| Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRalpha and TRbeta. | Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRα and TRβ.
Hönes GS, Geist D, Wenzek C, Pfluger PT, Müller TD, Aguilar-Pimentel JA, Amarie OV, Becker L, Dragano N, Garrett L, Hölter SM, Rathkolb B, Rozman J, Spielmann N, Treise I, Wolf E, Wurst W, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Führer D, Moeller LC. | 07/11/2024 |
| Hypothalamic Thyroid Hormone Receptor alpha1 Signaling Controls Body Temperature. | Hypothalamic Thyroid Hormone Receptor α1 Signaling Controls Body Temperature.
Sentis SC, Dore R, Oelkrug R, Kolms B, Iwen KA, Mittag J. | 06/28/2024 |
| Canonical and Noncanonical Contribution of Thyroid Hormone Receptor Isoforms Alpha and Beta to Cardiac Hypertrophy and Heart Rate in Male Mice. | Canonical and Noncanonical Contribution of Thyroid Hormone Receptor Isoforms Alpha and Beta to Cardiac Hypertrophy and Heart Rate in Male Mice.
Geist D, Hönes GS, Grund SC, Pape J, Siemes D, Spangenberg P, Tolstik E, Dörr S, Spielmann N, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Mittag J, Engel DR, Führer D, Lorenz K, Moeller LC. | 06/28/2024 |
| Aberrant expression of thyroidal hormone receptor alpha exasperating mitochondrial dysfunction induced sarcopenia in aged mice. | Aberrant expression of thyroidal hormone receptor α exasperating mitochondrial dysfunction induced sarcopenia in aged mice.
Sheng Y, Zhu X, Wei L, Zou Y, Qi X, Shi R, Xu W, Wang X, Ding G, Duan Y., Free PMC Article | 06/1/2024 |
| Thyroid hormone receptor Thra and Thrb knockout differentially affects osteoblast biology and thyroid hormone responsiveness in vitro. | Thyroid hormone receptor Thra and Thrb knockout differentially affects osteoblast biology and thyroid hormone responsiveness in vitro.
Lademann F, Tsourdi E, Hofbauer LC, Rauner M. | 12/21/2023 |
| Morphological and Functional Colonic Defects Caused by a Mutated Thyroid Hormone Receptor alpha. | Morphological and Functional Colonic Defects Caused by a Mutated Thyroid Hormone Receptor α.
Kim M, Kruhlak M, Hoffmann V, Zerfas P, Bishop K, Doolittle WKL, Edmondson EF, Zhu YJ, Cheng SY., Free PMC Article | 02/22/2023 |
| Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRalpha1, in intestinal lesions. | Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions.
Giolito MV, La Rosa T, Farhat D, Bodoirat S, Guardia GDA, Domon-Dell C, Galante PAF, Freund JN, Plateroti M., Free PMC Article | 12/17/2022 |
| Ontogeny of TRalpha1 expression in the mouse testis and epididymis during postnatal development. | Ontogeny of TRα1 expression in the mouse testis and epididymis during postnatal development.
Sarkar D, Jaiswal A, Singh SK. | 09/17/2022 |
| A disease-associated mutation in thyroid hormone receptor alpha1 causes hearing loss and sensory hair cell patterning defects in mice. | A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice.
Affortit C, Blanc F, Nasr J, Ceccato JC, Markossian S, Guyot R, Puel JL, Flamant F, Wang J. | 07/2/2022 |
| Thyroid Hormone Receptor alpha1 Mutants Impair B Lymphocyte Development in a Mouse Model. | Thyroid Hormone Receptor α1 Mutants Impair B Lymphocyte Development in a Mouse Model.
Park S, Zhu X, Kim M, Zhao L, Cheng SY., Free PMC Article | 01/22/2022 |
| Generation and Characterization of a New Resistance to Thyroid Hormone Mouse Model with Thyroid Hormone Receptor Alpha Gene Mutation. | Generation and Characterization of a New Resistance to Thyroid Hormone Mouse Model with Thyroid Hormone Receptor Alpha Gene Mutation.
Liang Y, Zhao D, Wang R, Dang P, Xi Y, Zhang D, Wang W, Shan Z, Teng X, Teng W. | 11/27/2021 |
| Thyroid Hormone Receptor alpha Regulates Autophagy, Mitochondrial Biogenesis, and Fatty Acid Use in Skeletal Muscle. | Thyroid Hormone Receptor α Regulates Autophagy, Mitochondrial Biogenesis, and Fatty Acid Use in Skeletal Muscle.
Zhou J, Gauthier K, Ho JP, Lim A, Zhu XG, Han CR, Sinha RA, Cheng SY, Yen PM., Free PMC Article | 10/23/2021 |
| Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor. | Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor.
Affortit C, Casas F, Ladrech S, Ceccato JC, Bourien J, Coyat C, Puel JL, Lenoir M, Wang J., Free PMC Article | 10/2/2021 |
| Murine intestinal stem cells are highly sensitive to modulation of the T3/TRalpha1-dependent pathway. | Murine intestinal stem cells are highly sensitive to modulation of the T3/TRα1-dependent pathway.
Godart M, Frau C, Farhat D, Giolito MV, Jamard C, Le Nevé C, Freund JN, Penalva LO, Sirakov M, Plateroti M. | 09/25/2021 |
| Regulation of mitochondrial activity controls the duration of skeletal muscle regeneration in response to injury. | Regulation of mitochondrial activity controls the duration of skeletal muscle regeneration in response to injury.
Pessemesse L, Tintignac L, Blanchet E, Cortade F, Jublanc E, Demangel R, Py G, Sar C, Cabello G, Wrutniak-Cabello C, Casas F., Free PMC Article | 10/24/2020 |
| Thra1(PV/+) mice show epithelial defects in a mouse model of resistance to thyroid hormone | Thyroid Hormone Receptor Alpha Mutations Lead to Epithelial Defects in the Adult Intestine in a Mouse Model of Resistance to Thyroid Hormone.
Bao L, Roediger J, Park S, Fu L, Shi B, Cheng SY, Shi YB., Free PMC Article | 02/29/2020 |
| TRalpha seems to have an inhibitory impact on angiotensin (AGT) and AT1Ra expression, and loss of TRalpha function in TRalpha(0/0) mice increases tissue renin-angiotensin system expression in the aortic wall. More importantly, TRalpha deletion significantly increases vascular smooth muscle cells cholesterol content. Our results are consistent with a protective role of TRalpha against atherosclerosis. | TRα inhibits arterial renin-angiotensin system expression and prevents cholesterol accumulation in vascular smooth muscle cells.
Neggazi S, Hamlat N, Canaple L, Gauthier K, Samarut J, Bricca G, Aouichat-Bouguerra S, Beylot M. | 08/31/2019 |
| thyroid hormone receptor alpha deletion in ApoE-/- mice slightly increases the expression of tissue renin-angiotensin system in the aorta and aggravates the dysregulation of cholesterol content in the vascular smooth muscle cells. | Thyroid Hormone Receptor Alpha Deletion in ApoE-/- Mice Alters the Arterial Renin-Angiotensin System and Vascular Smooth Muscular Cell Cholesterol Metabolism.
Neggazi S, Canaple L, Hamlat N, Gauthier K, Samarut J, Bricca G, Aouichat-Bouguerra S, Beylot M. | 08/31/2019 |
| Knockdown of the main TR in macrophages, TRalpha, impaired polarization into proinflammatory macrophages and amplified polarization into immunomodulatory macrophages. | Regulation of Intracellular Triiodothyronine Is Essential for Optimal Macrophage Function.
van der Spek AH, Surovtseva OV, Jim KK, van Oudenaren A, Brouwer MC, Vandenbroucke-Grauls CMJE, Leenen PJM, van de Beek D, Hernandez A, Fliers E, Boelen A., Free PMC Article | 01/19/2019 |
| Data suggest that gestational/maternal endocrine disruptor DEHP [di-(2-ethylhexyl) phthalate] exposure dose-dependently causes fetal IUGR (intrauterine growth restriction); mRNA levels of placental Thra1 and Thrb1 are reduced and nuclear translocation of placental Thra1 and Thrb1 is suppressed in DEHP-exposed mice. | Gestational di-(2-ethylhexyl) phthalate exposure causes fetal intrauterine growth restriction through disturbing placental thyroid hormone receptor signaling.
Yu Z, Han Y, Shen R, Huang K, Xu YY, Wang QN, Zhou SS, Xu DX, Tao FB. | 07/21/2018 |
| neonatal hypothyroidism alters localization and expression of THRalpha1. | Effect of neonatal hypothyroidism on prepubertal mouse testis in relation to thyroid hormone receptor alpha 1 (THRα1).
Sarkar D, Singh SK. | 12/23/2017 |
| Study demonstrated an anxiety-related phenotype in mice expressing a neuron-specific TRalpha mutation. This provides evidence that altered thyroid hormone signaling in the brain impacts adult behavior. | Neuronal expression of a thyroid hormone receptor α mutation alters mouse behaviour.
Richard S, Aguilera N, Thévenet M, Dkhissi-Benyahya O, Flamant F. | 12/2/2017 |
| the Gata-1 gene was a T3-directly regulated gene and that TRa1PV could impair erythropoiesis via repression of the Gata-1 gene and its regulated genes. These results provide new insights into how TRa1 mutants acted to cause erythroid abnormalities in patients with mutations of the THRA gene. | Defective erythropoiesis caused by mutations of the thyroid hormone receptor α gene.
Park S, Han CR, Park JW, Zhao L, Zhu X, Willingham M, Bodine DM, Cheng SY., Free PMC Article | 10/14/2017 |
| Using domain exchanges and individual amino acid switches between THRA1 and THRB2, three amino acidswere identified in helix 10 of the THRB2 ligand-binding domain that are required for negative regulation and are absent in THRA1. | Naturally Occurring Amino Acids in Helix 10 of the Thyroid Hormone Receptor Mediate Isoform-Specific TH Gene Regulation.
Pinto VMS, Minakhina S, Qiu S, Sidhaye A, Brotherton MP, Suhotliv A, Wondisford FE., Free PMC Article | 10/7/2017 |
| Hippocampal transcriptome profile of persistent memory rescue in a mouse model of Thra1 mutation-mediated resistance to thyroid hormone has been reported. | Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid Hormone.
Wang Y, Fisahn A, Sinha I, Nguyen DP, Sterzenbach U, Lallemend F, Hadjab S., Free PMC Article | 12/17/2016 |