| The electroneutral Na[+]-HCO3[-] cotransporter NBCn1 (SLC4A7) modulates colonic enterocyte pHi, proliferation, and migration. | The electroneutral Na(+)-HCO(3)(-) cotransporter NBCn1 (SLC4A7) modulates colonic enterocyte pH(i), proliferation, and migration.
Jiang M, Salari A, Stock C, Nikolovska K, Boedtkjer E, Amiri M, Seidler UE., | 06/5/2024 |
| Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor activity and hearing in mice. | Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor activity and hearing in mice.
Choi I, Beedholm K, Dam VS, Bae SH, Noble DJ, Garraway SM, Aalkjaer C, Boedtkjer E., Free PMC Article | 11/22/2021 |
| Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1. | Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1.
Schank JR, Lee S, Gonzalez-Islas CE, Nennig SE, Fulenwider HD, Chang J, Li JM, Kim Y, Jeffers LA, Chung J, Lee JK, Jin Z, Aalkjaer C, Boedtkjer E, Choi I., Free PMC Article | 12/12/2020 |
| Deletion of the Na/HCO3 Transporter NBCn1 Protects Hippocampal Neurons from NMDA-induced Seizures and Neurotoxicity in Mice. | Deletion of the Na/HCO(3) Transporter NBCn1 Protects Hippocampal Neurons from NMDA-induced Seizures and Neurotoxicity in Mice.
Park HJ, Gonzalez-Islas CE, Kang Y, Li JM, Choi I., Free PMC Article | 11/21/2020 |
| Disruption of Slc4a10 results in loss of Slc4a7 expression specifically in inner ear fibrocytes but not in other tissues. At the ultrastructural level, mitochondria of spiral ligament knockout fibrocytes show severe alterations. | Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice.
Huebner AK, Maier H, Maul A, Nietzsche S, Herrmann T, Praetorius J, Hübner CA., Free PMC Article | 06/27/2020 |
| NBCn1 regulates intracellular pH in ErbB2-induced breast cancer tissue by providing a pathway for cellular uptake of HCO3(-), which can neutralize metabolic acidic waste products | Na(+),HCO(3)(-)-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice.
Lee S, Axelsen TV, Jessen N, Pedersen SF, Vahl P, Boedtkjer E. | 03/2/2019 |
| This study showed that extracellular acidification inhibits NBCn1 and NHE1 activity in VSMCs; NBCn1 is equivalently inhibited when pCO2 is raised or the bicarbonate level decreased. Lowering the sodium level inhibits NBCn1 and NHE1 markedly only below the typical physiological and pathophysiological range. | Extracellular acidosis and very low [Na(+) ] inhibit NBCn1- and NHE1-mediated net acid extrusion from mouse vascular smooth muscle cells.
Bonde L, Boedtkjer E. | 02/10/2018 |
| Under physiological conditions NBCn1 bicarbonateuptake raises VSMC pHi and promotes filopodia, VSMC migration, and hypertrophic inward remodelling. Propose that axial pHi gradients enhance VSMC migration whereas global acidification inhibits VSMC proliferation and media hypertrophy after carotid artery ligation. | Na+, HCO3--cotransporter NBCn1 increases pHi gradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling.
Boedtkjer E, Bentzon JF, Dam VS, Aalkjaer C. | 10/21/2017 |
| NBCn1 facilitates acid extrusion from breast cancer tissue, maintains the alkaline intracellular environment and promotes aggressive cancer development and growth | Disrupting Na⁺, HCO₃⁻-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development.
Lee S, Axelsen TV, Andersen AP, Vahl P, Pedersen SF, Boedtkjer E. | 09/17/2016 |
| The electroneutral Na+-HCO3- cotransporter NBCn1 plays an essential role in murine duodenal acid-base balance and colonic mucus layer build-up in vivo | Essential role of the electroneutral Na+-HCO3- cotransporter NBCn1 in murine duodenal acid-base balance and colonic mucus layer build-up in vivo.
Singh AK, Xia W, Riederer B, Juric M, Li J, Zheng W, Cinar A, Xiao F, Bachmann O, Song P, Praetorius J, Aalkjaer C, Seidler U., Free PMC Article | 10/19/2013 |
| Slc4a7 is a major regulator of basal and FSK-stimulated duodenal HCO3 secretion | The electroneutral Na⁺:HCO₃⁻ cotransporter NBCn1 is a major pHi regulator in murine duodenum.
Chen M, Praetorius J, Zheng W, Xiao F, Riederer B, Singh AK, Stieger N, Wang J, Shull GE, Aalkjaer C, Seidler U., Free PMC Article | 12/8/2012 |
| Intracellular acidification of vascular smooth muscle and endothelial cells after knockout of NBCn1 inhibits nitric oxide-mediates signaling in isolated arteries and perturbs blood pressure regulation. | Disruption of Na+,HCO₃⁻ cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²⁺ sensitivity, and hypertension development in mice.
Boedtkjer E, Praetorius J, Matchkov VV, Stankevicius E, Mogensen S, Füchtbauer AC, Simonsen U, Füchtbauer EM, Aalkjaer C. | 12/10/2011 |
| We conclude that NBCn1 has a broad expression profile, supporting previous findings based on immunoreactivity, and suggest several new tissues where NBCn1 may be important. | Antibody-independent localization of the electroneutral Na+-HCO3- cotransporter NBCn1 (slc4a7) in mice.
Boedtkjer E, Praetorius J, Füchtbauer EM, Aalkjaer C. | 01/21/2010 |
| most cases, hypoxia reduced NBCn1 levels by 20-50%, and NCBE levels by 15-40% in cerebral cortex, subcortex, cerebellum, and hippocampus, both after 14 and 28 days, and in both pups and adults. | Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain.
Chen LM, Choi I, Haddad GG, Boron WF. | 01/21/2010 |
| Damage of the sensory epithelia at the high frequency zone of the cochlea suggests that NBC3 may play an important physiological role in this region. | Time course of auditory impairment in mice lacking the electroneutral sodium bicarbonate cotransporter NBC3 (slc4a7).
Lopez IA, Acuna D, Galbraith G, Bok D, Ishiyama A, Liu W, Kurtz I. | 01/21/2010 |
| NBCn1 mediates the Na+-dependent bicarbonate transport important for pH(i) regulation in smooth muscle cells of mouse mesenteric, coronary, and cerebral small arteries. | NBCn1 (slc4a7) mediates the Na+-dependent bicarbonate transport important for regulation of intracellular pH in mouse vascular smooth muscle cells.
Boedtkjer E, Praetorius J, Aalkjaer C. | 01/21/2010 |