| IL-36gamma Augments Ocular Angiogenesis by Promoting the Vascular Endothelial Growth Factor-Vascular Endothelial Growth Factor Receptor Axis. | IL-36γ Augments Ocular Angiogenesis by Promoting the Vascular Endothelial Growth Factor-Vascular Endothelial Growth Factor Receptor Axis.
Cho WJ, Elbasiony E, Singh A, Mittal SK, Chauhan SK., | 11/16/2023 |
| Role of interleukin-36gamma induced by ultraviolet radiation in chronic actinic dermatitis. | Role of interleukin-36γ induced by ultraviolet radiation in chronic actinic dermatitis.
Wang L, Tu Y, Wu W, Tu Y, Yang Z, Chai Y, Yang X, He L. | 11/16/2023 |
| Interleukin-36gamma is causative for liver damage upon infection with Rift Valley fever virus in type I interferon receptor-deficient mice. | Interleukin-36γ is causative for liver damage upon infection with Rift Valley fever virus in type I interferon receptor-deficient mice.
Anzaghe M, Niles MA, Korotkova E, Dominguez M, Kronhart S, Ortega Iannazzo S, Bechmann I, Bachmann M, Mühl H, Kochs G, Waibler Z., Free PMC Article | 09/28/2023 |
| IL-36gamma is secreted through an unconventional pathway using the Gasdermin D and P2X7R membrane pores. | IL-36γ is secreted through an unconventional pathway using the Gasdermin D and P2X7R membrane pores.
Manzanares-Meza LD, Gutiérrez-Román CI, Jiménez-Pineda A, Castro-Martínez F, Patiño-López G, Rodríguez-Arellano E, Valle-Rios R, Ortíz-Navarrete VF, Medina-Contreras O., Free PMC Article | 09/24/2022 |
| Non-immune and immune functions of interleukin-36gamma suppress epithelial repair at the ocular surface. | Non-immune and immune functions of interleukin-36γ suppress epithelial repair at the ocular surface.
Shukla S, Cho WK, Elbasiony E, Singh RB, Mittal SK, Chauhan SK., Free PMC Article | 07/16/2022 |
| Increased Levels of Interleukin-36 in Obesity and Type 2 Diabetes Fuel Adipose Tissue Inflammation by Inducing Its Own Expression and Release by Adipocytes and Macrophages. | Increased Levels of Interleukin-36 in Obesity and Type 2 Diabetes Fuel Adipose Tissue Inflammation by Inducing Its Own Expression and Release by Adipocytes and Macrophages.
Frühbeck G, Gómez-Ambrosi J, Ramírez B, Mentxaka A, Rodríguez A, Becerril S, Reina G, Valentí V, Moncada R, Silva C, Catalán V., Free PMC Article | 04/16/2022 |
| Interleukin-36gamma aggravates macrophage foam cell formation and atherosclerosis progression in ApoE knockout mice. | Interleukin-36γ aggravates macrophage foam cell formation and atherosclerosis progression in ApoE knockout mice.
Zhang M, Liu J, Gao R, Hu Y, Lu L, Liu C, Ai L, Pan J, Tian L, Fan J. | 02/19/2022 |
| Thrombospondin-1 Restricts Interleukin-36gamma-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection. | Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection.
Peñaloza HF, Olonisakin TF, Bain WG, Qu Y, van der Geest R, Zupetic J, Hulver M, Xiong Z, Newstead MW, Zou C, Alder JK, Ybe JA, Standiford TJ, Lee JS., Free PMC Article | 10/2/2021 |
| IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice. | IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice.
Koss CK, Wohnhaas CT, Baker JR, Tilp C, Przibilla M, Lerner C, Frey S, Keck M, Williams CMM, Peter D, Ramanujam M, Fine J, Gantner F, Thomas M, Barnes PJ, Donnelly LE, El Kasmi KC., Free PMC Article | 08/14/2021 |
| IL-36gamma drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes. | IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes.
Satoh TK, Mellett M, Meier-Schiesser B, Fenini G, Otsuka A, Beer HD, Rordorf T, Maul JT, Hafner J, Navarini AA, Contassot E, French LE., Free PMC Article | 11/21/2020 |
| IL-36gamma plays a key role in recruiting mature neutrophils to the vaginal microenvironment after HSV-2 infection and that IL-36gamma may function in a manner that protects against neuroinvasion and HSV-2 disease pathogenesis. | IL-36γ Is a Key Regulator of Neutrophil Infiltration in the Vaginal Microenvironment and Limits Neuroinvasion in Genital HSV-2 Infection.
Gardner JK, Swaims-Kohlmeier A, Herbst-Kralovetz MM., Free PMC Article | 06/6/2020 |
| data indicate that IL-36gamma may participate as a key player in host defense mechanisms against invading pathogens in the female reproductive tract. | IL-36γ induces a transient HSV-2 resistant environment that protects against genital disease and pathogenesis.
Gardner JK, Herbst-Kralovetz MM., Free PMC Article | 11/9/2019 |
| While Legionella pneumophila-induced mortality in IL-36alpha- or IL-36gamma-deficient mice was not different from that in wild-type animals, antibody-mediated neutralization of IL-36gamma in IL-36alpha(-/-) mice resulted in mortality similar to that observed in IL-36R(-/-) mice, indicating redundant and overlapping roles for these cytokines in experimental murine Legionella pneumophila pneumonia. | Overlapping Roles for Interleukin-36 Cytokines in Protective Host Defense against Murine Legionella pneumophila Pneumonia.
Nanjo Y, Newstead MW, Aoyagi T, Zeng X, Takahashi K, Yu FS, Tateda K, Standiford TJ., Free PMC Article | 07/6/2019 |
| these data identify a critical role for IL-36gamma in immunity against influenza virus | IL-36γ Protects against Severe Influenza Infection by Promoting Lung Alveolar Macrophage Survival and Limiting Viral Replication.
Wein AN, Dunbar PR, McMaster SR, Li ZT, Denning TL, Kohlmeier JE., Free PMC Article | 07/6/2019 |
| results uncover an important role for IkappaBzeta in IL-36 signaling and validate IkappaBzeta as an attractive target for psoriasis therapy. | IκBζ is a key transcriptional regulator of IL-36-driven psoriasis-related gene expression in keratinocytes.
Müller A, Hennig A, Lorscheid S, Grondona P, Schulze-Osthoff K, Hailfinger S, Kramer D., Free PMC Article | 10/20/2018 |
| This study defines a critical IL-36/IL-23/IL-22 cytokine network instrumental for antimicrobial peptide production and host defense in intestinal mucosa damage using a mouse inflammatory bowel disease model. | A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage.
Ngo VL, Abo H, Maxim E, Harusato A, Geem D, Medina-Contreras O, Merlin D, Gewirtz AT, Nusrat A, Denning TL., Free PMC Article | 09/8/2018 |
| these findings reveal a fundamental contribution for the IL-36/IL-36R axis in regulating the Treg-Th9 cell balance with broad implications for Th cell-mediated disorders, such as inflammatory bowel diseases and particularly ulcerative colitis | IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors.
Harusato A, Abo H, Ngo VL, Yi SW, Mitsutake K, Osuka S, Kohlmeier JE, Li JD, Gewirtz AT, Nusrat A, Denning TL., Free PMC Article | 06/2/2018 |
| skin injury increases IL-36gamma via the activation of TLR3-SLUG-VDR axis and IL-36gamma induces REG3A to promote wound healing | IL-36γ Induced by the TLR3-SLUG-VDR Axis Promotes Wound Healing via REG3A.
Jiang Z, Liu Y, Li C, Chang L, Wang W, Wang Z, Gao X, Ryffel B, Wu Y, Lai Y. | 12/9/2017 |
| IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin | IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.
Foster AM, Baliwag J, Chen CS, Guzman AM, Stoll SW, Gudjonsson JE, Ward NL, Johnston A., Free PMC Article | 08/23/2014 |
| Data presented herein shed further light on involvement of T-bet in innate immunity and suggest that IL-36gamma, besides IFNgamma, may contribute to functions of this transcription factor in immunopathology. | IL-36γ/IL-1F9, an innate T-bet target in myeloid cells.
Bachmann M, Scheiermann P, Härdle L, Pfeilschifter J, Mühl H., Free PMC Article | 02/16/2013 |
| Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity | Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity.
Towne JE, Renshaw BR, Douangpanya J, Lipsky BP, Shen M, Gabel CA, Sims JE., Free PMC Article | 02/25/2012 |
| A critical role of IL-36R ligands in the interface between innate and adaptive immunity, leading to the stimulation of T helper responses. | IL-36R ligands are potent regulators of dendritic and T cells.
Vigne S, Palmer G, Lamacchia C, Martin P, Talabot-Ayer D, Rodriguez E, Ronchi F, Sallusto F, Dinh H, Sims JE, Gabay C. | 01/28/2012 |