| Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke. | Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke.
Li Z, Gao T, Wang J, Zhang X, Zhang Y, Zhang L, Yang P, Liu J. | 06/5/2024 |
| CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy. | CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy.
Qiu F, Liu Y, Liu Y, Zhao Z, Zhou L, Chen P, Du Y, Wang Y, Sun H, Zeng C, Wang X, Liu Y, Pan H, Ke C., Free PMC Article | 12/20/2023 |
| CD137-CD137L Aggravates Calcification of Vascular Smooth Muscle Cell and Vasculature of ApoE[-/-] Mice Via Rab7-Mediated Autophagy. | CD137-CD137L Aggravates Calcification of Vascular Smooth Muscle Cell and Vasculature of ApoE(-/-) Mice Via Rab7-Mediated Autophagy.
Yang P, Zang G, Yan Y, Zhong W, Li B, Xu Y, Shao C, Wang Z, Pu J, Yuan W. | 12/17/2022 |
| Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis. | Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis.
Bella Á, Arrizabalaga L, Di Trani CA, Cirella A, Fernandez-Sendin M, Gomar C, Russo-Cabrera JS, Rodríguez I, González-Gomariz J, Alvarez M, Teijeira Á, Medina-Echeverz J, Hinterberger M, Hochrein H, Melero I, Berraondo P, Aranda F., Free PMC Article | 08/6/2022 |
| 4-1BBL-containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells. | 4-1BBL-containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells.
Swatler J, Turos-Korgul L, Brewinska-Olchowik M, De Biasi S, Dudka W, Le BV, Kominek A, Cyranowski S, Pilanc P, Mohammadi E, Cysewski D, Kozlowska E, Grabowska-Pyrzewicz W, Wojda U, Basak G, Mieczkowski J, Skorski T, Cossarizza A, Piwocka K., Free PMC Article | 05/7/2022 |
| Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis. | Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis.
Luu K, Patwardhan MV, Zeng Q, Wickström SL, Lundqvist A, Schwarz H., Free PMC Article | 10/16/2021 |
| Activation of 4-1BBL+ B cells with CD40 agonism and IFNgamma elicits potent immunity against glioblastoma. | Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma.
Lee-Chang C, Miska J, Hou D, Rashidi A, Zhang P, Burga RA, Jusué-Torres I, Xiao T, Arrieta VA, Zhang DY, Lopez-Rosas A, Han Y, Sonabend AM, Horbinski CM, Stupp R, Balyasnikova IV, Lesniak MS., Free PMC Article | 09/4/2021 |
| The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity. | The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity.
Choi BK, Lee HW., Free PMC Article | 05/1/2021 |
| The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137(+) FOXP3(+) Regulatory CD4 T Cells. | The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137(+) FOXP3(+) Regulatory CD4 T Cells.
Foda BM, Ciecko AE, Serreze DV, Ridgway WM, Geurts AM, Chen YG., Free PMC Article | 03/13/2021 |
| CD137 negatively affects ""browning"" of white adipose tissue during cold exposure. | CD137 negatively affects "browning" of white adipose tissue during cold exposure.
Srivastava RK, Moliner A, Lee ES, Nickles E, Sim E, Liu C, Schwarz H, Ibáñez CF., Free PMC Article | 10/24/2020 |
| Deletion of CD137 Ligand Exacerbates Renal and Cutaneous but Alleviates Cerebral Manifestations in Lupus. | Deletion of CD137 Ligand Exacerbates Renal and Cutaneous but Alleviates Cerebral Manifestations in Lupus.
Mak A, Dharmadhikari B, Kow NY, Thamboo TP, Tang Q, Wong LW, Sajikumar S, Wong HY, Schwarz H., Free PMC Article | 10/24/2020 |
| CD137-CD137L Signaling Affects Angiogenesis by Mediating Phenotypic Conversion of Macrophages. | CD137-CD137L Signaling Affects Angiogenesis by Mediating Phenotypic Conversion of Macrophages.
Xu Y, Yan Y, Geng T, Wang C, Xu Y, Yang P, Yan J. | 10/3/2020 |
| indicate that spinal cord CD137L contributes to the development of peripheral nerve injury-induced neuropathic pain | Contribution of CD137L to Sensory Hypersensitivity in a Murine Model of Neuropathic Pain.
Wakley AA, Leeming R, Malon J, Arabatzis TJ, Yuen Koh W, Cao L., Free PMC Article | 04/20/2019 |
| m4-1BBL and Gal-9 act together to aid aggregation of m4-1BB monomers to efficiently initiate m4-1BB signaling. | Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.
Bitra A, Doukov T, Wang J, Picarda G, Benedict CA, Croft M, Zajonc DM., Free PMC Article | 12/1/2018 |
| the CD137-CD137L pathway plays an important role in regulating VSMC phenotype transformation via activation of NFATc1 signaling pathway. | CD137-CD137L interaction modulates neointima formation and the phenotype transformation of vascular smooth muscle cells via NFATc1 signaling.
Zhong W, Li B, Yang P, Chen R, Wang C, Wang Z, Shao C, Yuan W, Yan J. | 07/14/2018 |
| this study shows that intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung | Intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung.
Zhou AC, Wagar LE, Wortzman ME, Watts TH. | 06/23/2018 |
| the role of CD137-CRDI (cysteine rich domain I) in the binding of CD137-CD137L was further investigated. | CD137-CRDI is not necessary in the role of contacting its natural ligand.
Yi L, Yan Z, Jia H, Wang X, Zhao Y, Zhang H. | 12/2/2017 |
| Data indicate that anti-CD137 agonists can function as inhibitors of CD137L signaling, resulting in the creation of tumor microenvironments unfavorable for tumor immune evasion. | Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Kang SW, Lee SC, Park SH, Kim J, Kim HH, Lee HW, Seo SK, Kwon BS, Cho HR, Kwon B. | 11/26/2017 |
| Constitutive interaction between 4-1BB and 4-1BBL on murine LPS-activated bone marrow dendritic cells masks detection of 4-1BBL by TKS-1 but not 19H3 antibody. | Constitutive interaction between 4-1BB and 4-1BBL on murine LPS-activated bone marrow dendritic cells masks detection of 4-1BBL by TKS-1 but not 19H3 antibody.
Mbanwi AN, Lin GHY, Wang KC, Watts TH. | 10/7/2017 |
| 4-1BBL can restrain effector T cell development, creating a more favorable regulatory T cell to effector cell balance under tolerogenic conditions, and this may be particularly active in mucosal barrier tissues | 4-1BB ligand signaling to T cells limits T cell activation.
Eun SY, Lee SW, Xu Y, Croft M., Free PMC Article | 02/27/2016 |
| These results demonstrate that 4-1BBL-engineered DCs can improve CIKs cytotoxicity against prostate cancer cells. | Potent anti-prostate cancer immune response induced by dendritic cells transduced with recombinant adenoviruses encoding 4-1BBL combined with cytokine-induced killer cells.
Youlin K, Jian K, Siming L, Li Z, Weiyang H, Chaodong L, Xin G. | 09/26/2015 |
| these observations suggest that inhibition of the TLR/4-1BBL complex formation may be highly efficient in protecting against continued inflammation | Inhibition of 4-1BBL-regulated TLR response in macrophages ameliorates endotoxin-induced sepsis in mice.
Bang BR, Kim SJ, Yagita H, Croft M, Kang YJ., Free PMC Article | 05/9/2015 |
| 4-1BB mediates the inflammatory responses in obese skeletal muscle by interacting with its ligand 4-1BBL on macrophages. | Blockade of 4-1BB and 4-1BBL interaction reduces obesity-induced skeletal muscle inflammation.
Le NH, Kim CS, Tu TH, Choi HS, Kim BS, Kawada T, Goto T, Park T, Park JH, Yu R., Free PMC Article | 10/18/2014 |
| CD137-CD137L interactions mediated via regulation of CyPA contribute to the progression of atherosclerosis. | CD137-CD137L interaction regulates atherosclerosis via cyclophilin A in apolipoprotein E-deficient mice.
Li Y, Yan J, Wu C, Wang Z, Yuan W, Wang D., Free PMC Article | 10/18/2014 |
| Data indicate that CD137L deficient mice displayed a variety of immunological dysfunctions. | Role of the CD137 ligand (CD137L) signaling pathway during Mycobacterium tuberculosis infection.
Martínez Gómez JM, Koh VH, Yan B, Lin W, Ang ML, Rahim SZ, Pethe K, Schwarz H, Alonso S. | 07/26/2014 |