| Understanding the Role of the SMN Complex Component GEMIN5 and Its Functional Relationship with Demethylase KDM6B in the Flunarizine-Mediated Neuroprotection of Motor Neuron Disease Spinal Muscular Atrophy. | Understanding the Role of the SMN Complex Component GEMIN5 and Its Functional Relationship with Demethylase KDM6B in the Flunarizine-Mediated Neuroprotection of Motor Neuron Disease Spinal Muscular Atrophy.
Salman B, Bon E, Delers P, Cottin S, Pasho E, Ciura S, Sapaly D, Lefebvre S., Free PMC Article | 10/3/2024 |
| Diabetic Wound Keratinocytes Induce Macrophage JMJD3-Mediated Nlrp3 Expression via IL-1R Signaling. | Diabetic Wound Keratinocytes Induce Macrophage JMJD3-Mediated Nlrp3 Expression via IL-1R Signaling.
Wolf SJ, Audu CO, Moon JY, Joshi AD, Melvin WJ, Barrett EC, Mangum K, de Jimenez GS, Rocco S, Buckley S, Ahmed Z, Wasikowski R, Kahlenberg JM, Tsoi LC, Gudjonsson JE, Gallagher KA., Free PMC Article | 10/1/2024 |
| High-intensity interval training ameliorates postnatal immune activation-induced mood disorders through KDM6B-regulated glial activation. | High-intensity interval training ameliorates postnatal immune activation-induced mood disorders through KDM6B-regulated glial activation.
Yao Y, Du J, Wang D, Li N, Tao Z, Wu D, Peng F, Shi J, Zhou W, Zhao T, Tang Y. | 08/29/2024 |
| YAP represses intestinal inflammation through epigenetic silencing of JMJD3. | YAP represses intestinal inflammation through epigenetic silencing of JMJD3.
Zhu H, Lu J, Fu M, Chen P, Yu Y, Chen M, Zhao Q, Wu M, Ye M., Free PMC Article | 02/1/2024 |
| KDM6B drives epigenetic reprogramming associated with lymphoid stromal cell early commitment and immune properties. | KDM6B drives epigenetic reprogramming associated with lymphoid stromal cell early commitment and immune properties.
Sylvestre M, Barbier N, Sibut V, Nayar S, Monvoisin C, Leonard S, Saint-Vanne J, Martin A, Guirriec M, Latour M, Jouan F, Baulande S, Bohec M, Verdière L, Mechta-Grigoriou F, Mourcin F, Bertheuil N, Barone F, Tarte K, Roulois D., Free PMC Article | 12/4/2023 |
| Osteoblast Jmjd3 regulates osteoclastogenesis via EphB4 and RANKL signalling. | Osteoblast Jmjd3 regulates osteoclastogenesis via EphB4 and RANKL signalling.
Wang R, Luo H, Yang D, Yu B, Guo J, Shao L, Okamura H, Qiu L. | 10/20/2023 |
| Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b-mediated chromatin demethylation. | Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b-mediated chromatin demethylation.
Phan QM, Salz L, Kindl SS, Lopez JS, Thompson SM, Makkar J, Driskell IM, Driskell RR., Free PMC Article | 10/5/2023 |
| Integrative bioinformatics and validation studies reveal KDM6B and its associated molecules as crucial modulators in Idiopathic Pulmonary Fibrosis. | Integrative bioinformatics and validation studies reveal KDM6B and its associated molecules as crucial modulators in Idiopathic Pulmonary Fibrosis.
Chen A, Sun Z, Sun D, Huang M, Fang H, Zhang J, Qian G., Free PMC Article | 06/13/2023 |
| KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress. | KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress.
Issa N, Bjeije H, Wilson ER, Krishnan A, Dunuwille WMB, Parsons TM, Zhang CR, Han W, Young AL, Ren Z, Ge K, Wang ES, Weng AP, Cashen A, Spencer DH, Challen GA., Free PMC Article | 04/12/2023 |
| JMJD3 downregulates IL4i1 aggravating lipopolysaccharide-induced acute lung injury via H3K27 and H3K4 demethylation. | JMJD3 downregulates IL4i1 aggravating lipopolysaccharide-induced acute lung injury via H3K27 and H3K4 demethylation.
Gao Y, Wang N, Jia D. | 03/20/2023 |
| KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2. | KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2.
Wang Y, Khandelwal N, Liu S, Zhou M, Bao L, Wang JE, Kumar A, Xing C, Gibson JR, Wang Y., Free PMC Article | 01/21/2023 |
| JMJD3 Is Required for Acute Pancreatitis and Pancreatitis-Associated Lung Injury. | JMJD3 Is Required for Acute Pancreatitis and Pancreatitis-Associated Lung Injury.
Chen L, Zhang X, Liu Y, Liu L, Liang X, Yang S, Xia Q, Jin T, Ma Y, Chen Y, Yuan X, Tie Y, Gu Y, Fang C, Chen S, Mo F, Yu T, Hu Y, Qian Z, Peng Y, Geng J, Zhou Z, Wu M, Ding J, Yang D, Wei X., Free PMC Article | 01/14/2023 |
| Jmjd3/IRF4 axis aggravates myeloid fibroblast activation and m2 macrophage to myofibroblast transition in renal fibrosis. | Jmjd3/IRF4 axis aggravates myeloid fibroblast activation and m2 macrophage to myofibroblast transition in renal fibrosis.
Liang H, Liu B, Gao Y, Nie J, Feng S, Yu W, Wen S, Su X., Free PMC Article | 10/1/2022 |
| JMJD3/H3K27me3 epigenetic modification regulates Th17/Treg cell differentiation in ulcerative colitis. | JMJD3/H3K27me3 epigenetic modification regulates Th17/Treg cell differentiation in ulcerative colitis.
Leng XY, Yang J, Fan H, Chen QY, Cheng BJ, He HX, Gao F, Zhu F, Yu T, Liu YJ. | 08/27/2022 |
| JMJD3 activated hyaluronan synthesis drives muscle regeneration in an inflammatory environment. | JMJD3 activated hyaluronan synthesis drives muscle regeneration in an inflammatory environment.
Nakka K, Hachmer S, Mokhtari Z, Kovac R, Bandukwala H, Bernard C, Li Y, Xie G, Liu C, Fallahi M, Megeney LA, Gondin J, Chazaud B, Brand M, Zha X, Ge K, Dilworth FJ. | 08/27/2022 |
| Cooperation between KDM6B overexpression and TET2 deficiency in the pathogenesis of chronic myelomonocytic leukemia. | Cooperation between KDM6B overexpression and TET2 deficiency in the pathogenesis of chronic myelomonocytic leukemia.
Wei Y, Kanagal-Shamanna R, Zheng H, Bao N, Lockyer PP, Class CA, Darbaniyan F, Lu Y, Lin K, Yang H, Montalban-Bravo G, Ganan-Gomez I, Soltysiak KA, Do KA, Colla S, Garcia-Manero G. | 08/13/2022 |
| The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRalphabeta(+)CD8alphaalpha(+) intestinal intraepithelial lymphocytes. | The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ(+)CD8αα(+) intestinal intraepithelial lymphocytes.
Zhang H, Hu Y, Liu D, Liu Z, Xie N, Liu S, Zhang J, Jiang Y, Li C, Wang Q, Chen X, Ye D, Sun D, Zhai Y, Yan X, Liu Y, Chen CD, Huang X, Eugene Chin Y, Shi Y, Wu B, Zhang X., Free PMC Article | 07/23/2022 |
| Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure. | Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure.
Feng S, Peden EK, Guo Q, Lee TH, Li Q, Yuan Y, Chen C, Huang F, Cheng J., Free PMC Article | 06/11/2022 |
| Jumonji Domain-containing Protein-3 (JMJD3/Kdm6b) Is Critical for Normal Ovarian Function and Female Fertility. | Jumonji Domain-containing Protein-3 (JMJD3/Kdm6b) Is Critical for Normal Ovarian Function and Female Fertility.
Roy S, Sinha N, Huang B, Cline-Fedewa H, Gleicher N, Wang J, Sen A., Free PMC Article | 05/14/2022 |
| KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. | KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.
Guo T, Han X, He J, Feng J, Jing J, Janečková E, Lei J, Ho TV, Xu J, Chai Y., Free PMC Article | 04/23/2022 |
| Synergistic effects of ISL1 and KDM6B on non-alcoholic fatty liver disease through the regulation of SNAI1. | Synergistic effects of ISL1 and KDM6B on non-alcoholic fatty liver disease through the regulation of SNAI1.
Zhao F, Ke J, Pan W, Pan H, Shen M., Free PMC Article | 04/2/2022 |
| Mitochondrial dysfunction-induced H3K27 hyperacetylation perturbs enhancers in Parkinson's disease. | Mitochondrial dysfunction-induced H3K27 hyperacetylation perturbs enhancers in Parkinson's disease.
Huang M, Lou D, Charli A, Kong D, Jin H, Zenitsky G, Anantharam V, Kanthasamy A, Wang Z, Kanthasamy AG., Free PMC Article | 03/26/2022 |
| Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation. | Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation.
Kania AK, Guo M, Scharer CD, Boss JM., Free PMC Article | 03/12/2022 |
| The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development. | The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.
Wang W, Cho H, Lee JW, Lee SK., Free PMC Article | 03/5/2022 |
| The anti-aging protein Klotho affects early postnatal myogenesis by downregulating Jmjd3 and the canonical Wnt pathway. | The anti-aging protein Klotho affects early postnatal myogenesis by downregulating Jmjd3 and the canonical Wnt pathway.
McKee CM, Chapski DJ, Wehling-Henricks M, Rosa-Garrido M, Kuro-O M, Vondriska TM, Tidball JG., Free PMC Article | 03/5/2022 |