| Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC). | Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC).
Sun A, Ge J, Ding K, Gao Z, Zhang Y. | 05/10/2024 |
| Tropomyosin 2 exerts anti-tumor effects in lung adenocarcinoma and is a novel prognostic biomarker. | Tropomyosin 2 exerts anti-tumor effects in lung adenocarcinoma and is a novel prognostic biomarker.
Duan P, Cui J, Li H, Yuan L. | 05/24/2023 |
| Trop2 Deficiency Reduces the Protective Effect of cortical bone-derived stem cells on Myocardial Ischemia/Reperfusion Injury. | Trop2 Guarantees Cardioprotective Effects of Cortical Bone-Derived Stem Cells on Myocardial Ischemia/Reperfusion Injury.
Li T, Su Y, Yu X, Mouniir DSA, Masau JF, Wei X, Yang J., Free PMC Article | 09/28/2019 |
| Tpm2 is involved in the progression of EMT during the wound healing process of mouse epithelial cells, suggesting that inhibition of Tpm2 may suppress Posterior capsular opacification. | Tropomyosin 2 heterozygous knockout in mice using CRISPR-Cas9 system displays the inhibition of injury-induced epithelial-mesenchymal transition, and lens opacity.
Shibata T, Shibata S, Ishigaki Y, Kiyokawa E, Ikawa M, Singh DP, Sasaki H, Kubo E., Free PMC Article | 12/22/2018 |
| Stress fibre formation and up-regulation of alpha-smooth muscle actin (alphaSMA) induced by TGFbeta2 could be reversed by Tpm1/2 knock-down by siRNA. | FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity.
Kubo E, Shibata S, Shibata T, Kiyokawa E, Sasaki H, Singh DP., Free PMC Article | 10/14/2017 |
| Trop2 marks fetal glandular epithelial cells of the stomach, growing as spheroids when cultured ex vivo. In adults, upon injury, Trop2 expression is reactivated in regenerative cells together with part of a fetal-like genetic program. | Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage.
Fernandez Vallone V, Leprovots M, Strollo S, Vasile G, Lefort A, Libert F, Vassart G, Garcia MI., Free PMC Article | 09/23/2017 |
| Trop-2 promotes an alpha5beta1 integrin-dependent pro-metastatic signaling pathway in PCa cells and that the altered expression of Trop-2 may be utilized for early identification of capsule-invading PCa. | Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts.
Trerotola M, Ganguly KK, Fazli L, Fedele C, Lu H, Dutta A, Liu Q, De Angelis T, Riddell LW, Riobo NA, Gleave ME, Zoubeidi A, Pestell RG, Altieri DC, Languino LR., Free PMC Article | 05/14/2016 |
| our findings help to establish a close functional link between Trop2 and MSCs, and to provide a tool for future investigation of Trop2 in other types of stem cells | Trop2 regulates the proliferation and differentiation of murine compact-bone derived MSCs.
Yang J, Zhu Z, Wang H, Li F, Du X, Ma RZ. | 04/12/2014 |
| data suggest that Trop2 regulates cell proliferation and motility and that it does so by regulating the ERK pathway and several critical components of the cell migration apparatus | Trop2 regulates motility and lamellipodia formation in cultured fetal lung fibroblasts.
McDougall AR, Hooper SB, Zahra VA, Cole TJ, Lo CY, Doran T, Wallace MJ. | 12/14/2013 |
| Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction. | Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction.
Yang J, Zhou Y, Liu B, Wang H, Du X. | 11/16/2013 |
| Generated chimeric alpha-/beta-tropomyosin protein to alter pathological consequences in mouse model of familial hypertrophic cardiomyopathy. | Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.
Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Arteaga GM, Solaro RJ, Liggett SB, Wieczorek DF. | 10/1/2010 |
| Differential expression of RhoGDI-1, cofilin 1 and tropomyosin 2 in calpain-deficient fibroblasts compared with wild-type fibroblasts | Genetic disruption of calpain correlates with loss of membrane blebbing and differential expression of RhoGDI-1, cofilin and tropomyosin.
Larsen AK, Lametsch R, Elce J, Larsen JK, Thomsen B, Larsen MR, Lawson MA, Greer PA, Ertbjerg P. | 01/21/2010 |
| Tm-2 is up-regulated during osteoclastogenesis, indicating potential cell-specific functions. | Tropomyosin isoforms localize to distinct microfilament populations in osteoclasts.
McMichael BK, Kotadiya P, Singh T, Holliday LS, Lee BS. | 01/21/2010 |