cells alters lattice order, thick and thin filament protein formation. | Titin force in muscle cells alters lattice order, thick and thin filament protein formation.
Hessel AL, Ma W, Mazara N, Rice PE, Nissen D, Gong H, Kuehn M, Irving T, Linke WA., Free PMC Article | 12/3/2022 |
| Active muscle stiffness is reduced during rapid unloading in muscles from TtnDelta112-158 mice with a large deletion to PEVK titin. | Active muscle stiffness is reduced during rapid unloading in muscles from TtnΔ112-158 mice with a large deletion to PEVK titin.
Hurley KL, Bassett JR, Monroy JA. | 08/27/2022 |
| Depletion of m(6) A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin. | Depletion of m(6) A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin.
Gao S, Sun H, Chen K, Gu X, Chen H, Jiang L, Chen L, Zhang S, Liu Y, Shi D, Liang D, Xu L, Yang J, Ruan Y, Chen H, Shen B, Ma H, Chen YH., Free PMC Article | 04/2/2022 |
| Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant. | Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant.
Jiang H, Hooper C, Kelly M, Steeples V, Simon JN, Beglov J, Azad AJ, Leinhos L, Bennett P, Ehler E, Kalisch-Smith JI, Sparrow DB, Fischer R, Heilig R, Isackson H, Ehsan M, Patone G, Huebner N, Davies B, Watkins H, Gehmlich K., Free PMC Article | 12/11/2021 |
| Titin M-line insertion sequence 7 is required for proper cardiac function in mice. | Titin M-line insertion sequence 7 is required for proper cardiac function in mice.
Biquand A, Spinozzi S, Tonino P, Cosette J, Strom J, Elbeck Z, Knöll R, Granzier H, Lostal W, Richard I., Free PMC Article | 10/30/2021 |
| Solution NMR Structure of Titin N2A Region Ig Domain I83 and Its Interaction with Metal Ions. | Solution NMR Structure of Titin N2A Region Ig Domain I83 and Its Interaction with Metal Ions.
Kelly C, Pace N, Gage M, Pfuhl M., Free PMC Article | 08/28/2021 |
| N2A Titin: Signaling Hub and Mechanical Switch in Skeletal Muscle. | N2A Titin: Signaling Hub and Mechanical Switch in Skeletal Muscle.
Nishikawa K, Lindstedt SL, Hessel A, Mishra D., Free PMC Article | 04/3/2021 |
| Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle. | Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle.
Li Y, Hessel AL, Unger A, Ing D, Recker J, Koser F, Freundt JK, Linke WA., Free PMC Article | 03/20/2021 |
| The Axial Alignment of Titin on the Muscle Thick Filament Supports Its Role as a Molecular Ruler. | The Axial Alignment of Titin on the Muscle Thick Filament Supports Its Role as a Molecular Ruler.
Bennett P, Rees M, Gautel M., Free PMC Article | 02/2/2021 |
| Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx). | Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx).
Loescher CM, Breitkreuz M, Li Y, Nickel A, Unger A, Dietl A, Schmidt A, Mohamed BA, Kötter S, Schmitt JP, Krüger M, Krüger M, Toischer K, Maack C, Leichert LI, Hamdani N, Linke WA., Free PMC Article | 12/19/2020 |
| Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin. | Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin.
Swist S, Unger A, Li Y, Vöge A, von Frieling-Salewsky M, Skärlén Å, Cacciani N, Braun T, Larsson L, Linke WA., Free PMC Article | 09/26/2020 |
| Effects of a titin mutation on force enhancement and force depression in mouse soleus muscles. | Effects of a titin mutation on force enhancement and force depression in mouse soleus muscles.
Tahir U, Monroy JA, Rice NA, Nishikawa KC. | 09/12/2020 |
| The small deletion in titin associated with mdm in skeletal muscles alters force production, suggesting an important regulatory role for titin in active force production. The molecular mechanisms for titin's role in regulating muscle force production remain to be elucidated. | Optimal length, calcium sensitivity and twitch characteristics of skeletal muscles from mdm mice with a deletion in N2A titin.
Hessel AL, Joumaa V, Eck S, Herzog W, Nishikawa KC. | 07/11/2020 |
| We analyzed left ventricular samples from young (6months) and old (20months) wild-type mice and healthy human donor patients grouped according to age in young (17-50years) and aged hearts (51-73years). We found no age-dependent differences in titin isoform composition of mouse or human hearts | Elastic titin properties and protein quality control in the aging heart.
Salcan S, Bongardt S, Monteiro Barbosa D, Efimov IR, Rassaf T, Krüger M, Kötter S. | 07/4/2020 |
| titin's C-zone does not extend all the way to the bare zone but instead terminates at the level of the second myosin crown. This study enhances insights in the molecular layout of the C-zone of titin, its relation to cMyBP-C, and its possible roles in cardiomyopathies. | Fine mapping titin's C-zone: Matching cardiac myosin-binding protein C stripes with titin's super-repeats.
Tonino P, Kiss B, Gohlke J, Smith JE 3rd, Granzier H., Free PMC Article | 06/27/2020 |
| Direct effects of the titin mutation lead to lower shivering frequency. Indirect effects likely lead to a lower capacity for non-shivering thermogenesis and increased thermal conductance through decreased body size | Severe thermoregulatory deficiencies in mice with a deletion in the titin gene TTN.
Miyano CA, Orezzoli SF, Buck CL, Nishikawa KC. | 06/13/2020 |
| Studied dynamics and role of titin expression, homeostasis, and localization in mouse cardiomyocytes and sarcomeres. | Resolving titin's lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes.
Rudolph F, Hüttemeister J, da Silva Lopes K, Jüttner R, Yu L, Bergmann N, Friedrich D, Preibisch S, Wagner E, Lehnart SE, Gregorio CC, Gotthardt M., Free PMC Article | 04/11/2020 |
| Metformin offers therapeutic benefit during HFpEF by lowering titin-based passive stiffness. | Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance.
Slater RE, Strom JG, Methawasin M, Liss M, Gotthardt M, Sweitzer N, Granzier HL., Free PMC Article | 03/21/2020 |
| Titin-based passive tension contributes to sarcomere length-dependent Ca(2+)-troponin regulation. | Sarcomere length-dependent effects on Ca(2+)-troponin regulation in myocardium expressing compliant titin.
Li KL, Methawasin M, Tanner BCW, Granzier HL, Solaro RJ, Dong WJ., Free PMC Article | 03/21/2020 |
| Progressive depletion of titin leads to sarcomere disassembly and atrophy in striated muscle. In the complete knockout, remaining titin molecules experience increased strain, resulting in mechanically induced trophic signaling and eventually dilated cardiomyopathy. | Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes.
Radke MH, Polack C, Methawasin M, Fink C, Granzier HL, Gotthardt M., Free PMC Article | 02/1/2020 |
| regulation of thick filament length depends on titin and is critical for maintaining muscle health. | The giant protein titin regulates the length of the striated muscle thick filament.
Tonino P, Kiss B, Strom J, Methawasin M, Smith JE 3rd, Kolb J, Labeit S, Granzier H., Free PMC Article | 05/5/2018 |