| Egr1 promotes Nlrc4-dependent neuronal pyroptosis through phlda1 in an in-vitro model of intracerebral hemorrhage. | Egr1 promotes Nlrc4-dependent neuronal pyroptosis through phlda1 in an in-vitro model of intracerebral hemorrhage.
Wang J, Gu D, Jin K, Shen H, Qian Y. | 05/31/2024 |
| Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice. | Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice.
Yousof TR, Bouchard CC, Alb M, Lynn EG, Lhoták S, Jiang H, MacDonald M, Li H, Byun JH, Makda Y, Athanasopoulos M, Maclean KN, Cherrington NJ, Naqvi A, Igdoura SA, Krepinsky JC, Steinberg GR, Austin RC., Free PMC Article | 03/6/2024 |
| FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis. | FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis.
Zhou DP, Deng LC, Feng X, Xu HJ, Tian Y, Yang WW, Zeng PP, Zou LH, Yan XH, Zhu XY, Shu DH, Guo Q, Huang XY, Bellusci S, Lou Z, Li XK, Zhang JS., Free PMC Article | 10/12/2023 |
| Knockdown of PHLDA1 alleviates sepsis-induced acute lung injury by downregulating NLRP3 inflammasome activation. | Knockdown of PHLDA1 alleviates sepsis-induced acute lung injury by downregulating NLRP3 inflammasome activation.
Meng L, Gu T, Wang J, Zhang H, Nan C. | 09/12/2023 |
| TDAG51 promotes transcription factor FoxO1 activity during LPS-induced inflammatory responses. | TDAG51 promotes transcription factor FoxO1 activity during LPS-induced inflammatory responses.
Park ES, Jeon H, Lee N, Yu J, Park HW, Satoh T, Akira S, Furuyama T, Lee CH, Choi JS, Rho J., Free PMC Article | 06/30/2023 |
| TDAG51 Attenuates Impaired Lipid Metabolism and Insulin Resistance in Gestational Diabetes Mellitus Through SREBP-1/ANGPTL8 Pathway. | TDAG51 Attenuates Impaired Lipid Metabolism and Insulin Resistance in Gestational Diabetes Mellitus Through SREBP-1/ANGPTL8 Pathway.
Wu X, Xiao B., Free PMC Article | 05/13/2023 |
| Knockdown of PHLDA1 Alleviates Necrotizing Enterocolitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling. | Knockdown of PHLDA1 Alleviates Necrotizing Enterocolitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling.
Yang X, Li X, Wu C, Zhang F. | 04/6/2023 |
| PHLDA1 knockdown alleviates mitochondrial dysfunction and endoplasmic reticulum stress-induced neuronal apoptosis via activating PPARgamma in cerebral ischemia-reperfusion injury. | PHLDA1 knockdown alleviates mitochondrial dysfunction and endoplasmic reticulum stress-induced neuronal apoptosis via activating PPARγ in cerebral ischemia-reperfusion injury.
Liu Y, Zhao H, Chen N, Li Y, Zheng Z, Sun Z, Zhang Z. | 02/24/2023 |
| TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3beta Pathway. | TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3β Pathway.
Liu C, Li Y, Wang X. | 06/18/2022 |
| PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip. | PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip.
Peng H, Wang J, Song X, Huang J, Hua H, Wang F, Xu Z, Ma J, Gao J, Zhao J, Nong A, Huang D, Liang B., Free PMC Article | 04/16/2022 |
| TDAG51 induces renal interstitial fibrosis through modulation of TGF-beta receptor 1 in chronic kidney disease. | TDAG51 induces renal interstitial fibrosis through modulation of TGF-β receptor 1 in chronic kidney disease.
Carlisle RE, Mohammed-Ali Z, Lu C, Yousof T, Tat V, Nademi S, MacDonald ME, Austin RC, Dickhout JG., Free PMC Article | 02/5/2022 |
| miR-194 ameliorates hepatic ischemia/reperfusion injury via targeting PHLDA1 in a TRAF6-dependent manner. | miR-194 ameliorates hepatic ischemia/reperfusion injury via targeting PHLDA1 in a TRAF6-dependent manner.
Luo YH, Huang ZT, Zong KZ, Cao ZR, Peng DD, Zhou BY, Shen A, Yan P, Wu ZJ. | 12/18/2021 |
| T-Cell Death Associated Gene 51 Is a Novel Negative Regulator of PPARgamma That Inhibits PPARgamma-RXRalpha Heterodimer Formation in Adipogenesis | T-Cell Death Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγ-RXRα Heterodimer Formation in Adipogenesis.
Kim S, Lee N, Park ES, Yun H, Ha TU, Jeon H, Yu J, Choi S, Shin B, Yu J, Rhee SD, Choi Y, Rho J., Free PMC Article | 08/14/2021 |
| TDAG51 (T-Cell Death-Associated Gene 51) Is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells. | TDAG51 (T-Cell Death-Associated Gene 51) Is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells.
Platko K, Lebeau PF, Gyulay G, Lhoták Š, MacDonald ME, Pacher G, Hyun Byun J, Boivin FJ, Igdoura SA, Cutz JC, Bridgewater D, Ingram AJ, Krepinsky JC, Austin RC. | 10/10/2020 |
| These findings indicate that TDAG51 plays a protective role against maternal care defects and depressive-like behavior after parturition. Thus, TDAG51 is a maternal care-associated gene that functions as a crucial regulator of maternal and depressive-like behavior after parturition. | TDAG51 is a crucial regulator of maternal care and depressive-like behavior after parturition.
Yun H, Park ES, Choi S, Shin B, Yu J, Yu J, Amarasekara DS, Kim S, Lee N, Choi JS, Choi Y, Rho J., Free PMC Article | 11/9/2019 |
| The data presented herein demonstrate TDAG51 expression to be upregulated in damaged skeletal muscle and its absence attenuates the early phases of muscle regeneration. | The Pleckstrin homology like domain family member, TDAG51, is temporally regulated during skeletal muscle regeneration.
Coleman SK, Cao AW, Rebalka IA, Gyulay G, Chambers PJ, Tupling AR, Austin RC, Hawke TJ. | 01/6/2018 |
| PHLDA1 plays a critical role in the development of progressive lung contusion and subsequent inflammation. | PHLDA1 Promotes Lung Contusion by Regulating the Toll-Like Receptor 2 Signaling Pathway.
Wang S, Zhang H, Wang A, Huang D, Fan J, Lu L, Chen X. | 02/18/2017 |
| These findings suggested that TDAG51 up-regulation is a dependent event during LPS-mediated proliferation and cell cycle progression, and which increase our understanding of the interaction mechanism between LPS and macrophages. | Up-regulation of TDAG51 is a dependent factor of LPS-induced RAW264.7 macrophages proliferation and cell cycle progression.
Jiao HW, Jia XX, Zhao TJ, Rong H, Zhang JN, Cheng Y, Zhu HP, Xu KL, Guo SY, Shi QY, Zhang H, Wang FY, Chen CF, Du L. | 12/17/2016 |
| The JAK2-ERK1/2-STAT3 pathway is an important signaling pathway for regulation of PHLDA1 expression. | Regulation of PHLDA1 Expression by JAK2-ERK1/2-STAT3 Signaling Pathway.
Lyu JH, Huang B, Park DW, Baek SH. | 11/5/2016 |
| TDAG51 has a protective role in oxidative stress-induced cell death in mouse embryonic fibroblasts. | TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts.
Park ES, Kim J, Ha TU, Choi JS, Soo Hong K, Rho J., Free PMC Article | 10/26/2013 |
| Our results suggest that the balance between the cell survival and death signals mediated by HSP70 and TDAG51, respectively, may be disturbed by the altered expression of HSF1 during the progression of disease in this amyotropic lateral sclerosis model. | Expression of heat shock transcription factor 1 and its downstream target protein T-cell death associated gene 51 in the spinal cord of a mouse model of amyotrophic lateral sclerosis.
Mimoto T, Morimoto N, Miyazaki K, Kurata T, Sato K, Ikeda Y, Abe K. | 05/4/2013 |
| TDAG51 is involved in energy homeostasis at least in part by regulating lipogenesis in liver and white adipose tissue. | Loss of TDAG51 results in mature-onset obesity, hepatic steatosis, and insulin resistance by regulating lipogenesis.
Basseri S, Lhoták S, Fullerton MD, Palanivel R, Jiang H, Lynn EG, Ford RJ, Maclean KN, Steinberg GR, Austin RC., Free PMC Article | 03/9/2013 |
| PHLDA1 expression marks the putative epithelial stem cells, downregulates ITGA2 and ITGA6, and contributes to intestinal tumorigenesis | PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.
Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM. | 07/23/2011 |
| TDAG51 is induced by homocysteine, promotes detachment-mediated PCD, and contributes to the development of atherosclerosis observed in hyperhomocysteinemia | TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia.
Hossain GS, van Thienen JV, Werstuck GH, Zhou J, Sood SK, Dickhout JG, de Koning AB, Tang D, Wu D, Falk E, Poddar R, Jacobsen DW, Zhang K, Kaufman RJ, Austin RC. | 01/21/2010 |