| TERT upregulation promotes cell proliferation via degradation of p21 and increases carcinogenic potential. | TERT upregulation promotes cell proliferation via degradation of p21 and increases carcinogenic potential.
Mishima M, Takai A, Takeda H, Iguchi E, Nakano S, Fujii Y, Ueno M, Ito T, Teramura M, Eso Y, Shimizu T, Maruno T, Hidema S, Nishimori K, Marusawa H, Hatano E, Seno H. | 10/10/2024 |
| TERT activation targets DNA methylation and multiple aging hallmarks. | TERT activation targets DNA methylation and multiple aging hallmarks.
Shim HS, Iaconelli J, Shang X, Li J, Lan ZD, Jiang S, Nutsch K, Beyer BA, Lairson LL, Boutin AT, Bollong MJ, Schultz PG, DePinho RA. | 09/3/2024 |
| An association between elevated telomerase reverse transcriptase expression and the immune tolerance disruption of dendritic cells. | An association between elevated telomerase reverse transcriptase expression and the immune tolerance disruption of dendritic cells.
Xu X, Mo L, Liao Y, Zhang KS, Zhang H, Liu L, Liu Y, Tang A, Yang P, Liu X., Free PMC Article | 06/3/2024 |
| TERT mediates the U-shape of glucocorticoids effects in modulation of hippocampal neural stem cells and associated brain function. | TERT mediates the U-shape of glucocorticoids effects in modulation of hippocampal neural stem cells and associated brain function.
Liu MY, Fan Y, Ni N, Yu T, Mao Z, Huang H, Zhang J, Tang Y, He H, Meng F, You Y, Zhou QG., Free PMC Article | 03/1/2024 |
| Telomere dysfunction in Tert knockout mice delays Braf[V600E] -induced melanoma development. | Telomere dysfunction in Tert knockout mice delays Braf(V600E) -induced melanoma development.
Zhang J, Zhang F, Porter KI, Dakup PP, Wang S, Robertson GP, Gaddameedhi S, Zhu J., | 01/4/2024 |
| The Wnt/beta-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: an in vivo and in vitro study. | The Wnt/β-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: an in vivo and in vitro study.
Cai Y, Sun H, Song X, Zhao J, Xu D, Liu M., Free PMC Article | 11/14/2023 |
| Prenatal stress modulates HPA axis homeostasis of offspring through dentate TERT independently of glucocorticoids receptor. | Prenatal stress modulates HPA axis homeostasis of offspring through dentate TERT independently of glucocorticoids receptor.
Liu MY, Wei LL, Zhu XH, Ding HC, Liu XH, Li H, Li YY, Han Z, Li LD, Du ZW, Zhou YP, Zhang J, Meng F, Tang YL, Liu X, Wang C, Zhou QG., Free PMC Article | 03/20/2023 |
| PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis. | PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis.
Huang E, Xu K, Gu X, Zhu Q. | 02/26/2022 |
| Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice. | Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice.
Zhang K, Wang L, Hong X, Chen H, Shi Y, Liu Y, Liu J, Liu JP., Free PMC Article | 01/15/2022 |
| Mitochondrial Telomerase Reverse Transcriptase Protects From Myocardial Ischemia/Reperfusion Injury by Improving Complex I Composition and Function. | Mitochondrial Telomerase Reverse Transcriptase Protects From Myocardial Ischemia/Reperfusion Injury by Improving Complex I Composition and Function.
Ale-Agha N, Jakobs P, Goy C, Zurek M, Rosen J, Dyballa-Rukes N, Metzger S, Greulich J, von Ameln F, Eckermann O, Unfried K, Brack F, Grandoch M, Thielmann M, Kamler M, Gedik N, Kleinbongard P, Heinen A, Heusch G, Gödecke A, Altschmied J, Haendeler J. | 01/8/2022 |
| The spatiotemporal expression of TERT and telomere repeat binding proteins in the postnatal mouse testes. | The spatiotemporal expression of TERT and telomere repeat binding proteins in the postnatal mouse testes.
Kosebent EG, Ozturk S. | 08/7/2021 |
| Interaction of the mTERT telomerase catalytic subunit with the c-Abl tyrosine kinase in mouse granulosa cells. | Interaction of the mTERT telomerase catalytic subunit with the c-Abl tyrosine kinase in mouse granulosa cells.
Yaba A, Agus S, Yıldırım E, Erdogan CS, Yılmaz B. | 04/24/2021 |
| Effect of exercise on telomere length and telomere proteins expression in mdx mice. | Effect of exercise on telomere length and telomere proteins expression in mdx mice.
Vita GL, Aguennouz M, Sframeli M, Sanarica F, Mantuano P, Oteri R, Polito F, Licata N, Romeo S, Distefano MG, La Rosa M, Bonanno C, Nicocia G, Vita G, De Luca A, Messina S. | 02/13/2021 |
| Telomerase Reverse Transcriptase and p53 Regulate Mammalian Peripheral Nervous System and CNS Axon Regeneration Downstream of c-Myc. | Telomerase Reverse Transcriptase and p53 Regulate Mammalian Peripheral Nervous System and CNS Axon Regeneration Downstream of c-Myc.
Ma JJ, Ju X, Xu RJ, Wang WH, Luo ZP, Liu CM, Yang L, Li B, Chen JQ, Meng B, Yang HL, Zhou FQ, Saijilafu., Free PMC Article | 07/4/2020 |
| PES1 facilitates telomerase assembly by promoting direct interaction between TERT and TR without affecting TERT and TR levels | PES1 is a critical component of telomerase assembly and regulates cellular senescence.
Cheng L, Yuan B, Ying S, Niu C, Mai H, Guan X, Yang X, Teng Y, Lin J, Huang J, Jin R, Wu J, Liu B, Chang S, Wang E, Zhang C, Hou N, Cheng X, Xu D, Yang X, Gao S, Ye Q., Free PMC Article | 06/6/2020 |
| Both telomerase reverse transcriptase mTert (+/+) and mTert (-/-) fibroblasts show comparable and extremely short telomere length. mTert (-/-) cells approach cellular senescence faster and exhibit a higher rate of malignant transformation than mTert (+/+) cells. TERT expression is up regulated in mTert (+/+) cells at the presenescence stage. | Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts.
Sun L, Chiang JY, Choi JY, Xiong ZM, Mao X, Collins FS, Hodes RJ, Cao K., Free PMC Article | 04/4/2020 |
| In the carotid atherosclerotic plaques from miR-216a-treated apolipoprotein E(-/-) mice, the numbers of M1 macrophages were increased whereas M2 cells reduced, accompanying with inhibited Smad3 expression and upregulated inflammatory markers and TERT activity. | MicroRNA-216a promotes M1 macrophages polarization and atherosclerosis progression by activating telomerase via the Smad3/NF-κB pathway.
Yang S, Li J, Chen Y, Zhang S, Feng C, Hou Z, Cai J, Wang Y, Hui R, Lv B, Zhang W. | 03/7/2020 |
| TERT has a protective role in type II alveolar epithelial cell, unlike its pro-fibrotic activity, observed previously in fibroblasts, indicating that TERT's role in pulmonary fibrosis is cell type-specific. | Telomerase reverse transcriptase ameliorates lung fibrosis by protecting alveolar epithelial cells against senescence.
Liu T, Gonzalez De Los Santos F, Zhao Y, Wu Z, Rinke AE, Kim KK, Phan SH., Free PMC Article | 02/22/2020 |
| Telomerase contributes to lymphocyte proliferation but plays no major role in Treg function, provided that telomere length is not critically short. Oxidative stress may contribute to atherosclerosis via suppression of telomerase and acceleration of telomere attrition in Tregs. | Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells.
Richardson GD, Sage A, Bennaceur K, Al Zhrany N, Coelho-Lima J, Dookun E, Draganova L, Saretzki G, Breault DT, Mallat Z, Spyridopoulos I., Free PMC Article | 07/13/2019 |
| Data show that snail family zinc finger 1 (Snail1)-deficient mesenchymal stem cells (MSC) present higher levels of both telomerase activity and the long non-coding RNA called telomeric repeat-containing RNA (TERRA), an RNA that controls telomere integrity. | Snail1 transcription factor controls telomere transcription and integrity.
Mazzolini R, Gonzàlez N, Garcia-Garijo A, Millanes-Romero A, Peiró S, Smith S, García de Herreros A, Canudas S., Free PMC Article | 07/13/2019 |
| This study revealed a dynamic hTERT regulation by chromatin environment and promoter-bound transcription factors during embryonic stem cell differentiation. | Regulation of human and mouse telomerase genes by genomic contexts and transcription factors during embryonic stem cell differentiation.
Cheng D, Wang S, Jia W, Zhao Y, Zhang F, Kang J, Zhu J., Free PMC Article | 07/6/2019 |
| Par-4 activation and binding to TERT are key steps required for inducing the apoptosis of islet beta cells under high-glucose/fatty acid conditions in type 2 diabetes. | TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes.
Liu C, QiNan W, XiaoTian L, MengLiu Y, XiaGuang G, WeiLing L, ZiWen L, Ling Z, GangYi Y, Bing C., Free PMC Article | 12/22/2018 |
| Tert-deficient but not Terc-deficient mice develop hepatocyte injury and frank steatosis when challenged with liquid high-fat diet. | Telomerase enzyme deficiency promotes metabolic dysfunction in murine hepatocytes upon dietary stress.
Alves-Paiva RM, Kajigaya S, Feng X, Chen J, Desierto M, Wong S, Townsley DM, Donaires FS, Bertola A, Gao B, Young NS, Calado RT., Free PMC Article | 12/22/2018 |
| identification of a subset of hepatocytes that expresses high levels of telomerase and show that this hepatocyte subset repopulates the liver during homeostasis and injury | Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury.
Lin S, Nascimento EM, Gajera CR, Chen L, Neuhöfer P, Garbuzov A, Wang S, Artandi SE., Free PMC Article | 08/18/2018 |
| These preclinical data in mouse models and human cells provide a strong rationale for the development of pharmacological approaches to target BMI1-mediated mitochondrial regulation and protection from DNA damage to sustain the regenerative potential of the skeletal muscle in conditions of chronic muscle wasting. | Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development.
Zhou QG, Liu MY, Lee HW, Ishikawa F, Devkota S, Shen XR, Jin X, Wu HY, Liu Z, Liu X, Jin X, Zhou HH, Ro EJ, Zhang J, Zhang Y, Lin YH, Suh H, Zhu DY., Free PMC Article | 04/28/2018 |