| Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells. | Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells.
Wang Y, Popovic Z, Charkoftaki G, Garcia-Milian R, Lam TT, Thompson DC, Chen Y, Vasiliou V., | 01/30/2024 |
| Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. | Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1.
Feng Z, Hom ME, Bearrood TE, Rosenthal ZC, Fernández D, Ondrus AE, Gu Y, McCormick AK, Tomaske MG, Marshall CR, Kline T, Chen CH, Mochly-Rosen D, Kuo CJ, Chen JK., Free PMC Article | 10/8/2022 |
| Aldehyde Dehydrogenase 1B1 Is Implicated in DNA Damage Response in Human Colorectal Adenocarcinoma. | Aldehyde Dehydrogenase 1B1 Is Implicated in DNA Damage Response in Human Colorectal Adenocarcinoma.
Tsochantaridis I, Kontopoulos A, Voulgaridou GP, Tsifintaris M, Triantafyllou C, Pappa A., Free PMC Article | 07/16/2022 |
| AMBRA1 Negatively Regulates the Function of ALDH1B1, a Cancer Stem Cell Marker, by Controlling Its Ubiquitination. | AMBRA1 Negatively Regulates the Function of ALDH1B1, a Cancer Stem Cell Marker, by Controlling Its Ubiquitination.
Baek SH, Jang YK., Free PMC Article | 01/15/2022 |
| Aldehyde dehydrogenase 1B1 is a potential marker of colorectal tumors. | Aldehyde dehydrogenase 1B1 is a potential marker of colorectal tumors.
Wang H, Li Y, Zhou D, Li X, Jia S, Qi S, Huang J. | 12/25/2021 |
| Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women. | Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women.
Park B, Kim JH, Lee ES, Jung SY, Lee SY, Kang HS, Lee EG, Han JH., Free PMC Article | 11/28/2020 |
| We identified AMI-5, a protein methyltransferase inhibitor, as an Aldh1b1 inducer and showed that it can maintain Aldh1b1 expression in embryonic pancreas explants. This led to a selective reduction in endocrine specification. This effect was due to a downregulation of Ngn3, and it was mediated through Aldh1b1 since the effect was abolished in Aldh1b1 null pancreata. | Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression.
Giannios I, Serafimidis I, Anastasiou V, Pezzolla D, Lesche M, Andree C, Bickle M, Gavalas A., Free PMC Article | 05/2/2020 |
| These results suggest that ALDH1B1 is a novel human colorectal cancer biomarker | Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer.
Matsumoto A, Arcaroli J, Chen Y, Gasparetto M, Neumeister V, Thompson DC, Singh S, Smith C, Messersmith W, Vasiliou V., Free PMC Article | 11/18/2017 |
| The aims of this study were: (i) to use bioinformatic techniques to characterize the possible effects of selected variants in ALDH1B1 on protein structure and function; and, (ii) to genotype three missense and one stop-gain, protein-altering, non-synonymous single nucleotide polymorphisms in 1478 alcohol dependent cases and 1254 controls of matched British and Irish ancestry. | Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study.
Way MJ, Ali MA, McQuillin A, Morgan MY., Free PMC Article | 09/23/2017 |
| ALDH1B1 is expressed at very high levels in human pancreatic cancer, and it contributes to proliferation in these tumor cells. | Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma.
Singh S, Arcaroli JJ, Orlicky DJ, Chen Y, Messersmith WA, Bagby S, Purkey A, Quackenbush KS, Thompson DC, Vasiliou V., Free PMC Article | 09/24/2016 |
| High expression of ALDH1A2 and ALDH1B1 mRNA was found to be significantly correlated to worser survival in all NSCLC patients. | Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer.
You Q, Guo H, Xu D., Free PMC Article | 07/16/2016 |
| Data show that ALDH1B1 may promote colon cancer tumorigenesis by modulating the Wnt/beta-catenin, Notch and PI3K/Akt signaling pathways. | ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways.
Singh S, Arcaroli J, Chen Y, Thompson DC, Messersmith W, Jimeno A, Vasiliou V., Free PMC Article | 02/27/2016 |
| ALDH1B1 metabolizes nitroglycerin and all-trans-retinaldehyde. One of the three human polymorphisms, ALDH1B1*2, is catalytically inactive, likely due to poor NAD(+) binding. | Human ALDH1B1 polymorphisms may affect the metabolism of acetaldehyde and all-trans retinaldehyde--in vitro studies and computational modeling.
Jackson BC, Reigan P, Miller B, Thompson DC, Vasiliou V., Free PMC Article | 01/2/2016 |
| Our findings provide clear evidence for both individual and interactive associations of ALDH1b1 and ALDH2 genes with the development of coronary artery disease in Han Chinese. | Synergistic association between two alcohol metabolism relevant genes and coronary artery disease among Chinese hypertensive patients.
Wang Y, Du F, Zhao H, Yu X, Liu J, Xiao Y, Lu C, Li X, Wang Y, Wang B, Niu W., Free PMC Article | 11/21/2015 |
| ALDH1B1 SNPs play a role in shaping the alcohol drinking patterns among the Inuit in Greenland. | Genetic variation in alcohol metabolizing enzymes among Inuit and its relation to drinking patterns.
Bjerregaard P, Mikkelsen SS, Becker U, Hansen T, Tolstrup JS. | 10/31/2015 |
| ALDH1 is indicative of stemness and is a biomarker marker in colon cancer. | The impact of Aldehyde dehydrogenase 1 expression on prognosis for metastatic colon cancer.
Fitzgerald TL, Rangan S, Dobbs L, Starr S, Sigounas G. | 12/20/2014 |
| Telomere lengths in 52 distinct iodine-unstained lesions with reference to both their size and multiplicity, ALDH2 and ADH1B genotypes, and smoking history, were investigated. | Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history.
Aida J, Yokoyama A, Shimomura N, Nakamura K, Ishikawa N, Terai M, Poon S, Matsuura M, Fujiwara M, Sawabe M, Arai T, Takubo K., Free PMC Article | 12/21/2013 |
| Molecular modeling studies examining predicted protein-protein interactions indicated that heterotetramerization between ALDH2 and ALDH1B1 subunits was highly probable and may partially explain a lack of compensation by ALDH1B1 in ALDH2( *)2 individuals. | Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2.
Jackson BC, Holmes RS, Backos DS, Reigan P, Thompson DC, Vasiliou V., Free PMC Article | 08/10/2013 |
| Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol. | Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol.
Mukhopadhyay A, Wei B, Weiner H., Free PMC Article | 08/10/2013 |
| ALDH1B1 is more profoundly expressed in the adenocarcinomas examined in this study relative to ALDH1A1 and that ALDH1B1 is dramatically upregulated in human colonic adenocarcinoma, making it a potential biomarker for human colon cancer. | Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer.
Chen Y, Orlicky DJ, Matsumoto A, Singh S, Thompson DC, Vasiliou V., Free PMC Article | 04/9/2011 |
| An ALDHX model based on the crystal structure of human ALDH2, reveals similarities with the previously described ALDH structures. Analyses indicate a close structural and functional relationship between the two isoenzymes of human origin | Structural modeling studies of aldehyde dehydrogenase X: insights into key interactions in the tetrameric assembly of the isoenzyme.
Lutfullah G, Khan NQ, Amin F, Kakakhel L, Azhar N. | 03/5/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.
Husemoen LL, Jørgensen T, Borch-Johnsen K, Hansen T, Pedersen O, Linneberg A., Free PMC Article | 12/5/2010 |
| a common SNP encoding ALDH1b1 (rs2228093) was found to be significantly associated with alcohol-induced hypersensitivity. | Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians.
Linneberg A, Gonzalez-Quintela A, Vidal C, Jørgensen T, Fenger M, Hansen T, Pedersen O, Husemoen LL, Linneberg A, Gonzalez-Quintela A, Vidal C, Jørgensen T, Fenger M, Hansen T, Pedersen O, Husemoen LL. | 06/28/2010 |
| ALDH1b1 ala69val was associated with diastolic blood pressure in a Caucasian population sample | The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors.
Husemoen LL, Fenger M, Friedrich N, Tolstrup JS, Beenfeldt Fredriksen S, Linneberg A. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. A large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ. Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians.
Linneberg A, Gonzalez-Quintela A, Vidal C, Jørgensen T, Fenger M, Hansen T, Pedersen O, Husemoen LL, Linneberg A, Gonzalez-Quintela A, Vidal C, Jørgensen T, Fenger M, Hansen T, Pedersen O, Husemoen LL. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito A, Kawamoto M, Kamatani N. Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men.
Yokoyama A, Tsutsumi E, Imazeki H, Suwa Y, Nakamura C, Yokoyama T. | 03/13/2008 |