| Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model. | Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model.
Nakayama T, Singh AK, Fukutomi T, Uchida N, Terao Y, Hamada H, Muraoka T, Muthusamy E, Kundu TK, Akagawa K. | 05/9/2024 |
| The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release rely on the integrity of the C-terminal half of the SNARE domain of syntaxin-1A. | The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release rely on the integrity of the C-terminal half of the SNARE domain of syntaxin-1A.
Salazar Lázaro A, Trimbuch T, Vardar G, Rosenmund C., Free PMC Article | 03/25/2024 |
| Myosin Va, a Novel Interaction Partner of STXBP1, Is Required to Transport Syntaxin1A to the Plasma Membrane. | Myosin Va, a Novel Interaction Partner of STXBP1, Is Required to Transport Syntaxin1A to the Plasma Membrane.
Taura Y, Tozawa T, Fujimoto T, Ichise E, Chiyonobu T, Itoh K, Iehara T. | 07/27/2023 |
| Syntaxin-1A modulates vesicle fusion in mammalian neurons via juxtamembrane domain dependent palmitoylation of its transmembrane domain. | Syntaxin-1A modulates vesicle fusion in mammalian neurons via juxtamembrane domain dependent palmitoylation of its transmembrane domain.
Vardar G, Salazar-Lázaro A, Zobel S, Trimbuch T, Rosenmund C., Free PMC Article | 06/18/2022 |
| Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion from central murine synapses. | Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion from central murine synapses.
Vardar G, Salazar-Lázaro A, Brockmann M, Weber-Boyvat M, Zobel S, Kumbol VW, Trimbuch T, Rosenmund C., Free PMC Article | 10/23/2021 |
| Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly. | Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly.
Kalyana Sundaram RV, Jin H, Li F, Shu T, Coleman J, Yang J, Pincet F, Zhang Y, Rothman JE, Krishnakumar SS., Free PMC Article | 07/31/2021 |
| Phosphorylation of Syntaxin-1a by casein kinase 2alpha regulates pre-synaptic vesicle exocytosis from the reserve pool. | Phosphorylation of Syntaxin-1a by casein kinase 2α regulates pre-synaptic vesicle exocytosis from the reserve pool.
Shi VH, Craig TJ, Bishop P, Nakamura Y, Rocca D, Wilkinson KA, Henley JM., Free PMC Article | 05/8/2021 |
| Microglial expression of GAT-1 in the cerebral cortex. | Microglial expression of GAT-1 in the cerebral cortex.
Fattorini G, Catalano M, Melone M, Serpe C, Bassi S, Limatola C, Conti F. | 11/21/2020 |
| The results demonstrate that MUNC18-1 regulates the F-actin network independently of syntaxin1 targeting via hydrophobicity in beta-sheet 10. The abnormally dense F-actin network in Munc18-1-deficient cells is not a rate-limiting barrier in secretory vesicle docking or fusion. | MUNC18-1 regulates the submembrane F-actin network, independently of syntaxin1 targeting, via hydrophobicity in β-sheet 10.
Pons-Vizcarra M, Kurps J, Tawfik B, Sørensen JB, van Weering JRT, Verhage M. | 07/25/2020 |
| The role of syntaxin 1A in GLP1 release from intestinal cells as a response to external stimuli is reported. | The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1.
Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL., Free PMC Article | 10/21/2017 |
| proteins, such as syntaxin-1, Munc18-1, or SNAP-25, modulate alpha-synuclein neuropathy and/or are dysregulated in Alzheimer's disease, understanding this type of neurodegeneration may provide new links between synaptic defects and neurodegeneration in humans | Early Golgi Abnormalities and Neurodegeneration upon Loss of Presynaptic Proteins Munc18-1, Syntaxin-1, or SNAP-25.
Santos TC, Wierda K, Broeke JH, Toonen RF, Verhage M., Free PMC Article | 08/5/2017 |
| Therefore, our work provides insights into differential functions of Stx1 in neuronal maintenance and neurotransmission, with the latter explored further into its functions in vesicle docking and fusion. | Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons.
Vardar G, Chang S, Arancillo M, Wu YJ, Trimbuch T, Rosenmund C., Free PMC Article | 07/15/2017 |
| Syn-1A actions on newcomer SGs were partly mediated by Syn-1A interactions with newcomer SG VAMP8 | New Roles of Syntaxin-1A in Insulin Granule Exocytosis and Replenishment.
Liang T, Qin T, Xie L, Dolai S, Zhu D, Prentice KJ, Wheeler M, Kang Y, Osborne L, Gaisano HY., Free PMC Article | 07/8/2017 |
| The results of this study suggested that STX1A plays an important role in social behavior through regulation of the OXTergic neural system. | Unusual social behavior in HPC-1/syntaxin1A knockout mice is caused by disruption of the oxytocinergic neural system.
Fujiwara T, Sanada M, Kofuji T, Akagawa K. | 06/3/2017 |
| Data suggest that porosome-associated proteins SNAP25, TREK-1, syntaxin-1A, and Gai3 exhibit stability and functionality such that isolated proteins can be reconstituted as insulin-secreting porosomes in cell membrane of live cells. | Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells.
Naik AR, Kulkarni SP, Lewis KT, Taatjes DJ, Jena BP., Free PMC Article | 05/21/2016 |
| syntaxin 1 and vesicle-associated membrane protein 1 are more suitable targets to abolish functional soluble N-ethylmaleimide-sensitive factor attachment protein receptor complexes | Selective cleavage of SNAREs in sensory neurons unveils protein complexes mediating peptide exocytosis triggered by different stimuli.
Meng J, Dolly JO, Wang J. | 09/12/2015 |
| Data show a significant increase of vesicle-associated membrane protein 2 (VAMP-2) mRNA expression, however, the expressions of synaptosome-associated protein of 25 kDa (SNAP-25) and syntaxin 1A did not exhibit the changes in hippocampus. | Effects of chronic fluoride exposure on object recognition memory and mRNA expression of SNARE complex in hippocampus of male mice.
Han H, Du W, Zhou B, Zhang W, Xu G, Niu R, Sun Z. | 05/16/2015 |
| Although STX1A and STX1B share a basic function as neuronal t-SNAREs, STX1B but not STX1A is necessary for the regulation of spontaneous and evoked synaptic vesicle exocytosis in fast transmission. | Syntaxin 1B, but not syntaxin 1A, is necessary for the regulation of synaptic vesicle exocytosis and of the readily releasable pool at central synapses.
Mishima T, Fujiwara T, Sanada M, Kofuji T, Kanai-Azuma M, Akagawa K., Free PMC Article | 11/8/2014 |
| we found that STX1A and STX1B play distinct roles in neuronal survival using | HPC-1/syntaxin 1A and syntaxin 1B play distinct roles in neuronal survival.
Kofuji T, Fujiwara T, Sanada M, Mishima T, Akagawa K. | 10/4/2014 |
| point mutation in syntaxin-1A causes abnormal regulation of neuronal plasticity and vesicle recycling and that the affected syntaxin-1A/CaMKII interaction is essential for normal brain and synaptic functions in vivo. | Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity.
Watanabe Y, Katayama N, Takeuchi K, Togano T, Itoh R, Sato M, Yamazaki M, Abe M, Sato T, Oda K, Yokoyama M, Takao K, Fukaya M, Miyakawa T, Watanabe M, Sakimura K, Manabe T, Igarashi M., Free PMC Article | 02/22/2014 |
| overall release efficiency of affected hippocampal neurons was severely impaired by reducing levels of Stx1, as demonstrated by a smaller readily releasable pool size, slower refilling rate of primed vesicles, and lower release probability. | Titration of Syntaxin1 in mammalian synapses reveals multiple roles in vesicle docking, priming, and release probability.
Arancillo M, Min SW, Gerber S, Münster-Wandowski A, Wu YJ, Herman M, Trimbuch T, Rah JC, Ahnert-Hilger G, Riedel D, Südhof TC, Rosenmund C., Free PMC Article | 12/14/2013 |
| CAPS1 binds to the full-length of cytoplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1. | Calcium-dependent activator protein for secretion 1 (CAPS1) binds to syntaxin-1 in a distinct mode from Munc13-1.
Parsaud L, Li L, Jung CH, Park S, Saw NM, Park S, Kim MY, Sugita S., Free PMC Article | 11/2/2013 |
| The N-terminal syntaxin-1 domains mediate different functions in synaptic vesicle fusion, probably via formation of distinct Munc18/SNARE-protein complexes. | Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion.
Zhou P, Pang ZP, Yang X, Zhang Y, Rosenmund C, Bacaj T, Südhof TC., Free PMC Article | 03/16/2013 |
| Direct interaction between syntaxin 1A and the Kv2.1 C-terminus is required for efficient insulin exocytosis and glucose-stimulated insulin secretion. | The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.
Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, Hajmrle C, Spigelman AF, Kin T, Singer-Lahat D, Kang Y, Shapiro AM, Gaisano HY, Lotan I, Macdonald PE. | 09/1/2012 |
| Nesca directly binds KIF5B, kinesin light-chain and syntaxin-1 | Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons.
MacDonald JI, Dietrich A, Gamble S, Hryciw T, Grant RI, Meakin SO. | 08/18/2012 |