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    Thbs1 thrombospondin 1 [ Mus musculus (house mouse) ]

    Gene ID: 21825, updated on 25-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma.

    Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma.
    Shu H, Parada I, Delgado A, Prince DA, Gu F.

    09/19/2024
    Decreased thrombospondin-1 impairs endometrial stromal decidualization in unexplained recurrent spontaneous abortiondagger.

    Decreased thrombospondin-1 impairs endometrial stromal decidualization in unexplained recurrent spontaneous abortion†.
    Hu J, Qin C, Xu Y, Liu X, Wei X, Wu J, Zhao X, Chen C, Lin Y.

    08/20/2024
    Thbs1 regulates skeletal muscle mass in a TGFbeta-Smad2/3-ATF4-dependent manner.

    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner.
    Vanhoutte D, Schips TG, Minerath RA, Huo J, Kavuri NSS, Prasad V, Lin SC, Bround MJ, Sargent MA, Adams CM, Molkentin JD., Free PMC Article

    06/14/2024
    Thrombospondin-1 promotes mechanical stress-mediated ligamentum flavum hypertrophy through the TGFbeta1/Smad3 signaling pathway.

    Thrombospondin-1 promotes mechanical stress-mediated ligamentum flavum hypertrophy through the TGFβ1/Smad3 signaling pathway.
    Zhao R, Dong J, Liu C, Li M, Tan R, Fei C, Chen Y, Yang X, Shi J, Xu J, Wang L, Li P, Zhang Z.

    04/18/2024
    Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure.

    Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure.
    Hassan HM, Liang X, Xin J, Lu Y, Cai Q, Shi D, Ren K, Li J, Chen Q, Li J, Li P, Guo B, Yang H, Luo J, Yao H, Zhou X, Hu W, Jiang J, Li J., Free PMC Article

    03/6/2024
    Scleral remodeling during myopia development in mice eyes: a potential role of thrombospondin-1.

    Scleral remodeling during myopia development in mice eyes: a potential role of thrombospondin-1.
    Chen J, Ikeda SI, Yang Y, Zhang Y, Ma Z, Liang Y, Negishi K, Tsubota K, Kurihara T., Free PMC Article

    02/21/2024
    Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair.

    Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair.
    Pei L, Ouyang Z, Zhang H, Huang S, Jiang R, Liu B, Tang Y, Feng M, Yuan M, Wang H, Yao S, Shi S, Yu Z, Xu D, Gong G, Wei K.

    02/12/2024
    Splenocytes with fucosylation deficiency promote T cell proliferation and differentiation through thrombospondin-1 downregulation.

    Splenocytes with fucosylation deficiency promote T cell proliferation and differentiation through thrombospondin-1 downregulation.
    Ko JH, Ryu JS, Oh JH, Oh JY.

    01/30/2024
    LRRK2 Gly2019Ser Mutation Promotes ER Stress via Interacting with THBS1/TGF-beta1 in Parkinson's Disease.

    LRRK2 Gly2019Ser Mutation Promotes ER Stress via Interacting with THBS1/TGF-β1 in Parkinson's Disease.
    Yao L, Lu F, Koc S, Zheng Z, Wang B, Zhang S, Skutella T, Lu G., Free PMC Article

    11/1/2023
    CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis.

    CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis.
    Singla B, Aithbathula RV, Pervaiz N, Kathuria I, Swanson M, Ekuban FA, Ahn W, Park F, Gyamfi M, Cherian-Shaw M, Singh UP, Kumar S., Free PMC Article

    06/28/2023
    O-fucosylation of thrombospondin type I repeats is dispensable for trafficking thrombospondin 1 to platelet secretory granules.

    O-fucosylation of thrombospondin type I repeats is dispensable for trafficking thrombospondin 1 to platelet secretory granules.
    Berardinelli SJ, Sillato AR, Grady RC, Neupane S, Ito A, Haltiwanger RS, Holdener BC., Free PMC Article

    05/20/2023
    Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma.

    Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma.
    Fu H, Siggs OM, Knight LS, Staffieri SE, Ruddle JB, Birsner AE, Collantes ER, Craig JE, Wiggs JL, D'Amato RJ., Free PMC Article

    12/10/2022
    Hypoxia Inhibits Subretinal Inflammation Resolution Thrombospondin-1 Dependently.

    Hypoxia Inhibits Subretinal Inflammation Resolution Thrombospondin-1 Dependently.
    Touhami S, Béguier F, Yang T, Augustin S, Roubeix C, Blond F, Conart JB, Sahel JA, Bodaghi B, Delarasse C, Guillonneau X, Sennlaub F., Free PMC Article

    02/26/2022
    Thrombospondin-1 expression and modulation of Wnt and hippo signaling pathways during the early phase of Trypanosoma cruzi infection of heart endothelial cells.

    Thrombospondin-1 expression and modulation of Wnt and hippo signaling pathways during the early phase of Trypanosoma cruzi infection of heart endothelial cells.
    Arun A, Rayford KJ, Cooley A, Rana T, Rachakonda G, Villalta F, Pratap S, Lima MF, Sheibani N, Nde PN., Free PMC Article

    02/19/2022
    Thrombospondin-1 induced programmed death-ligand 1-mediated immunosuppression by activating the STAT3 pathway in osteosarcoma.

    Thrombospondin-1 induced programmed death-ligand 1-mediated immunosuppression by activating the STAT3 pathway in osteosarcoma.
    Liu Z, Wen J, Hu F, Wang J, Hu C, Zhang W., Free PMC Article

    02/12/2022
    Role of Thrombospondin1 in sepsisinduced myocardial injury.

    Role of Thrombospondin‑1 in sepsis‑induced myocardial injury.
    Xie Y, Zhang J, Jin W, Tian R, Wang R.

    02/12/2022
    Contribution of Thrombospondin-1 and -2 to Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.

    Contribution of Thrombospondin-1 and -2 to Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.
    Li Q, Fu X, Yuan J, Han S., Free PMC Article

    12/11/2021
    The protein-protein interaction between connective tissue growth factor and annexin A2 is relevant to pannus formation in rheumatoid arthritis.

    The protein-protein interaction between connective tissue growth factor and annexin A2 is relevant to pannus formation in rheumatoid arthritis.
    Yin G, Yang C, Wu G, Yu X, Tian Q, Chen D, Cao B, Zhao L, Xu N, Jin S, Zhang W, Wang J., Free PMC Article

    11/6/2021
    Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts.

    Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts.
    Alford AI, Stephan C, Kozloff KM, Hankenson KD., Free PMC Article

    10/30/2021
    Thrombospondin-1 Restricts Interleukin-36gamma-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection.

    Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection.
    Peñaloza HF, Olonisakin TF, Bain WG, Qu Y, van der Geest R, Zupetic J, Hulver M, Xiong Z, Newstead MW, Zou C, Alder JK, Ybe JA, Standiford TJ, Lee JS., Free PMC Article

    10/2/2021
    Interstitial macrophage-derived thrombospondin-1 contributes to hypoxia-induced pulmonary hypertension.

    Interstitial macrophage-derived thrombospondin-1 contributes to hypoxia-induced pulmonary hypertension.
    Kumar R, Mickael C, Kassa B, Sanders L, Hernandez-Saavedra D, Koyanagi DE, Kumar S, Pugliese SC, Thomas S, McClendon J, Maloney JP, Janssen WJ, Stenmark KR, Tuder RM, Graham BB., Free PMC Article

    08/28/2021
    Aging-associated changes in CD47 arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging.

    Aging-associated changes in CD47 arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging.
    Wang F, Liu YH, Zhang T, Gao J, Xu Y, Xie GY, Zhao WJ, Wang H, Yang YG., Free PMC Article

    08/28/2021
    Endothelial MT1-MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis.

    Endothelial MT1-MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis.
    Esteban S, Clemente C, Koziol A, Gonzalo P, Rius C, Martínez F, Linares PM, Chaparro M, Urzainqui A, Andrés V, Seiki M, Gisbert JP, Arroyo AG., Free PMC Article

    07/31/2021
    Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy.

    Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy.
    Vanhoutte D, Schips TG, Vo A, Grimes KM, Baldwin TA, Brody MJ, Accornero F, Sargent MA, Molkentin JD., Free PMC Article

    07/17/2021
    TSP-1 (Thrombospondin-1) Deficiency Protects ApoE(-/-) Mice Against Leptin-Induced Atherosclerosis.

    TSP-1 (Thrombospondin-1) Deficiency Protects ApoE(-/-) Mice Against Leptin-Induced Atherosclerosis.
    Ganguly R, Khanal S, Mathias A, Gupta S, Lallo J, Sahu S, Ohanyan V, Patel A, Storm K, Datta S, Raman P., Free PMC Article

    06/5/2021
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