| TMT-based quantitative proteomic analysis revealed that FBLN2 and NPR3 are involved in the early osteogenic differentiation of mesenchymal stem cells (MSCs). | TMT-based quantitative proteomic analysis revealed that FBLN2 and NPR3 are involved in the early osteogenic differentiation of mesenchymal stem cells (MSCs).
Liu J, He S, Ma B, Li X, Wang Y, Xiong J., Free PMC Article | 08/25/2023 |
| Fibulin-2 Facilitates Malignant Progression of Hepatocellular Carcinoma. | Fibulin-2 Facilitates Malignant Progression of Hepatocellular Carcinoma.
Hu X, Liu T, Li L, Gan H, Wang T, Pang P, Mao J., Free PMC Article | 06/13/2023 |
| Knockdown of FBLN2 suppresses TGF-beta1-induced MRC-5 cell migration and fibrosis by downregulating VTN. | Knockdown of FBLN2 suppresses TGF-β1-induced MRC-5 cell migration and fibrosis by downregulating VTN.
Zhang Y, Zhang W, Zhang R, Xia Y. | 03/30/2023 |
| Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. | Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH.
Zhu N, Swietlik EM, Welch CL, Pauciulo MW, Hagen JJ, Zhou X, Guo Y, Karten J, Pandya D, Tilly T, Lutz KA, Martin JM, Treacy CM, Rosenzweig EB, Krishnan U, Coleman AW, Gonzaga-Jauregui C, Lawrie A, Trembath RC, Wilkins MR, Regeneron Genetics Center, PAH Biobank Enrolling Centers’ Investigators, NIHR BioResource for Translational Research - Rare Diseases, National Cohort Study of Idiopathic and Heritable PAH, Morrell NW, Shen Y, Gräf S, Nichols WC, Chung WK., Free PMC Article | 02/19/2022 |
| Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer. | Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer.
Klingen TA, Chen Y, Aas H, Wik E, Akslen LA., Free PMC Article | 10/16/2021 |
| Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2. | Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2.
Vaes N, Schonkeren SL, Rademakers G, Holland AM, Koch A, Gijbels MJ, Keulers TG, de Wit M, Moonen L, Van der Meer JRM, van den Boezem E, Wolfs TGAM, Threadgill DW, Demmers J, Fijneman RJA, Jimenez CR, Vanden Berghe P, Smits KM, Rouschop KMA, Boesmans W, Hofstra RMW, Melotte V., Free PMC Article | 08/21/2021 |
| Fibulin-2: A Novel Biomarker for Differentiating Grade II from Grade I Meningiomas. | Fibulin-2: A Novel Biomarker for Differentiating Grade II from Grade I Meningiomas.
Sofela AA, Hilton DA, Ammoun S, Baiz D, Adams CL, Ercolano E, Jenkinson MD, Kurian KM, Teo M, Whitfield PC, Sahm F, Hanemann CO., Free PMC Article | 04/3/2021 |
| An Investigation of Fibulin-2 in Hypertrophic Cardiomyopathy. | An Investigation of Fibulin-2 in Hypertrophic Cardiomyopathy.
Ibrahim AM, Roshdy M, Elshorbagy S, Hosny M, Halawa S, Yehia D, Elfawy HA, Eldessouki A, Mohamed F, Ellithy A, Abdelfattah M, Elsawy A, Elkhatib M, Allouba M, Elguindy A, Aguib Y, Yacoub M., Free PMC Article | 03/6/2021 |
| Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing. | Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing.
Toma C, Díaz-Gay M, Soares de Lima Y, Arnau-Collell C, Franch-Expósito S, Muñoz J, Overs B, Bonjoch L, Carballal S, Ocaña T, Cuatrecasas M, Díaz de Bustamante A, Castells A, Bujanda L, Cubiella J, Balaguer F, Rodríguez-Alcalde D, Fullerton JM, Castellví-Bel S., Free PMC Article | 09/26/2020 |
| Gene-based tests indicated an association between intracranial aneurysms and FBLN2, a gene encoding an extracellular matrix protein implicated in vascular wall remodeling. | Exome-chip association analysis of intracranial aneurysms.
van 't Hof FNG, Lai D, van Setten J, Bots ML, Vaartjes I, Broderick J, Woo D, Foroud T, Rinkel GJE, de Bakker PIW, Ruigrok YM., Free PMC Article | 05/23/2020 |
| The enriched epithelial cells of peripheral blood lymphocytes of decreased FBLN2 expression was found to be correlated with metastasis. The fibulin-2 molecules might induce the metastatic potential through interaction with the other molecules in the microenvironment. | The expression level of fibulin-2 in the circulating RNA (ctRNA) of epithelial tumor cells of peripheral blood and tumor tissue of patients with metastatic lung cancer.
Avsar M, Tambas M, Yalniz Z, Akdeniz D, Tuncer SB, Kilic S, Sukruoglu Erdogan O, Ciftci R, Dagoglu N, Vatansever S, Yazici H. | 02/22/2020 |
| Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 is a better substrate for ADAMTS-5 than it is for ADAMTS-4. Fibulin-2 degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells. | Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells.
Fontanil T, Álvarez-Teijeiro S, Villaronga MÁ, Mohamedi Y, Solares L, Moncada-Pazos A, Vega JA, García-Suárez O, Pérez-Basterrechea M, García-Pedrero JM, Obaya AJ, Cal S., Free PMC Article | 09/23/2017 |
| levels of fibulin 2 dramatically increased in the retinal pigment epithelium following retinal detachment, suggesting a direct role for fibulin 2 in the re-attachment of the retina to the retinal pigment epithelium. | Fibulin 2, a tyrosine O-sulfated protein, is up-regulated following retinal detachment.
Kanan Y, Brobst D, Han Z, Naash MI, Al-Ubaidi MR., Free PMC Article | 06/28/2014 |
| Study identified and validated a novel bona fide target of miR-1, Fibullin-2 (Fbln2), a secreted protein implicated in extracellular matrix remodeling. | Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling.
Karakikes I, Chaanine AH, Kang S, Mukete BN, Jeong D, Zhang S, Hajjar RJ, Lebeche D., Free PMC Article | 09/21/2013 |
| Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension. | Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension.
Vallvé JC, Serra N, Zalba G, Fortuño A, Beloqui O, Ferre R, Ribalta J, Masana L., Free PMC Article | 05/4/2013 |
| Data provide evidence that FBLN2 short isoform (FBLN2S) has an important tumor-suppressive and anti-angiogenic role in nasopharyngeal carcinoma (NPC). | Anti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma.
Law EW, Cheung AK, Kashuba VI, Pavlova TV, Zabarovsky ER, Lung HL, Cheng Y, Chua D, Lai-Wan Kwong D, Tsao SW, Sasaki T, Stanbridge EJ, Lung ML. | 05/12/2012 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesHuman variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL. Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.
Chattopadhyay I, Singh A, Phukan R, Purkayastha J, Kataki A, Mahanta J, Saxena S, Kapur S. | 04/7/2010 |
| fibulin-1 and -2 respond differentially to single and repeated damaging noxae, and their expression is differently present in liver cells | Expression of ECM proteins fibulin-1 and -2 in acute and chronic liver disease and in cultured rat liver cells.
Piscaglia F, Dudás J, Knittel T, Di Rocco P, Kobold D, Saile B, Zocco MA, Timpl R, Ramadori G., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK., Free PMC Article | 12/2/2009 |