| Exosomes from Adipose Mesenchymal Stem Cells Overexpressing Stanniocalcin-1 Promote Reendothelialization After Carotid Endarterium Mechanical Injury. | Exosomes from Adipose Mesenchymal Stem Cells Overexpressing Stanniocalcin-1 Promote Reendothelialization After Carotid Endarterium Mechanical Injury.
Liu K, Shi H, Peng Z, Wu X, Li W, Lu X. | 07/23/2022 |
| Stanniocalcin 1 is a serum biomarker and potential therapeutic target for HBV-associated liver fibrosis. | Stanniocalcin 1 is a serum biomarker and potential therapeutic target for HBV-associated liver fibrosis.
Chan KK, Hon TC, Au KY, Choi HL, Wong DK, Chan AC, Yuen MF, Lai CL, Lo RC. | 05/7/2022 |
| STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts. | STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts.
Avalle L, Raggi L, Monteleone E, Savino A, Viavattene D, Statello L, Camperi A, Stabile SA, Salemme V, De Marzo N, Marino F, Guglielmi C, Lobascio A, Zanini C, Forni M, Incarnato D, Defilippi P, Oliviero S, Poli V. | 04/23/2022 |
| Stanniocalcin-1 Protected Astrocytes from Hypoxic Damage Through the AMPK Pathway. | Stanniocalcin-1 Protected Astrocytes from Hypoxic Damage Through the AMPK Pathway.
Sun B, He S, Liu B, Xu G, Guoji E, Feng L, Xu L, Chen D, Zhao W, Chen J, Gao Y, Zhang E. | 02/5/2022 |
| Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance. | Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance.
Lin H, Kryczek I, Li S, Green MD, Ali A, Hamasha R, Wei S, Vatan L, Szeliga W, Grove S, Li X, Li J, Wang W, Yan Y, Choi JE, Li G, Bian Y, Xu Y, Zhou J, Yu J, Xia H, Wang W, Alva A, Chinnaiyan AM, Cieslik M, Zou W., Free PMC Article | 11/22/2021 |
| Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development. | Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.
Kamata T, So TY, Ahmed Q, Giblett S, Patel B, Luo J, Reddel R, Pritchard C., Free PMC Article | 05/1/2021 |
| STC-1 is a downstream effector molecule in latanoprost signaling that is independent of the F2a receptor, equivalent and non-additive in the early intraocular pressure response in wild-type mice | Stanniocalcin-1 (STC-1), a downstream effector molecule in latanoprost signaling, acts independent of the FP receptor for intraocular pressure reduction.
Roddy GW, Rinkoski TA, Monson KJ, Chowdhury UR, Fautsch MP., Free PMC Article | 08/12/2020 |
| The results suggest that Stc1 may be a downstream candidate of Gpnmb, and that both genes interact with other genes in a network to develop glaucoma through mechanisms such as apoptosis and oxidative stress. | Investigating a downstream gene of Gpnmb using the systems genetics method.
Lu Y, Zhou D, Lu H, Xu F, Yue J, Tong J, Lu L., Free PMC Article | 08/31/2019 |
| Latanoprost-induced reduction of intraocular pressure is mediated through the downstream signaling molecule STC-1. When used by itself, STC-1 exhibits ocular hypotensive properties. | Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure-Lowering Effects of Latanoprost.
Roddy GW, Viker KB, Winkler NS, Bahler CK, Holman BH, Sheikh-Hamad D, Roy Chowdhury U, Stamer WD, Fautsch MP., Free PMC Article | 07/22/2017 |
| STC-1 maybe improve anti-inflammation, anti-oxidant and anti-apoptosis activities by affecting reactive oxygen species -mediated pathways, especially the phospho-modifications of the respective proteins, resulting in the increase of Superoxide dismutase and reduce of capase-3, p53, IL-6 and IFN-gamma. | Stanniocalcin-1 Protects a Mouse Model from Renal Ischemia-Reperfusion Injury by Affecting ROS-Mediated Multiple Signaling Pathways.
Liu D, Shang H, Liu Y., Free PMC Article | 04/1/2017 |
| STC1 blunts bleomycin-induced rise in thrombin protein and activity, diminishes thrombin-induced signaling through PAR1 to ERK, and inhibits bleomycin-induced pneumonitis. | Stanniocalcin-1 inhibits thrombin-induced signaling and protects from bleomycin-induced lung injury.
Huang L, Zhang L, Ju H, Li Q, Pan JS, Al-Lawati Z, Sheikh-Hamad D., Free PMC Article | 10/22/2016 |
| Stanniocalcin 1 is expressed in thyroid side population cells and thyroid cancer cells. | Expression of stanniocalcin 1 in thyroid side population cells and thyroid cancer cells.
Hayase S, Sasaki Y, Matsubara T, Seo D, Miyakoshi M, Murata T, Ozaki T, Kakudo K, Kumamoto K, Ylaya K, Cheng SY, Thorgeirsson SS, Hewitt SM, Ward JM, Kimura S., Free PMC Article | 01/16/2016 |
| Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using Stc1. | Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1.
Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, Nukiwa T, Irokawa T, Ogawa H, Akaike T, Okada Y, Kurosawa H, Kikuchi T, Ichinose M., Free PMC Article | 11/21/2015 |
| Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway. | Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway.
Pan JS, Huang L, Belousova T, Lu L, Yang Y, Reddel R, Chang A, Ju H, DiMattia G, Tong Q, Sheikh-Hamad D., Free PMC Article | 04/25/2015 |
| STC1 is an endogenous stress protein that may counteract LPS-induced lung injury by inhibiting the inflammatory cascade and inducing antioxidant and antiapoptotic mechanisms. | Stanniocalcin-1 ameliorates lipopolysaccharide-induced pulmonary oxidative stress, inflammation, and apoptosis in mice.
Tang SE, Wu CP, Wu SY, Peng CK, Perng WC, Kang BH, Chu SJ, Huang KL. | 01/10/2015 |
| critical for kidney tubular epithelial survival under physiologic conditions | AKI after conditional and kidney-specific knockdown of stanniocalcin-1.
Huang L, Belousova T, Pan JS, Du J, Ju H, Lu L, Zhang P, Truong LD, Nuotio-Antar A, Sheikh-Hamad D., Free PMC Article | 12/20/2014 |
| Remarkably, X-linked genes are not overexpressed in female Stc1(-/-) mice, revealing the existence of a mechanism(s) that can compensate for a persistent XCI deficiency to regulate X-linked gene expression. | Genetic and pharmacological reactivation of the mammalian inactive X chromosome.
Bhatnagar S, Zhu X, Ou J, Lin L, Chamberlain L, Zhu LJ, Wajapeyee N, Green MR., Free PMC Article | 11/22/2014 |
| Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury. | Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury in mice.
Huang L, Belousova T, Chen M, DiMattia G, Liu D, Sheikh-Hamad D., Free PMC Article | 07/13/2013 |
| STC1 was not crucial for the development of ischemic tolerance triggered by hypoxic preconditioning, or for preserving blood-brain barrier integrity but may be involved in functional recovery after stroke. | Stanniocalcin 1 is important for poststroke functionality, but dispensable for ischemic tolerance.
Durukan Tolvanen A, Westberg JA, Serlachius M, Chang AC, Reddel RR, Andersson LC, Tatlisumak T. | 06/8/2013 |
| the inner medullary STC-1 gene is differentially regulated in rat and mouse by arginine vasopressin and angiotensin II | Vasopressin controls stanniocalcin-1 gene expression in rat and mouse kidney.
Law AY, Wong CK, Turner J, Gonzalez AA, Prieto MC, Wagner GF. | 03/10/2012 |
| Vascular endothelial growth factor-D stimulates endothelial cell VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects. | Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects.
Jauhiainen S, Häkkinen SK, Toivanen PI, Heinonen SE, Jyrkkänen HK, Kansanen E, Leinonen H, Levonen AL, Ylä-Herttuala S. | 08/20/2011 |
| STC-1 could have a role in salt and water balance as dehydration necessitates water conservation as well as controlled natriuresis and kaliuresis. | Induction of the renal stanniocalcin-1 gene in rodents by water deprivation.
Turner J, Sazonova O, Wang H, Pozzi A, Wagner GF. | 01/22/2011 |
| Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2. | Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2.
Wang Y, Huang L, Abdelrahim M, Cai Q, Truong A, Bick R, Poindexter B, Sheikh-Hamad D., Free PMC Article | 01/21/2010 |
| Stc1 acts in a negative feedback loop in the prosurvival ERK1/2 signaling pathway during oxidative stress. | Stanniocalcin-1 acts in a negative feedback loop in the prosurvival ERK1/2 signaling pathway during oxidative stress.
Nguyen A, Chang AC, Reddel RR. | 01/21/2010 |
| stanniocalcin-1 is a potent anti-inflammatory and renal protective protein. | Anti-inflammatory and renal protective actions of stanniocalcin-1 in a model of anti-glomerular basement membrane glomerulonephritis.
Huang L, Garcia G, Lou Y, Zhou Q, Truong LD, DiMattia G, Lan XR, Lan HY, Wang Y, Sheikh-Hamad D., Free PMC Article | 01/21/2010 |