| Suv39h-catalyzed H3K9me3 is critical for euchromatic genome organization and the maintenance of gene transcription. | Suv39h-catalyzed H3K9me3 is critical for euchromatic genome organization and the maintenance of gene transcription.
Keenan CR, Coughlan HD, Iannarella N, Tapia Del Fierro A, Keniry A, Johanson TM, Chan WF, Garnham AL, Whitehead LW, Blewitt ME, Smyth GK, Allan RS., Free PMC Article | 08/7/2024 |
| HBV PreC interacts with SUV39H1 to induce viral replication by blocking the proteasomal degradation of viral polymerase. | HBV PreC interacts with SUV39H1 to induce viral replication by blocking the proteasomal degradation of viral polymerase.
Hou L, Zhao J, Cai L, Jin L, Liu B, Li S, Yang J, Ji T, Li S, Shi L, Shen B, Yu H, Wang Y, Cai X. | 04/30/2024 |
| Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis. | Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis.
Kong M, Zhou J, Kang A, Kuai Y, Xu H, Li M, Miao X, Guo Y, Fan Z, Xu Y, Li Z. | 04/11/2024 |
| Suv39h1 contributes to activation of hepatic stellate cells in non-alcoholic fatty liver disease by enabling anaerobic glycolysis. | Suv39h1 contributes to activation of hepatic stellate cells in non-alcoholic fatty liver disease by enabling anaerobic glycolysis.
Wu X, Shen Y, Meng Y, Chen J, Zhang Y, Zeng S, Xu H. | 02/29/2024 |
| The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma. | The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
Kalita B, Sahu S, Bharadwaj A, Panneerselvam L, Martinez-Cebrian G, Agarwal M, Mathew SJ. | 02/15/2024 |
| Suv39h1 Silencing Recovers Memory Decline in Scopolamine-Induced Amnesic Mouse Model. | Suv39h1 Silencing Recovers Memory Decline in Scopolamine-Induced Amnesic Mouse Model.
Kushwaha A, Thakur MK. | 01/26/2024 |
| SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors. | SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors.
López-Cobo S, Fuentealba JR, Gueguen P, Bonté PE, Tsalkitzi K, Chacón I, Glauzy S, Bohineust A, Biquand A, Silva L, Gouveia Z, Goudot C, Perez F, Saitakis M, Amigorena S. | 01/17/2024 |
| Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP. | Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP.
Li R, Teng Y, Guo Y, Ren J, Li R, Luo H, Chen D, Feng Z, Fu Z, Zou X, Wang W, Zhou C. | 11/3/2023 |
| SUV39H1 Inhibits Angiogenesis in Limb Ischemia of Mice. | SUV39H1 Inhibits Angiogenesis in Limb Ischemia of Mice.
Niu W, Cao W, Wu F, Liang C., Free PMC Article | 11/3/2023 |
| OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency. | OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency.
Bernard LD, Dubois A, Heurtier V, Fischer V, Gonzalez I, Chervova A, Tachtsidi A, Gil N, Owens N, Bates LE, Vandormael-Pournin S, Silva JCR, Ulitsky I, Cohen-Tannoudji M, Navarro P., Free PMC Article | 07/30/2022 |
| Suv39h1 regulates memory stability by inhibiting the expression of Shank1 in hippocampal newborn neurons. | Suv39h1 regulates memory stability by inhibiting the expression of Shank1 in hippocampal newborn neurons.
Chen QN, Ding XL, Guo XX, Zhou G, Guan JS. | 04/16/2022 |
| The histone methyltransferase Suv39h regulates 3T3-L1 adipogenesis. | The histone methyltransferase Suv39h regulates 3T3-L1 adipogenesis.
Jing J, Li F, Zha L, Yang X, Wu R, Wang S, Xue B, Shi H., Free PMC Article | 07/17/2021 |
| FUS-dependent loading of SUV39H1 to OCT4 pseudogene-lncRNA programs a silencing complex with OCT4 promoter specificity. | FUS-dependent loading of SUV39H1 to OCT4 pseudogene-lncRNA programs a silencing complex with OCT4 promoter specificity.
Scarola M, Comisso E, Rosso M, Del Sal G, Schneider C, Schoeftner S, Benetti R., Free PMC Article | 07/3/2021 |
| Extreme disruption of heterochromatin is required for accelerated hematopoietic aging. | Extreme disruption of heterochromatin is required for accelerated hematopoietic aging.
Keenan CR, Iannarella N, Naselli G, Bediaga NG, Johanson TM, Harrison LC, Allan RS. | 02/13/2021 |
| Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity. | Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity.
Costantino S, Paneni F, Virdis A, Hussain S, Mohammed SA, Capretti G, Akhmedov A, Dalgaard K, Chiandotto S, Pospisilik JA, Jenuwein T, Giorgio M, Volpe M, Taddei S, Lüscher TF, Cosentino F. | 09/5/2020 |
| Tumor-infiltrating cytotoxic T-Lymphocytes (CTLs) in the colon tumor microenvironment have high expression of the H3K9me3-specific histone methyltransferase (SUV39H1). SUV39H1 enzyme inhibitor F5446 inhibits H3K9me3, thereby upregulating the expression CTL effector genes and suppressing colon carcinoma growth in a CD8(+) CTL-dependent manner. | SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion.
Lu C, Yang D, Klement JD, Oh IK, Savage NM, Waller JL, Colby AH, Grinstaff MW, Oberlies NH, Pearce CJ, Xie Z, Kulp SK, Coss CC, Phelps MA, Albers T, Lebedyeva IO, Liu K., Free PMC Article | 05/23/2020 |
| Removal of the acetyl-group at K230 in Sirt1 due to the absence of Sirt7 leads to hyperactivation of Sirt1 and thereby to constantly increased activity of Suv39h1. | Sirt7 inhibits Sirt1-mediated activation of Suv39h1.
Kumari P, Popescu D, Yue S, Bober E, Ianni A, Braun T., Free PMC Article | 11/16/2019 |
| CRL4-DCAF13-mediated SUV39H1 degradation is an essential step for progressive genome reprogramming during preimplantation embryonic development. | DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.
Zhang YL, Zhao LW, Zhang J, Le R, Ji SY, Chen C, Gao Y, Li D, Gao S, Fan HY., Free PMC Article | 10/5/2019 |
| studies establish SUV39H1 as an oncogene in melanoma and underscore the role of chromatin factors in regulating tumorigenesis. | SUV39H1/DNMT3A-dependent methylation of the RB1 promoter stimulates PIN1 expression and melanoma development.
Kim G, Kim JY, Lim SC, Lee KY, Kim O, Choi HS. | 04/6/2019 |
| SUV39H augments intracellular reactive oxygen species levels in a SIRT1-dependent manner. | The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.
Yang G, Weng X, Zhao Y, Zhang X, Hu Y, Dai X, Liang P, Wang P, Ma L, Sun X, Hou L, Xu H, Fang M, Li Y, Jenuwein T, Xu Y, Sun A., Free PMC Article | 11/10/2018 |
| this novel defense mechanism against mycobacteria represents a surrogate function of the epigenetic modulator, SUV39H1, and operates by interfering with their cell-cell adhesion ability. | Histone methyltransferase SUV39H1 participates in host defense by methylating mycobacterial histone-like protein HupB.
Yaseen I, Choudhury M, Sritharan M, Khosla S., Free PMC Article | 09/15/2018 |
| the Suv39h1 paralog, is identified as a unique enhancer of HP1alpha sumoylation | The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin.
Maison C, Bailly D, Quivy JP, Almouzni G., Free PMC Article | 09/1/2018 |
| The authors show here that the mouse Suv39h2 enzyme differs from Suv39h1 by containing an N-terminal basic domain that facilitates retention at mitotic chromatin and provides an additional affinity for major satellite repeat RNA. | Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation.
Velazquez Camacho O, Galan C, Swist-Rosowska K, Ching R, Gamalinda M, Karabiber F, De La Rosa-Velazquez I, Engist B, Koschorz B, Shukeir N, Onishi-Seebacher M, van de Nobelen S, Jenuwein T., Free PMC Article | 04/7/2018 |
| Suv39h1 plays a critical role in marking chromatin to silence stem/memory genes during CD8+ T effector terminal differentiation | The epigenetic control of stemness in CD8(+) T cell fate commitment.
Pace L, Goudot C, Zueva E, Gueguen P, Burgdorf N, Waterfall JJ, Quivy JP, Almouzni G, Amigorena S. | 02/10/2018 |
| Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin and p21(WAF1) in mesangial cells | Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin and p21(WAF1) in mesangial cells.
Lin SH, Ho WT, Wang YT, Chuang CT, Chuang LY, Guh JY. | 11/26/2017 |