| Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin. | Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin.
Hitsumoto T, Tsukamoto O, Matsuoka K, Li J, Liu L, Kuramoto Y, Higo S, Ogawa S, Fujino N, Yoshida S, Kioka H, Kato H, Hakui H, Saito Y, Okamoto C, Inoue H, Hyejin J, Ueda K, Segawa T, Nishimura S, Asano Y, Asanuma H, Tani A, Imamura R, Komagawa S, Kanai T, Takamura M, Sakata Y, Kitakaze M, Haruta JI, Takashima S., Free PMC Article | 06/23/2023 |
| A temporal Ca(2+) desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKbeta/PP2A pathways. | A temporal Ca(2+) desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKβ/PP2A pathways.
Kitazawa T, Matsui T, Katsuki S, Goto A, Akagi K, Hatano N, Tokumitsu H, Takeya K, Eto M. | 09/25/2021 |
| Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not. | Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not.
Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV, Stewart M, Tinker A, Cox RD, Metherell LA., Free PMC Article | 05/29/2021 |
| Pharmacological study revealed that lamellipodia formation mediated by arp2/3 and contractility regulated by myosin light chain kinase (MLCK) were responsible for the intriguing turning behavior of T cells climbing the ramp-like structures. | Turning behaviors of T cells climbing up ramp-like structures are regulated by myosin light chain kinase activity and lamellipodia formation.
Song KH, Lee J, Jung HR, Park H, Doh J., Free PMC Article | 06/29/2019 |
| Acanthopanax senticosus polysaccharide pretreatment may be associated with inhibition of the NF-kappaB/MLCK pathway and concomitant amelioration of LPS-induced tight junction dysfunction of intestinal epithelium in endotoxemia | Acanthopanax senticosus polysaccharides-induced intestinal tight junction injury alleviation via inhibition of NF-κB/MLCK pathway in a mouse endotoxemia model.
Han J, Li JH, Bai G, Shen GS, Chen J, Liu JN, Wang S, Liu XJ., Free PMC Article | 12/2/2017 |
| that MLCK is competing with centrally active ROCK for a limiting pool of monomer with which to drive lamellar filament assembly | Actin dynamics and competition for myosin monomer govern the sequential amplification of myosin filaments.
Beach JR, Bruun KS, Shao L, Li D, Swider Z, Remmert K, Zhang Y, Conti MA, Adelstein RS, Rusan NM, Betzig E, Hammer JA., Free PMC Article | 07/15/2017 |
| This study demonstrated that catchlike property during dynamic performance in mouse hindlimb muscles with (wild-type) and without MLCK(-/-) ) the primary mechanism for PTP (myosin phosphorylation). | Interaction of posttetanic potentiation and the catchlike property in mouse skeletal muscle.
Gittings W, Bunda J, Stull JT, Vandenboom R. | 07/1/2017 |
| Ablation of cardiac Mylk3 suggests that Mylk3 plays a pivotal role in the transition from compensated to decompensated hypertrophy via cardiac myocyte atrophy and sarcomeric disorganization. | Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.
Massengill MT, Ashraf HM, Chowdhury RR, Chrzanowski SM, Kar J, Warren SA, Walter GA, Zeng H, Kang BH, Anderson RH, Moss RL, Kasahara H., Free PMC Article | 02/18/2017 |
| Data suggest that galectin-3 in hepatocellular carcinoma cells promotes cell migration by inducing RhoA GTPase activity, activating Mlck, up-regulating phosphorylation of MLC2 (myosin light chain 2), and inducing actin rearrangement. | Galectin 3 regulates HCC cell invasion by RhoA and MLCK activation.
Serizawa N, Tian J, Fukada H, Baghy K, Scott F, Chen X, Kiss Z, Olson K, Hsu D, Liu FT, Török NJ, Zhao B, Jiang JX., Free PMC Article | 01/16/2016 |
| epithelial MLCK-activated brush border fanning by IFN-gamma promotes adherence and internalization of normally noninvasive enteric bacteria | Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-γ.
Wu LL, Peng WH, Kuo WT, Huang CY, Ni YH, Lu KS, Turner JR, Yu LC., Free PMC Article | 04/4/2015 |
| MLCK may regulate the structure and the motility of stereocilia through F-actin polymerization. | Myosin light chain kinase regulates hearing in mice by influencing the F-actin cytoskeleton of outer hair cells and cochleae.
Yang X, Wang JG, Ma DB, Ma XF, Zhu GJ, Zhou H, Yu CJ, Qian XY, Gao X. | 10/25/2014 |
| Silencing TNFR2, but not TNFR1, resulted in restoration of epithelial tight junction (TJ) associated with decreased MLCK expression. | Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis.
Suzuki M, Nagaishi T, Yamazaki M, Onizawa M, Watabe T, Sakamaki Y, Ichinose S, Totsuka M, Oshima S, Okamoto R, Shimonaka M, Yagita H, Nakamura T, Watanabe M., Free PMC Article | 10/18/2014 |
| Calcium regulation of MLCK facilitates GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. | Regulation of myosin light chain kinase during insulin-stimulated glucose uptake in 3T3-L1 adipocytes.
Woody S, Stall R, Ramos J, Patel YM., Free PMC Article | 06/21/2014 |
| nmMLCK has a critical role in thrombin-induced endothelial cell inflammation and lung PMN infiltration | Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration.
Fazal F, Bijli KM, Murrill M, Leonard A, Minhajuddin M, Anwar KN, Finkelstein JN, Watterson DM, Rahman A., Free PMC Article | 01/11/2014 |
| these studies show that the IL-1beta-induced increase in intestinal tight junction permeability was regulated by p38 kinase activation of ATF-2 and by ATF-2 regulation of MLCK gene activity | Mechanism of IL-1β modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation.
Al-Sadi R, Guo S, Ye D, Dokladny K, Alhmoud T, Ereifej L, Said HM, Ma TY., Free PMC Article | 08/31/2013 |
| analysis of differential contributions of MLCK to signaling in smooth muscles | Signaling through myosin light chain kinase in smooth muscles.
Gao N, Huang J, He W, Zhu M, Kamm KE, Stull JT., Free PMC Article | 05/18/2013 |
| MLCK-dependent MLC phosphorylation mediates intestinal epithelial barrier dysfunction after severe burn injury. | Myosin light chain kinase mediates intestinal barrier disruption following burn injury.
Chen C, Wang P, Su Q, Wang S, Wang F., Free PMC Article | 11/24/2012 |
| Nonmuscle myosin light-chain kinase contributes to atherosclerosis by regulating endothelial barrier function and monocyte migration via mechanisms involving not only kinase-mediated MLC phosphorylation but also Src activation. | Nonmuscle myosin light-chain kinase deficiency attenuates atherosclerosis in apolipoprotein E-deficient mice via reduced endothelial barrier dysfunction and monocyte migration.
Sun C, Wu MH, Yuan SY., Free PMC Article | 10/8/2011 |
| guanylyl cyclase C signaling plays a protective role in the integrity of the intestinal mucosal barrier by regulating myosin light chain kinase activation and tight junction disassembly. | Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier.
Han X, Mann E, Gilbert S, Guan Y, Steinbrecher KA, Montrose MH, Cohen MB., Free PMC Article | 08/6/2011 |
| cMLCK appears to be the predominant protein kinase that maintains basal RLC phosphorylation that is required for normal physiological cardiac performance in vivo | Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo.
Ding P, Huang J, Battiprolu PK, Hill JA, Kamm KE, Stull JT., Free PMC Article | 01/29/2011 |
| MLCK is involved in the activation process of nonselective cationic currents by muscarinic stimulation in murine ileal myocytes | Role of calmodulin and myosin light chain kinase in the activation of carbachol-activated cationic current in murine ileal myocytes.
Kim BJ, Jeon JH, Kim SJ, So I. | 01/21/2010 |
| characterization of cardiac MKLCK; both overexpression and knockdown of cardiac MLCK in cultured cardiomyocytes revealed that cardiac MLCK is likely a new regulator of MLC2 phosphorylation, sarcomere organization, and cardiomyocyte contraction | Identification of cardiac-specific myosin light chain kinase.
Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H., Free PMC Article | 01/21/2010 |
| MLCK is involved in egg polarity because inhibitors prevent sperm chromatin-induced cortical reorganization. | Role of MAP kinase and myosin light chain kinase in chromosome-induced development of mouse egg polarity.
Deng M, Williams CJ, Schultz RM. | 01/21/2010 |
| Inhibiting MLCK increases the number of apoptotic cells and retards the growth of mammary cancer cells in mice. | Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo.
Fazal F, Gu L, Ihnatovych I, Han Y, Hu W, Antic N, Carreira F, Blomquist JF, Hope TJ, Ucker DS, de Lanerolle P., Free PMC Article | 01/21/2010 |
| Ubiquitously expressed smooth muscle MLCK activity in MLCK null mice may be sufficient, but is not necessary for cytokinesis and early morphogenesis; other Ca2+-dependent kinases can phosphorylate myosin light-chain (20) and induce contraction in embryos. | Myosin light chain kinase knockout.
Somlyo AV, Wang H, Choudhury N, Khromov AS, Majesky M, Owens GK, Somlyo AP. | 01/21/2010 |