| TRAF1 improves cisplatin-induced acute kidney injury via inhibition of inflammation and metabolic disorders. | TRAF1 improves cisplatin-induced acute kidney injury via inhibition of inflammation and metabolic disorders.
Zhang X, Xu Y, Zhang W, Yang B, Zhang Y, Jia Z, Huang S, Zhang A, Li S. | 08/14/2023 |
| Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout. | Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout.
Mirzaesmaeili A, Zangiabadi S, Raspanti J, Akram A, Inman RD, Abdul-Sater AA. | 03/11/2023 |
| LINC00313 alleviates osteoarthritis progression in mice through promoting TRAF1 promoter methylation and inhibiting the ASK1/JNK signaling pathway. | LINC00313 alleviates osteoarthritis progression in mice through promoting TRAF1 promoter methylation and inhibiting the ASK1/JNK signaling pathway.
Li H, Wang Q, Gong D. | 10/8/2022 |
| TRAF1 suppresses antifungal immunity through CXCL1-mediated neutrophil recruitment during Candida albicans intradermal infection. | TRAF1 suppresses antifungal immunity through CXCL1-mediated neutrophil recruitment during Candida albicans intradermal infection.
Bai W, Wang Q, Deng Z, Li T, Xiao H, Wu Z., Free PMC Article | 07/10/2021 |
| these data point to an important role for 4-1BB, TRAF1, and mTOR in the persistence of CD8 effector T cells in the lung parenchyma, thereby allowing the transition to Trm. | 4-1BB Regulates Effector CD8 T Cell Accumulation in the Lung Tissue through a TRAF1-, mTOR-, and Antigen-Dependent Mechanism to Enhance Tissue-Resident Memory T Cell Formation during Respiratory Influenza Infection.
Zhou AC, Batista NV, Watts TH. | 12/28/2019 |
| TRAF1 deletion blocks lipopolysaccharide-induced JNK activation in vivo and in vitro. | TRAF1 meditates lipopolysaccharide-induced acute lung injury by up regulating JNK activation.
Bin W, Ming X, Wen-Xia C. | 12/14/2019 |
| TRAF-1-/- mice fed with high fat diet failed to gain weight, and showed improved insulin resistance, increased lipid breakdown in adipocytes and UCP-1-enabled thermogenesis. | Inflammatory Pathways Regulated by Tumor Necrosis Receptor-Associated Factor 1 Protect From Metabolic Consequences in Diet-Induced Obesity.
Anto Michel N, Colberg C, Buscher K, Sommer B, Pramod AB, Ehinger E, Dufner B, Hoppe N, Pfeiffer K, Marchini T, Willecke F, Stachon P, Hilgendorf I, Heidt T, von Zur Muhlen C, von Elverfeldt D, Pfeifer D, Schüle R, Kintscher U, Brachs S, Ley K, Bode C, Zirlik A, Wolf D., Free PMC Article | 08/10/2019 |
| this study shows that Traf1 gene knock-out mice show increased susceptibility to lipopolysaccharide-induced septic shock | The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease.
Abdul-Sater AA, Edilova MI, Clouthier DL, Mbanwi A, Kremmer E, Watts TH. | 07/1/2017 |
| NFkappaB anti-apoptotic target genes TNF receptor-associated factor 1 (TRAF1), TNF receptor-associated factor 2 (TRAF2), cellular inhibitor of apoptosis (cIAP2), and Ferritin heavy chain (FTH1) were increased following Losartan treatment | Life or death by NFκB, Losartan promotes survival in dy2J/dy2J mouse of MDC1A.
Elbaz M, Yanay N, Laban S, Rabie M, Mitrani-Rosenbaum S, Nevo Y., Free PMC Article | 12/5/2015 |
| TRAF1 is a crucial early mediator of hepatic ischemia/reperfusion injury. | TRAF1 is a key mediator for hepatic ischemia/reperfusion injury.
Zhang XF, Zhang R, Huang L, Wang PX, Zhang Y, Jiang DS, Zhu LH, Tian S, Zhang XD, Li H., Free PMC Article | 06/20/2015 |
| Increased neuronal TRAF1 leads to elevated neuronal death and enlarged ischaemic lesions. | TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death.
Lu YY, Li ZZ, Jiang DS, Wang L, Zhang Y, Chen K, Zhang XF, Liu Y, Fan GC, Chen Y, Yang Q, Zhou Y, Zhang XD, Liu DP, Li H., Free PMC Article | 10/11/2014 |
| The pathogenesis of spontaneous KRN/I-A(g7) arthritis can largely proceed by TRAF1-independent pathways. | Tumor necrosis factor receptor-associated factor 1 influences KRN/I-Ag7 mouse arthritis autoantibody production.
Cheng T, Choi Y, Finkel TH, Tsao PY, Ji MQ, Eisenberg RA., Free PMC Article | 11/16/2013 |
| Together, these findings define the importance of the basal phosphorylation state of the TRAF1 Serine 139 residue in coordinating signalling events downstream of 4-1BB in primary T cells. | TRAF1 phosphorylation on Serine 139 modulates NF-κB activity downstream of 4-1BB in T cells.
Oussa NA, Soumounou Y, Sabbagh L. | 09/21/2013 |
| TRAF1 and LSP1 cooperate downstream of 4-1BB to activate ERK signaling and down-modulate the levels of Bim leading to enhanced T cell survival. | Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells.
Sabbagh L, Andreeva D, Laramée GD, Oussa NA, Lew D, Bisson N, Soumounou Y, Pawson T, Watts TH. | 07/20/2013 |
| TRAF1 plays a critical role in regulating T cell activation both through restricting the costimulation independent activation of NIK in activated T cells and by promoting the 4-1BB-induced classical NF-kappaB pathway. | Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells.
McPherson AJ, Snell LM, Mak TW, Watts TH., Free PMC Article | 09/15/2012 |
| These findings identify TRAF1 as a potential biomarker of HIV-specific CD8 T cell fitness during the chronic phase of disease and a target for therapy. | Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.
Wang C, McPherson AJ, Jones RB, Kawamura KS, Lin GH, Lang PA, Ambagala T, Pellegrini M, Calzascia T, Aidarus N, Elford AR, Yue FY, Kremmer E, Kovacs CM, Benko E, Tremblay C, Routy JP, Bernard NF, Ostrowski MA, Ohashi PS, Watts TH., Free PMC Article | 04/14/2012 |
| combined signaling from the TNF or IL-1 receptors promotes maximal lung inflammation that may contribute to the severity of disease caused by H5N1 virus infection | Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus.
Perrone LA, Szretter KJ, Katz JM, Mizgerd JP, Tumpey TM., Free PMC Article | 09/27/2010 |
| TRAF1 deficiency attenuates atherogenesis in mice, most likely owing to impaired monocyte recruitment to the vessel wall | Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall.
Missiou A, Köstlin N, Varo N, Rudolf P, Aichele P, Ernst S, Münkel C, Walter C, Stachon P, Sommer B, Pfeifer D, Zirlik K, MacFarlane L, Wolf D, Tsitsikov E, Bode C, Libby P, Zirlik A., Free PMC Article | 06/14/2010 |
| TRAF1 has a prosurvival effect in CD8 T cells via the 4-1BB-mediated up-regulation of anti-apoptosis regulatory protein Bcl-x(L) and extracellular-regulated MAP kinase (ERK)-dependent Bim apoptosis facilitator down-modulation. | ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo.
Sabbagh L, Pulle G, Liu Y, Tsitsikov EN, Watts TH. | 01/21/2010 |
| The expression of TRAF1 in resident lung cells is required for the development of asthma. | TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammation.
Oyoshi MK, Bryce P, Goya S, Pichavant M, Umetsu DT, Oettgen HC, Tsitsikov EN. | 01/21/2010 |
| The TRAF1 signaling axis is critical for CD8 memory T cell survival in vivo. | A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival.
Sabbagh L, Srokowski CC, Pulle G, Snell LM, Sedgmen BJ, Liu Y, Tsitsikov EN, Watts TH., Free PMC Article | 01/21/2010 |
| TRAF1 reglates the subcellular localization and reveals mechanism of TRAF2 signaling. | Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling.
Arron JR, Pewzner-Jung Y, Walsh MC, Kobayashi T, Choi Y., Free PMC Article | 01/21/2010 |
| cellular levels of TRAF1 may play an important role in modulating the degradation of TRAF2 and TRAF3 in response to signals from the TNFR superfamily | Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling.
Xie P, Hostager BS, Munroe ME, Moore CR, Bishop GA. | 01/21/2010 |
| TRAF1 limit the induction of Th2 responses by decreasing NIP45 concentration to the nucleus down-regulating the expression of NIP45-dependent IL-4 gene transcription. | TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.
Bryce PJ, Oyoshi MK, Kawamoto S, Oettgen HC, Tsitsikov EN. | 01/21/2010 |
| Results implicate endothelial TRAF-1, -2, -3, -5, and -6 in CD40 signaling in atherogenesis, identifying these molecules as potential targets for selective therapeutic intervention. | TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells.
Zirlik A, Bavendiek U, Libby P, MacFarlane L, Gerdes N, Jagielska J, Ernst S, Aikawa M, Nakano H, Tsitsikov E, Schönbeck U. | 01/21/2010 |