| Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation. | Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation.
Shao F, Phan AV, Yu W, Guo Y, Thompson J, Coppinger C, Venugopalan SR, Amendt BA, Van Otterloo E, Cao H., Free PMC Article | 09/13/2024 |
| Crucial role of TFAP2B in the nervous system for regulating NREM sleep. | Crucial role of TFAP2B in the nervous system for regulating NREM sleep.
Nakai A, Kashiwagi M, Fujiyama T, Iwasaki K, Hirano A, Funato H, Yanagisawa M, Sakurai T, Hayashi Y., Free PMC Article | 02/29/2024 |
| TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway. | TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway.
Nguyen TT, Mitchell JM, Kiel MD, Kenny CP, Li H, Jones KL, Cornell RA, Williams TJ, Nichols JT, Van Otterloo E., Free PMC Article | 01/4/2024 |
| Tfap2b acts in GABAergic neurons to control sleep in mice. | Tfap2b acts in GABAergic neurons to control sleep in mice.
Hu Y, Bringmann H., Free PMC Article | 06/7/2023 |
| Deletion of transcription factor AP-2beta from the developing murine trabecular meshwork region leads to progressive glaucomatous changes. | Deletion of transcription factor AP-2β from the developing murine trabecular meshwork region leads to progressive glaucomatous changes.
Taiyab A, Akula M, Dham J, Deschamps P, Sheardown H, Williams T, Borrás T, West-Mays JA., Free PMC Article | 04/9/2022 |
| Conditional Deletion of AP-2beta in the Periocular Mesenchyme of Mice Alters Corneal Epithelial Cell Fate and Stratification. | Conditional Deletion of AP-2β in the Periocular Mesenchyme of Mice Alters Corneal Epithelial Cell Fate and Stratification.
Walker H, Taiyab A, Deschamps P, Williams T, West-Mays JA., Free PMC Article | 09/25/2021 |
| Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control. | Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control.
Hu Y, Korovaichuk A, Astiz M, Schroeder H, Islam R, Barrenetxea J, Fischer A, Oster H, Bringmann H., Free PMC Article | 07/17/2021 |
| Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2beta. | Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β.
Nakai A, Fujiyama T, Nagata N, Kashiwagi M, Ikkyu A, Takagi M, Tatsuzawa C, Tanaka K, Kakizaki M, Kanuka M, Kawano T, Mizuno S, Sugiyama F, Takahashi S, Funato H, Sakurai T, Yanagisawa M, Hayashi Y., Free PMC Article | 07/17/2021 |
| Anomalous incisor morphology indicates tissue-specific roles for Tfap2a and Tfap2b in tooth development. | Anomalous incisor morphology indicates tissue-specific roles for Tfap2a and Tfap2b in tooth development.
Woodruff ED, Gutierrez GC, Van Otterloo E, Williams T, Cohn MJ., Free PMC Article | 06/26/2021 |
| In an ongoing expression screen, this study identified that Tfap2b, Casq2, Penk, Zic1, and Zic3 are expressed in unique cell types in and around the developing eye. | Localization of Tfap2β, Casq2, Penk, Zic1, and Zic3 Expression in the Developing Retina, Muscle, and Sclera of the Embryonic Mouse Eye.
Wan Y, White C, Robert N, Rogers MB, Szabo-Rogers HL., Free PMC Article | 06/27/2020 |
| Using the Tfap2b c.435_438delCCGG homozygous mice, study verified the nature of the human c.435_438delCCGG mutation and established a new and useful animal model to explore the function of Tfap2b and the mechanisms of patent ductus arteriosus and renal formation. | Tfap2b mutation in mice results in patent ductus arteriosus and renal malformation.
Wang J, Ji W, Zhu D, Wang W, Chen Y, Zhang Z, Li F. | 03/16/2019 |
| these findings reveal that the AP-2 genes have a major function in mammalian neural crest development, influencing patterning of the craniofacial skeleton | AP-2α and AP-2β cooperatively orchestrate homeobox gene expression during branchial arch patterning.
Van Otterloo E, Li H, Jones KL, Williams T., Free PMC Article | 03/31/2018 |
| AP-2beta is required in the periocular mesenchyme for normal development of the anterior segment of the eye. | Conditional deletion of AP-2β in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma.
Martino VB, Sabljic T, Deschamps P, Green RM, Akula M, Peacock E, Ball A, Williams T, West-Mays JA., Free PMC Article | 12/9/2017 |
| Study systematically examined the expression profile of AP-2 family in the developing mouse and chick spinal cord and found that AP-2alpha and AP-2beta are specifically expressed in post-mitotic dorsal interneurons. Subsequent functional assessment in chick embryos demonstrated that AP-2alpha and AP-2beta have distinct functions in dorsal interneuron specification and differentiation. | AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord.
Xu X, Liu Z, Huang H, Zheng K, Hu X, Zhang Z, Qiu M. | 11/11/2017 |
| AP-2 beta and beta-catenin interact both in vitro through GST pull-down assays and in vivo by co-immunoprecipitation. We further identified the interaction regions to the DNA-binding domain of AP-2 beta and the 1-9 Armadillo repeats of beta-catenin. | Transcription factor AP-2β suppresses cervical cancer cell proliferation by promoting the degradation of its interaction partner β-catenin.
Wang F, Huang W, Hu X, Chen C, Li X, Qiu J, Liang Z, Zhang J, Li L, Wang X, Ding X, Xiang S, Zhang J. | 09/30/2017 |
| the Tfap2a and Tfap2b transcription factors were identified as two major downstream effectors of Ptf1a. | Tfap2a and 2b act downstream of Ptf1a to promote amacrine cell differentiation during retinogenesis.
Jin K, Jiang H, Xiao D, Zou M, Zhu J, Xiang M., Free PMC Article | 01/23/2016 |
| critical roles for AP-2 activity in retinogenesis, delineating the overlapping expression patterns of Tcfap2a, Tcfap2b, and Tcfap2c in the neural retina, and revealing a redundant requirement for Tcfap2a and Tcfap2b in horizontal and amacrine cell development | Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina.
Bassett EA, Korol A, Deschamps PA, Buettner R, Wallace VA, Williams T, West-Mays JA., Free PMC Article | 04/27/2013 |
| Tfap2b is associated with the development and remodeling of mouse ductus arteriosus and limb patterning. | A heart-hand syndrome gene: Tfap2b plays a critical role in the development and remodeling of mouse ductus arteriosus and limb patterning.
Zhao F, Bosserhoff AK, Buettner R, Moser M., Free PMC Article | 12/10/2011 |
| PKD is thus a common modulator of the DNA binding activity of AP-2alpha and AP-2beta through their phosphorylation for negative regulation of the ABCA1 and adiponectin genes expression, respectively. | Protein kinase D regulates the adiponectin gene expression through phosphorylation of AP-2: a common pathway to the ABCA1 gene regulation.
Iwamoto N, Yokoyama S. | 08/27/2011 |
| postprandial activation of PKCmicro plays a role in disordered postprandial adipocytokine expression through AP-2beta. | Postprandial activation of protein kinase Cµ regulates the expression of adipocytokines via the transcription factor AP-2β.
Kondo M, Ugi S, Morino K, Fuke T, Obata T, Yoshizaki T, Nishio Y, Maeda S, Kashiwagi A, Maegawa H. | 08/20/2011 |
| Whereas AP-2alpha/beta transcription factors are in vivo not required for the onset or maintenance of noradrenergic differentiation, their essential survival functions are demonstrated for sympathetic progenitors and noradrenergic neurons. | The transcription factors AP-2β and AP-2α are required for survival of sympathetic progenitors and differentiated sympathetic neurons.
Schmidt M, Huber L, Majdazari A, Schütz G, Williams T, Rohrer H. | 08/13/2011 |
| Data suggest that AP-2beta plays critical roles in the epinephrine phenotype and maturation of adrenal chromaffin cells. | Transcription factor AP-2β regulates the neurotransmitter phenotype and maturation of chromaffin cells.
Hong SJ, Huh YH, Leung A, Choi HJ, Ding Y, Kang UJ, Yoo SH, Buettner R, Kim KS., Free PMC Article | 07/9/2011 |
| Tfap2beta, Et-1, and Hif2alpha act in a transcriptional network during ductal smooth muscle development. Disruption of this pathway may contribute to patent ductus arteriosus by affecting development of smooth muscle in the ductus arteriosus. | Transcriptional regulation during development of the ductus arteriosus.
Ivey KN, Sutcliffe D, Richardson J, Clyman RI, Garcia JA, Srivastava D., Free PMC Article | 10/28/2010 |
| AP-2beta transcriptional factor is a unique regulator of IRS-1 and a candidate gene for insulin resistance. | Transcription factor AP-2beta: a negative regulator of IRS-1 gene expression.
Meng X, Kondo M, Morino K, Fuke T, Obata T, Yoshizaki T, Ugi S, Nishio Y, Maeda S, Araki E, Kashiwagi A, Maegawa H. | 03/22/2010 |
| The results clearly show that AP-2beta directly enhanced MCP-1 secretion by binding to its promoter. Results propose that AP-2beta positively regulates MCP-1 expression. | Transcription factor activating protein-2beta: a positive regulator of monocyte chemoattractant protein-1 gene expression.
Kondo M, Maegawa H, Obata T, Ugi S, Ikeda K, Morino K, Nakai Y, Nishio Y, Maeda S, Kashiwagi A. | 01/21/2010 |