| Abeta-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation. | Aβ-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation.
Kim DK, Jeong H, Bae J, Cha MY, Kang M, Shin D, Ha S, Hyeon SJ, Kim H, Suh K, Choi MS, Ryu H, Yu SW, Kim JI, Kim YS, Lee SW, Hwang D, Mook-Jung I., Free PMC Article | 10/15/2022 |
| KDM5A mutations identified in autism spectrum disorder using forward genetics. | KDM5A mutations identified in autism spectrum disorder using forward genetics.
El Hayek L, Tuncay IO, Nijem N, Russell J, Ludwig S, Kaur K, Li X, Anderton P, Tang M, Gerard A, Heinze A, Zacher P, Alsaif HS, Rad A, Hassanpour K, Abbaszadegan MR, Washington C, DuPont BR, Louie RJ, CAUSES Study, Couse M, Faden M, Rogers RC, Abou Jamra R, Elias ER, Maroofian R, Houlden H, Lehman A, Beutler B, Chahrour MH., Free PMC Article | 04/3/2021 |
| C/EBPbeta knockdown impaired the recruitment of KDM5A to the Wnt6 promoter | Histone demethylase KDM5A is transactivated by the transcription factor C/EBPβ and promotes preadipocyte differentiation by inhibiting Wnt/β-catenin signaling.
Guo L, Guo YY, Li BY, Peng WQ, Tang QQ., Free PMC Article | 02/29/2020 |
| Our results uncover a regulatory mechanism in which HDAC1 negatively regulates RBPJ binding on mitotic chromatin in a KDM5A-dependent manner. We propose that relative chromatin affinity of a minimal regulatory complex, reflecting a specific transcription program, renders selective RBPJ binding on mitotic chromatin. | HDAC1 negatively regulates selective mitotic chromatin binding of the Notch effector RBPJ in a KDM5A-dependent manner.
Dreval K, Lake RJ, Fan HY., Free PMC Article | 11/23/2019 |
| Conditional, systemic ablation of RBP2 in pituitary or thyroid tumor-bearing Rb1(+/-) mice is sufficient to slow tumor growth and significantly extend survival without causing obvious toxicity to the host. These findings show that established Rb1-null tumors require RBP2 for growth. | Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.
McBrayer SK, Olenchock BA, DiNatale GJ, Shi DD, Khanal J, Jennings RB, Novak JS, Oser MG, Robbins AK, Modiste R, Bonal D, Moslehi J, Bronson RT, Neuberg D, Nguyen QD, Signoretti S, Losman JA, Kaelin WG Jr., Free PMC Article | 09/1/2018 |
| KDM5A-mediated H3K4me3 modification participated in the etiology of osteoporosis and may provide new strategies to improve the clinical efficacy of BMP2 in osteoporotic conditions. | KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis.
Wang C, Wang J, Li J, Hu G, Shan S, Li Q, Zhang X., Free PMC Article | 10/14/2017 |
| Kdm5a associates with p50 and binds to the Socs1 promoter region in resting natural killer cells. | H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1.
Zhao D, Zhang Q, Liu Y, Li X, Zhao K, Ding Y, Li Z, Shen Q, Wang C, Li N, Cao X. | 12/31/2016 |
| Data show that NP23 and NJL belong to a subset of chromatin-modifying fusion oncoproteins causing leukemia. | NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function.
Gough SM, Lee F, Yang F, Walker RL, Zhu YJ, Pineda M, Onozawa M, Chung YJ, Bilke S, Wagner EK, Denu JM, Ning Y, Xu B, Wang GG, Meltzer PS, Aplan PD., Free PMC Article | 12/19/2015 |
| Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A. | Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A.
Chaturvedi CP, Somasundaram B, Singh K, Carpenedo RL, Stanford WL, Dilworth FJ, Brand M., Free PMC Article | 02/2/2013 |
| In terminally differentiated cells, common KDM5A and E2F4 gene targets were bound by the pRB-related protein p130, a DREAM complex component. | Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation.
Beshiri ML, Holmes KB, Richter WF, Hess S, Islam AB, Yan Q, Plante L, Litovchick L, Gévry N, Lopez-Bigas N, Kaelin WG Jr, Benevolenskaya EV., Free PMC Article | 01/26/2013 |
| Study reports that RBP2 is a demethylase that specifically catalyzes demethylation on histone H3 lysine 4, whose methylation is normally associated with transcriptionally active genes. | The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG Jr. | 10/24/2011 |
| JARID1a formed a complex with CLOCK-BMAL1 which was recruited to Per2 promoter;it increased histone acetylation by inhibiting histone deacetylase 1 function and enhanced transcription by CLOCK-BMAL1; JARID1a depletion shortened period of circadian rhythms | Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.
DiTacchio L, Le HD, Vollmers C, Hatori M, Witcher M, Secombe J, Panda S., Free PMC Article | 10/22/2011 |
| KDM5A interacts physically with RBP-J | Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex.
Liefke R, Oswald F, Alvarado C, Ferres-Marco D, Mittler G, Rodriguez P, Dominguez M, Borggrefe T., Free PMC Article | 03/29/2010 |
| A functional interplay between the PRC2 complex and the H3K4me3 demethylase Rbp2 (Jarid1a) in mouse embryonic stem (ES) cells. | Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.
Pasini D, Hansen KH, Christensen J, Agger K, Cloos PA, Helin K., Free PMC Article | 01/21/2010 |
| mutation can downregulate cardiac cell proliferation by repressing cyclin D1 expression in the same way as jumonji | Modifiers of the jumonji mutation downregulate cyclin D1 expression and cardiac cell proliferation.
Ohno T, Nakajima K, Kojima M, Toyoda M, Takeuchi T. | 01/21/2010 |