| Role of the telomeric factor TRF2 in post-hypoxic brain damages. | Role of the telomeric factor TRF2 in post-hypoxic brain damages.
Gao S, Huang S, Xu Y, Wang B, Cheng P, Lu Y, Gilson E, Ye J., Free PMC Article | 10/2/2024 |
| TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA. | TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA.
Kaur P, Barnes R, Pan H, Detwiler AC, Liu M, Mahn C, Hall J, Messenger Z, You C, Piehler J, Smart RC, Riehn R, Opresko PL, Wang H., Free PMC Article | 01/15/2022 |
| Molecular Consequences of Depression Treatment: A Potential In Vitro Mechanism for Antidepressants-Induced Reprotoxic Side Effects. | Molecular Consequences of Depression Treatment: A Potential In Vitro Mechanism for Antidepressants-Induced Reprotoxic Side Effects.
Sołek P, Mytych J, Tabęcka-Łonczyńska A, Koziorowski M., Free PMC Article | 12/18/2021 |
| Mitochondrial function in skeletal myofibers is controlled by a TRF2-SIRT3 axis over lifetime. | Mitochondrial function in skeletal myofibers is controlled by a TRF2-SIRT3 axis over lifetime.
Robin JD, Jacome Burbano MS, Peng H, Croce O, Thomas JL, Laberthonniere C, Renault V, Lototska L, Pousse M, Tessier F, Bauwens S, Leong W, Sacconi S, Schaeffer L, Magdinier F, Ye J, Gilson E., Free PMC Article | 05/15/2021 |
| TRF2-mediated telomere protection is dispensable in pluripotent stem cells. | TRF2-mediated telomere protection is dispensable in pluripotent stem cells.
Markiewicz-Potoczny M, Lobanova A, Loeb AM, Kirak O, Olbrich T, Ruiz S, Lazzerini Denchi E., Free PMC Article | 02/27/2021 |
| TRF2-independent chromosome end protection during pluripotency. | TRF2-independent chromosome end protection during pluripotency.
Ruis P, Van Ly D, Borel V, Kafer GR, McCarthy A, Howell S, Blassberg R, Snijders AP, Briscoe J, Niakan KK, Marzec P, Cesare AJ, Boulton SJ., Free PMC Article | 02/27/2021 |
| klotho serves as a part of the cellular defense mechanism engaged in the protection of neurons against amitriptyline-mediated toxicity. | Klotho-Mediated Changes in Shelterin Complex Promote Cytotoxic Autophagy and Apoptosis in Amitriptyline-Treated Hippocampal Neuronal Cells.
Mytych J, Solek P, Tabecka-Lonczynska A, Koziorowski M. | 02/1/2020 |
| Trf2 deletion leads to telomere uncapping, increased senescence signaling, and oxidative stress mediated functional impairments in the vasculature. | Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress.
Morgan RG, Walker AE, Trott DW, Machin DR, Henson GD, Reihl KD, Cawthon RM, Denchi EL, Liu Y, Bloom SI, Phuong TT, Richardson RS, Lesniewski LA, Donato AJ., Free PMC Article | 01/11/2020 |
| Mammary glands lacking TRF2 expression exhibited increased telomere DNA damage response, histopathological and functional degeneration, and prominent ductal fibrosis. TRF2-deficient mammary tumors exhibited rapid onset and increased proliferation. | Molecular and cellular basis of mammary gland fibrosis and cancer risk.
Wu J, Crowe DL. | 08/10/2019 |
| This review focuses on the current knowledge of shelterin-mediated telomere protection, highlights differences between human and mouse shelterin, and discusses some of the questions that remain | Shelterin-Mediated Telomere Protection.
de Lange T. | 07/20/2019 |
| It plays a role in hematopoietic stem cell regulation and in the maintenance of the HSC pool and the development of hematological disorders. | The role of telomere binding molecules for normal and abnormal hematopoiesis.
Hosokawa K, Arai F. | 06/30/2018 |
| shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development and aging | The differential spatiotemporal expression pattern of shelterin genes throughout lifespan.
Wagner KD, Ying Y, Leong W, Jiang J, Hu X, Chen Y, Michiels JF, Lu Y, Gilson E, Wagner N, Ye J., Free PMC Article | 02/17/2018 |
| Selective inactivation of Terf2 in neural progenitors induced apoptosis, resulting in a complete loss of the brain structure. | Involvement of Atm and Trp53 in neural cell loss due to Terf2 inactivation during mouse brain development.
Kim J, Choi I, Lee Y., Free PMC Article | 11/11/2017 |
| The authors propose that TRF2 masks and stabilizes the t-loop three-way junction, thereby protecting telomeres from detrimental deletions and PARP1 activation. | TRF2 binds branched DNA to safeguard telomere integrity.
Schmutz I, Timashev L, Xie W, Patel DJ, de Lange T. | 09/16/2017 |
| TRF2, a component of shelterin, binds to core histones to protect chromosome ends from inappropriate DNA damage response and loss of telomeric DNA. The N-terminal Gly/Arg-rich domain (GAR domain) of TRF2 directly binds to the globular domain of core histones. | TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends.
Konishi A, Izumi T, Shimizu S., Free PMC Article | 05/20/2017 |
| Overexpressing TRF2-S and silencing FMRP promotes mRNA entry to axons and enhances axonal outgrowth and neurotransmitter release from presynaptic terminals. | Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity.
Zhang P, Abdelmohsen K, Liu Y, Tominaga-Yamanaka K, Yoon JH, Ioannis G, Martindale JL, Zhang Y, Becker KG, Yang IH, Gorospe M, Mattson MP., Free PMC Article | 07/2/2016 |
| TRF2 binds and transactivates the promoter of the angiogenic tyrosine kinase platelet-derived growth factor receptor beta (PDGFRbeta). | The Telomeric Protein TRF2 Regulates Angiogenesis by Binding and Activating the PDGFRβ Promoter.
El Maï M, Wagner KD, Michiels JF, Ambrosetti D, Borderie A, Destree S, Renault V, Djerbi N, Giraud-Panis MJ, Gilson E, Wagner N. | 07/25/2015 |
| role of TRF2 in skin homeostasis, is reported. | Essential role for the TRF2 telomere protein in adult skin homeostasis.
Martínez P, Ferrara-Romeo I, Flores JM, Blasco MA., Free PMC Article | 04/4/2015 |
| shelterin protein TIN2 can protect chromosome ends as a TRF2-tethered TIN2/TPP1/POT1 complex that lacks a physical connection to TRF1 | TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1.
Frescas D, de Lange T., Free PMC Article | 05/17/2014 |
| We concluded that genomic instability resulting from loss of TRF2 expression provides biological advantages to the cancer stem cell population | Stem cell expansion during carcinogenesis in stem cell-depleted conditional telomeric repeat factor 2 null mutant mice.
Bojovic B, Ho HY, Wu J, Crowe DL., Free PMC Article | 01/4/2014 |
| Conditional deletion of individual components of shelterin showed that TRF2 was required for the formation and/or maintenance of t-loops, whereas deletion of TRF1, Rap1, or the POT1 proteins (POT1a and POT1b) had no effect on the frequency of t-loop occurrence. | Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.
Doksani Y, Wu JY, de Lange T, Zhuang X., Free PMC Article | 12/21/2013 |
| TAF7L associates with TRF2 both in vitro and in testis, suggesting that TAF7L likely cooperates directly with TRF2 at promoters of a subset of postmeiotic genes to regulate spermiogenesis. | Taf7l cooperates with Trf2 to regulate spermiogenesis.
Zhou H, Grubisic I, Zheng K, He Y, Wang PJ, Kaplan T, Tjian R., Free PMC Article | 12/14/2013 |
| Experiments in cells from knockout mice showed that uPAR controls the ubiquitin-proteasome system in VSMC & regulates doxorubicin-induced TRF2 ubiquitination and proteasomal degradation via this mechanism. | Urokinase receptor mediates doxorubicin-induced vascular smooth muscle cell senescence via proteasomal degradation of TRF2.
Hodjat M, Haller H, Dumler I, Kiyan Y. | 04/27/2013 |
| the molecular properties of TRF2 that are both necessary and sufficient to protect chromosome ends in mouse embryonic fibroblasts: the data support a two-step mechanism for TRF2-mediated end protection | A two-step mechanism for TRF2-mediated chromosome-end protection.
Okamoto K, Bartocci C, Ouzounov I, Diedrich JK, Yates JR 3rd, Denchi EL., Free PMC Article | 03/30/2013 |
| Mouse gene deletion experiments revealed DNA-damage-response pathways that threaten chromosome ends and how the components of the telomeric shelterin complex prevent activation of these pathways.[Shelterin] | How shelterin solves the telomere end-protection problem.
de Lange T. | 10/25/2011 |