| WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion. | WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
Rodriguez-Hernandez I, Maiques O, Kohlhammer L, Cantelli G, Perdrix-Rosell A, Monger J, Fanshawe B, Bridgeman VL, Karagiannis SN, Penin RM, Marcolval J, Marti RM, Matias-Guiu X, Fruhwirth GO, Orgaz JL, Malanchi I, Sanz-Moreno V., Free PMC Article | 11/28/2020 |
| we generated Daam-deficient mice by gene targeting and found that Daam1, but not Daam2, is necessary for fetal survival. Embryonic development of Daam1 mutants was delayed most likely due to functional defects in the labyrinthine layer of the placenta. Examination of Daam2 and Daam1/2 double mutants revealed that Daam1 and Daam2 are functionally redundant during placental development. | Placental defects lead to embryonic lethality in mice lacking the Formin and PCP proteins Daam1 and Daam2.
Nakaya MA, Gudmundsson KO, Komiya Y, Keller JR, Habas R, Yamaguchi TP, Ajima R., Free PMC Article | 07/25/2020 |
| MTSS1's C terminus binds to DAAM1 and paused DAAM1-mediated F-actin polymerization. | MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells.
Kawabata Galbraith K, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N, Kengaku M. | 12/14/2019 |
| The data suggested that Daam1 affected actin assembly during oocyte meiotic division via the regulation of fascin expression. | Daam1 regulates fascin for actin assembly in mouse oocyte meiosis.
Lu Y, Zhang Y, Pan MH, Kim NH, Sun SC, Cui XS., Free PMC Article | 04/21/2018 |
| DAAM1 organizes actin filaments into a nodal complex | Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network.
Luo W, Lieu ZZ, Manser E, Bershadsky AD, Sheetz MP., Free PMC Article | 06/10/2017 |
| DAAM1 loss evokes invasive abilities of epithelial cells. | DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility.
Nishimura T, Ito S, Saito H, Hiver S, Shigetomi K, Ikenouchi J, Takeichi M., Free PMC Article | 06/3/2017 |
| Daam1 knockout mice that were also homozygous for Daam2 had stronger noncompaction cardiomyopathy, severely reduced cardiac function, disrupted sarcomere structure, and increased myocardial proliferation. | DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.
Ajima R, Bisson JA, Helt JC, Nakaya MA, Habas R, Tessarollo L, He X, Morrisey EE, Yamaguchi TP, Cohen ED., Free PMC Article | 05/28/2016 |
| Fascin and Daam1 coimmunoprecipitated from cell extracts, and silencing of fascin led to a striking loss of Daam1 localization to filopodial shafts. Purified fascin bound directly to Daam1; fascin recruited Daam1 to and stabilized Daam1 on actin bundles. | The formin Daam1 and fascin directly collaborate to promote filopodia formation.
Jaiswal R, Breitsprecher D, Collins A, Corrêa IR Jr, Xu MQ, Goode BL., Free PMC Article | 03/15/2014 |
| Daam1 is important for regulating filamentous actin assembly and organization, and consequently for cytoskeletal function in cardiomyocytes, which contributes to proper heart morphogenesis. | Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
Li D, Hallett MA, Zhu W, Rubart M, Liu Y, Yang Z, Chen H, Haneline LS, Chan RJ, Schwartz RJ, Field LJ, Atkinson SJ, Shou W., Free PMC Article | 01/29/2011 |
| a carboxyl-terminal binding partner, Dvl, has a role in activation of Daam1 | Mechanism of activation of the Formin protein Daam1.
Liu W, Sato A, Khadka D, Bharti R, Diaz H, Runnels LW, Habas R., Free PMC Article | 01/21/2010 |
| involved in pivotal steps in neuronal cell differentiation and movement | Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system.
Kida Y, Shiraishi T, Ogura T. | 01/21/2010 |
| Daams are expressed in tissues known to require Wnts, so effectors of Wnt signaling during vertebrate development. | Identification and comparative expression analyses of Daam genes in mouse and Xenopus.
Nakaya MA, Habas R, Biris K, Dunty WC Jr, Kato Y, He X, Yamaguchi TP. | 01/21/2010 |