| MARCH8 inhibits pseudorabies virus replication by trapping the viral cell-to-cell fusion complex in the trans-Golgi network. | MARCH8 inhibits pseudorabies virus replication by trapping the viral cell-to-cell fusion complex in the trans-Golgi network.
Rao CH, Huang R, Bai YZ, Yu C, Chen M, Peng JM, Xu SJ, Sun MX, Wang SJ, Yang YB, An TQ, Tian ZJ, Lyu C, Cai XH, Zheng C, Meng F, Tang YD. | 07/31/2024 |
| The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer. | The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
Khalil MI, Yang C, Vu L, Chadha S, Nabors H, James CD, Morgan IM, Pyeon D., Free PMC Article | 02/22/2024 |
| Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain. | Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain.
Yu C, Bai Y, Tan W, Bai Y, Li X, Zhou Y, Zhai J, Xue M, Tang YD, Zheng C, Liu Q. | 02/9/2024 |
| EGR1 functions as a new host restriction factor for SARS-CoV-2 to inhibit virus replication through the E3 ubiquitin ligase MARCH8. | EGR1 functions as a new host restriction factor for SARS-CoV-2 to inhibit virus replication through the E3 ubiquitin ligase MARCH8.
Zhao Y, Sui L, Wu P, Li L, Liu L, Ma B, Wang W, Chi H, Wang Z-D, Wei Z, Hou Z, Zhang K, Niu J, Jin N, Li C, Zhao J, Wang G, Liu Q., Free PMC Article | 01/4/2024 |
| E3 Ubiquitin Ligase MARCH8 Promotes Pancreatic Cancer Growth and Metastasis by Activating STAT3 via Degradation of PTPN4. | E3 Ubiquitin Ligase MARCH8 Promotes Pancreatic Cancer Growth and Metastasis by Activating STAT3 via Degradation of PTPN4.
Chen C, Wang Y, Zhao Q, Li GD, Wang YH, Xu LC, Huang HZ, Song G, Li WT, He XH. | 12/20/2023 |
| Ubiquitin ligase MARCH8 promotes the malignant progression of hepatocellular carcinoma through PTEN ubiquitination and degradation. | Ubiquitin ligase MARCH8 promotes the malignant progression of hepatocellular carcinoma through PTEN ubiquitination and degradation.
Xu Y, Zhang D, Ji J, Zhang L. | 06/16/2023 |
| HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer. | HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer.
Khalil MI, Yang C, Vu L, Chadha S, Nabors H, Welbon C, James CD, Morgan IM, Spanos WC, Pyeon D., Free PMC Article | 03/22/2023 |
| Membrane-associated RING-CH protein (MARCH8) is a novel glycolysis repressor targeted by miR-32 in colorectal cancer. | Membrane-associated RING-CH protein (MARCH8) is a novel glycolysis repressor targeted by miR-32 in colorectal cancer.
Wang Z, Wang MM, Geng Y, Ye CY, Zang YS., Free PMC Article | 09/24/2022 |
| Membrane-Associated RING-CH 8 Functions as a Novel PD-L1 E3 Ligase to Mediate PD-L1 Degradation Induced by EGFR Inhibitors. | Membrane-Associated RING-CH 8 Functions as a Novel PD-L1 E3 Ligase to Mediate PD-L1 Degradation Induced by EGFR Inhibitors.
Qian G, Guo J, Vallega KA, Hu C, Chen Z, Deng Y, Wang Q, Fan S, Ramalingam SS, Owonikoko TK, Wei W, Sun SY., Free PMC Article | 02/19/2022 |
| MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells. | MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells.
Villalón-Letelier F, Brooks AG, Londrigan SL, Reading PC., Free PMC Article | 01/22/2022 |
| MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes. | MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes.
Liu X, Xu F, Ren L, Zhao F, Huang Y, Wei L, Wang Y, Wang C, Fan Z, Mei S, Song J, Zhao Z, Cen S, Liang C, Wang J, Guo F., Free PMC Article | 07/31/2021 |
| MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation. | MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation.
Yu C, Li S, Zhang X, Khan I, Ahmad I, Zhou Y, Li S, Shi J, Wang Y, Zheng YH., Free PMC Article | 07/10/2021 |
| MARCH8 inhibits viral infection by two different mechanisms. | MARCH8 inhibits viral infection by two different mechanisms.
Zhang Y, Tada T, Ozono S, Kishigami S, Fujita H, Tokunaga K., Free PMC Article | 02/13/2021 |
| MicroRNA-199a-5p regulates glioma progression via targeting MARCH8. | MicroRNA-199a-5p regulates glioma progression via targeting MARCH8.
Zhang C, Chen Q, Zhu JW, Liu ZF. | 10/10/2020 |
| MHC II ubiquitination by E3 ubiquitin-protein ligase MARCH8 (MARCH8) and CD83 antigen (CD83) plays a critical role in T cell thymic selection [Review]. | MARCH ligases in immunity.
Liu H, Mintern JD, Villadangos JA. | 07/11/2020 |
| MARCH8, a RING-finger E3 ligase, catalyzes K63-linked NS2 polyubiquitination in vitro and in HCV-infected cells. MARCH8 is required for infection with HCV, dengue, and Zika viruses and specifically mediates HCV envelopment. | MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.
Kumar S, Barouch-Bentov R, Xiao F, Schor S, Pu S, Biquand E, Lu A, Lindenbach BD, Jacob Y, Demeret C, Einav S., Free PMC Article | 04/25/2020 |
| Knockdown of MARCH8 inactivated the PI3K and ss-catenin stat3 signaling pathways by changing protein expression levels or the phosphorylation of related proteins and inhibited migration and invasion of MKN-45 and AGS cells. | Sh-MARCH8 Inhibits Tumorigenesis via PI3K Pathway in Gastric Cancer.
Yin J, Ji Z, Hong Y, Song Z, Hu N, Zhuang M, Bian B, Liu Y, Wu F. | 09/22/2018 |
| Two additional regulators of BST2 constitutive ubiquitylation and sorting to the lysosomes: the E3 ubiquitin ligases NEDD4 and MARCH8, are reported. | Characterization of E3 ligases involved in lysosomal sorting of the HIV-1 restriction factor BST2.
Roy N, Pacini G, Berlioz-Torrent C, Janvier K., Free PMC Article | 01/27/2018 |
| Salmonella typhimurium SteD caused MARCH8-dependent ubiquitination and depletion of surface-localized mature MHC class II antigens. | The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation.
Bayer-Santos E, Durkin CH, Rigano LA, Kupz A, Alix E, Cerny O, Jennings E, Liu M, Ryan AS, Lapaque N, Kaufmann SHE, Holden DW., Free PMC Article | 09/9/2017 |
| YopJ mediates Ser- and Lys-acetylation and affects auto-ubiquitination of ubiquitin ligase MARCH8 in human cells. | Yersinia pestis acetyltransferase-mediated dual acetylation at the serine and lysine residues enhances the auto-ubiquitination of ubiquitin ligase MARCH8 in human cells.
Li C, Wang D, Lv X, Jing R, Bi B, Chen X, Guo J, Wang F, Sun S, Azadzoi KM, Yang JH., Free PMC Article | 07/1/2017 |
| Kaposi's sarcoma-associated herpesvirus RTA not only downregulated HLA-DRalpha at the protein level through direct binding and degradation through the proteasome pathway but also indirectly downregulated the protein level of HLA-DRalpha by enhancing the expression of MARCH8, a member of the membrane-associated RING-CH (MARCH) proteins. | Major Histocompatibility Complex Class II HLA-DRα Is Downregulated by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Lytic Transactivator RTA and MARCH8.
Sun Z, Jha HC, Pei YG, Robertson ES., Free PMC Article | 05/13/2017 |
| MARCH8 is highly expressed in terminally differentiated myeloid cells, and that it is a potent antiviral protein that targets viral envelope glycoproteins and reduces their incorporation into virions. | MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.
Tada T, Zhang Y, Koyama T, Tobiume M, Tsunetsugu-Yokota Y, Yamaoka S, Fujita H, Tokunaga K. | 05/14/2016 |
| MARCH 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor. | Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor.
Fujita H, Iwabu Y, Tokunaga K, Tanaka Y. | 01/18/2014 |
| MARCH8 protein localizes in lysosomes in HeLa cells | Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.
Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A. | 12/13/2013 |
| endogenous MARCH-8 regulates the steady-state cell surface expression of TRAIL-R1. | Ubiquitination by the membrane-associated RING-CH-8 (MARCH-8) ligase controls steady-state cell surface expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptor 1.
van de Kooij B, Verbrugge I, de Vries E, Gijsen M, Montserrat V, Maas C, Neefjes J, Borst J., Free PMC Article | 05/11/2013 |