| TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF). | TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF).
Morimoto Y, Tokumitsu A, Sone T, Hirota Y, Tamura R, Sakamoto A, Nakajima K, Toda M, Kawakami Y, Okano H, Ohta S. | 09/24/2022 |
| Translationally Controlled Tumor Protein-Mediated Stabilization of Host Antiapoptotic Protein MCL-1 Is Critical for Establishment of Infection by Intramacrophage Parasite Leishmania donovani. | Translationally Controlled Tumor Protein-Mediated Stabilization of Host Antiapoptotic Protein MCL-1 Is Critical for Establishment of Infection by Intramacrophage Parasite Leishmania donovani.
Giri J, Basu M, Roy S, Mishra T, Jana K, Chande A, Ukil A. | 05/28/2022 |
| TCTP overexpression reverses age-associated telomere attrition by upregulating telomerase activity in mouse oocytes. | TCTP overexpression reverses age-associated telomere attrition by upregulating telomerase activity in mouse oocytes.
Jeon HJ, Kang M, Kim JS, Oh JS. | 05/7/2022 |
| Blockade of translationally controlled tumor protein attenuated the aggressiveness of fibroblast-like synoviocytes and ameliorated collagen-induced arthritis. | Blockade of translationally controlled tumor protein attenuated the aggressiveness of fibroblast-like synoviocytes and ameliorated collagen-induced arthritis.
Kim M, Choe Y, Lee H, Jeon MG, Park JH, Noh HS, Cheon YH, Park HJ, Park J, Shin SJ, Lee K, Lee SI., Free PMC Article | 02/19/2022 |
| Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice. | Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice.
Jeon Y, Choi JY, Jang EH, Seong JK, Lee K., Free PMC Article | 01/29/2022 |
| TCTP is Essential for Cell Proliferation and Survival during CNS Development. | TCTP is Essential for Cell Proliferation and Survival during CNS Development.
Chen SH, Lu CH, Tsai MJ., Free PMC Article | 01/16/2021 |
| Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling. | Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling.
Lin Z, Zhang X, Wang J, Liu W, Liu Q, Ye Y, Dai B, Guo D, Zhang P, Yang P, Zhang R, Wang L, Dou K., Free PMC Article | 11/21/2020 |
| The biological effects of Na,K-ATPase and TCTP interaction are reviewed. | Some Biological Consequences of the Inhibition of Na,K-ATPase by Translationally Controlled Tumor Protein (TCTP).
Jung J, Ryu S, Ki IA, Woo HA, Lee K., Free PMC Article | 10/20/2018 |
| that TPT1 knockdown altered the BECN1 interactome, a representative MTOR-independent pathway, to stimulate autophagosome formation | TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway.
Bae SY, Byun S, Bae SH, Min DS, Woo HA, Lee K., Free PMC Article | 03/31/2018 |
| The first crystal structure of murine HRF to 4.0A resolution, reveals a conserved fold. A model for the role of murine HRF in mast cell activation was created based on the human HRF structure. | Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.
Doré KA, Kashiwakura JI, McDonnell JM, Gould HJ, Kawakami T, Sutton BJ, Davies AM., Free PMC Article | 01/27/2018 |
| Fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of this stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal levels. | Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death.
Pinkaew D, Chattopadhyay A, King MD, Chunhacha P, Liu Z, Stevenson HL, Chen Y, Sinthujaroen P, McDougal OM, Fujise K., Free PMC Article | 11/4/2017 |
| TCTP-mediated spindle dynamics play a key role in maintaining oocyte quality during postovulatory aging. Overexpression of TCTP is sufficient to prevent aging-associated abnormalities in mouse oocytes. | TCTP regulates spindle assembly during postovulatory aging and prevents deterioration in mouse oocyte quality.
Jeon HJ, Cui XS, Guo J, Lee JM, Kim JS, Oh JS. | 10/28/2017 |
| Leads to the enhanced and previously un-described interaction of RACK1 and TCTP. | Over-expression of insulin-response element binding protein-1 (IRE-BP1) in mouse pancreatic islets increases expression of RACK1 and TCTP: Beta cell markers of high glucose sensitivity.
Villafuerte BC, Barati MT, Rane MJ, Isaacs S, Li M, Wilkey DW, Merchant ML., Free PMC Article | 09/30/2017 |
| These data suggest the presence of a novel oxidative-stress-handling pathway where the anti-p53 molecule fortilin augments the peroxidase PRX1 by protecting it against degradation and inactivation of the enzyme. | Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice.
Chattopadhyay A, Pinkaew D, Doan HQ, Jacob RB, Verma SK, Friedman H, Peterson AC, Kuyumcu-Martinez MN, McDougal OM, Fujise K., Free PMC Article | 12/17/2016 |
| results demonstrate that TCTP is a microtubule-associating protein required to regulate spindle microtubule dynamics during meiotic maturation in mouse oocytes. | TCTP regulates spindle microtubule dynamics by stabilizing polar microtubules during mouse oocyte meiosis.
Jeon HJ, You SY, Park YS, Chang JW, Kim JS, Oh JS. | 06/11/2016 |
| TCTP over-expression-induced RhoA activation indicates that silencing of cellular TCTP may offer therapeutic approaches for the regulation of hypertension by inhibiting RhoA/Rho kinase pathway and modulating vascular contractility. | Up-regulation of Rhoa/Rho kinase pathway by translationally controlled tumor protein in vascular smooth muscle cells.
Maeng J, Sheverdin V, Shin H, Ha I, Bae SS, Yang-Yen HF, Lee K., Free PMC Article | 01/31/2015 |
| osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21 | Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21.
Choi SW, Shin HK, Yang-Yen HF, Lee MS, Lee CH, Park SJ, Kim KJ, Lee K, Kim SH. | 01/24/2015 |
| TPT1 is a p53 target gene that promotes cell survival. | Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival.
Chen W, Wang H, Tao S, Zheng Y, Wu W, Lian F, Jaramillo M, Fang D, Zhang DD., Free PMC Article | 03/8/2014 |
| Fortilin, induced in the proatherosclerotic microenvironment in macrophages, protects macrophages against Bax-induced apoptosis, allows them to propagate, and accelerates atherosclerosis. | Fortilin reduces apoptosis in macrophages and promotes atherosclerosis.
Pinkaew D, Le RJ, Chen Y, Eltorky M, Teng BB, Fujise K., Free PMC Article | 01/11/2014 |
| Overexpression of translationally controlled tumor protein increases the severity of atherosclerosis and hypertension in apolipoprotein E knock-out mice | Hypertension resulting from overexpression of translationally controlled tumor protein increases the severity of atherosclerosis in apolipoprotein E knock-out mice.
Cho Y, Maeng J, Ryu J, Shin H, Kim M, Oh GT, Lee MY, Lee K. | 05/18/2013 |
| These findings suggest that TCTP might play an important role in the process of podocyte hypertrophy under diabetic conditions via the regulation of mTORC1 activity and the induction of cell-cycle arrest. | Translationally controlled tumour protein is associated with podocyte hypertrophy in a mouse model of type 1 diabetes.
Kim DK, Nam BY, Li JJ, Park JT, Lee SH, Kim DH, Kim JY, Kang HY, Han SH, Yoo TH, Han DS, Kang SW. | 08/11/2012 |
| The TCTP downregulates the Oct4 expression by binding the Sf1 site of Oct4 promoter in mouse pluripotent cells. | Translationally controlled tumor protein (TCTP) downregulates Oct4 expression in mouse pluripotent cells.
Cheng X, Li J, Deng J, Li Z, Meng S, Wang H. | 07/7/2012 |
| TCTP may play a significant role in embryo implantation in mice | Expression of translationally controlled tumor protein (TCTP) in the uterus of mice of early pregnancy and its possible significance during embryo implantation.
Li S, Chen X, Ding Y, Liu X, Wang Y, He J. | 03/31/2012 |
| knockdown of Tctp resulted in increased amounts of P53 accompanied by a 50% reduction in the efficiency of tumor mammosphere formation | Reciprocal repression between P53 and TCTP.
Amson R, Pece S, Lespagnol A, Vyas R, Mazzarol G, Tosoni D, Colaluca I, Viale G, Rodrigues-Ferreira S, Wynendaele J, Chaloin O, Hoebeke J, Marine JC, Di Fiore PP, Telerman A. | 03/17/2012 |
| Identified a subset of IgE and IgG antibodies as TCTP(HRF)-interacting molecules in vitro. HRF was able to dimerize and bind to Igs via interactions of its N-terminal and internal regions with the Fab region of Igs. | Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy.
Kashiwakura JC, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho MH, Zajonc DM, Ozeki T, Ra C, MacDonald SM, Siraganian RP, Broide DH, Kawakami Y, Kawakami T., Free PMC Article | 03/10/2012 |