| Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma. | Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma.
Shu H, Parada I, Delgado A, Prince DA, Gu F. | 09/19/2024 |
| Heterozygous THBS2 pathogenic variant causes Ehlers-Danlos syndrome with prominent vascular features in humans and mice. | Heterozygous THBS2 pathogenic variant causes Ehlers-Danlos syndrome with prominent vascular features in humans and mice.
Hadar N, Porgador O, Cohen I, Levi H, Dolgin V, Yogev Y, Sued-Hendrickson S, Shelef I, Didkovsky E, Eskin-Schwartz M, Birk OS., Free PMC Article | 05/3/2024 |
| Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration. | Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration.
Li X, Ding Y, Zhou M, Zhou Z, Xie T, Wang Y, Liu Z, Si Y, Shi Z. | 01/21/2023 |
| Contribution of Thrombospondin-1 and -2 to Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. | Contribution of Thrombospondin-1 and -2 to Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.
Li Q, Fu X, Yuan J, Han S., Free PMC Article | 12/11/2021 |
| Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts. | Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts.
Alford AI, Stephan C, Kozloff KM, Hankenson KD., Free PMC Article | 10/30/2021 |
| Thrombospondin-2 spatiotemporal expression in skeletal fractures. | Thrombospondin-2 spatiotemporal expression in skeletal fractures.
Zondervan RL, Jenkins DC, Reicha JD, Hankenson KD., Free PMC Article | 05/1/2021 |
| Inhibiting role of long non-coding RNA LINC01197 in inflammation in rheumatoid arthritis through the microRNA-150/THBS2 axis. | Inhibiting role of long non-coding RNA LINC01197 in inflammation in rheumatoid arthritis through the microRNA-150/THBS2 axis.
Zhao F, Dong J, Guo J, Bi L. | 02/2/2021 |
| TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro. | TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro.
Shearer D, Mervis MO, Manley E Jr, Reddy AB, Alford AI. | 08/22/2020 |
| Findings demonstrate a novel link between TSP2, LOX, and miR-29 that is regulated by the presence or absence of TSP2 in the extracellular environment, forming a feedback loop between cells and its extracellular matrix substrate. | Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29.
Calabro NE, Barrett A, Chamorro-Jorganes A, Tam S, Kristofik NJ, Xing H, Loye AM, Sessa WC, Hansen K, Kyriakides TR., Free PMC Article | 05/9/2020 |
| Though the TSP2-deficient mice developed obesity and hyperglycemia comparable with diabetic control mice, they exhibited significantly improved healing, characterized by accelerated reepithelialization and increased granulation tissue formation, fibroblast migration, and blood vessel maturation. | Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes.
Kunkemoeller B, Bancroft T, Xing H, Morris AH, Luciano AK, Wu J, Fernandez-Hernando C, Kyriakides TR., Free PMC Article | 03/21/2020 |
| THBS2 protein was confirmed to be enhanced in Liver Fibrosis rodent models, which could promote hepatic stellate cell activation and proliferation and facilitate NOTCH1/JAG1 expression in hepatic stellate cells. | Multitranscriptome analyses reveal prioritized genes specifically associated with liver fibrosis progression independent of etiology.
Chen W, Wu X, Yan X, Xu A, Yang A, You H. | 02/15/2020 |
| We observed an upregulation in the expression of TSP1 and TSP2 mRNA in control mouse cochleae following noise exposure. afferent synaptic counts and auditory brainstem responses (ABRs) in noise-exposed TSP1 and TSP2 knockout (-/-) mice exhibited a worst recovery than controls. TSP2-/- mice showed greater susceptibility to noise-induced hearing loss at mid and high frequencies. | TSP1 and TSP2 Have Unique and Overlapping Roles in Protecting against Noise-Induced Auditory Synaptopathy.
Smeriglio P, Wangsawihardja FV, Leu R, Mustapha M., Free PMC Article | 01/11/2020 |
| Data provide evidence that TSP2 transcription is suppressed by hypoxia through a mechanism that requires HIF-1alpha. | HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2.
MacLauchlan SC, Calabro NE, Huang Y, Krishna M, Bancroft T, Sharma T, Yu J, Sessa WC, Giordano F, Kyriakides TR., Free PMC Article | 11/24/2018 |
| TSP2 deficiency imparted a brittle phenotype on cortical bone. electron microscopy revealed less intensely stained collagen fibrils with altered morphology in the extracellular matrix assembled by osteoblasts on the anterior surface of TSP2-KO femora. | Thrombospondin-2 deficiency in growing mice alters bone collagen ultrastructure and leads to a brittle bone phenotype.
Manley E Jr, Perosky JE, Khoury BM, Reddy AB, Kozloff KM, Alford AI., Free PMC Article | 08/6/2016 |
| Enhanced levels of TSP-2 in the skin result in reduced susceptibility to chemically-induced skin carcinogenesis. | Thrombospondin-2 overexpression in the skin of transgenic mice reduces the susceptibility to chemically induced multistep skin carcinogenesis.
Kunstfeld R, Hawighorst T, Streit M, Hong YK, Nguyen L, Brown LF, Detmar M., Free PMC Article | 12/20/2014 |
| in the context of osteoblast differentiation, TSP2 promotes the assembly of a type-I collagen-rich matrix by facilitating pro-collagen processing. | Thrombospondin-2 facilitates assembly of a type-I collagen-rich matrix in marrow stromal cells undergoing osteoblastic differentiation.
Alford AI, Golicz AZ, Cathey AL, Reddy AB., Free PMC Article | 03/29/2014 |
| The proposed mechanism for the shift in stem cell fate in fracture healing is that increased vascular density and hence oxygen availability in TSP2-null mice regulates differentiation. | The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice.
Burke D, Dishowitz M, Sweetwyne M, Miedel E, Hankenson KD, Kelly DJ. | 11/2/2013 |
| The upregulation of TSP-2 mediated by increased oxidative stress contributes to angiogenesis dysfunction in diabetic bone marrow derived angiogenic cells. | Oxidative stress-mediated thrombospondin-2 upregulation impairs bone marrow-derived angiogenic cell function in diabetes mellitus.
Bae ON, Wang JM, Baek SH, Wang Q, Yuan H, Chen AF., Free PMC Article | 09/28/2013 |
| TSP2 is a negative regulator of ischemic fracture healing, and in the absence of TSP2 bone regeneration is enhanced. | Disruption of thrombospondin-2 accelerates ischemic fracture healing.
Miedel E, Dishowitz MI, Myers MH, Dopkin D, Yu YY, Miclau TS, Marcucio R, Ahn J, Hankenson KD. | 06/15/2013 |
| Using a TSP-2-knockout mouse model and cardiac cell transplantation, we found significantly reduced fibrosis and increased endothelial cell density in the peri-graft region. | Lack of thrombospondin-2 reduces fibrosis and increases vascularity around cardiac cell grafts.
Reinecke H, Robey TE, Mignone JL, Muskheli V, Bornstein P, Murry CE., Free PMC Article | 06/1/2013 |
| TSP1-null and TSP2-null mice have lower IOPs than their WT counterparts. The rate of aqueous turnover suggests that the mechanism is enhanced outflow facility. | Thrombospondin-1 (TSP1)-null and TSP2-null mice exhibit lower intraocular pressures.
Haddadin RI, Oh DJ, Kang MH, Villarreal G Jr, Kang JH, Jin R, Gong H, Rhee DJ., Free PMC Article | 12/22/2012 |
| the two TSP2 isforms are differentially modulated at injured and noninjured skeletal sites in an animal undergoing fracture healing. | Two molecular weight species of thrombospondin-2 are present in bone and differentially modulated in fractured and nonfractured tibiae in a murine model of bone healing.
Alford AI, Reddy AB, Goldstein SA, Murthy P, Tayim R, Sharma G., Free PMC Article | 10/20/2012 |
| TSP-2 has a protective role against cardiac inflammation, injury, and dysfunction in acute viral myocarditis. | Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells.
Papageorgiou AP, Swinnen M, Vanhoutte D, VandenDriessche T, Chuah M, Lindner D, Verhesen W, de Vries B, D'hooge J, Lutgens E, Westermann D, Carmeliet P, Heymans S. | 07/21/2012 |
| astrocyte-derived TSP-2 is critical for the maintenance of physiological MMP-2 and MMP-9 levels during the foreign body response and contributes to the repair of the BBB | Astrocyte-derived thrombospondin-2 is critical for the repair of the blood-brain barrier.
Tian W, Sawyer A, Kocaoglu FB, Kyriakides TR., Free PMC Article | 04/14/2012 |
| Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2 | Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2.
MacLauchlan S, Yu J, Parrish M, Asoulin TA, Schleicher M, Krady MM, Zeng J, Huang PL, Sessa WC, Kyriakides TR., Free PMC Article | 01/28/2012 |