| Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1. | Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1.
Kim N, Li Y, Yu R, Kwon HS, Song A, Jun MH, Jeong JY, Lee JH, Lim HH, Kim MJ, Kim JW, Oh WJ., Free PMC Article | 04/12/2024 |
| Metastasis suppressor 1 controls osteoblast differentiation and bone homeostasis through regulating Src-Wnt/beta-catenin signaling. | Metastasis suppressor 1 controls osteoblast differentiation and bone homeostasis through regulating Src-Wnt/β-catenin signaling.
Chen M, Shan L, Gan Y, Tian L, Zhou J, Zhu E, Yuan H, Li X, Wang B., Free PMC Article | 02/12/2022 |
| Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness. | Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness.
Grandits AM, Nguyen CH, Schlerka A, Hackl H, Sill H, Etzler J, Heyes E, Stoiber D, Grebien F, Heller G, Wieser R., Free PMC Article | 01/1/2022 |
| lncRNA Mtss1 promotes inflammatory responses and secondary brain injury after intracerebral hemorrhage by targeting miR-709 in mice. | lncRNA Mtss1 promotes inflammatory responses and secondary brain injury after intracerebral hemorrhage by targeting miR-709 in mice.
Chen JX, Wang YP, Zhang X, Li GX, Zheng K, Duan CZ. | 10/2/2021 |
| Missing-in-Metastasis/Metastasis Suppressor 1 Regulates B Cell Receptor Signaling, B Cell Metabolic Potential, and T Cell-Independent Immune Responses. | Missing-in-Metastasis/Metastasis Suppressor 1 Regulates B Cell Receptor Signaling, B Cell Metabolic Potential, and T Cell-Independent Immune Responses.
Sarapulov AV, Petrov P, Hernández-Pérez S, Šuštar V, Kuokkanen E, Cords L, Samuel RVM, Vainio M, Fritzsche M, Carrasco YR, Mattila PK., Free PMC Article | 03/27/2021 |
| MTSS1's C terminus binds to DAAM1 and paused DAAM1-mediated F-actin polymerization. | MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells.
Kawabata Galbraith K, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N, Kengaku M. | 12/14/2019 |
| Mtss1 is a key linker between the actin cytoskeleton and the cell membrane, for the development and maintenance of a paradigmatic neuronal circuit, the cerebellar cortex. | Mtss1 promotes maturation and maintenance of cerebellar neurons via splice variant-specific effects.
Sistig T, Lang F, Wrobel S, Baader SL, Schilling K, Eiberger B. | 02/3/2018 |
| Study showed that MTSS1 regulates neurite outgrowth and dendritic arborization in primary neurons in vitro, possibly through a Rac1- and PIP-dependent pathway. | Metastasis suppressor 1 regulates neurite outgrowth in primary neuron cultures.
Yu J, Lin S, Wang M, Liang L, Zou Z, Zhou X, Wang M, Chen P, Wang Y. | 09/9/2017 |
| role of MIM in the homeostasis of BM cells, including HSPCs, through modulation of the CXCR4/SDF-1 axis and interactions of BM leukocytes with their microenvironments. | MIM regulates the trafficking of bone marrow cells via modulating surface expression of CXCR4.
Zhan T, Cao C, Li L, Gu N, Civin CI, Zhan X., Free PMC Article | 09/2/2017 |
| Identify the inverse-BAR (I-BAR) protein MIM/MTSS1 as a nucleator of dendritic spines. MIM accumulated to future spine initiation sites in a PIP2-dependent manner and deformed the plasma membrane outward into a proto-protrusion via its I-BAR domain. | MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation.
Saarikangas J, Kourdougli N, Senju Y, Chazal G, Segerstråle M, Minkeviciene R, Kuurne J, Mattila PK, Garrett L, Hölter SM, Becker L, Racz I, Hans W, Klopstock T, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, von Ossowski L, Taira T, Lappalainen P, Rivera C, Hotulainen P. | 08/29/2015 |
| The data demonstrated for the first time an important role for missing-in-metastasis protein in B-cell development. There was a predisposition of missing-in-metastasis-null mice to develop diffuse large B lymphomas. | Mice deficient in MIM expression are predisposed to lymphomagenesis.
Yu D, Zhan XH, Zhao XF, Williams MS, Carey GB, Smith E, Scott D, Zhu J, Guo Y, Cherukuri S, Civin CI, Zhan X., Free PMC Article | 10/20/2012 |
| MTSS1 might be involved in shaping neuronal membranes in vivo. | Cellular distribution of metastasis suppressor 1 and the shape of cell bodies are temporarily altered in Engrailed-2 overexpressing cerebellar Purkinje cells.
Hayn-Leichsenring G, Liebig C, Miething A, Schulz A, Kumar S, Schwalbe M, Eiberger B, Baader SL. | 02/25/2012 |
| endogenous MIM protein regulates globally the cell architecture and endocytosis that ultimately influence a variety of cellular behaviors, including cell polarity, motility, receptor signaling and membrane ruffling | Murine missing in metastasis (MIM) mediates cell polarity and regulates the motility response to growth factors.
Yu D, Zhan XH, Niu S, Mikhailenko I, Strickland DK, Zhu J, Cao M, Zhan X., Free PMC Article | 10/22/2011 |
| MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. | Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.
Saarikangas J, Mattila PK, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J, Tost M, Jennen L, Rathkolb B, Hans W, Horsch M, Hyvönen ME, Perälä N, Fuchs H, Gailus-Durner V, Esposito I, Wolf E, de Angelis MH, Frilander MJ, Savilahti H, Sariola H, Sainio K, Lehtonen S, Taipale J, Salminen M, Lappalainen P. | 09/3/2011 |
| Results suggest that MIM promotes ciliogenesis by antagonizing Src-dependent phosphorylation of Cortactin and describe a mechanism linking regulation of the actin cytoskeleton with ciliogenesis and Shh signaling during tissue regeneration. | MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling.
Bershteyn M, Atwood SX, Woo WM, Li M, Oro AE., Free PMC Article | 09/20/2010 |
| potential role of Mtss1 for cytoskeletal dynamics in developing and mature cerebellar neurons | Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells.
Glassmann A, Molly S, Surchev L, Nazwar TA, Holst M, Hartmann W, Baader SL, Oberdick J, Pietsch T, Schilling K., Free PMC Article | 01/21/2010 |
| tissue-specific regulator of cytoskeletal dynamics that interacts with ATP-actin monomers through its C-terminal WH2 domain | Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain.
Mattila PK, Salminen M, Yamashiro T, Lappalainen P. | 01/21/2010 |
| Mtss1 represents a novel signaling pathway from PDGF receptor to the actin cytoskeleton via Src-related kinases. | Tyrosine phosphorylation of missing in metastasis protein is implicated in platelet-derived growth factor-mediated cell shape changes.
Wang Y, Zhou K, Zeng X, Lin J, Zhan X. | 01/21/2010 |
| The crystal structures of MIM's IMD and that of its WH2 bound to actin was determined. | Structural basis for the actin-binding function of missing-in-metastasis.
Lee SH, Kerff F, Chereau D, Ferron F, Klug A, Dominguez R., Free PMC Article | 01/21/2010 |
| Hedgehog-responsive gene MIM cooperates with receptor protein tyrosine phosphatase-delta to induce cytoskeletal remodeling. | Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4.
Gonzalez-Quevedo R, Shoffer M, Horng L, Oro AE., Free PMC Article | 01/21/2010 |