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    Slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 [ Mus musculus (house mouse) ]

    Gene ID: 216227, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    VGLUT3 Deletion Rescues Motor Deficits and Neuronal Loss in the zQ175 Mouse Model of Huntington's Disease.

    VGLUT3 Deletion Rescues Motor Deficits and Neuronal Loss in the zQ175 Mouse Model of Huntington's Disease.
    Ibrahim KS, El Mestikawy S, Abd-Elrahman KS, Ferguson SSG., Free PMC Article

    06/15/2023
    Spinal VGLUT3 lineage neurons drive visceral mechanical allodynia but not sensitized visceromotor reflexes.

    Spinal VGLUT3 lineage neurons drive visceral mechanical allodynia but not sensitized visceromotor reflexes.
    Qi L, Lin SH, Ma Q.

    03/7/2023
    Absence of VGLUT3 Expression Leads to Impaired Fear Memory in Mice.

    Absence of VGLUT3 Expression Leads to Impaired Fear Memory in Mice.
    de Almeida C, Chabbah N, Eyraud C, Fasano C, Bernard V, Pietrancosta N, Fabre V, El Mestikawy S, Daumas S., Free PMC Article

    02/28/2023
    VGLUT3 Ablation Differentially Modulates Glutamate Receptor Densities in Mouse Brain.

    VGLUT3 Ablation Differentially Modulates Glutamate Receptor Densities in Mouse Brain.
    Ibrahim KS, El Mestikawy S, Abd-Elrahman KS, Ferguson SSG., Free PMC Article

    05/14/2022
    Neurochemically and Hodologically Distinct Ascending VGLUT3 versus Serotonin Subsystems Comprise the r2-Pet1 Median Raphe.

    Neurochemically and Hodologically Distinct Ascending VGLUT3 versus Serotonin Subsystems Comprise the r2-Pet1 Median Raphe.
    Senft RA, Freret ME, Sturrock N, Dymecki SM., Free PMC Article

    08/21/2021
    Interrelationships between Cellular Density, Mosaic Patterning, and Dendritic Coverage of VGluT3 Amacrine Cells.

    Interrelationships between Cellular Density, Mosaic Patterning, and Dendritic Coverage of VGluT3 Amacrine Cells.
    Keeley PW, Lebo MC, Vieler JD, Kim JJ, St John AJ, Reese BE., Free PMC Article

    04/3/2021
    Low-Threshold Mechanosensitive VGLUT3-Lineage Sensory Neurons Mediate Spinal Inhibition of Itch by Touch.

    Low-Threshold Mechanosensitive VGLUT3-Lineage Sensory Neurons Mediate Spinal Inhibition of Itch by Touch.
    Sakai K, Sanders KM, Lin SH, Pavlenko D, Funahashi H, Lozada T, Hao S, Chen CC, Akiyama T., Free PMC Article

    01/16/2021
    Consequences of VGluT3 deficiency on learning and memory in mice.

    Consequences of VGluT3 deficiency on learning and memory in mice.
    Fazekas CL, Balázsfi D, Horváth HR, Balogh Z, Aliczki M, Puhova A, Balagova L, Chmelova M, Jezova D, Haller J, Zelena D.

    09/26/2020
    Spontaneous repair of synapses after noise depends on the level of Vglut3 protein or the level of glutamate release during the recovery period. One copy of the Vglut3 gene is sufficient for noise-induced threshold shift and loss of ribbon synapses, but both copies are required for normal recovery of hearing function and ribbon synapse number.

    Vesicular Glutamatergic Transmission in Noise-Induced Loss and Repair of Cochlear Ribbon Synapses.
    Kim KX, Payne S, Yang-Hood A, Li SZ, Davis B, Carlquist J, V-Ghaffari B, Gantz JA, Kallogjeri D, Fitzpatrick JAJ, Ohlemiller KK, Hirose K, Rutherford MA., Free PMC Article

    06/27/2020
    the expression of VGLUT3 in multiple brain areas is pivotal in gating amphetamine-induced psychomotor adaptations

    VGLUT3 gates psychomotor effects induced by amphetamine.
    Mansouri-Guilani N, Bernard V, Vigneault E, Vialou V, Daumas S, El Mestikawy S, Gangarossa G.

    11/2/2019
    Glia cells in spiral ganglion region expressed vGlut3 in a novel vGlut3-P2A-iCreER knockin mouse strain with cochlea expression.

    Characterizing a novel vGlut3-P2A-iCreER knockin mouse strain in cochlea.
    Li C, Shu Y, Wang G, Zhang H, Lu Y, Li X, Li G, Song L, Liu Z.

    08/3/2019
    Five inbred mouse strains express very different levels of VGLUT3. Cocaine-induced hyperlocomotion and anxiety was highly heterogeneous and only partially correlated to VGLUT3 levels.

    Differential expression of VGLUT3 in laboratory mouse strains: Impact on drug-induced hyperlocomotion and anxiety-related behaviors.
    Sakae DY, Ramet L, Henrion A, Poirel O, Jamain S, El Mestikawy S, Daumas S.

    05/4/2019
    The abundance of dural afferent neurons expressing vglut3 in adult mice.

    Quantitative Analysis of Mouse Dural Afferent Neurons Expressing TRPM8, VGLUT3, and NF200.
    Ren L, Chang MJ, Zhang Z, Dhaka A, Guo Z, Cao YQ., Free PMC Article

    03/30/2019
    VGluT3 KO mice show innate fear without significant influence on fear memory and generalization.

    Enhanced innate fear and altered stress axis regulation in VGluT3 knockout mice.
    Balázsfi D, Fodor A, Török B, Ferenczi S, Kovács KJ, Haller J, Zelena D.

    12/22/2018
    VGluT3-expressing amacrine cells provide selective glycinergic input to a retinal ganglion cell type suppressed by contrast and motion

    Target-Specific Glycinergic Transmission from VGluT3-Expressing Amacrine Cells Shapes Suppressive Contrast Responses in the Retina.
    Tien NW, Kim T, Kerschensteiner D., Free PMC Article

    09/30/2017
    Results reveal that VGLUT3 plays an important role in the development of l-DOPA-induced dyskinesia (LID), and should be considered as a potential and promising therapeutic target for prevention of LID

    Role of the atypical vesicular glutamate transporter VGLUT3 in l-DOPA-induced dyskinesia.
    Gangarossa G, Guzman M, Prado VF, Prado MA, Daumas S, El Mestikawy S, Valjent E.

    10/22/2016
    Synaptic excitation of W3 ganglion cells is diminished, and responses to object motion are suppressed in mice lacking VGluT3.

    An excitatory amacrine cell detects object motion and provides feature-selective input to ganglion cells in the mouse retina.
    Kim T, Soto F, Kerschensteiner D., Free PMC Article

    03/12/2016
    Measurements of time spent in noisy versus attenuated environments reveal noise-avoidance behavior in mice expressing VGLUT3 whereas Vglut3-/- mice showed no preference.

    A non-canonical pathway from cochlea to brain signals tissue-damaging noise.
    Flores EN, Duggan A, Madathany T, Hogan AK, Márquez FG, Kumar G, Seal RP, Edwards RH, Liberman MC, García-Añoveros J., Free PMC Article

    01/16/2016
    Transient expression of VGLUT3 by a discrete population of neurons in the dorsal horn is required for mechanical pain.

    Dorsal Horn Circuits for Persistent Mechanical Pain.
    Peirs C, Williams SP, Zhao X, Walsh CE, Gedeon JY, Cagle NE, Goldring AC, Hioki H, Liu Z, Marell PS, Seal RP., Free PMC Article

    11/21/2015
    Results showed that VGLUT3 expression has little or no effect on vesicular synergy at the immature glycinergic synapse of brainstem

    VGLUT3 does not synergize GABA/glycine release during functional refinement of an inhibitory auditory circuit.
    Case DT, Alamilla J, Gillespie DC., Free PMC Article

    08/1/2015
    The possible contribution of VGLUT3 upregulation in the cochlear degeneration is discussed.

    Vesicular glutamate transporter 3 is strongly upregulated in cochlear inner hair cells and spiral ganglion cells of developing circling mice.
    Lee Y, Kim HR, Ahn SC.

    06/27/2015
    Our data demonstrate that VGLUT3 is required for normal cholinergic signaling onto striatal fast-spiking interneurons, as well as for acetylcholine-dependent disynaptic inhibition of medium spiny neurons.

    Striatal cholinergic neurotransmission requires VGLUT3.
    Nelson AB, Bussert TG, Kreitzer AC, Seal RP., Free PMC Article

    08/23/2014
    This study demonistrated that vglut3 are present in synaptic vesicles in acetylcholinergic nerve terminals in the striatum.

    Vesicular glutamate transporter-3 in the rodent brain: vesicular colocalization with vesicular γ-aminobutyric acid transporter.
    Stensrud MJ, Chaudhry FA, Leergaard TB, Bjaalie JG, Gundersen V.

    02/22/2014
    VGLUT3 contributes to protection against neonatal hypoxic stress

    The vesicular glutamate transporter VGLUT3 contributes to protection against neonatal hypoxic stress.
    Miot S, Voituron N, Sterlin A, Vigneault E, Morel L, Matrot B, Ramanantsoa N, Amilhon B, Poirel O, Lepicard E, Mestikawy SE, Hilaire G, Gallego J., Free PMC Article

    06/22/2013
    The physiological properties and anatomical features of the VGLUT3+ amacrine cells suggest that this bistratified interneuron may play a role in disinhibitory signaling.

    Genetic targeting and physiological features of VGLUT3+ amacrine cells.
    Grimes WN, Seal RP, Oesch N, Edwards RH, Diamond JS., Free PMC Article

    01/28/2012
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