| Natural variation in the zinc-finger-encoding exon of Prdm9 affects hybrid sterility phenotypes in mice. | Natural variation in the zinc-finger-encoding exon of Prdm9 affects hybrid sterility phenotypes in mice.
AbuAlia KFN, Damm E, Ullrich KK, Mukaj A, Parvanov E, Forejt J, Odenthal-Hesse L., Free PMC Article | 03/11/2024 |
| Genic and chromosomal components of Prdm9-driven hybrid male sterility in mice (Mus musculus). | Genic and chromosomal components of Prdm9-driven hybrid male sterility in mice (Mus musculus).
Valiskova B, Gregorova S, Lustyk D, Šimeček P, Jansa P, Forejt J., Free PMC Article | 09/24/2022 |
| Altering the Binding Properties of PRDM9 Partially Restores Fertility across the Species Boundary. | Altering the Binding Properties of PRDM9 Partially Restores Fertility across the Species Boundary.
Davies B, Gupta Hinch A, Cebrian-Serrano A, Alghadban S, Becker PW, Biggs D, Hernandez-Pliego P, Preece C, Moralli D, Zhang G, Myers S, Donnelly P., Free PMC Article | 04/2/2022 |
| Differential effects of two catalytic mutations on full-length PRDM9 and its isolated PR/SET domain reveal a case of pseudomodularity. | Differential effects of two catalytic mutations on full-length PRDM9 and its isolated PR/SET domain reveal a case of pseudomodularity.
Powers NR, Billings T, Paigen K, Petkov PM., Free PMC Article | 02/19/2022 |
| PRDM9-directed recombination hotspots depleted near meiotically transcribed genes. | PRDM9-directed recombination hotspots depleted near meiotically transcribed genes.
Schwarzkopf EJ, Cornejo OE. | 02/12/2022 |
| EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8. | EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8.
Tian H, Billings T, Petkov PM., Free PMC Article | 08/14/2021 |
| Meiotic epigenetic factor PRDM9 impacts sperm quality of hybrid mice. | Meiotic epigenetic factor PRDM9 impacts sperm quality of hybrid mice.
Kusari F, Mihola O, Schimenti JC, Trachtulec Z. | 06/19/2021 |
| Refined spatial temporal epigenomic profiling reveals intrinsic connection between PRDM9-mediated H3K4me3 and the fate of double-stranded breaks. | Refined spatial temporal epigenomic profiling reveals intrinsic connection between PRDM9-mediated H3K4me3 and the fate of double-stranded breaks.
Chen Y, Lyu R, Rong B, Zheng Y, Lin Z, Dai R, Zhang X, Xie N, Wang S, Tang F, Lan F, Tong MH., Free PMC Article | 05/29/2021 |
| PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment. | PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment.
Imai Y, Biot M, Clément JA, Teragaki M, Urbach S, Robert T, Baudat F, Grey C, de Massy B., Free PMC Article | 05/15/2021 |
| Prdm9 Intersubspecific Interactions in Hybrid Male Sterility of House Mouse. | Prdm9 Intersubspecific Interactions in Hybrid Male Sterility of House Mouse.
Mukaj A, Piálek J, Fotopulosova V, Morgan AP, Odenthal-Hesse L, Parvanov ED, Forejt J., Free PMC Article | 05/15/2021 |
| The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair. | The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair.
Huang T, Yuan S, Gao L, Li M, Yu X, Zhan J, Yin Y, Liu C, Zhang C, Lu G, Li W, Liu J, Chen ZJ, Liu H., Free PMC Article | 03/20/2021 |
| ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair. | ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.
Wells D, Bitoun E, Moralli D, Zhang G, Hinch A, Jankowska J, Donnelly P, Green C, Myers SR., Free PMC Article | 02/27/2021 |
| ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis. | ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis.
Paiano J, Wu W, Yamada S, Sciascia N, Callen E, Paola Cotrim A, Deshpande RA, Maman Y, Day A, Paull TT, Nussenzweig A., Free PMC Article | 04/25/2020 |
| hot spot activation in which HELLS and PRDM9 form a pioneer complex to create a unique epigenomic environment of open chromatin, permitting correct placement and repair of DSBs | HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots.
Spruce C, Dlamini S, Ananda G, Bronkema N, Tian H, Paigen K, Carter GW, Baker CL., Free PMC Article | 04/25/2020 |
| STAG3 deficiency has a major effect on DNA double-strand breaks number even in the absence of PRDM9, showing that its role is not restricted to canonical PRDM9-activated hotspots. | Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes.
Bhattacharyya T, Walker M, Powers NR, Brunton C, Fine AD, Petkov PM, Handel MA., Free PMC Article | 04/11/2020 |
| Despite the rapid evolution of PRDM9 and the variability detected in natural populations, functional constraints could facilitate the accumulation of allelic combinations that maintain recombination hotspot symmetry. | PRDM9 Diversity at Fine Geographical Scale Reveals Contrasting Evolutionary Patterns and Functional Constraints in Natural Populations of House Mice.
Vara C, Capilla L, Ferretti L, Ledda A, Sánchez-Guillén RA, Gabriel SI, Albert-Lizandra G, Florit-Sabater B, Bello-Rodríguez J, Ventura J, Searle JB, Mathias ML, Ruiz-Herrera A., Free PMC Article | 02/8/2020 |
| Study demonstrates that PRDM9 forms a trimer as a free soluble protein, as well as, when complexed to the DNA. This trimerization is likely mediated by ZnF interactions within the long ZnF domain, and unexpectedly the trimer binds to only one specific DNA target molecule at a time. | PRDM9 forms a trimer by interactions within the zinc finger array.
Schwarz T, Striedner Y, Horner A, Haase K, Kemptner J, Zeppezauer N, Hermann P, Tiemann-Boege I., Free PMC Article | 01/18/2020 |
| the role of Prdm9 in fertility; male mice with multiple genetic backgrounds are fertile despite lacking a functional PRDM9 protein | Histone methyltransferase PRDM9 is not essential for meiosis in male mice.
Mihola O, Pratto F, Brick K, Linhartova E, Kobets T, Flachs P, Baker CL, Sedlacek R, Paigen K, Petkov PM, Camerini-Otero RD, Trachtulec Z., Free PMC Article | 01/11/2020 |
| Within species, Prdm9 determines the sites of programmed DNA double-strand breaks (DSBs) and meiotic recombination hotspots. To investigate the relation between Prdm9-controlled meiotic arrest and asynapsis, we inserted random stretches of consubspecific homology on several autosomal pairs in sterile hybrids, and analyzed their ability to form synaptonemal complexes and to rescue male fertility. | Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice.
Gregorova S, Gergelits V, Chvatalova I, Bhattacharyya T, Valiskova B, Fotopulosova V, Jansa P, Wiatrowska D, Forejt J., Free PMC Article | 07/6/2019 |
| Data suggest that the asynapsis and male sterility were mainly a consequence of the evolutionary erosion of PR domain containing 9 histone-lysine N-methyltransferase (PRDM9) binding sites . | Cisplatin-induced DNA double-strand breaks promote meiotic chromosome synapsis in PRDM9-controlled mouse hybrid sterility.
Wang L, Valiskova B, Forejt J., Free PMC Article | 05/4/2019 |
| PRDM9 activity leads to the erosion of its own binding sites and the rapid evolution of its DNA-binding domain. PRDM9 may also contribute to reproductive isolation, as it is involved in hybrid sterility potentially due to a reduction of its activity in specific heterozygous contexts. [Review] | PRDM9, a driver of the genetic map.
Grey C, Baudat F, de Massy B., Free PMC Article | 01/19/2019 |
| PRDM9 influences the possibility of genetic exchange by determining the locations of meiotic recombination hotspots in most mammals. (Review) | PRDM9 and Its Role in Genetic Recombination.
Paigen K, Petkov PM., Free PMC Article | 01/5/2019 |
| several basic principles of PRDM9-dependent DSB site determination, in which an excess of sites are designated through PRDM9 binding and subsequent histone methylation, from which a subset is selected for DSB formation. | PRDM9 Methyltransferase Activity Is Essential for Meiotic DNA Double-Strand Break Formation at Its Binding Sites.
Diagouraga B, Clément JAJ, Duret L, Kadlec J, de Massy B, Baudat F. | 01/5/2019 |
| Post-SET zinc finger and the KRAB domains are not essential for the methyltransferase activity of PRDM9 in cell culture. KRAB domain mutant mice show only residual PRDM9 methyltransferase activity and undergo meiotic arrest. | Interrogating the Functions of PRDM9 Domains in Meiosis.
Thibault-Sennett S, Yu Q, Smagulova F, Cloutier J, Brick K, Camerini-Otero RD, Petukhova GV., Free PMC Article | 10/6/2018 |
| we show that truncation of the KRAB domain of mouse PRDM9 leads to loss of PRDM9 function and altered meiotic prophase and gametogenesis. | The PRDM9 KRAB domain is required for meiosis and involved in protein interactions.
Imai Y, Baudat F, Taillepierre M, Stanzione M, Toth A, de Massy B., Free PMC Article | 06/30/2018 |