| An N-terminal fusion allele to study melanin concentrating hormone receptor 1. | An N-terminal fusion allele to study melanin concentrating hormone receptor 1.
Jasso KR, Kamba TK, Zimmerman AD, Bansal R, Engle SE, Everett T, Wu CH, Kulaga H, Reed RR, Berbari NF, McIntyre JC., Free PMC Article | 02/19/2022 |
| Transcriptome analysis of ciliary-dependent MCH signaling in differentiating 3T3-L1 pre-adipocytes. | Transcriptome analysis of ciliary-dependent MCH signaling in differentiating 3T3-L1 pre-adipocytes.
Cook LB, Ophardt HD, Shen R, Pratt BH, Galbier LA., Free PMC Article | 12/18/2021 |
| The Transition Zone Protein AHI1 Regulates Neuronal Ciliary Trafficking of MCHR1 and Its Downstream Signaling Pathway. | The Transition Zone Protein AHI1 Regulates Neuronal Ciliary Trafficking of MCHR1 and Its Downstream Signaling Pathway.
Hsiao YC, Muñoz-Estrada J, Tuz K, Ferland RJ., Free PMC Article | 11/22/2021 |
| Properties of primary cilia in melanin-concentrating hormone receptor 1-bearing hippocampal neurons in vivo and in vitro. | Properties of primary cilia in melanin-concentrating hormone receptor 1-bearing hippocampal neurons in vivo and in vitro.
Kobayashi Y, Okada T, Miki D, Sekino Y, Koganezawa N, Shirao T, Diniz GB, Saito Y. | 10/30/2021 |
| Ciliary melanin-concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex-independent manner. | Ciliary melanin-concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex-independent manner.
Diniz GB, Battagello DS, Klein MO, Bono BSM, Ferreira JGP, Motta-Teixeira LC, Duarte JCG, Presse F, Nahon JL, Adamantidis A, Chee MJ, Sita LV, Bittencourt JC. | 09/18/2021 |
| MCHR1 deletion from GABAergic neurons, specifically those within the accumbens nucleus, also led to increased locomotor activity. A hyperdopaminergic state underlies this increased locomotor activity, and is consistent with our finding that MCH signaling within the accumbens nucleus suppresses dopamine release. | Conditional deletion of melanin-concentrating hormone receptor 1 from GABAergic neurons increases locomotor activity.
Chee MJ, Hebert AJ, Briançon N, Flaherty SE 3rd, Pissios P, Maratos-Flier E., Free PMC Article | 05/30/2020 |
| This study demonstrated that the Neurochemical Heterogeneity Among Lateral Hypothalamic Melanin-Concentrating Hormone Neurons. | Neurochemical Heterogeneity Among Lateral Hypothalamic Hypocretin/Orexin and Melanin-Concentrating Hormone Neurons Identified Through Single-Cell Gene Expression Analysis.
Mickelsen LE, Kolling FW 4th, Chimileski BR, Fujita A, Norris C, Chen K, Nelson CE, Jackson AC., Free PMC Article | 06/2/2018 |
| following pups retrieval, MCHR1 knockout mice display a lower level of Fos expression than wild type mice in the ventral tegmental area, and nucleus accumbens | Inactivation of the melanin concentrating hormone system impairs maternal behavior.
Alachkar A, Alhassen L, Wang Z, Wang L, Onouye K, Sanathara N, Civelli O., Free PMC Article | 01/27/2018 |
| This study showed that KO of mchr1 mice had significantly higher levels of both punished and non-punished food maintained responding. | Consequences of constitutive deletion of melanin-concentrating hormone-1 receptors for feeding and foraging behaviors of mice.
Eiler WJ 2nd, Chen Y, Slieker LJ, Ardayfio PA, Statnick MA, Witkin JM. | 11/25/2017 |
| MCH1-Rs regulate the rewarding properties of alcohol through interactions with signaling cascades in the nucleus accumbens shell. | The melanin-concentrating hormone-1 receptor modulates alcohol-induced reward and DARPP-32 phosphorylation.
Karlsson C, Rehman F, Damadzic R, Atkins AL, Schank JR, Gehlert DR, Steensland P, Thorsell A, Heilig M. | 02/18/2017 |
| The present work is the first study to systematically compare the effects of MCH signaling on behavioral and metabolic phenotypes.[Meta-analysis] | Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypes.
Takase K, Kikuchi K, Tsuneoka Y, Oda S, Kuroda M, Funato H., Free PMC Article | 12/19/2015 |
| This study supports the use of the Mchr1-cre mouse for outlining the neuroanatomical distribution and neurochemical phenotype of MCHR1 neurons. | Neurochemical characterization of neurons expressing melanin-concentrating hormone receptor 1 in the mouse hypothalamus.
Chee MJ, Pissios P, Maratos-Flier E., Free PMC Article | 11/16/2013 |
| This study demonistrated that lack of MCH receptor provoked a ventricular size increase and beat frequency of ependymal cilia. | Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.
Conductier G, Brau F, Viola A, Langlet F, Ramkumar N, Dehouck B, Lemaire T, Chapot R, Lucas L, Rovère C, Maitre P, Hosseiny S, Petit-Paitel A, Adamantidis A, Lakaye B, Risold PY, Prévot V, Meste O, Nahon JL, Guyon A. | 09/7/2013 |
| Mchr1 and Sstr3 are expressed and colocalized within cilia in multiple mouse brain regions, and they form heteromers. | Heteromerization of ciliary G protein-coupled receptors in the mouse brain.
Green JA, Gu C, Mykytyn K., Free PMC Article | 02/23/2013 |
| Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function | Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function.
Chung S, Liao XH, Di Cosmo C, Van Sande J, Wang Z, Refetoff S, Civelli O., Free PMC Article | 02/2/2013 |
| The elevated basal body temperature and reduction in NREM sleep time resulting from shorter NREM episode durations observed in knockout mice suggests that central MCH(1) receptor has a role in thermoregulation and presumably stabilization of NREM sleep. | Contribution of melanin-concentrating hormone (MCH1) receptor to thermoregulation and sleep stabilization: evidence from MCH1 (-/-) mice.
Ahnaou A, Dautzenberg FM, Huysmans H, Steckler T, Drinkenburg WH. | 05/28/2011 |
| Data show that the melanin-concentrating hormone/MCH1R system is one of the players mediating behavioral and metabolic responses upon increased caloric consumption. | Acute homeostatic responses to increased fat consumption in MCH1R knockout mice.
Chung S, Wong T, Nagasaki H, Civelli O., Free PMC Article | 04/16/2011 |
| In melanin-concentrating hormone receptor 1 knock-out mice, long-term synaptic depression was strongly diminished in hippocampus. | Major impairments of glutamatergic transmission and long-term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor-1.
Pachoud B, Adamantidis A, Ravassard P, Luppi PH, Grisar T, Lakaye B, Salin PA., Free PMC Article | 04/2/2011 |
| The data indicate that the MCH system is involved in the regulation of PTZ and pilocarpine seizure threshold. | Mice lacking Melanin Concentrating Hormone 1 receptor are resistant to seizures.
Parks GS, Okumura SM, Gohil K, Civelli O., Free PMC Article | 01/15/2011 |
| These results demonstrate that MCH, in addition to its known role in feeding and weight regulation, plays a critical role in regulating Acb dopamine signaling and related behavioral responses. | Dysregulation of the mesolimbic dopamine system and reward in MCH-/- mice.
Pissios P, Frank L, Kennedy AR, Porter DR, Marino FE, Liu FF, Pothos EN, Maratos-Flier E. | 01/21/2010 |
| Animals with genetically inactivated melanin-concentrating hormone receptor 1 signaling exhibit altered vigilance state architecture and sleep homeostasis. | Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice.
Adamantidis A, Salvert D, Goutagny R, Lakaye B, Gervasoni D, Grisar T, Luppi PH, Fort P. | 01/21/2010 |
| Our results do not support the hypothesis of a functional contribution of MCHR1 receptors to the addictive effects of D-amphetamine | Deletion of Melanin-Concentrating Hormone Receptor-1 gene accentuates D-amphetamine-induced psychomotor activation but neither the subsequent development of sensitization nor the expression of conditioned activity in mice.
Tyhon A, Lakaye B, Grisar T, Tirelli E. | 01/21/2010 |
| a lack of ciliary localization of somatostatin receptor type 3 (Sstr3) and melanin-concentrating hormone receptor 1 (Mchr1) in neurons from mice lacking the Bbs2 or Bbs4 gene | Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia.
Berbari NF, Lewis JS, Bishop GA, Askwith CC, Mykytyn K., Free PMC Article | 01/21/2010 |
| MCH(1) receptor KO mice are hypersensitive to the behavioral and molecular effects of the dopaminergic psychostimulant d-amphetamine and Increased frontal cortical MAPK phosphorylation and c-fos expression. | Behavioral and biochemical responses to d-amphetamine in MCH1 receptor knockout mice.
Smith DG, Qi H, Svenningsson P, Wade M, Davis RJ, Gehlert DR, Nomikos GG. | 01/21/2010 |
| MCH1 receptor signalling is involved in the development of fatty liver, as well as obesity, in ovariectomized mice | Blockade of MCH1 receptor signalling ameliorates obesity and related hepatic steatosis in ovariectomized mice.
Gomori A, Ishihara A, Ito M, Matsushita H, Ito M, Mashiko S, Iwaasa H, Matsuda M, Bednarek MA, Qian S, Macneil DJ, Kanatani A., Free PMC Article | 01/21/2010 |