| TGF-beta3 mediates mitochondrial dynamics through the p-Smad3/AMPK pathway. | TGF-β3 mediates mitochondrial dynamics through the p-Smad3/AMPK pathway.
Du X, Duan M, Kan S, Yang Y, Xu S, Wei J, Li J, Chen H, Zhou X, Xie J., Free PMC Article | 05/24/2024 |
| Lack of Elevated Expression of TGFbeta3 Contributes to the Delay of Epithelial Wound Healing in Diabetic Corneas. | Lack of Elevated Expression of TGFβ3 Contributes to the Delay of Epithelial Wound Healing in Diabetic Corneas.
Gao N, Yu FS., Free PMC Article | 04/2/2024 |
| Up-regulation of CREB-1 regulates tendon adhesion in the injury tendon healing through the CREB-1/TGF-beta3 signaling pathway. | Up-regulation of CREB-1 regulates tendon adhesion in the injury tendon healing through the CREB-1/TGF-β3 signaling pathway.
Wu LM, Wang YJ, Li SF, Wang JK, Liu J, Fan CC, Xiong Y., Free PMC Article | 07/19/2023 |
| Latent transforming growth factor beta binding protein 3 controls adipogenesis. | Latent transforming growth factor β binding protein 3 controls adipogenesis.
Singh K, Sachan N, Ene T, Dabovic B, Rifkin D. | 10/8/2022 |
| Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy. | Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy.
Zhang R, Xu X, Chen X, Hao C, Ji Z, Zuo P, Yang M, Ma G, Li Y., Free PMC Article | 08/27/2022 |
| Dedifferentiated Schwann cell-derived TGF-beta3 is essential for the neural system to promote wound healing. | Dedifferentiated Schwann cell-derived TGF-β3 is essential for the neural system to promote wound healing.
Ou MY, Tan PC, Xie Y, Liu K, Gao YM, Yang XS, Zhou SB, Li QF., Free PMC Article | 08/6/2022 |
| Transforming growth factor beta3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney. | Transforming growth factor β3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney.
Escasany E, Lanzón B, García-Carrasco A, Izquierdo-Lahuerta A, Torres L, Corrales P, Rodríguez Rodríguez AE, Luis-Lima S, Martínez Álvarez C, Javier Ruperez F, Ros M, Porrini E, Rydén M, Medina-Gómez G., Free PMC Article | 04/9/2022 |
| Diverse Signaling by TGFbeta Isoforms in Response to Focal Injury is Associated with Either Retinal Regeneration or Reactive Gliosis. | Diverse Signaling by TGFβ Isoforms in Response to Focal Injury is Associated with Either Retinal Regeneration or Reactive Gliosis.
Conedera FM, Quintela Pousa AM, Presby DM, Mercader N, Enzmann V, Tschopp M., Free PMC Article | 08/14/2021 |
| SMAD2 overexpression rescues the TGF-beta3 null mutant mice cleft palate by increased apoptosis. | SMAD2 overexpression rescues the TGF-β3 null mutant mice cleft palate by increased apoptosis.
AlMegbel AM, Shuler CF. | 10/10/2020 |
| the involvement of Socs3 in Runx1-Tgfb3 signaling might explain, at least in part, the anteriorly specific downregulation of Tgfb3 expression and Stat3 activity in Runx1 mutants. This is the first study to show that the novel Runx1-Stat3-Tgfb3 axis is essential in anterior palatogenesis. | Runx1-Stat3-Tgfb3 signaling network regulating the anterior palatal development.
Sarper SE, Kurosaka H, Inubushi T, Ono Minagi H, Kuremoto KI, Sakai T, Taniuchi I, Yamashiro T., Free PMC Article | 10/19/2019 |
| The comparison of transforming growth factor beta family (TGFbeta) expression showed significantly higher levels of Tgfbeta3 transcript between nude and Balb/c mice but no differences were detected for Tgfbeta1. Nude DFs were specifically sensitive to the presence of the pro-regenerative TGFbeta3 isoform, showing increased collagen I deposition and alpha smooth muscle actin expression. | Effect of TGFβ1, TGFβ3 and keratinocyte conditioned media on functional characteristics of dermal fibroblasts derived from reparative (Balb/c) and regenerative (Foxn1 deficient; nude) mouse models.
Bukowska J, Kopcewicz M, Kur-Piotrowska A, Szostek-Mioduchowska AZ, Walendzik K, Gawronska-Kozak B., Free PMC Article | 12/22/2018 |
| Data indicated that autophagy was required for TGF-beta3 induced airway mucous hyper-production. | TGF-β3 Promotes MUC5AC Hyper-Expression by Modulating Autophagy Pathway in Airway Epithelium.
Zhang Y, Tang H, Yuan X, Ran Q, Wang X, Song Q, Zhang L, Qiu Y, Wang X., Free PMC Article | 11/10/2018 |
| Results suggest that the miR-140-3p is involved in osteoblast differentiation as a critical regulatory factor between Wnt3a and TGFbeta3 signaling pathways. | Involvement of miR-140-3p in Wnt3a and TGFβ3 signaling pathways during osteoblast differentiation in MC3T3-E1 cells.
Fushimi S, Nohno T, Nagatsuka H, Katsuyama H. | 10/20/2018 |
| Egr2 and Egr3 expressed in T cells cooperatively prevent humoral immune responses by supporting TGF-beta3 secretion. | Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.
Morita K, Okamura T, Inoue M, Komai T, Teruya S, Iwasaki Y, Sumitomo S, Shoda H, Yamamoto K, Fujio K., Free PMC Article | 04/7/2018 |
| We identified TGF-beta3 as the top-ranked gene, a critical component of the transforming growth factor-b (TGF-b) and mitogen activated protein kinase (MAPK) signalling pathways in cardiac fibrosis | Expression signature of lncRNAs and their potential roles in cardiac fibrosis of post-infarct mice.
Qu X, Song X, Yuan W, Shu Y, Wang Y, Zhao X, Gao M, Lu R, Luo S, Zhao W, Zhang Y, Sun L, Lu Y., Free PMC Article | 12/9/2017 |
| Data (including data from studies using knockout mice) suggest Garp/Lrrc32 is involved in up-regulation of Tgfb3 and is essential for normal embryogenesis of palate; knockout of Garp causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Garp = glycoprotein A repetitions predominant protein; Smad2 = MAD homolog protein 2) | Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis.
Wu BX, Li A, Lei L, Kaneko S, Wallace C, Li X, Li Z., Free PMC Article | 11/25/2017 |
| TGFb3-induced down-regulation of p63 in the medial edge epithelia of the palatal shelves is a pre-requisite for palatal fusion by facilitating periderm migration from, and reducing the proliferative potential of, the midline epithelial seam thereby preventing cleft palate. | p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate.
Richardson R, Mitchell K, Hammond NL, Mollo MR, Kouwenhoven EN, Wyatt ND, Donaldson IJ, Zeef L, Burgis T, Blance R, van Heeringen SJ, Stunnenberg HG, Zhou H, Missero C, Romano RA, Sinha S, Dixon MJ, Dixon J., Free PMC Article | 07/29/2017 |
| Early activation of hepatic stellate cell and imbalance expression of TGF-beta1 and TGF-beta3 existed in ConA-induced acute autoimmune liver injury. | Stellate Cell Activation and Imbalanced Expression of TGF-β1/TGF-β3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice.
Wang L, Tu L, Zhang J, Xu K, Qian W., Free PMC Article | 03/18/2017 |
| CCN4 has a positive influence on chondrogenic differentiation by modulating the effects of TGF-beta3. | CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function.
Yoshioka Y, Ono M, Maeda A, Kilts TM, Hara ES, Khattab H, Ueda J, Aoyama E, Oohashi T, Takigawa M, Young MF, Kuboki T., Free PMC Article | 10/22/2016 |
| TGFbeta3 increases IRF6 expression and subsequently regulates SNAI2 expression; IRF6 appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2. | IRF6 is the mediator of TGFβ3 during regulation of the epithelial mesenchymal transition and palatal fusion.
Ke CY, Xiao WL, Chen CM, Lo LJ, Wong FH., Free PMC Article | 08/6/2016 |
| Analysis of the Tgf-beta-3 knockout mouse model has enabled identification of miRNAs with altered expression that may contribute to the cleft palate phenotype. | Temporal Expression of miRNAs in Laser Capture Microdissected Palate Medial Edge Epithelium from Tgfβ3(-/-) Mouse Fetuses.
Warner D, Ding J, Mukhopadhyay P, Brock G, Smolenkova IA, Seelan RS, Webb CL, Wittliff JL, Greene RM, Pisano MM. | 06/28/2016 |
| TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells have a role in controlling humoral immune responses | TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K., Free PMC Article | 03/19/2016 |
| Pathological TGF-beta release from osteolytic bone metastases contributes to muscle weakness in cancer by decreasing Ca(2+)-induced muscle force production. | Excess TGF-β mediates muscle weakness associated with bone metastases in mice.
Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, Benassi MS, Witzmann FA, Zhen G, Wang X, Cao X, Roodman GD, Marks AR, Guise TA., Free PMC Article | 02/20/2016 |
| Ephrin reverse signaling mediates palatal fusion and epithelial-to-mesenchymal transition independently of Tgfss3. | Ephrin reverse signaling mediates palatal fusion and epithelial-to-mesenchymal transition independently of Tgfß3.
Serrano MJ, Liu J, Svoboda KK, Nawshad A, Benson MD., Free PMC Article | 11/21/2015 |
| TGF-beta3 significantly downregulates JAM-B expression via post-transcriptional and post-translational modulation and results in the disruption of BTB and apical ES. | Transforming growth factor-β3 regulates cell junction restructuring via MAPK-mediated mRNA destabilization and Smad-dependent protein degradation of junctional adhesion molecule B (JAM-B).
Zhang X, Lui WY. | 08/29/2015 |