| Clostridioides difficile Binary Toxin Is Recognized by the Toll-Like Receptor 2/6 Heterodimer to Induce a Nuclear Factor-kappaB Response. | Clostridioides difficile Binary Toxin Is Recognized by the Toll-Like Receptor 2/6 Heterodimer to Induce a Nuclear Factor-κB Response.
Simpson M, Frisbee A, Kumar P, Schwan C, Aktories K, Petri WA., Free PMC Article | 04/23/2022 |
| Toll-like Receptor-6 Signaling Prevents Inflammation and Impacts Composition of the Microbiota During Inflammation-Induced Colorectal Cancer. | Toll-like Receptor-6 Signaling Prevents Inflammation and Impacts Composition of the Microbiota During Inflammation-Induced Colorectal Cancer.
Kim JH, Kordahi MC, Chac D, DePaolo RW. | 04/3/2021 |
| TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS. | TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS.
Monlish DA, Greenberg ZJ, Bhatt ST, Leonard KM, Romine MP, Dong Q, Bendesky L, Duncavage EJ, Magee JA, Schuettpelz LG., Free PMC Article | 12/12/2020 |
| TLR2 and TLR6 are upregulated in ischemic muscle and play a role in ischemia-induced muscle damage. | Toll-like receptors 2 and 6 mediate apoptosis and inflammation in ischemic skeletal myotubes.
Patel H, Yong C, Navi A, Shaw SG, Shiwen X, Abraham D, Baker DM, Tsui JC. | 09/21/2019 |
| Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist. | Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist.
Ryu KA, McGonnigal B, Moore T, Kargupta T, Mancini RJ, Esser-Kahn AP., Free PMC Article | 04/18/2019 |
| findings show that TLR6 and mannose receptor participate as macrophage receptors for Mycobacterium lepraemurium | Mycobacterium lepraemurium uses TLR-6 and MR, but not lipid rafts or DC-sign, to gain access into mouse macrophages.
Silva-Miranda M, Arce-Paredes P, Rojas-Espinosa O. | 07/14/2018 |
| recombinant NS1, expressed and purified from eukaryotic cells, induces cytokine production via TLR4 but not TLR2/6. | Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6.
Modhiran N, Watterson D, Blumenthal A, Baxter AG, Young PR, Stacey KJ. | 03/3/2018 |
| the cooperative role of TLR9 with TLR2 or TLR6 receptors in sensing Brucella, was determined. | TLR9 is required for MAPK/NF-κB activation but does not cooperate with TLR2 or TLR6 to induce host resistance to Brucella abortus.
Gomes MT, Campos PC, Pereira Gde S, Bartholomeu DC, Splitter G, Oliveira SC., Free PMC Article | 09/2/2017 |
| Data suggest that the transmembrane domains of Tlr4 and Tlr6 have essential roles in Tlr4/Tlr6/Cd36 receptor multimerization and activation; disruption of receptor multimerization (here, using a recombinant peptide fragment from Tlr4 transmembrane domain) reduces secretion of proinflammatory mediators from microglia and ultimately rescues neurons from death. | Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.
Shmuel-Galia L, Klug Y, Porat Z, Charni M, Zarmi B, Shai Y., Free PMC Article | 08/26/2017 |
| TLR6 knockout alleviates generation of myocardial fibrosis by suppressing collagen deposition. | Toll-like receptor-6 (TLR6) deficient mice are protected from myocardial fibrosis induced by high fructose feeding through anti-oxidant and inflammatory signaling pathway.
Zhang Y, Zhang Y. | 09/10/2016 |
| Dengue virus NS1 protein is the viral protein responsible for the activation of TLR2 and TLR6 during Dengue virus infection | Activation of TLR2 and TLR6 by Dengue NS1 Protein and Its Implications in the Immunopathogenesis of Dengue Virus Infection.
Chen J, Ng MM, Chu JJ., Free PMC Article | 04/9/2016 |
| Hepatic expression of Tlr6, but not that of Tlr8 is epigenetically controlled, and that the dysregulations of Tlr6 and Tlr8 critically contribute to Testosterone (T)-induced persistent susceptibility to P. chabaudi malaria. | Testosterone persistently dysregulates hepatic expression of Tlr6 and Tlr8 induced by Plasmodium chabaudi malaria.
Al-Quraishy S, Dkhil MA, Abdel-Baki AA, Araúzo-Bravo MJ, Delic D, Wunderlich F. | 10/31/2015 |
| lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface. | Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes.
Motoi Y, Shibata T, Takahashi K, Kanno A, Murakami Y, Li X, Kasahara T, Miyake K. | 05/30/2015 |
| Transmembrane oligomeric form of Vibrio cholerae cytolysin (VCC) triggers TLR2/TLR6-dependent proinflammatory responses in monocytes and macrophages. | Transmembrane oligomeric form of Vibrio cholerae cytolysin triggers TLR2/TLR6-dependent proinflammatory responses in monocytes and macrophages.
Khilwani B, Mukhopadhaya A, Chattopadhyay K. | 04/18/2015 |
| The inhibition of TLR receptors 2 and 6 in the presence of their specific ligands restored the ability of the spheroids to bind to the endometrial cells. | Local activation of uterine Toll-like receptor 2 and 2/6 decreases embryo implantation and affects uterine receptivity in mice.
Sanchez-Lopez JA, Caballero I, Montazeri M, Maslehat N, Elliott S, Fernandez-Gonzalez R, Calle A, Gutierrez-Adan A, Fazeli A. | 11/22/2014 |
| long-term exposure to nicotine up-regulated the expression of TLR4 and -6 via a JNK-related pathway, causing an exaggeration of the LPS-induced local airway inflammation and increased airway hyperreactivity | Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4.
Xu Y, Zhang Y, Cardell LO. | 10/25/2014 |
| The results demonstrate that inflammatory responses caused by ZNPs-activated macrophages strongly depend on TLR6-mediated MAPK signalling. | Toll-like receptor 6 mediated inflammatory and functional responses of zinc oxide nanoparticles primed macrophages.
Roy R, Singh SK, Das M, Tripathi A, Dwivedi PD., Free PMC Article | 10/4/2014 |
| aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes. | Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.
Aplin AC, Ligresti G, Fogel E, Zorzi P, Smith K, Nicosia RF. | 08/23/2014 |
| TLR6 on bone marrow dendritic cells can sense Mycobacterium avium and this receptor is required for full resistance to M. avium infections. | Toll-like receptor 6 senses Mycobacterium avium and is required for efficient control of mycobacterial infection.
Marinho FA, de Paula RR, Mendes AC, de Almeida LA, Gomes MT, Carvalho NB, Oliveira FS, Caliari MV, Oliveira SC. | 11/23/2013 |
| The toll-like receptor 2/6 agonist MALP-2 promotes reendothelialization and inhibits neointima formation after experimental vascular injury via enhanced proliferation and migration of endothelial cells. | Toll-like receptor 2/6 agonist macrophage-activating lipopeptide-2 promotes reendothelialization and inhibits neointima formation after vascular injury.
Grote K, Sonnenschein K, Kapopara PR, Hillmer A, Grothusen C, Salguero G, Kotlarz D, Schuett H, Bavendiek U, Schieffer B. | 11/16/2013 |
| In this study, we report that transmembrane domain (TMD)-derived peptides from TLR2 and TLR6 specifically inhibit TLR2 activation | Assembly of the TLR2/6 transmembrane domains is essential for activation and is a target for prevention of sepsis.
Fink A, Reuven EM, Arnusch CJ, Shmuel-Galia L, Antonovsky N, Shai Y. | 08/31/2013 |
| the results presented here indicate that TLR6 is required to trigger innate immune responses against B. abortus in vivo and is required for the full activation of dendritic cells to induce robust proinflammatory cytokine production. | Toll-like receptor 6 plays an important role in host innate resistance to Brucella abortus infection in mice.
de Almeida LA, Macedo GC, Marinho FA, Gomes MT, Corsetti PP, Silva AM, Cassataro J, Giambartolomei GH, Oliveira SC., Free PMC Article | 06/22/2013 |
| Innate immune detection of Aspergillus fumigatus is mediated by TLR4 and TLR2 together with TLR1 or TLR6 in mice. | Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.
Rubino I, Coste A, Le Roy D, Roger T, Jaton K, Boeckh M, Monod M, Latgé JP, Calandra T, Bochud PY. | 04/21/2012 |
| TLR6 activation is critical for IL-23 production and Th17 responses, which both regulate the allergic inflammatory response in chronic fungal-induced asthma. | The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A.
Moreira AP, Cavassani KA, Ismailoglu UB, Hullinger R, Dunleavy MP, Knight DA, Kunkel SL, Uematsu S, Akira S, Hogaboam CM., Free PMC Article | 01/7/2012 |
| Hemolysin induces Toll-like receptor (TLR)-independent apoptosis and TLR 2, 4 and 6-associated parallel activation of macrophages through a mechanism involving CD40 | Hemolysin induces Toll-like receptor (TLR)-independent apoptosis and multiple TLR-associated parallel activation of macrophages.
Chakraborty DC, Mukherjee G, Banerjee P, Banerjee KK, Biswas T., Free PMC Article | 12/10/2011 |