| The aged microenvironment impairs BCL6 and CD40L induction in CD4[+] T follicular helper cell differentiation. | The aged microenvironment impairs BCL6 and CD40L induction in CD4(+) T follicular helper cell differentiation.
Fisher JS, Adán-Barrientos I, Kumar NR, Lancaster JN., Free PMC Article | 06/15/2024 |
| B cells in the pneumococcus-infected lung are heterogeneous and require CD4[+] T cell help including CD40L to become resident memory B cells. | B cells in the pneumococcus-infected lung are heterogeneous and require CD4(+) T cell help including CD40L to become resident memory B cells.
Etesami NS, Barker KA, Shenoy AT, De Ana CL, Arafa EI, Grifno GN, Matschulat AM, Vannini ME, Pihl RMF, Breen MP, Soucy AM, Goltry WN, Ha CT, Betsuyaku H, Browning JL, Varelas X, Traber KE, Jones MR, Quinton LJ, Maglione PJ, Nia HT, Belkina AC, Mizgerd JP., Free PMC Article | 06/3/2024 |
| CD40L modulates CD4[+] T-cell activation through receptor for activated C kinase 1. | CD40L modulates CD4(+) T-cell activation through receptor for activated C kinase 1.
van Os BW, Vos WG, Bosmans LA, van Tiel CM, Toom MD, Beckers L, Admiraal M, Hoeksema MA, de Winther MP, Lutgens E. | 12/28/2023 |
| CD40-CD40 ligand interaction between periodontal ligament cells and cementoblasts enhances periodontal tissue remodeling in response to mechanical stress. | CD40-CD40 ligand interaction between periodontal ligament cells and cementoblasts enhances periodontal tissue remodeling in response to mechanical stress.
Yamamoto Y, Fujihara C, Nantakeeratipat T, Matsumoto M, Noguchi T, Kitagawa M, Yamada S, Takata T, Kitaura H, Murakami S. | 11/20/2023 |
| Importance of CD40/CD40 dyad in the course of infection with Trypanosoma cruzi: Impact of its inhibition. | Importance of CD40/CD40 dyad in the course of infection with Trypanosoma cruzi: Impact of its inhibition.
Frank FM, Wagner DH Jr, Postan M, Petray PB. | 09/20/2023 |
| Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD. | Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD.
Ma C, Fu Q, Diggs LP, McVey JC, McCallen J, Wabitsch S, Ruf B, Brown Z, Heinrich B, Zhang Q, Rosato U, Wang S, Cui L, Berzofsky JA, Kleiner DE, Bosco DB, Wu LJ, Lai CW, Rotman Y, Xie C, Korangy F, Greten TF., Free PMC Article | 10/1/2022 |
| Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis. | Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis.
Bella Á, Arrizabalaga L, Di Trani CA, Cirella A, Fernandez-Sendin M, Gomar C, Russo-Cabrera JS, Rodríguez I, González-Gomariz J, Alvarez M, Teijeira Á, Medina-Echeverz J, Hinterberger M, Hochrein H, Melero I, Berraondo P, Aranda F., Free PMC Article | 08/6/2022 |
| 3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation. | 3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation.
Yang B, Hou S, Zhao J, Li Y., Free PMC Article | 02/26/2022 |
| CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking. | CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking.
França TT, Al-Sbiei A, Bashir G, Mohamed YA, Salgado RC, Barreiros LA, Maria da Silva Napoleão S, Weber CW, Fernandes Severo Ferreira J, Aranda CS, Prando C, de Barros Dorna MB, Jurisica I, Fernandez-Cabezudo MJ, Ochs HD, Condino-Neto A, Al-Ramadi BK, Cabral-Marques O., Free PMC Article | 02/26/2022 |
| Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures. | Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures.
Pototskiy E, Vinokuroff K, Ojeda A, Major CK, Sharma D, Anderson T, Howard K, Borenstein R, Musto AE., Free PMC Article | 11/13/2021 |
| Signalling Pathways Mediating the Effects of CD40-Activated CD40L Reverse Signalling on Inhibitory Medium Spiny Neuron Neurite Growth. | Signalling Pathways Mediating the Effects of CD40-Activated CD40L Reverse Signalling on Inhibitory Medium Spiny Neuron Neurite Growth.
Carriba P, Davies AM., Free PMC Article | 10/23/2021 |
| CD103(+) cDC1 and endogenous CD8(+) T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function. | CD103(+) cDC1 and endogenous CD8(+) T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.
Kuhn NF, Lopez AV, Li X, Cai W, Daniyan AF, Brentjens RJ., Free PMC Article | 12/19/2020 |
| Evidence of CD40L/CD40 pathway involvement in experimental transfusion-related acute lung injury. | Evidence of CD40L/CD40 pathway involvement in experimental transfusion-related acute lung injury.
Tariket S, Hamzeh-Cognasse H, Laradi S, Arthaud CA, Eyraud MA, Bourlet T, Berthelot P, Garraud O, Cognasse F., Free PMC Article | 11/21/2020 |
| The Interplay Between Innate Immunity (TLR-4) and sCD40L in the Context of an Animal Model of Colitis-associated Cancer. | The Interplay Between Innate Immunity (TLR-4) and sCD40L in the Context of an Animal Model of Colitis-associated Cancer.
Angelou A, Papalois AE, Antoniou E, Wang J, Amini N, Pikouli A, Andreatos N, Buettner S, Munir M, Theodoropoulos G, Zografos GC, Sarantis P, Pulvirenti A, Kamphues C, Theocharis S, Pikoulis E, Margonis GA. | 10/10/2020 |
| it is the combination of CD40L and the cytokines secreted by activated t-cells that licenses dendritic cellss and influences the effector class of the immune response | Cutting Edge: Quantitative Determination of CD40L Threshold for IL-12 and IL-23 Production from Dendritic Cells.
Abdi K, Laky K, Padhan K, Petrovas C, Skinner J, Kabat J, Dorward DW, Brzostowski J, Long EO, Trinchieri G, Varma R., Free PMC Article | 07/20/2019 |
| Deficiency of (hematopoietic) CD40L protects against dissecting aneurysm formation and reduces the incidence of fatal rupture. This is associated with a decreased accumulation and activation of inflammatory cells and a dampened protease activity in the arterial wall. | CD40L Deficiency Protects Against Aneurysm Formation.
Kusters PJH, Seijkens TTP, Beckers L, Lievens D, Winkels H, de Waard V, Duijvestijn A, Lindquist Liljeqvist M, Roy J, Daugherty A, Newby A, Gerdes N, Lutgens E. | 07/13/2019 |
| T-cell zone-specific TCRbeta repertoires revealed that CD154 deficiency shifts the distribution of Vbeta-Jbeta genes after antigen exposure | CD154 Costimulation Shifts the Local T-Cell Receptor Repertoire Not Only During Thymic Selection but Also During Peripheral T-Dependent Humoral Immune Responses.
Fähnrich A, Klein S, Sergé A, Nyhoegen C, Kombrink S, Möller S, Keller K, Westermann J, Kalies K., Free PMC Article | 07/13/2019 |
| CD40L controls obesity-associated vascular inflammation, oxidative stress and endothelial dysfunction in mice and potentially humans. | CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db/db mice.
Steven S, Dib M, Hausding M, Kashani F, Oelze M, Kröller-Schön S, Hanf A, Daub S, Roohani S, Gramlich Y, Lutgens E, Schulz E, Becker C, Lackner KJ, Kleinert H, Knosalla C, Niesler B, Wild PS, Münzel T, Daiber A. | 05/25/2019 |
| These results suggest that combination of IL-21, anti-Tim1 and CD40L treatment induced B10 cell's IL-10 competency in vitro and inhibited periodontal bone loss in ligature-induced experimental periodontitis. | IL-21/anti-Tim1/CD40 ligand promotes B10 activity in vitro and alleviates bone loss in experimental periodontitis in vivo.
Hu Y, Yu P, Yu X, Hu X, Kawai T, Han X., Free PMC Article | 12/1/2018 |
| MR1-induced bone accrual was associated with increased Treg development and elevated production of cytotoxic T lymphocyte antigen 4, a costimulation inhibitor that promotes T cell anergy and CD8+ T cell expression of the bone anabolic ligand Wnt-10b. | Neutralization of CD40 ligand costimulation promotes bone formation and accretion of vertebral bone mass in mice.
Roser-Page S, Vikulina T, Yu K, McGee-Lawrence ME, Weitzmann MN., Free PMC Article | 07/21/2018 |
| These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms. | CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons.
Carriba P, Davies AM., Free PMC Article | 06/23/2018 |
| Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in focal segmental glomerulosclerosis. | Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in FSGS.
Doublier S, Zennaro C, Musante L, Spatola T, Candiano G, Bruschi M, Besso L, Cedrino M, Carraro M, Ghiggeri GM, Camussi G, Lupia E., Free PMC Article | 12/23/2017 |
| studies identify a novel molecular mechanism of regulation of CD40L by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 signaling | Novel Molecular Mechanism of Regulation of CD40 Ligand by the Transcription Factor GLI2.
Han W, Jackson DA, Matissek SJ, Misurelli JA, Neil MS, Sklavanitis B, Amarsaikhan N, Elsawa SF., Free PMC Article | 09/23/2017 |
| our results unambiguously demonstrate that while CD40L is critical to generate effective primary CD8(+) T-cell responses also under inflammatory conditions, CD40L expression by CD8(+) T cells themselves is dispensable in acute lymphocytic choriomeningitis virus infection. | CD40L expression by CD4(+) but not CD8(+) T cells regulates antiviral immune responses in acute LCMV infection in mice.
Durlanik S, Loyal L, Stark R, Sercan Alp Ö, Hartung A, Radbruch A, von Herrath M, Matzmohr N, Frentsch M, Thiel A. | 07/22/2017 |
| Platelets promote allergic asthma through the expression of CD154. | Platelets promote allergic asthma through the expression of CD154.
Tian J, Zhu T, Liu J, Guo Z, Cao X., Free PMC Article | 08/13/2016 |