| TG-interacting factor 1 regulates mitotic clonal expansion during adipocyte differentiation. | TG-interacting factor 1 regulates mitotic clonal expansion during adipocyte differentiation.
Chang YH, Tseng YH, Wang JM, Tsai YS, Huang HS. | 06/28/2024 |
| MircoRNA-25-3p in skin precursor cell-induced Schwann cell-derived extracellular vesicles promotes axon regeneration by targeting Tgif1. | MircoRNA-25-3p in skin precursor cell-induced Schwann cell-derived extracellular vesicles promotes axon regeneration by targeting Tgif1.
Cong M, Li J, Wang L, Liu C, Zheng M, Zhou Q, Du M, Ye X, Feng M, Ye Y, Zhang S, Xu W, Lu Y, Wang C, Xia Y, Xie H, Zhang Y, He Q, Gong L, Gu Y, Sun H, Zhang Q, Zhao J, Ding F, Gu X, Zhou S. | 05/22/2024 |
| Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling. | Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling.
Bolamperti S, Saito H, Heerdmann S, Hesse E, Taipaleenmäki H., Free PMC Article | 05/17/2024 |
| Loss of TG-Interacting Factor 1 decreases survival in mouse models of myeloid leukaemia. | Loss of TG-Interacting Factor 1 decreases survival in mouse models of myeloid leukaemia.
Yan L, Davé UP, Engel M, Brandt SJ, Hamid R., Free PMC Article | 05/15/2021 |
| Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment. | Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment.
Haider MT, Saito H, Zarrer J, Uzhunnumpuram K, Nagarajan S, Kari V, Horn-Glander M, Werner S, Hesse E, Taipaleenmäki H., Free PMC Article | 10/3/2020 |
| our results suggest that proper control of TGF-beta/Smads/CRMP2 signaling pathways is critical for the precise execution of neuronal morphogenesis, whose impairment eventually results in neurodevelopmental disorders | Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression.
Nakashima H, Tsujimura K, Irie K, Ishizu M, Pan M, Kameda T, Nakashima K., Free PMC Article | 10/26/2019 |
| Tgifs play an important role in regulating basic energy metabolism in normal cells, and that this function of Tgifs is amplified in some cancers. | TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth.
Shah A, Melhuish TA, Fox TE, Frierson HF Jr, Wotton D., Free PMC Article | 04/20/2019 |
| Tgif1 is a novel regulator of bone remodeling and an essential component of the PTH anabolic action. | TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone.
Saito H, Gasser A, Bolamperti S, Maeda M, Matthies L, Jähn K, Long CL, Schlüter H, Kwiatkowski M, Saini V, Pajevic PD, Bellido T, van Wijnen AJ, Mohammad KS, Guise TA, Taipaleenmäki H, Hesse E., Free PMC Article | 04/20/2019 |
| Zic2-binding to the cis-regulatory element near the Tgif1 promoter may be involved in the mechanism underlying forebrain development and incidences of holoprosencephaly. | Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.
Ishiguro A, Hatayama M, Otsuka MI, Aruga J., Free PMC Article | 01/12/2019 |
| Proteomic analyses show that HOXA1 physically interacts on chromatin with PBX, MEIS, and PREP family members, but not with TGIF, suggesting that TGIF may have an independent input into HOXA1-bound regions.complex cross-regulatory network of HOXA1 and TALE proteins. This study provides new insight into a regulatory network involving combinatorial interactions between HOXA1 and TALE proteins | HOXA1 and TALE proteins display cross-regulatory interactions and form a combinatorial binding code on HOXA1 targets.
De Kumar B, Parker HJ, Paulson A, Parrish ME, Pushel I, Singh NP, Zhang Y, Slaughter BD, Unruh JR, Florens L, Zeitlinger J, Krumlauf R., Free PMC Article | 05/5/2018 |
| Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. | Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.
Anderson AE, Taniguchi K, Hao Y, Melhuish TA, Shah A, Turner SD, Sutherland AE, Wotton D., Free PMC Article | 07/15/2017 |
| loss of Tgif1 causes axial patterning defects that are enhanced by mutations in Tgif2 | Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.
Melhuish TA, Taniguchi K, Wotton D., Free PMC Article | 07/15/2017 |
| Tgif2 participates in photoreceptor cell differentiation in the early stages of retinal development and regulates proper subretinal localization of the cone photoreceptors. | Role of transcription factor Tgif2 in photoreceptor differentiation in the mouse retina.
Kuribayashi H, Tsuhako A, Kikuchi M, Yoshida N, Koso H, Watanabe S. | 06/24/2017 |
| Tgif1 counterbalances the activity of core pluripotency factors, Oct4, Sox2, and Nanog, in mouse embryonic stem cells. | Tgif1 Counterbalances the Activity of Core Pluripotency Factors in Mouse Embryonic Stem Cells.
Lee BK, Shen W, Lee J, Rhee C, Chung H, Kim KY, Park IH, Kim J. | 07/16/2016 |
| Tgif1 suppresses stem cell self-renewal. | Tgif1 regulates quiescence and self-renewal of hematopoietic stem cells.
Yan L, Womack B, Wotton D, Guo Y, Shyr Y, Davé U, Li C, Hiebert S, Brandt S, Hamid R., Free PMC Article | 02/1/2014 |
| The identification and characterization of the Tgif mutant supports the role of TGFbeta signalling in the development of chronic OM. | Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory disease.
Tateossian H, Morse S, Parker A, Mburu P, Warr N, Acevedo-Arozena A, Cheeseman M, Wells S, Brown SD., Free PMC Article | 01/11/2014 |
| Tgif1 mutation in mouse contributes to Holoprosencephaly pathogenesis due to disruption of the Shh pathway | Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.
Taniguchi K, Anderson AE, Sutherland AE, Wotton D., Free PMC Article | 02/23/2013 |
| TGIF1 plays a role in TNF-alpha- and radiation-induced inflammation and it could be a target in limiting this event in the vascular compartment | The TG-interacting factor TGIF1 regulates stress-induced proinflammatory phenotype of endothelial cells.
Hneino M, Blirando K, Buard V, Tarlet G, Benderitter M, Hoodless P, François A, Milliat F., Free PMC Article | 02/2/2013 |
| TGF-beta/Smad co-repressor TGIF1 plays a role in radiation-induced normal tissue damage by a Smad-independent mechanism. | The TGF-β/Smad repressor TG-interacting factor 1 (TGIF1) plays a role in radiation-induced intestinal injury independently of a Smad signaling pathway.
Hneino M, François A, Buard V, Tarlet G, Abderrahmani R, Blirando K, Hoodless PA, Benderitter M, Milliat F., Free PMC Article | 09/22/2012 |
| Data suggest that in the absence of Tgif1, a persistent increase in TGFbeta responsive transcription and a reduced ability to deal with hyperoxic stress result in premature senescence in primary MEFs. | Premature senescence and increased TGFβ signaling in the absence of Tgif1.
Zerlanko BJ, Bartholin L, Melhuish TA, Wotton D., Free PMC Article | 09/1/2012 |
| mRNA for positive regulators of Fshb expression, such as Fos and Jun, were up-regulated at slower pulse frequencies than a number of potential negative regulators, such as the corepressors Skil, Crem, and Tgif1. | Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1.
Mistry DS, Tsutsumi R, Fernandez M, Sharma S, Cardenas SA, Lawson MA, Webster NJ., Free PMC Article | 11/26/2011 |
| Tgif1 can regulate nuclear receptor complexes, in addition to those containing retinoic acid receptors, but also indicates that there is some specificity to which NR target genes are repressed by Tgif1. | Tgif1 represses apolipoprotein gene expression in liver.
Melhuish TA, Chung DD, Bjerke GA, Wotton D., Free PMC Article | 01/29/2011 |
| Data show that loss-of-function mutations in both Tgif1 and Tgif2 result in a failure of gastrulation. | Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.
Powers SE, Taniguchi K, Yen W, Melhuish TA, Shen J, Walsh CA, Sutherland AE, Wotton D., Free PMC Article | 01/21/2010 |
| TGIF is essential for EGF-mediated downregulation of tropoelastin expression | EGF antagonizes TGF-beta-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF.
Yang S, Nugent MA, Panchenko MP., Free PMC Article | 01/21/2010 |
| Tgif functions in the normal development of the placenta, and suggest a role for maternal factors in regulating the morphogenesis of embryonically-derived placental tissues. | Maternal Tgif is required for vascularization of the embryonic placenta.
Bartholin L, Melhuish TA, Powers SE, Goddard-Léon S, Treilleux I, Sutherland AE, Wotton D., Free PMC Article | 01/21/2010 |