| Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs. | Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs.
Nakanishi Y, Izumi M, Matsushita H, Koyama Y, Diez D, Takamatsu H, Koyama S, Nishide M, Naito M, Mizuno Y, Yamaguchi Y, Mae T, Noda Y, Nakaya K, Nojima S, Sugihara F, Okuzaki D, Ikawa M, Shimada S, Kang S, Kumanogoh A. | 10/25/2024 |
| Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer. | Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer.
Hirai T, Naito Y, Koyama S, Nakanishi Y, Masuhiro K, Izumi M, Kuge T, Naito M, Mizuno Y, Yamaguchi Y, Kang S, Yaga M, Futami Y, Nojima S, Nishide M, Morita T, Kato Y, Tsuda T, Takemoto N, Kinugasa-Katayama Y, Aoshi T, Villa JK, Yamashita K, Enokida T, Hoshi Y, Matsuura K, Tahara M, Takamatsu H, Takeda Y, Inohara H, Kumanogoh A., Free PMC Article | 02/14/2024 |
| Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons. | Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons.
Prieur DS, Francius C, Gaspar P, Mason CA, Rebsam A., Free PMC Article | 08/11/2023 |
| Semaphorin 6D regulate corralling, hematoma compaction and white matter injury in mice after intracerebral hemorrhage. | Semaphorin 6D regulate corralling, hematoma compaction and white matter injury in mice after intracerebral hemorrhage.
Sun T, Zeng H, Fan L, Fei J, Chen G. | 10/29/2022 |
| Embryonic heart deletion of Sema6D significantly impaired the cardiac contraction of male adult hearts, while having a minor effect on female mutant hearts, suggesting that the effect of Sema6D-deletion in adult hearts is sex dependent. | SEMA6D regulates perinatal cardiomyocyte proliferation and maturation in mice.
Sun Q, Peng Y, Zhao Q, Yan S, Liu S, Yang Q, Liu K, Rokosh DG, Jiao K., Free PMC Article | 02/15/2020 |
| these findings highlight crucial roles for Sema6D reverse signaling in macrophage polarization, coupling immunity, and metabolism via PPARgamma. | Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization.
Kang S, Nakanishi Y, Kioi Y, Okuzaki D, Kimura T, Takamatsu H, Koyama S, Nojima S, Nishide M, Hayama Y, Kinehara Y, Kato Y, Nakatani T, Shimogori T, Takagi J, Toyofuku T, Kumanogoh A. | 04/27/2019 |
| Shear stress-regulated miR-27b promotes the interaction of endothelial cells with pericytes, partly by repressing SEMA6A and SEMA6D. | Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D.
Demolli S, Doddaballapur A, Devraj K, Stark K, Manavski Y, Eckart A, Zehendner CM, Lucas T, Korff T, Hecker M, Massberg S, Liebner S, Kaluza D, Boon RA, Dimmeler S. | 03/3/2018 |
| BMP-SEMA6D-Rho axis plays a key role in the initial stages of AV cushion mesenchyme formation. | Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice.
Peng Y, Song L, Li D, Kesterson R, Wang J, Wang L, Rokosh G, Wu B, Wang Q, Jiao K., Free PMC Article | 01/20/2018 |
| Class 6 transmembrane semaphorins are unlikely to serve as major PlexA receptor ligands for the assembly of murine retinal circuit laminar organization. | Sema6B, Sema6C, and Sema6D expression and function during mammalian retinal development.
Matsuoka RL, Sun LO, Katayama K, Yoshida Y, Kolodkin AL., Free PMC Article | 11/30/2013 |
| These findings suggest a mechanism by which a complex of Sema6D, Nr-CAM, and Plexin-A1 at the chiasm midline alters the sign of Sema6D and signals Nr-CAM/Plexin-A1 receptors on retinal ganglion cells to implement the contralateral retinal cell projection. | Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.
Kuwajima T, Yoshida Y, Takegahara N, Petros TJ, Kumanogoh A, Jessell TM, Sakurai T, Mason C., Free PMC Article | 08/4/2012 |
| A mouse null mutation of Sema6d results in ectopic placement of the shafts of proprioceptive axons and their associated oligodendrocytes in the superficial dorsal horn, disrupting its synaptic organization. | Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation.
Leslie JR, Imai F, Fukuhara K, Takegahara N, Rizvi TA, Friedel RH, Wang F, Kumanogoh A, Yoshida Y., Free PMC Article | 11/5/2011 |
| This work reveals a role for semaphorin 6D as a regulator of the late phase of primary immune responses. | Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses.
O'Connor BP, Eun SY, Ye Z, Zozulya AL, Lich JD, Moore CB, Iocca HA, Roney KE, Holl EK, Wu QP, van Deventer HW, Fabry Z, Ting JP., Free PMC Article | 01/21/2010 |
| Sema6D coordinates both compact-layer expansion and trabeculation, functioning as both a ligand and a receptor for Plexin-A1. | Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling.
Toyofuku T, Zhang H, Kumanogoh A, Takegahara N, Yabuki M, Harada K, Hori M, Kikutani H. | 01/21/2010 |
| Plexin-S1, with Sema6D, exerts distinct biological activities at adjacent regions, crucial for complex cardiac morphogenesis. | Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2.
Toyofuku T, Zhang H, Kumanogoh A, Takegahara N, Suto F, Kamei J, Aoki K, Yabuki M, Hori M, Fujisawa H, Kikutani H., Free PMC Article | 01/21/2010 |