| Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells. | Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells.
Jacobse J, Brown RE, Li J, Pilat JM, Pham L, Short SP, Peek CT, Rolong A, Washington MK, Martinez-Barricarte R, Byndloss MX, Shelton C, Markle JG, Latour YL, Allaman MM, Cassat JE, Wilson KT, Choksi YA, Williams CS, Lau KS, Flynn CR, Casanova JL, Rings EHHM, Samsom JN, Goettel JA., Free PMC Article | 10/6/2023 |
| Interleukin-23 receptor defines T helper 1-like regulatory T cells in oral squamous cell carcinoma. | Interleukin-23 receptor defines T helper 1-like regulatory T cells in oral squamous cell carcinoma.
Li W, An N, Wang M, Liu X, Mei Z., Free PMC Article | 12/3/2022 |
| Interleukin-23 receptor expressing gammadelta T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice. | Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice.
Gil-Pulido J, Amézaga N, Jorgacevic I, Manthey HD, Rösch M, Brand T, Cidlinsky P, Schäfer S, Beilhack A, Saliba AE, Lorenz K, Boon L, Prinz I, Waisman A, Korn T, Cochain C, Zernecke A. | 11/19/2022 |
| Allergic airway inflammation induces upregulation of the expression of IL-23R by macrophages and not in CD3 + T cells and CD11c(+)F4/80(-) dendritic cells of the lung. | Allergic airway inflammation induces upregulation of the expression of IL-23R by macrophages and not in CD3 + T cells and CD11c(+)F4/80(-) dendritic cells of the lung.
Leitner M, Heck S, Nguyen K, Nguyen PQ, Harfoush S, Rosenkranz E, Bals R, Dinh QT., Free PMC Article | 06/25/2022 |
| IL23R on myeloid cells is involved in murine pulmonary granuloma formation. | IL23R on myeloid cells is involved in murine pulmonary granuloma formation.
Schreiber T, Falk-Paulsen M, Kuiper J, Aden K, Noth R, Gisch N, Schreiber S, Rosenstiel P, Bewig B. | 01/22/2022 |
| IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation. | IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation.
Razawy W, Alves CH, Koedam M, Asmawidjaja PS, Mus AMC, Oukka M, Leenen PJM, Visser JA, van der Eerden BCJ, Lubberts E., Free PMC Article | 11/13/2021 |
| EBV-induced gene 3 augments IL-23Ralpha protein expression through a chaperone calnexin. | EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin.
Mizoguchi I, Ohashi M, Hasegawa H, Chiba Y, Orii N, Inoue S, Kawana C, Xu M, Sudo K, Fujita K, Kuroda M, Hashimoto SI, Matsushima K, Yoshimoto T., Free PMC Article | 02/20/2021 |
| ERalpha Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation. | ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation.
Fuseini H, Cephus JY, Wu P, Davis JB, Contreras DC, Gandhi VD, Rathmell JC, Newcomb DC., Free PMC Article | 11/21/2020 |
| IL-23R-dependent T cell-mediated synovitis is dependent on CD4(+) CCR6(+) T cells and not on gammadelta T cells. | CD4(+) CCR6(+) T cells, but not γδ T cells, are important for the IL-23R-dependent progression of antigen-induced inflammatory arthritis in mice.
Razawy W, Asmawidjaja PS, Mus AM, Salioska N, Davelaar N, Kops N, Oukka M, Alves CH, Lubberts E., Free PMC Article | 07/18/2020 |
| To define the minimum signals required for development of encephalitogenic T cells that cause CNS autoimmunity, myelin-specific T cells were differentiated with various cytokine cocktails, and pathogenicity was determined by transfer into mice. IL-6+IL-23 or IL-12+IL-23 generated encephalitogenic T cells and recapitulated the essential cytokine signals provided by antigen-presenting cells, and both IL-6 and IL-12 induced | IL-23R-activated STAT3/STAT4 is essential for Th1/Th17-mediated CNS autoimmunity.
Lee PW, Smith AJ, Yang Y, Selhorst AJ, Liu Y, Racke MK, Lovett-Racke AE., Free PMC Article | 08/17/2019 |
| Results suggest that the use of vectors carrying Soluble Interleukin-23 Receptor (sIL-23R) to block the interleukin-23/IL-23R interaction may be a new therapeutic strategy for the treatment of multiple sclerosis. | Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor.
Miralles M, Eixarch H, Tejero M, Costa C, Hirota K, Castaño AR, Puig M, Stockinger G, Montalban X, Bosch A, Espejo C, Chillon M., Free PMC Article | 07/21/2018 |
| RBPJ binds and trans-activates the Il23r promoter and induces IL-23R expression and represses anti-inflammatory IL-10 production in Th17 cells. | RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression.
Meyer Zu Horste G, Wu C, Wang C, Cong L, Pawlak M, Lee Y, Elyaman W, Xiao S, Regev A, Kuchroo VK., Free PMC Article | 12/2/2017 |
| Epithelial IL-23R signaling enables protective IL-22 responses in experimental colitis. | Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.
Aden K, Rehman A, Falk-Paulsen M, Secher T, Kuiper J, Tran F, Pfeuffer S, Sheibani-Tezerji R, Breuer A, Luzius A, Jentzsch M, Häsler R, Billmann-Born S, Will O, Lipinski S, Bharti R, Adolph T, Iovanna JL, Kempster SL, Blumberg RS, Schreiber S, Becher B, Chamaillard M, Kaser A, Rosenstiel P., Free PMC Article | 11/18/2017 |
| Study highlights the importance of IL-23R expression level and the instability of Foxp3+ regulatory T cells in the development of inflammatory bowel diseases. | Elevated IL-23R Expression and Foxp3+Rorgt+ Cells in Intestinal Mucosa During Acute and Chronic Colitis.
Yang J, Xu L., Free PMC Article | 03/25/2017 |
| Differential splicing generates antagonistic soluble IL-23R (sIL-23R) variants, which might limit IL-23-mediated immune responses. Here, ectodomain shedding of IL-23R was identified as an alternative pathway for the generation of sIL-23R. | Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17.
Franke M, Schröder J, Monhasery N, Ackfeld T, Hummel TM, Rabe B, Garbers C, Becker-Pauly C, Floss DM, Scheller J., Free PMC Article | 12/17/2016 |
| Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma. | Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma.
Newcomb DC, Cephus JY, Boswell MG, Fahrenholz JM, Langley EW, Feldman AS, Zhou W, Dulek DE, Goleniewska K, Woodward KB, Sevin CM, Hamilton RG, Kolls JK, Peebles RS Jr., Free PMC Article | 01/16/2016 |
| Data show the contribution of IL-23/IL-23 receptor and IL-7/IL-7 receptor signaling in Th17 and Th1 cell dynamics during experimental autoimmune encephalomyelitis (EAE). | IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis.
Arbelaez CA, Glatigny S, Duhen R, Eberl G, Oukka M, Bettelli E., Free PMC Article | 12/19/2015 |
| Study provides evidence that IL-23/IL-23R plays a critical role in brain ischemic injury | Damage effect of interleukin (IL)-23 on oxygen-glucose-deprived cells of the neurovascular unit via IL-23 receptor.
Wang M, Zhong D, Zheng Y, Li H, Chen H, Ma S, Sun Y, Yan W, Li G. | 12/5/2015 |
| IL-23 plus T-cell receptor signalling results in significant upregulation of IL-23 receptor expressed predominantly on CD4(hi)CD8(hi)CD3(+)alphabetaTCR(+) thymocytes, and leads to RORgammat-dependent apoptosis. | IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt.
Li H, Hsu HC, Wu Q, Yang P, Li J, Luo B, Oukka M, Steele CH 3rd, Cua DJ, Grizzle WE, Mountz JD., Free PMC Article | 11/21/2015 |
| Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota. | Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota.
Shih VF, Cox J, Kljavin NM, Dengler HS, Reichelt M, Kumar P, Rangell L, Kolls JK, Diehl L, Ouyang W, Ghilardi N., Free PMC Article | 04/25/2015 |
| Characterization of potent IL-23R small-peptide modulator, 2305 (teeeqqly), that decreases inflammatory response. | Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response.
Quiniou C, Domínguez-Punaro M, Cloutier F, Erfani A, Ennaciri J, Sivanesan D, Sanchez M, Chognard G, Hou X, Rivera JC, Beauchamp C, Charron G, Vilquin M, Kuchroo V, Michnick S, Rioux JD, Lesage S, Chemtob S. | 01/24/2015 |
| Although they share a common subunit, IL-23 and IL-12 receptors are not expressed on the same cell populations | The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.
Chognard G, Bellemare L, Pelletier AN, Dominguez-Punaro MC, Beauchamp C, Guyon MJ, Charron G, Morin N, Sivanesan D, Kuchroo V, Xavier R, Michnick SW, Chemtob S, Rioux JD, Lesage S., Free PMC Article | 01/3/2015 |
| IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism. | IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism.
Eken A, Singh AK, Treuting PM, Oukka M., Free PMC Article | 08/23/2014 |
| the balance between the enhancing and inhibitory effects of gamma-delta T cells is regulated by their level of IL-23R expression. | IL-23 receptor expression on γδ T cells correlates with their enhancing or suppressive effects on autoreactive T cells in experimental autoimmune uveitis.
Liang D, Zuo A, Shao H, Born WK, O'Brien RL, Kaplan HJ, Sun D., Free PMC Article | 10/19/2013 |
| Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor. | Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor.
Floss DM, Mrotzek S, Klöcker T, Schröder J, Grötzinger J, Rose-John S, Scheller J., Free PMC Article | 09/14/2013 |