| Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes. | Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes.
Ullah Khan F, Khongorzul P, Gris D, Amrani A. | 06/20/2024 |
| STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth. | STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth.
Vaparanta K, Jokilammi A, Paatero I, Merilahti JA, Heliste J, Hemanthakumar KA, Kivelä R, Alitalo K, Taimen P, Elenius K., Free PMC Article | 05/8/2023 |
| Constitutively Active STAT5b Feminizes Mouse Liver Gene Expression. | Constitutively Active STAT5b Feminizes Mouse Liver Gene Expression.
Lau-Corona D, Ma H, Vergato C, Sarmento-Cabral A, Del Rio-Moreno M, Kineman RD, Waxman DJ., Free PMC Article | 05/14/2022 |
| Growth Hormone-induced STAT5B Regulates Star Gene Expression Through a Cooperation With cJUN in Mouse MA-10 Leydig Cells. | Growth Hormone-induced STAT5B Regulates Star Gene Expression Through a Cooperation With cJUN in Mouse MA-10 Leydig Cells.
Hébert-Mercier PO, Bergeron F, Robert NM, Mehanovic S, Pierre KJ, Mendoza-Villarroel RE, de Mattos K, Brousseau C, Tremblay JJ., Free PMC Article | 02/19/2022 |
| Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice. | Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice.
Beghini M, Wagner T, Luca AC, Metz M, Kaltenecker D, Spirk K, Hackl MT, Haybaeck J, Moriggl R, Kautzky-Willer A, Scherer T, Fürnsinn C., Free PMC Article | 01/8/2022 |
| Stat5B is required for IgE-Mediated mast cell function in vitro and in vivo. | Stat5B is required for IgE-Mediated mast cell function in vitro and in vivo.
Kiwanuka KN, Motunrayo Kolawole E, Mcleod JJA, Baker B, Paez PA, Zellner MP, Haque TT, Paranjape A, Jackson K, Kee SA, Dailey J, Martin RK, Ryan JJ., Free PMC Article | 11/27/2021 |
| STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes. | STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.
Hao P, Waxman DJ., Free PMC Article | 02/6/2021 |
| The neonatal microenvironment programs innate gammadelta T cells through the transcription factor STAT5. | The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5.
Kadekar D, Agerholm R, Rizk J, Neubauer HA, Suske T, Maurer B, Viñals MT, Comelli EM, Taibi A, Moriggl R, Bekiaris V., Free PMC Article | 02/2/2021 |
| IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis. | IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis.
Bauché D, Joyce-Shaikh B, Fong J, Villarino AV, Ku KS, Jain R, Lee YC, Annamalai L, Yearley JH, Cua DJ. | 01/2/2021 |
| Hhex regulates murine lymphoid progenitor survival independently of Stat5 and Cdkn2a. | Hhex regulates murine lymphoid progenitor survival independently of Stat5 and Cdkn2a.
Jackson JT, O'Donnell K, Light A, Goh W, Huntington ND, Tarlinton DM, McCormack MP. | 12/12/2020 |
| Nontoxic sulfur enhances growth hormone signaling through the JAK2/STAT5b/IGF1 pathway in C2C12 cells. | Non‑toxic sulfur enhances growth hormone signaling through the JAK2/STAT5b/IGF‑1 pathway in C2C12 cells.
Kang DY, Sp N, Jo ES, Kim HD, Kim IH, Bae SW, Jang KJ, Yang YM. | 12/5/2020 |
| STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus. | STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus.
Fu Y, Wang J, Panangipalli G, Ulrich BJ, Koh B, Xu C, Kharwadkar R, Chu X, Wang Y, Gao H, Wu W, Sun J, Tepper RS, Zhou B, Janga SC, Yang K, Kaplan MH., Free PMC Article | 10/24/2020 |
| STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice. | STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.
Kaltenecker D, Themanns M, Mueller KM, Spirk K, Golob-Schwarzl N, Friedbichler K, Kenner L, Haybaeck J, Moriggl R. | 08/29/2020 |
| STAT5B appears to mediate GH signalling in skeletal muscles of males at all ages, but only until puberty in females. STAT5B also appears to mediate the actions of androgens and oestrogens in both males and females, but sexually dimorphic growth persists in STAT5B(-/-) mice. | Regulation of murine skeletal muscle growth by STAT5B is age- and sex-specific.
Paul RG, Hennebry AS, Elston MS, Conaglen JV, McMahon CD., Free PMC Article | 05/9/2020 |
| data suggest that JAK and Aurora kinase inhibitors should be further explored as potential therapeutics for lymphoma and leukemia patients with the STAT5BN642H mutation who respond poorly to conventional chemotherapy. | STAT5BN642H is a driver mutation for T cell neoplasia.
Pham HTT, Maurer B, Prchal-Murphy M, Grausenburger R, Grundschober E, Javaheri T, Nivarthi H, Boersma A, Kolbe T, Elabd M, Halbritter F, Pencik J, Kazemi Z, Grebien F, Hengstschläger M, Kenner L, Kubicek S, Farlik M, Bock C, Valent P, Müller M, Rülicke T, Sexl V, Moriggl R., Free PMC Article | 05/11/2019 |
| study enables us to conclude that beta-cell stress is aggravated by the incapability of STAT5B to induce Nos2 resulting in HO accumulation and the ensuing oxidative stress enhances beta-cell damage. | Transcriptional Regulation of Nos2 via STAT5B Binding to Nos2 Gene Promoter Mediates Nitric Oxide Production: Relevance in β-Cell Maintenance.
Joseph A, Nair LCR, Johnson BS, Thomas PL, Padmanabhan RA, Puthumadathil N, Laloraya M. | 03/9/2019 |
| Study used a gene expression biomarker that can accurately predict the activation status of the oxidant-induced transcription factor Nrf2 in a microarray database and uncovered a strong linkage between increased Nrf2 activity and feminization of the male liver mediated by suppression of STAT5b. Examination of female versus male comparisons showed that Nrf2 is subtly but reproducibly activated to higher levels in females. | Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor.
Rooney J, Oshida K, Vasani N, Vallanat B, Ryan N, Chorley BN, Wang X, Bell DA, Wu KC, Aleksunes LM, Klaassen CD, Kensler TW, Corton JC., Free PMC Article | 01/26/2019 |
| NK cell numbers are decreased in Stat5a-Stat5b tetramer-deficient double knockin mice, but the mechanism was not investigated. Here we show that STAT5 dimers are sufficient for NK cell development, whereas STAT5 tetramers mediate NK cell maturation and the expression of maturation-associated genes | Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells.
Lin JX, Du N, Li P, Kazemian M, Gebregiorgis T, Spolski R, Leonard WJ., Free PMC Article | 09/8/2018 |
| Study investigated whether RGS4 could participate in signalling pathways to regulate neurotropic events. These observations suggest that RGS4 is implicated in opioid dependent neuronal differentiation and neurite outgrowth via a "non-canonical" signaling pathway regulating STAT5B-directed responses. | A novel regulatory role of RGS4 in STAT5B activation, neurite outgrowth and neuronal differentiation.
Pallaki P, Georganta EM, Serafimidis I, Papakonstantinou MP, Papanikolaou V, Koutloglou S, Papadimitriou E, Agalou A, Tserga A, Simeonof A, Thomaidou D, Gaitanou M, Georgoussi Z. | 05/5/2018 |
| STAT5B is a crucial regulator of RICD in memory T cells in mice | STAT5B: A Differential Regulator of the Life and Death of CD4(+) Effector Memory T Cells.
Majri SS, Fritz JM, Villarino AV, Zheng L, Kanellopoulou C, Chaigne-Delalande B, Grönholm J, Niemela JE, Afzali B, Biancalana M, Pittaluga S, Sun A, Cohen JL, Holland SM, O'Shea JJ, Uzel G, Lenardo MJ., Free PMC Article | 01/6/2018 |
| Our work is the first to report that an active form of Stat5b restored DCs tolerogenic functions that re-educated Tregs to re-establish and to sustain long-term protective immune response against diabetes in NOD mice. | Constitutively active Stat5b signaling confers tolerogenic functions to dendritic cells of NOD mice and halts diabetes progression.
Zerif E, Maalem A, Gaudreau S, Guindi C, Ramzan M, Véroneau S, Gris D, Stankova J, Rola-Pleszczynski M, Mourad W, Dupuis G, Amrani A. | 12/23/2017 |
| Instead, we find that STAT5B is dominant over STAT5A in CD4(+) 'helper' T cells for both effector and regulatory (Treg) responses and, therefore, uniquely necessary for immunological tolerance. | Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.
Villarino A, Laurence A, Robinson GW, Bonelli M, Dema B, Afzali B, Shih HY, Sun HW, Brooks SR, Hennighausen L, Kanno Y, O'Shea JJ., Free PMC Article | 11/18/2017 |
| STAT5 signaling axis drives abnormal cell proliferation in autosomal dominant polycystic kidney disease. | STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease.
Fragiadaki M, Lannoy M, Themanns M, Maurer B, Leonhard WN, Peters DJ, Moriggl R, Ong AC. | 11/4/2017 |
| These studies establish the importance of STAT5 in macrophages during ductal morphogenesis in the mammary gland and demonstrate that altering STAT5 function in macrophages can affect the development of tissue-specific disease. | STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.
Brady NJ, Farrar MA, Schwertfeger KL., Free PMC Article | 10/7/2017 |
| Data indicate that 89% of signal transducer and activator of transcription 5 (Stat5b)-CA mice in which the T2/Onc transposon had been mobilized died of progenitor B-cell acute lymphoblastic leukemia (B-ALL) by 3 months of age. | Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.
Heltemes-Harris LM, Larson JD, Starr TK, Hubbard GK, Sarver AL, Largaespada DA, Farrar MA., Free PMC Article | 09/16/2017 |