| Thromboxane A2 Modulates de novo Synthesis of Adrenal Corticosterone in Mice via p38/14-3-3gamma/StAR Signaling. | Thromboxane A(2) Modulates de novo Synthesis of Adrenal Corticosterone in Mice via p38/14-3-3γ/StAR Signaling.
Yan S, Wang Y, Wang B, Zuo S, Yu Y., Free PMC Article | 07/31/2024 |
| Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease. | Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.
Dai Y, Xu R, Chen J, Fang J, Zhang H, Li H, Chen W. | 03/12/2024 |
| Deletion of vascular thromboxane A2 receptors and its impact on angiotensin II-induced hypertension and atherosclerotic lesion formation in the aorta of Ldlr-deficient mice. | Deletion of vascular thromboxane A(2) receptors and its impact on angiotensin II-induced hypertension and atherosclerotic lesion formation in the aorta of Ldlr-deficient mice.
Braun H, Hauke M, Petermann M, Eckenstaler R, Ripperger A, Schwedhelm E, Ludwig-Kraus B, Bernhard Kraus F, Jalal Ahmed Shawon M, Dubourg V, Zernecke A, Schreier B, Gekle M, Benndorf RA. | 01/3/2024 |
| Inhibition of TP signaling promotes endometriosis growth and neovascularization. | Inhibition of TP signaling promotes endometriosis growth and neovascularization.
Furue A, Hattori K, Hosono K, Tanabe M, Sato E, Honda M, Sekiguchi K, Ito Y, Majima M, Narumiya S, Kato K, Amano H., Free PMC Article | 11/18/2023 |
| Roles of Thromboxane Receptor Signaling in Enhancement of Lipopolysaccharide-Induced Lymphangiogenesis and Lymphatic Drainage Function in Diaphragm. | Roles of Thromboxane Receptor Signaling in Enhancement of Lipopolysaccharide-Induced Lymphangiogenesis and Lymphatic Drainage Function in Diaphragm.
Matsuda H, Ito Y, Hosono K, Tsuru S, Inoue T, Nakamoto S, Kurashige C, Hirashima M, Narumiya S, Okamoto H, Majima M. | 06/5/2021 |
| Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis. | Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis.
Chueh TH, Cheng YH, Chen KH, Chien CT. | 12/12/2020 |
| PGF2alpha potentiates platelet aggregation in vitro via EP3 receptor and thromboxane A2 receptor, but not PGF2a receptor | Prostaglandin F2α Facilitates Platelet Activation by Acting on Prostaglandin E2 Receptor Subtype EP3 and Thromboxane A2 Receptor TP in Mice.
Kashiwagi H, Yuhki KI, Imamichi Y, Kojima F, Kumei S, Tasaki Y, Narumiya S, Ushikubi F. | 03/14/2020 |
| this study shows that genetic depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor signaling prevents microvascular dysfunction in ischemia reperfusion injury | Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury.
Chiang CY, Chien CY, Qiou WY, Chang C, Yu IS, Chang PY, Chien CT. | 01/12/2019 |
| The results suggest that EP3 along with TP contributes to vasoconstrictor responses evoked by PGI2, and hence imply a novel mechanism for endothelial cyclooxygenase metabolites (which consist mainly of PGI2) in regulating vascular functions. | Role of E-type prostaglandin receptor EP3 in the vasoconstrictor activity evoked by prostacyclin in thromboxane-prostanoid receptor deficient mice.
Li Z, Zhang Y, Liu B, Luo W, Li H, Zhou Y., Free PMC Article | 11/3/2018 |
| platelet GP6 and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation | GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation.
Pierre S, Linke B, Suo J, Tarighi N, Del Turco D, Thomas D, Ferreiros N, Stegner D, Frölich S, Sisignano M, Meyer Dos Santos S, deBruin N, Nüsing RM, Deller T, Nieswandt B, Geisslinger G, Scholich K. | 07/29/2017 |
| Genetic deletion of thromboxane receptor in adipose-derived stromal cells accelerated endothelial cell differentiation. | Thromboxane Governs the Differentiation of Adipose-Derived Stromal Cells Toward Endothelial Cells In Vitro and In Vivo.
Shen Y, Zuo S, Wang Y, Shi H, Yan S, Chen D, Xiao B, Zhang J, Gong Y, Shi M, Tang J, Kong D, Lu L, Yu Y, Zhou B, Duan SZ, Schneider C, Funk CD, Yu Y. | 09/17/2016 |
| PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2, possibly via increased pulmonary arterial TP receptor expression. | PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.
Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M. | 07/2/2016 |
| Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor, which partially requires the activation of P2X1R through an endothelium-dependent mechanism. | Mechanisms underlying uridine adenosine tetraphosphate-induced vascular contraction in mouse aorta: Role of thromboxane and purinergic receptors.
Zhou Z, Sun C, Tilley SL, Mustafa SJ., Free PMC Article | 07/2/2016 |
| It is an active player in the pathogenesis of Alzheimer's disease. | Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor.
Lauretti E, Di Meco A, Chu J, Praticò D. | 09/26/2015 |
| Adhesion of platelets through thromboxane A receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity. | Adhesion of platelets through thromboxane A₂ receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity.
Minamino T, Ito Y, Ohkubo H, Shimuzu Y, Kojo K, Nishizwa N, Amano H, Narumiya S, Koizumi W, Majima M. | 08/22/2015 |
| The results indicate that the beta1-subunit can form a tripartite complex with TP and MaxiKalpha, has the ability to associate with each protein independently. | The β1-subunit of the MaxiK channel associates with the thromboxane A2 receptor and reduces thromboxane A2 functional effects.
Li M, Zhang Z, Koh H, Lu R, Jiang Z, Alioua A, Garcia-Valdes J, Stefani E, Toro L., Free PMC Article | 03/30/2013 |
| Blocking the expression of the thromboxane receptor significantly suppresses the prothrombotic effect of C-reactive protein. | Role of thromboxane receptor in C-reactive protein-induced thrombosis.
Grad E, Pachino RM, FitzGerald GA, Danenberg HD. | 01/12/2013 |
| The thromboxane A(2) receptor agonist 11-deoxy PGF(2alpha) can partially alleviate embryo crowding in the Lpar3((-/-)) females and embryo crowding likely contributes to reduced litter size in the Lpar3((-/-)) females. | 11-deoxy prostaglandin F(2α), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3((-/-)) females.
Ye X, Diao H, Chun J., Free PMC Article | 04/28/2012 |
| We show here that thromboxane receptor in the striatum locally facilitates dopamine overflow. | Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake.
Mitsumori T, Furuyashiki T, Momiyama T, Nishi A, Shuto T, Hayakawa T, Ushikubi F, Kitaoka S, Aoki T, Inoue H, Matsuoka T, Narumiya S. | 12/10/2011 |
| thromboxane A2 receptor signalling does not contribute critically to the pathogenesis of ischemic acute kidney injury | Thromboxane receptor signalling in renal ischemia reperfusion injury.
Snoeijs MG, Hoogland PR, Boonen B, Coffman TM, Peutz-Kootstra CJ, Buurman WA, van Heurn LW. | 10/1/2011 |
| Thromboxane A2 receptor activation via PKC-zeta-mediated NAD(P)H oxidase activation increases superoxide and peroxynitrite, resulting in eNOS uncoupling in endothelial cells. | Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase.
Zhang M, Song P, Xu J, Zou MH., Free PMC Article | 01/22/2011 |
| Genetic variations exist in this protein in platelet function disorders. | Phenotypic approaches to gene mapping in platelet function disorders - identification of new variant of P2Y12, TxA2 and GPVI receptors.
Watson S, Daly M, Dawood B, Gissen P, Makris M, Mundell S, Wilde J, Mumford A. | 05/3/2010 |
| thromboxane synthase, prostacyclin synthase and thromboxane receptor have roles in atherosclerotic lesions and correlate with plaque composition | Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: correlation with plaque composition.
Cyrus T, Ding T, Praticò D. | 04/19/2010 |
| thromboxane receptor knockout mice showed normal pain behavior in all tests | Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.
Popp L, Häussler A, Olliges A, Nüsing R, Narumiya S, Geisslinger G, Tegeder I. | 01/21/2010 |
| COX-1 contributes to the enhanced formation of both PGI(2) and TXA(2) in atherosclerosis, and to the development of the disease | Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse.
McClelland S, Gawaz M, Kennerknecht E, Konrad CS, Sauer S, Schuerzinger K, Massberg S, Fitzgerald DJ, Belton O. | 01/21/2010 |