| A novel antidiuretic hormone governs tumour-induced renal dysfunction. | A novel antidiuretic hormone governs tumour-induced renal dysfunction.
Xu W, Li G, Chen Y, Ye X, Song W. | 12/20/2023 |
| The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function. | The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function.
Guo F, Fernando T, Zhu X, Shi Y. | 02/27/2023 |
| Tachykinin receptor 3 in the lateral habenula alleviates pain and anxiety comorbidity in mice. | Tachykinin receptor 3 in the lateral habenula alleviates pain and anxiety comorbidity in mice.
Zhang WW, Chen T, Li SY, Wang XY, Liu WB, Wang YQ, Mi WL, Mao-Ying QL, Wang YQ, Chu YX., Free PMC Article | 02/13/2023 |
| Neurokinin 3 receptor antagonist-induced adipocyte activation improves obesity and metabolism in PCOS-like mice. | Neurokinin 3 receptor antagonist-induced adipocyte activation improves obesity and metabolism in PCOS-like mice.
Zhang L, Fernando T, Liu Y, Liu Y, Zhu X, Li M, Shi Y. | 11/19/2022 |
| Nk3R blockade has sex-divergent effects on memory in mice. | Nk3R blockade has sex-divergent effects on memory in mice.
Florido A, Moreno E, Canela EI, Andero R., Free PMC Article | 06/18/2022 |
| Characterization of the Action of Tachykinin Signaling on Pulsatile LH Secretion in Male Mice. | Characterization of the Action of Tachykinin Signaling on Pulsatile LH Secretion in Male Mice.
Talbi R, Ferrari K, Choi JH, Gerutshang A, McCarthy EA, Dischino D, León S, Navarro VM., Free PMC Article | 10/23/2021 |
| A single-nucleotide polymorphism induced alternative splicing in Tacr3 involves in hypoxic-ischemic brain damage. | A single-nucleotide polymorphism induced alternative splicing in Tacr3 involves in hypoxic-ischemic brain damage.
Xue LL, Wang F, Xiong LL, Du RL, Zhou HL, Zou Y, Wu MX, Yang MA, Dai J, He MX, Wang TH. | 06/12/2021 |
| Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia. | Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia.
Cui WQ, Zhang WW, Chen T, Li Q, Xu F, Mao-Ying QL, Mi WL, Wang YQ, Chu YX., Free PMC Article | 01/16/2021 |
| we demonstrate that in the presence of E2, NKB signaling induces LH release in a kisspeptin-independent manner through the activation of NK3R (NKB receptor) neurons in the posterodorsal medial amygdala (MePD). Importantly, we show that chemogenetic activation of MePD Kiss1 neurons induces LH release, however, the stimulatory action of NKB in this area is Kiss1 neuron-independent. | NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice.
Fergani C, Leon S, Padilla SL, Verstegen AM, Palmiter RD, Navarro VM., Free PMC Article | 03/30/2019 |
| Data suggest that neurokinin 3 receptor (NK3R) might be a potential target for the anti-angiogenesis therapy. | Targeting neurokinin-3 receptor: a novel anti-angiogenesis strategy for cancer treatment.
Wang T, Chen S, Wang S, Shi L, Wang C, Zhang J, Gao Y, Li G, Qi Y, An X, Chen L., Free PMC Article | 04/14/2018 |
| Data suggest that activation of neurokinin 3 and kappa-opioid receptors (NK3R and KOR) excites and inhibits kisspeptin, neurokinin B (NKB), and dynorphin (KNDy neurons). | Regulation of arcuate neurons coexpressing kisspeptin, neurokinin B, and dynorphin by modulators of neurokinin 3 and κ-opioid receptors in adult male mice.
Ruka KA, Burger LL, Moenter SM., Free PMC Article | 11/2/2013 |
| NKB-NK3R signaling plays a role in pubertal maturation; its alterations may contribute to pubertal disorders linked to metabolic stress and negative energy balance. | Role of neurokinin B in the control of female puberty and its modulation by metabolic status.
Navarro VM, Ruiz-Pino F, Sánchez-Garrido MA, García-Galiano D, Hobbs SJ, Manfredi-Lozano M, León S, Sangiao-Alvarellos S, Castellano JM, Clifton DK, Pinilla L, Steiner RA, Tena-Sempere M., Free PMC Article | 04/28/2012 |
| although capable of fertility, Tacr3-deficient mice have central reproductive defects | Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men.
Yang JJ, Caligioni CS, Chan YM, Seminara SB., Free PMC Article | 04/21/2012 |
| neurokinin 3 receptor activation in the median preoptic nucleus modulates body temperature | Activation of neurokinin 3 receptors in the median preoptic nucleus decreases core temperature in the rat.
Dacks PA, Krajewski SJ, Rance NE., Free PMC Article | 02/18/2012 |
| Together, these results support a role for the NK3 receptor in reactivity to dopaminergic stimuli, but the lack of robust changes indicates that the sensitivity to dopamine may be activity-dependent or benign in nature. | Characterization of behavioral response to amphetamine, tyrosine hydroxylase levels, and dopamine receptor levels in neurokinin 3 receptor knockout mice.
Nordquist RE, Savignac H, Pauly-Evers M, Walker G, Knoflach F, Borroni E, Glaentzlin P, Bohrmann B, Messer J, Ozmen L, Albientz A, Spooren W. | 01/21/2010 |
| these results support a role for the NK(3) receptor in performance of operant tasks and in spatial learning but not in working memory | Cognitive performance in neurokinin 3 receptor knockout mice.
Nordquist RE, Delenclos M, Ballard TM, Savignac H, Pauly-Evers M, Ozmen L, Spooren W. | 01/21/2010 |
| Studies suggest a role for NK3 in learning and memory. | Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits.
Siuciak JA, McCarthy SA, Martin AN, Chapin DS, Stock J, Nadeau DM, Kantesaria S, Bryce-Pritt D, McLean S. | 01/21/2010 |
| The co-expression of NK-3R and NMDA/AMPA receptor subunits in the nigral neurons has provided a structural basis for functional modulation of neuronal glutamate receptors by neurokinin-3. | Differential co-localization of neurokinin-3 receptor and NMDA/AMPA receptor subunits in neurons of the substantia nigra of C57/BL mice.
Wang YQ, Hu HJ, Cao R, Chen LW. | 01/21/2010 |
| NK3-receptors are not involved in the development of lung inflammation and inflammatory cell recruitment into airways of antigen-challenged mice. | Tachykinin NK3-receptor deficiency does not inhibit pulmonary eosinophilia in allergic mice.
Kung TT, Crawley Y, Jones H, Luo B, Gilchrest H, Greenfeder S, Anthes JC, Lira S, Wiekowski M, Cook DN, Hey JA, Egan RW, Chapman RW. | 01/21/2010 |
| Tachykinin NK3 receptor genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function. | A role for tachykinins in female mouse and rat reproductive function.
Pintado CO, Pinto FM, Pennefather JN, Hidalgo A, Baamonde A, Sanchez T, Candenas ML. | 01/21/2010 |
| In neurokinin 1 receptor knockout retinas no major changes were detected: neurokinin 3 receptor mRNA levels as well as substance P and neurokinin 3 receptor immunostainings were similar to wild types. | Expression of substance P, neurokinin 1 receptors (NK1) and neurokinin 3 receptors in the developing mouse retina and in the retina of NK1 knockout mice.
Catalani E, Dal Monte M, Gangitano C, Lucattelli M, Fineschi S, Bosco L, Bagnoli P, Casini G. | 01/21/2010 |